No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
91 |
4. Check minimum number of eventsNone |
91 |
5. Include endpointsNone |
91 |
6. Filter based on genotype QC (FinnGen only) |
91 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G91
- Name in latin
- Hydrocephalia posttraumatica non specificata
Similar endpoints
↥List of similar endpoints to
Post-traumatic hydrocephalus, unspecified
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 825 | 244 | 570 |
| Only index persons | 682 | 217 | 465 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 60.74 | 61.47 | 60.20 |
| Only index persons | 60.24 | 61.26 | 59.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 91 | 28 | 63 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 65.79 | 61.08 | 67.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 86
- Matched controls
- 861
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
123.8
86
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
60.8
51
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
29.9
27
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
26.4
24
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
22.9
21
*
AAF00
NOMESCO Finland
Ventriculostomy
+∞
21.8
20
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
26.3
21.5
30
17
T90.5
ICD-10 Finland
Sequelae of intracranial injury
96.8
20.8
22
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
19.5
18
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
19.5
18
*
AA1AD
NOMESCO Finland
CT of head and brain
8.1
17.6
51
130
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
18.1
17.2
27
21
ZXD05
NOMESCO Finland
Urgent procedure
6.9
15.7
57
190
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.8
13.3
54
193
AA1AA
NOMESCO Finland
Head X-ray examination
82.3
13.0
14
*
S06.3
ICD-10 Finland
Focal brain injury
44.7
12.7
15
*
ZXE10
NOMESCO Finland
More than one and less than three hours
5.4
12.3
52
189
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
11.7
11
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
11.7
11
*
L28
ICPC
Limited function/disability (L)
6.0
10.4
32
77
S06.2
ICD-10 Finland
Diffuse brain injury
25.1
9.7
13
6
N06AB04
ATC
citalopram; systemic
5.5
9.6
31
79
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
55.8
8.9
10
*
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
16.7
8.5
13
9
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
8.5
8
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
8.5
8
*
N18
ICPC
Paralysis/weakness
24.9
8.2
11
5
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.8
7.7
15
18
K90
ICPC
Stroke/cerebrovascular accident
12.5
7.6
13
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.8
7.5
27
75
Z2445
NOMESCO Finland
Psychologist
17.7
7.4
11
7
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.0
7.4
18
31
WX730
NOMESCO Finland
Conventional respirator
+∞
7.4
7
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
7.4
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.6
7.3
27
77
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
6.3
7.2
19
37
TAB00
NOMESCO Finland
Lumbar puncture
15.5
7.1
11
8
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
7.0
7.1
17
29
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.1
7.0
30
99
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
75.1
6.5
7
*
N99
ICPC
Neurological disease other
75.1
6.5
7
*
X59
ICD-10 Finland
Exposure to unspecified factor
4.3
6.5
25
74
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCPOSTRAU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCPOSTRAU | 3.131 [2.25, 4.35] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.551 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 207 females with G6_HCPOSTRAU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCPOSTRAU | 4.172 [3.17, 5.49] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 486 males with G6_HCPOSTRAU died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCPOSTRAU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.262% | 0.89% |
| 5 | 1.526% | 4.357% |
| 10 | 4.536% | 10.32% |
| 15 | 9.383% | 18.425% |
| 20 | 16.445% | 30.377% |
Relationships between endpoints
↥Index endpoint: G6_HCPOSTRAU – Post-traumatic hydrocephalus, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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