Post-traumatic hydrocephalus, unspecified

G6_HCPOSTRAU

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G91.3 Cause of death: ICD-10 — G91.3 2 out of 7 registries used, show all original rules.	91
4. Check minimum number of events None	91
5. Include endpoints None	91
6. Filter based on genotype QC (FinnGen only)	91

Control definitions (FinnGen only)

Control exclude: G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G91
Name in latin: Hydrocephalia posttraumatica non specificata

NAME	G6_HCPOSTRAU
CONTROL_EXCLUDE	G6_HYDROCEPH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G913
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G913
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Post-traumatic hydrocephalus, unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	825	244	570
Only index persons	682	217	465
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.02
Only index persons	0.01	0.01	0.02
Median age at first event (years)
Whole population	60.74	61.47	60.20
Only index persons	60.24	61.26	59.77

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	91	28	63
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	65.79	61.08	67.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
86: Matched controls
861

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G91.3

ICD-10 Finland

Post-traumatic hydrocephalus, unspecified

+∞

123.8

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

+∞

60.8

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

+∞

29.9

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

+∞

26.4

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

22.9

AAF00

NOMESCO Finland

Ventriculostomy

+∞

21.8

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

26.3

21.5

T90.5

ICD-10 Finland

Sequelae of intracranial injury

96.8

20.8

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

+∞

19.5

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

+∞

19.5

AA1AD

NOMESCO Finland

CT of head and brain

8.1

17.6

130

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

18.1

17.2

ZXD05

NOMESCO Finland

Urgent procedure

6.9

15.7

190

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

5.8

13.3

193

AA1AA

NOMESCO Finland

Head X-ray examination

82.3

13.0

S06.3

ICD-10 Finland

Focal brain injury

44.7

12.7

ZXE10

NOMESCO Finland

More than one and less than three hours

5.4

12.3

189

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

+∞

11.7

AAF15

NOMESCO Finland

Ventriculoatrial shunt

+∞

11.7

L28

ICPC

Limited function/disability (L)

6.0

10.4

S06.2

ICD-10 Finland

Diffuse brain injury

25.1

9.7

N06AB04

ATC

citalopram; systemic

5.5

9.6

S06.6

ICD-10 Finland

Traumatic subarachnoid haemorrhage

55.8

8.9

AAD10

NOMESCO Finland

Evacuation of chronic subdural haematoma

16.7

8.5

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

+∞

8.5

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

8.5

N18

ICPC

Paralysis/weakness

24.9

8.2

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

9.8

7.7

K90

ICPC

Stroke/cerebrovascular accident

12.5

7.6

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.8

7.5

Z2445

NOMESCO Finland

Psychologist

17.7

7.4

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.0

7.4

WX730

NOMESCO Finland

Conventional respirator

+∞

7.4

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

+∞

7.4

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.6

7.3

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

6.3

7.2

TAB00

NOMESCO Finland

Lumbar puncture

15.5

7.1

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

7.0

7.1

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

4.1

7.0

AAD05

NOMESCO Finland

Evacuation of acute subdural haematoma

75.1

6.5

N99

ICPC

Neurological disease other

75.1

6.5

X59

ICD-10 Finland

Exposure to unspecified factor

4.3

6.5

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

17.01

19.93

2.0

1.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

41.18

14.08

1.9

1.6

—

(3016018) Differential panel - Cerebral spinal fluid

18.47

6.91

1.8

1.3

—

(3023410) Appearance of Cerebral spinal fluid

10.69

4.08

2.7

1.3

—

(3018418) pH of Serum or Plasma

177

2.25

3.14

4.2

4.1

7.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.07

2.53

2.0

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

106

2.28

2.51

7.1

3.1

mmol/l

0.8

0.74

(3026008) Bacteria identified in Urine by Culture

199

1.94

2.21

2.6

3.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

286

1.87

2.21

7.0

5.5

mmol/l

1.2

0.06

258

(3023183) Ammonium ion [Moles/volume] in Plasma

3.94

1.97

1.7

2.2

umol/l

33.2

30.5

—

(21494755) Public health laboratory ask at order entry panel

0.00

1.76

0.0

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.14

1.61

1.2

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

111

1.90

1.54

2.2

1.9

—

(40761535) Cells panel - Urine sediment

2.19

1.51

2.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

653

0.60

1.49

4.3

5.0

mmol/l

2.4

2.6

1.29

592

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.06

1.42

4.3

4.0

—

(1761868) Lipid panel - Serum or Plasma

221

0.52

1.36

2.3

3.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

1.35

0.0

1.6

—

(3032080) INR in Blood by Coagulation assay

292

1.59

1.31

6.1

9.0

inr

1.2

1.3

0.28

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

331

1.57

1.27

7.5

6.0

mmol/l

1.2

0.06

280

(3003458) Phosphate [Moles/volume] in Serum or Plasma

103

1.80

1.23

8.7

4.6

mmol/l

0.9

1.0

0.67

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

632

0.64

1.20

4.1

4.4

mmol/l

1.3

1.4

0.57

574

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

280

0.59

1.19

3.6

4.4

17.7

20.9

—

131

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

1.19

0.0

2.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

631

0.65

1.18

4.6

4.8

mmol/l

5.7

6.0

1.46

572

(3020961) Endomysium IgA Ab [Titer] in Serum

0.00

1.17

0.0

1.1

—

(3009542) Hematocrit [Volume Fraction] of Blood

582

0.66

1.14

31.6

15.5

39.9

0.00

399

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.84

1.13

2.3

1.8

—

(3029937) Albumin [Presence] in Urine by Test strip

185

1.57

1.05

4.3

3.7

estimate

0.0

0.00

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

634

0.67

1.04

4.1

4.5

mmol/l

4.1

4.5

2.01

581

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

297

1.48

1.00

3.5

4.1

ng/l

57.9

67.1

0.10

223

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.99

0.0

4.1

—

436.6

—

(40768443) Skin Pathology biopsy report

0.00

0.99

0.0

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.99

0.0

5.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.99

0.0

1.8

—

43.3

—

(3021589) Normoblasts [#/volume] in Blood

308

1.47

0.97

10.0

e9/l

0.0

0.62

253

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

602

0.68

0.97

5.6

6.3

mmol/mol

40.6

41.1

0.15

549

(40768804) Tissue Pathology biopsy report

246

0.62

0.96

1.9

2.1

—

(3022313) Gas panel - Capillary blood

2.14

0.91

4.3

4.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.73

0.90

2.3

1.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

617

0.69

0.89

4.3

4.0

mmol/l

1.4

1.3

0.63

558

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.94

0.83

3.7

2.7

mmol/l

23.8

24.5

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.80

0.0

4.2

—

8.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.80

0.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.80

0.0

1.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.80

0.0

4.0

—

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.69

0.79

10.0

9.9

—

(3044640) Blood type and Crossmatch panel - Blood

208

1.42

0.74

5.0

2.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.81

0.73

1.6

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.72

0.72

3.0

3.7

—

(36304419) Bacteria [Presence] in Urine

196

1.38

0.62

4.0

2.7

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.61

0.0

1.3

—

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.7

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.61

0.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

403

0.75

0.61

15.8

8.6

e9/l

4.9

4.3

0.64

348

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.60

0.0

1.2

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.60

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.60

0.0

1.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

272

1.33

0.59

3.9

3.0

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.59

0.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.59

0.0

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

145

1.39

0.54

3.5

2.3

—

(42870588) Differential panel, method unspecified - Blood

230

0.73

0.52

9.8

5.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

151

0.69

0.47

6.4

5.5

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

213

0.75

0.43

5.1

2.9

u/l

27.9

29.2

0.24

201

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

3.1

—

(3019225) pH of Specimen

1.36

0.41

4.1

4.9

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.40

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.40

0.0

1.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.40

0.0

1.7

—

2.4

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.40

0.0

1.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

157

0.73

0.40

1.1

1.6

mmol/l

1.7

1.3

—

129

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.39

0.0

1.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.39

0.0

3.6

—

4.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.2

—

0.2

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.39

0.0

3.6

—

105.7

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.39

0.0

1.5

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.39

0.0

3.6

—

(3022145) Colonoscopy Study observation

1.34

0.38

1.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

277

1.24

0.38

2.1

2.0

pmol/l

94.9

93.1

0.09

143

(40768797) Stomach Pathology biopsy report

1.38

0.38

1.5

1.3

—

(3023368) Bacteria identified in Blood by Culture

220

1.25

0.37

9.0

4.4

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

1.30

0.37

2.8

3.4

kpa

6.1

5.8

—

(3000494) Fungus identified in Specimen by Culture

0.62

0.37

2.6

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

137

1.30

0.35

5.3

3.1

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.72

0.33

5.9

3.8

u/l

194.6

237.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.40

0.32

1.3

2.2

—

(3000991) Gas panel - Venous blood

1.35

0.31

11.0

6.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.32

0.31

1.4

1.6

—

(3044889) 12 lead EKG panel

478

0.85

0.29

4.9

4.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.34

0.27

3.5

1.4

—

(3012544) pH of Venous blood

1.28

0.27

2.9

3.6

—

(3013707) Erythrocyte sedimentation rate by Westergren method

494

0.86

0.25

3.5

4.2

mm/h

11.9

12.3

0.06

448

(3019198) Lymphocytes [#/volume] in Blood

343

0.85

0.24

11.7

5.4

e9/l

2.0

1.9

0.08

306

(3035350) Ketones [Presence] in Urine by Test strip

328

1.16

0.24

4.3

3.6

estimate

0.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.9

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

2.7

—

4.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

2.7

—

57.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.20

0.0

1.1

—

(3019060) Gas panel - Arterial blood

1.19

0.20

5.2

3.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

264

1.14

0.19

4.1

3.8

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.25

0.18

10.0

5.6

kpa

4.8

5.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.25

0.18

10.0

5.6

kpa

13.5

11.1

—

(3001604) Monocytes [#/volume] in Blood

336

0.88

0.17

11.5

5.4

e9/l

0.6

0.08

291

(3013115) Eosinophils [#/volume] in Blood

346

0.88

0.17

12.0

5.7

e9/l

0.2

0.07

304

(3006315) Basophils [#/volume] in Blood

335

0.89

0.16

12.1

5.5

e9/l

0.0

0.47

292

(3020564) Creatinine [Moles/volume] in Serum or Plasma

701

0.88

0.15

28.1

17.8

umol/l

78.3

84.3

0.76

701

(3009261) Glucose [Presence] in Urine by Test strip

337

1.11

0.14

4.3

3.6

estimate

0.0

0.00

(3037467) Urinalysis macro (dipstick) panel - Urine

447

1.11

0.14

4.6

4.4

—

(3012516) Albumin [Mass/volume] in Urine

189

0.88

0.13

3.2

mg/l

46.0

367.9

0.55

136

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

591

0.90

0.13

4.5

4.3

mu/l

1.7

2.1

1.59

519

(3002385) Erythrocyte distribution width [Ratio]

550

0.91

0.12

27.6

18.3

14.0

13.8

0.33

535

(3013512) EKG study

218

0.89

0.11

4.0

4.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

207

0.90

0.11

3.7

4.0

mg/mmol

4.6

9.8

0.95

141

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

302

1.09

0.10

5.1

4.0

—

(3022621) pH of Urine by Test strip

1.17

0.10

2.4

2.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

332

1.09

0.10

4.9

estimate

0.0

0.00

(3042936) Bacteria identified in Isolate by Culture

107

1.14

0.09

4.5

2.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

275

0.92

0.08

3.3

2.5

ug/l

129.1

119.5

0.15

250

(3002256) Pathology report gross observation

0.80

0.08

1.5

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.07

0.07

1.5

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.07

0.07

1.3

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

621

0.95

0.04

20.7

15.0

ml/min/173m2

84.9

78.1

1.43

508

(40758558) Short blood count panel - Blood

170

1.07

0.04

16.7

6.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

200

0.94

0.04

3.1

3.6

—

(40761511) CBC panel - Blood by Automated count

693

1.04

0.01

19.3

14.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

234

1.03

0.00

2.5

3.2

ng/l

2130.8

1799.4

0.15

191

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

354

1.03

0.00

2.8

2.9

—

(3003694) ABO and Rh group [Type] in Blood

163

0.98

0.00

1.4

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

467

1.01

0.00

3.7

3.6

pmol/l

15.0

14.8

0.25

407

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

671

0.99

0.00

26.0

15.4

mg/l

26.2

25.7

0.04

544

(46235355) HIV 1 and 2 tests - Meaningful Use set

101

0.99

0.00

1.8

1.7

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

3.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

80.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

2.2

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

2.2

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.94

0.00

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

2.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

2.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.6

—

13.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

0.89

0.00

2.2

3.1

ng/l

75.4

270.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

4.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.1

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.6

—

149.8

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.7

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.1

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.5

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

3.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.3

—

(4306422)

0.00

0.0

1.2

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

2.3

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.9

—

14.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.2

—

180.6

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.98

0.00

2.2

2.0

g/l

9.5

8.9

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.0

1.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.4

—

(4027681)

0.00

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.1

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.9

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

8.6

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.2

—

32.1

—

(4268621)

0.00

0.0

1.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.5

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCPOSTRAU and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HCPOSTRAU	3.131 [2.25, 4.35]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.551

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 207 females with G6_HCPOSTRAU died.

Males

Parameter	HR [95% CI]	p-value
G6_HCPOSTRAU	4.172 [3.17, 5.49]	< 0.001
Birth year	0.983 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 486 males with G6_HCPOSTRAU died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCPOSTRAU.

N-year risk	Females	Males
1	0.262%	0.89%
5	1.526%	4.357%
10	4.536%	10.32%
15	9.383%	18.425%
20	16.445%	30.377%

Relationships between endpoints

↥

Index endpoint: G6_HCPOSTRAU – Post-traumatic hydrocephalus, unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Post-traumatic hydrocephalus, unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints