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Other and unspecified hydrocephalus

DOID EFO Endpoint Browser PheWeb

G6_HCOTHUNS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G91.8, G91.9
  • Hospital discharge: ICD-8 — 34793
  • Cause of death: ICD-10 — G91.8, G91.9
  • Cause of death: ICD-8 — 34793

2 out of 7 registries used, show all original rules.

665

4. Check minimum number of events

None

665

5. Include endpoints

None

665

6. Filter based on genotype QC (FinnGen only)

665

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6159 3013 3080
Only index persons 4640 2370 2270
Unadjusted period prevalence (%)
Whole population 0.09 0.09 0.09
Only index persons 0.09 0.09 0.09
Median age at first event (years)
Whole population 56.12 58.51 53.59
Only index persons 54.55 57.40 51.57

-FinnGen-

Key figures

All Female Male
Number of individuals 665 366 299
Unadjusted period prevalence (%) 0.13 0.12 0.13
Median age at first event (years) 60.24 58.65 62.20

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
611
Matched controls
6108
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
323.0
302
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
323.0
503
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
291.8
256
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
180.4
164
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
179.2
163
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
164.2
150
*
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
134.5
124
*
AAF00
NOMESCO Finland
Ventriculostomy
285.6
117.3
116
5
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
110.9
103
*
AA1AD
NOMESCO Finland
CT of head and brain
7.3
106.3
341
900
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
96.5
90
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
81.1
76
*
AA1AA
NOMESCO Finland
Head X-ray examination
74.1
79.0
89
14
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
14.4
73.1
129
111
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
61.5
58
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
649.3
60.8
59
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.2
52.8
140
243
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
56.6
44.4
52
10
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.3
44.4
128
245
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.2
43.8
129
253
R51.80
ICD-10 Finland
Headache
4.6
41.2
165
456
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
40.0
38
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
30.4
39.7
53
19
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
401.3
38.5
38
*
ZXD05
NOMESCO Finland
Urgent procedure
3.1
35.2
270
1245
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
13.1
30.3
54
45
N03AX14
ATC
levetiracetam; systemic
9.7
29.9
62
70
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
28.3
27
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.1
28.0
94
210
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
43.5
27.0
33
8
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
26.5
156
575
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.5
26.5
83
171
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
26.2
25
*
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
26.2
25
*
N03AG01
ATC
valproic acid; systemic, rectal
5.2
24.9
81
174
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
24.4
275
1505
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.7
24.4
64
105
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
9.9
23.2
47
51
2132
FHL
Ventricular operators sunt
+∞
22.0
21
*
G04BD07
ATC
tolterodine; oral
5.1
21.7
71
153
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.4
21.4
42
43
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
21.1
137
533
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
21.0
20
*
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
19.9
19
*
G93.0
ICD-10 Finland
Cerebral cysts
76.1
19.8
22
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.5
19.2
51
85
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
6.0
18.1
51
92
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
20.8
17.9
26
13
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
17.9
198
1034
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
17.8
17
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
17.8
17
*
TAB00
NOMESCO Finland
Lumbar puncture
5.1
17.8
57
120
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
17.8
138
596
XA800
NOMESCO Finland
Neuropsychological investigation
5.2
17.2
54
111
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
16.5
17.2
27
17
L28
ICPC
Limited function/disability (L)
2.7
17.1
136
592
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
18.0
17.1
26
15
2133
FHL
Suntin revisio
+∞
16.7
16
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
+∞
16.7
16
*
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
174.5
16.6
17
*
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
11.6
16.4
30
27
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
16.0
219
1250
R42
ICD-10 Finland
Dizziness and giddiness
2.3
15.9
177
918
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
15.7
15
*
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
87.4
15.6
17
*
F03
ICD-10 Finland
Unspecified dementia
4.2
15.3
59
151
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
8.8
15.2
32
38
R53
ICD-10 Finland
Malaise and fatigue
2.4
15.1
156
776
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
10.4
15.1
29
29
N05AH04
ATC
quetiapine; oral
2.7
14.9
115
487
A28
ICPC
Limited function/disability NOS
2.4
14.7
139
662
H47.1
ICD-10 Finland
Papilloedema, unspecified
27.9
14.3
19
7
N29
ICPC
Neurological sympt/complt other
7.5
14.2
33
46
G04BD08
ATC
solifenacin; oral
3.5
14.2
68
210
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
10.4
14.1
27
27
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
14.1
135
645
N18
ICPC
Paralysis/weakness
7.0
13.9
34
51
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.0
13.8
57
155
N05AX08
ATC
risperidone; systemic
3.3
13.7
71
233
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
76.9
13.6
15
*
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
76.9
13.6
15
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
11.3
13.6
25
23
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
13.6
13
*
G91
ICD-10 Finland
Hydrocephalus
+∞
13.6
13
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
8.0
13.5
30
39
U04
ICPC
Incontinence urine
4.3
13.5
50
123
N30.0
ICD-10 Finland
Acute cystitis
2.5
13.3
112
500
T90.5
ICD-10 Finland
Sequelae of intracranial injury
15.5
13.2
21
14
A06AD11
ATC
lactulose; oral
2.4
12.9
117
541
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
20.6
12.5
18
9
N06AB04
ATC
citalopram; systemic
2.2
12.5
144
750
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
12.4
82
315
G04BD12
ATC
mirabegron; oral
2.8
12.2
81
313
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.4
12.0
59
186
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
47.6
11.9
14
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
9.2
11.8
24
27
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
9.2
11.8
24
27
N05BA01
ATC
diazepam; systemic, rectal
2.4
11.7
103
469
N05BA09
ATC
clobazam; oral
12.9
11.7
20
16
2130
FHL
Ventricular atrial shunt
+∞
11.5
11
*
N03AB02
ATC
phenytoin; systemic
8.1
11.5
25
32
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
35.7
11.3
14
*
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
35.7
11.3
14
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
11.2
64
225
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.0
11.2
30
52
SPAT1216
SPAT
Assessment of functional ability
2.2
11.1
123
627
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
12.2
10.9
19
16
N03AF02
ATC
oxcarbazepine; oral
4.2
10.8
41
104
183
Kela drug reimbursment
Lamotrigin and topiramate
10.3
10.6
20
20
S06.0
ICD-10 Finland
Concussion
2.6
10.6
80
336
N05AH03
ATC
olanzapine; systemic
3.6
10.5
48
143
N28
ICPC
Limited function/disability (N)
6.6
10.4
26
41
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.7
10.4
71
279
P20
ICPC
Memory disturbance
2.3
10.2
102
490
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
10.2
136
746
SPAT1229
SPAT
Assessment of need for aid
2.7
10.2
71
284
SPAT1301
SPAT
No procedures
1.8
10.1
208
1339
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
10.0
66
254
N03AF01
ATC
carbamazepine; oral, rectal
3.5
10.0
46
138
G04BD04
ATC
oxybutynin; oral, transdermal
3.2
10.0
52
172
R11
ICD-10 Finland
Nausea and vomiting
2.7
10.0
69
274
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.6
9.9
73
301
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.7
9.9
33
74
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
26.5
9.8
13
5
GBB00
NOMESCO Finland
Tracheostomy
10.9
9.8
18
17
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
6.0
9.8
26
45
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
13.7
9.7
16
12
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.7
72
299
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.9
9.7
39
105
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
9.7
109
555
SPAT1262
SPAT
Handing over of treatment supplies
2.1
9.6
119
634
G41.9
ICD-10 Finland
Status epilepticus, unspecified
17.9
9.4
14
8
N06AX11
ATC
mirtazapine; oral
1.8
9.4
189
1203
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
12.6
9.4
16
13
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
9.4
9
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
9.4
9
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
+∞
9.4
9
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
9.4
9
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
+∞
9.4
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
9.4
115
605
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
9.3
40
922
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.3
9.3
87
407
N03AX18
ATC
lacosamide; systemic
11.7
9.1
16
14
N03AX09
ATC
lamotrigine; oral
3.8
9.1
38
106
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.3
9.1
45
144
H47.2
ICD-10 Finland
Optic atrophy
15.9
9.1
14
9
H53.4
ICD-10 Finland
Visual field defects
5.2
9.0
27
54
G81.1
ICD-10 Finland
Spastic hemiplegia
37.3
9.0
11
*
R50.9
ICD-10 Finland
Fever, unspecified
2.2
9.0
99
501
ZXC86
NOMESCO Finland
Use of endoscopic device
18.9
9.0
13
7
R41.0
ICD-10 Finland
Disorientation, unspecified
4.1
8.9
33
83
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
8.8
8.8
18
21
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
10.9
8.8
16
15
N06DA02
ATC
donepezil; oral
2.9
8.8
52
188
R32
ICD-10 Finland
Unspecified urinary incontinence
4.5
8.7
30
70
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
50.7
8.7
10
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
8.6
61
245
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.6
8.6
64
265
WX402
NOMESCO Finland
General anaesthesia
2.1
8.5
96
489
K90
ICPC
Stroke/cerebrovascular accident
3.9
8.4
33
88
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
8.3
8
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
8.3
164
1031
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
7.2
8.3
19
27
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
8.2
91
461
N02BE01
ATC
paracetamol; systemic, rectal
1.8
8.1
502
4371
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
33.8
8.1
10
*
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
10.2
8.1
15
15
N99
ICPC
Neurological disease other
6.7
7.9
19
29
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
7.9
79
382
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.9
180
1179
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
7.8
106
583
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.2
7.8
23
46
N02AA05
ATC
oxycodone; systemic
2.0
7.6
101
549
TJD20
NOMESCO Finland
Change of gastrostomy tube
18.6
7.6
11
6
WX730
NOMESCO Finland
Conventional respirator
6.3
7.6
19
31
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
6.3
7.6
19
31
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
25.4
7.6
10
*
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
25.4
7.6
10
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
9.0
7.6
15
17
G40.10
ICD-10 Finland
Simple partial seizures
10.2
7.6
14
14
ABE50
NOMESCO Finland
Occipitocervical decompression
81.0
7.4
8
*
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
81.0
7.4
8
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
9.5
7.3
14
15
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
9.5
7.3
14
15
AAF45
NOMESCO Finland
Fenestration of intracranial cyst
+∞
7.3
7
*
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
+∞
7.3
7
*
AAW99
NOMESCO Finland
Other intracranial operation
+∞
7.3
7
*
G44.2
ICD-10 Finland
Tension-type headache
2.1
7.3
79
396
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.4
7.3
59
256
XKC03
NOMESCO Finland
Water cystometry
4.0
7.2
27
70
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
20.3
7.1
10
5
M03BX01
ATC
baclofen; systemic
6.1
7.1
18
30
G81.9
ICD-10 Finland
Hemiplegia, unspecified
7.1
7.0
16
23
R33
ICD-10 Finland
Retention of urine
2.5
7.0
55
236
N05CF01
ATC
zopiclone; oral
1.7
6.9
192
1324
PA2AD
NOMESCO Finland
CT angiography of brain
14.0
6.9
11
8
N05AB03
ATC
perphenazine; systemic, rectal
3.6
6.9
29
83
JDB10
NOMESCO Finland
Percutaneous gastrostomy
8.4
6.9
14
17
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.8
6.8
16
24
Z2445
NOMESCO Finland
Psychologist
3.2
6.8
34
111
WX704
NOMESCO Finland
Intubation
2.6
6.8
50
205
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.6
6.8
48
196
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
6.7
34
112
N06AB10
ATC
escitalopram; oral
1.9
6.7
110
647
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
6.7
90
491
WYA20
NOMESCO Finland
Home visit
5.3
6.7
19
37
XCK00
NOMESCO Finland
Perimetry
2.6
6.7
49
201
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
7.9
6.6
14
18
J01EA01
ATC
trimethoprim; systemic
1.7
6.6
155
1018
H53.2
ICD-10 Finland
Diplopia
3.5
6.6
29
86
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.6
6.5
21
47
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
6.3
6.5
16
26
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.5
6.5
49
207
ZXD00
NOMESCO Finland
Emergency procedure
3.7
6.5
26
72
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
6.4
24
62
AAK80
NOMESCO Finland
Partial excision of skull cap
70.6
6.4
7
*
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
70.6
6.4
7
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.0
6.3
34
118
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
18.2
6.3
9
5
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
18.2
6.3
9
5
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
18.2
6.3
9
5
SPAT1053
SPAT
Memory test
1.8
6.3
106
626
N06AX16
ATC
venlafaxine; oral
2.0
6.3
76
400
R29.2
ICD-10 Finland
Abnormal reflex
+∞
6.3
6
*
2139
FHL
Other measure in this category
+∞
6.3
6
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
6.3
6
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
27.0
6.2
8
*
N30.9
ICD-10 Finland
Cystitis, unspecified
2.7
6.1
39
148
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
12.7
6.1
10
8
G03.9
ICD-10 Finland
Meningitis, unspecified
12.7
6.1
10
8
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.2
6.1
30
98
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.6
6.1
25
71

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCOTHUNS 3.018 [2.63, 3.46] < 0.001
Birth year 0.998 [0.99, 1.01] 0.569

During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2228 females with G6_HCOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_HCOTHUNS 3.131 [2.67, 3.68] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 826 out of 2254 males with G6_HCOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCOTHUNS.

N-year risk Females Males
1 0.299% 0.595%
5 2.223% 3.345%
10 5.219% 8.599%
15 10.012% 15.221%
20 16.312% 24.269%

Relationships between endpoints

↥

Index endpoint: G6_HCOTHUNS – Other and unspecified hydrocephalus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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