No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
557 |
4. Check minimum number of eventsNone |
557 |
5. Include endpointsNone |
557 |
6. Filter based on genotype QC (FinnGen only) |
557 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G91
- Name in latin
- Hydrocephalia obstructiva
Similar endpoints
↥List of similar endpoints to
Obstructive hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5759 | 2782 | 2921 |
| Only index persons | 4149 | 2069 | 2080 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 50.19 | 53.09 | 47.07 |
| Only index persons | 46.90 | 51.02 | 42.81 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 557 | 288 | 269 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | 55.11 | 52.12 | 58.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 516
- Matched controls
- 5161
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
323.0
481
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4790.4
265.4
233
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
168.1
152
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
167.0
151
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
164.6
149
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
143.6
131
*
AAF00
NOMESCO Finland
Ventriculostomy
530.0
129.0
123
*
AA1AD
NOMESCO Finland
CT of head and brain
8.4
103.1
301
735
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
14.5
99.8
182
186
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
900.0
80.7
77
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
432.9
76.9
75
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
831.8
75.2
72
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
392.5
70.4
69
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
9.4
64.0
144
203
AA1AA
NOMESCO Finland
Head X-ray examination
81.9
64.0
71
10
ZXD05
NOMESCO Finland
Urgent procedure
4.7
57.6
281
1046
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
57.4
54
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
53.0
50
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
561.5
52.4
51
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
11.0
50.0
100
110
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
33.1
45.1
59
20
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
14.9
39.4
67
51
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.2
37.9
89
127
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
36.9
35
*
R51.80
ICD-10 Finland
Headache
4.5
34.4
140
394
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.1
34.1
158
503
ZXE10
NOMESCO Finland
More than one and less than three hours
3.2
33.4
255
1200
2132
FHL
Ventricular operators sunt
+∞
30.5
29
*
N03AX14
ATC
levetiracetam; systemic
11.7
28.8
54
51
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
38.5
28.7
36
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
28.4
136
437
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
30.5
28.0
37
13
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
+∞
27.3
26
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
12.8
27.3
49
42
ZXC86
NOMESCO Finland
Use of endoscopic device
31.1
26.6
35
12
XA800
NOMESCO Finland
Neuropsychological investigation
6.8
26.2
69
115
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
25.6
195
875
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
12.6
23.9
43
37
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.8
23.3
83
199
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
23.1
22
*
2133
FHL
Suntin revisio
+∞
23.1
22
*
H47.2
ICD-10 Finland
Optic atrophy
65.5
22.0
25
*
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
22.0
21
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
21.4
127
472
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.7
20.9
49
69
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
19.3
20.7
31
17
N03AG01
ATC
valproic acid; systemic, rectal
5.3
20.6
66
140
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
19.9
19
*
N03AF02
ATC
oxcarbazepine; oral
8.3
19.7
44
57
R42
ICD-10 Finland
Dizziness and giddiness
2.8
19.2
148
647
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
19.7
18.8
28
15
L28
ICPC
Limited function/disability (L)
3.2
18.8
115
430
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.8
18.5
142
618
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
18.4
18.4
28
16
2130
FHL
Ventricular atrial shunt
+∞
17.8
17
*
XCK00
NOMESCO Finland
Perimetry
4.5
17.4
64
157
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.0
17.4
57
124
N03AB02
ATC
phenytoin; systemic
20.1
17.0
25
13
TAB00
NOMESCO Finland
Lumbar puncture
5.5
16.6
50
99
Z2445
NOMESCO Finland
Psychologist
4.9
16.5
55
122
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.0
16.2
67
184
ZXE20
NOMESCO Finland
More than three and less than five hours
2.9
16.2
110
441
H02AB02
ATC
dexamethasone; systemic
3.6
15.9
77
242
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
27.3
15.7
21
8
N28
ICPC
Limited function/disability (N)
14.3
15.7
26
19
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
10.5
15.6
30
30
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
10.2
15.4
30
31
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
24.2
15.2
21
9
ZXD35
NOMESCO Finland
Usual procedure
6.1
15.0
41
72
N18
ICPC
Paralysis/weakness
9.6
14.9
30
33
SPAT1229
SPAT
Assessment of need for aid
3.8
14.8
64
183
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
9.3
14.7
30
34
D33.07
ICD-10 Finland
Colloid coast in cerebral ventricle
+∞
14.6
14
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
82.5
14.6
16
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
14.1
64
191
N03AF01
ATC
carbamazepine; oral, rectal
4.8
14.0
47
105
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
9.5
13.9
28
31
D33.30
ICD-10 Finland
Acoustic neuroma
24.6
13.9
19
8
G91
ICD-10 Finland
Hydrocephalus
+∞
13.6
13
*
K90
ICPC
Stroke/cerebrovascular accident
6.5
13.6
35
57
183
Kela drug reimbursment
Lamotrigin and topiramate
13.3
13.5
23
18
C71.60
ICD-10 Finland
Malignant tumor of cerebellum without histology
143.5
13.5
14
*
ZXA00
NOMESCO Finland
Right side
2.2
13.3
161
870
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
41.2
13.2
16
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.5
13.0
111
503
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
5.6
12.8
37
70
AA1BD
NOMESCO Finland
Extensive CT of head and brain
6.0
12.8
35
62
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.0
12.7
51
137
AAA10
NOMESCO Finland
Biopsy through craniotomy
71.6
12.6
14
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
71.6
12.6
14
*
H53.2
ICD-10 Finland
Diplopia
6.1
12.6
34
59
G81.1
ICD-10 Finland
Spastic hemiplegia
133.0
12.5
13
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
12.0
12.4
22
19
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
9.3
12.4
25
28
H02AB09
ATC
hydrocortisone; systemic
7.7
12.4
28
38
G93.0
ICD-10 Finland
Cerebral cysts
38.5
12.3
15
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
13.8
12.0
20
15
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
19.5
11.7
17
9
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
66.5
11.6
13
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
11.5
65
228
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
8.1
11.5
25
32
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
122.6
11.5
12
*
N05BA09
ATC
clobazam; oral
12.2
11.4
20
17
N29
ICPC
Neurological sympt/complt other
8.6
11.4
24
29
101
Kela drug reimbursment
Anterior pituitary hypofunction
15.5
11.4
18
12
H47.1
ICD-10 Finland
Papilloedema, unspecified
25.7
11.2
15
6
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
14.3
11.0
18
13
SPAT1216
SPAT
Assessment of functional ability
2.5
11.0
95
433
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
10.9
70
266
GBB00
NOMESCO Finland
Tracheostomy
12.3
10.9
19
16
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
28.7
10.8
14
5
R11
ICD-10 Finland
Nausea and vomiting
3.1
10.6
59
204
N99
ICPC
Neurological disease other
10.3
10.6
20
20
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.0
10.5
61
219
C71.69
ICD-10 Finland
Malignant tumor of the cerebellum other or unspecified histology
+∞
10.4
10
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
10.4
10
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
13.5
10.2
17
13
H53.4
ICD-10 Finland
Visual field defects
6.7
10.1
25
39
A28
ICPC
Limited function/disability NOS
2.4
10.1
96
456
E23.00
ICD-10 Finland
Panhypopituitarism
40.9
10.0
12
*
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
40.9
10.0
12
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
40.9
10.0
12
*
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
56.0
9.7
11
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
56.0
9.7
11
*
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
56.0
9.7
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
9.7
201
1316
WX730
NOMESCO Finland
Conventional respirator
7.4
9.6
22
31
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.5
9.6
33
77
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.3
9.5
48
156
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.9
9.5
58
213
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
101.8
9.4
10
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
30.6
9.4
12
*
2139
FHL
Other measure in this category
+∞
9.4
9
*
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
9.4
9
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
22.2
9.4
13
6
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
22.2
9.4
13
6
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
9.2
64
257
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
11.7
9.1
16
14
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
11.7
9.1
16
14
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
15.9
9.1
14
9
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
37.4
9.0
11
*
G04BD07
ATC
tolterodine; oral
3.7
9.0
38
108
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
7.4
8.8
20
28
R4110
NOMESCO Finland
Physiotherapy
1.9
8.7
142
846
R1250
NOMESCO Finland
Evaluation of functional capability
6.8
8.7
21
32
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
7.8
8.7
19
25
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
7.8
8.7
19
25
130
Kela drug reimbursment
Malignant tumour
2.9
8.6
51
186
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.5
8.5
19
26
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
28.0
8.5
11
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
91.4
8.4
9
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.5
8.4
69
304
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
8.1
8.4
18
23
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
+∞
8.4
8
*
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
+∞
8.4
8
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
8.4
8
*
C71.70
ICD-10 Finland
Malignant tumor of the brainstem without histology
+∞
8.4
8
*
P20
ICPC
Memory disturbance
2.4
8.3
73
331
Z3226
NOMESCO Finland
Physiotherapist
2.1
8.3
107
581
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
7.3
8.3
19
27
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
14.8
8.2
13
9
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
8.3
8.1
17
21
R41.0
ICD-10 Finland
Disorientation, unspecified
4.5
8.1
27
62
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
8.0
60
249
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.8
8.0
33
92
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
8.0
71
326
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.6
7.9
22
41
JDB10
NOMESCO Finland
Percutaneous gastrostomy
8.6
7.9
16
19
ZXC95
NOMESCO Finland
Use of surgical navigator
9.6
7.8
15
16
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
7.7
115
660
F83
ICD-10 Finland
Mixed specific developmental disorders
7.6
7.7
17
23
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.2
7.6
16
20
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.2
7.6
16
20
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
18.7
7.6
11
6
L01AX03
ATC
temozolomide; systemic
25.4
7.6
10
*
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
25.4
7.6
10
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
10.2
7.6
14
14
H01AC01
ATC
somatropin; parenteral
10.2
7.6
14
14
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
7.5
81
406
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
13.6
7.4
12
9
R4150
NOMESCO Finland
Neuropsychological rehabilitation
13.6
7.4
12
9
A06AD11
ATC
lactulose; oral
2.2
7.4
81
410
R4120
NOMESCO Finland
Occupational therapy
2.9
7.4
44
162
ZXE00
NOMESCO Finland
One hour or less
1.7
7.3
195
1351
G40.10
ICD-10 Finland
Simple partial seizures
11.1
7.3
13
12
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
11.1
7.3
13
12
N03AX18
ATC
lacosamide; systemic
11.1
7.3
13
12
D33.7
ICD-10 Finland
Benign neoplasm: Other specified parts of central nervous system
+∞
7.3
7
*
C71.89
ICD-10 Finland
Overall malignant tumor of the brain other or unspecified histology
+∞
7.3
7
*
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
7.3
7
*
AAA50
NOMESCO Finland
Intracranial endoscopy
+∞
7.3
7
*
D33.12
ICD-10 Finland
Cerebellum
+∞
7.3
7
*
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
7.3
7
*
AAW99
NOMESCO Finland
Other intracranial operation
+∞
7.3
7
*
D33.10
ICD-10 Finland
Benign pilosytic astrocytoma of brain stem
+∞
7.3
7
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
7.3
7
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
7.3
7
*
R27.0
ICD-10 Finland
Ataxia, unspecified
16.0
7.3
11
7
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.5
7.2
24
55
WX882
NOMESCO Finland
High dependency care
3.5
7.2
32
96
TJD20
NOMESCO Finland
Change of gastrostomy tube
20.3
7.2
10
5
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.2
7.1
18
30
H50.31
ICD-10 Finland
Intermittent exotropia
12.2
7.1
12
10
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
6.9
91
497
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
5.2
6.9
20
40
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
17.0
6.8
10
6
9560/0-C72.4
ICD-O-3
Schwannoma, NOS, of acoustic nerve
22.8
6.7
9
*
K91
ICPC
Cerebrovascular disease
6.6
6.7
16
25
SPAT1252
SPAT
Overall medication plan or its review
2.8
6.6
40
150
RT150
NOMESCO Finland
NA
10.2
6.6
12
12
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
6.5
32
104
WX872
NOMESCO Finland
Intensive care
3.1
6.5
34
116
2161
FHL
Neck ligation, big brain
70.7
6.4
7
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
70.7
6.4
7
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
6.4
64
312
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
6.4
63
304
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.6
6.3
17
31
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.6
6.3
17
31
Z3231
NOMESCO Finland
Registered nurse
1.7
6.3
145
955
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
6.3
47
197
C71.6
ICD-10 Finland
Malignant neoplasm: Cerebellum
+∞
6.3
6
*
Q04.6
ICD-10 Finland
Congenital cerebral cysts
+∞
6.3
6
*
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
6.3
6
*
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
+∞
6.3
6
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
6.3
6
*
AAF45
NOMESCO Finland
Fenestration of intracranial cyst
+∞
6.3
6
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
6.3
6
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
7.2
6.3
14
20
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
27.0
6.2
8
*
N03AX09
ATC
lamotrigine; oral
3.4
6.2
28
86
H53.0
ICD-10 Finland
Amblyopia ex anopsia
7.8
6.2
13
17
XX4AW
NOMESCO Finland
NA
7.8
6.2
13
17
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.3
6.1
29
92
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
12.7
6.1
10
8
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
12.7
6.1
10
8
R1260
NOMESCO Finland
Evaluation of communicative skills
5.0
6.1
18
37
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCOBSTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOBSTR | 4.198 [3.58, 4.93] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.317 |
During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1803 females with G6_HCOBSTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCOBSTR | 4.142 [3.49, 4.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 664 out of 1881 males with G6_HCOBSTR died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCOBSTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.303% | 0.858% |
| 5 | 2.097% | 4.966% |
| 10 | 5.729% | 12.13% |
| 15 | 11.161% | 22.418% |
| 20 | 19.411% | 35.9% |
Relationships between endpoints
↥Index endpoint: G6_HCOBSTR – Obstructive hydrocephalus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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