normal pressure hydrocephalus: A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1722 |
4. Check minimum number of eventsNone |
1722 |
5. Include endpointsNone |
1722 |
6. Filter based on genotype QC (FinnGen only) |
1722 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G91
- Name in latin
- Hydrocephalia normotensiva
Similar endpoints
↥List of similar endpoints to
Normal-pressure hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8138 | 4029 | 4003 |
| Only index persons | 6703 | 3428 | 3275 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.12 | 0.11 |
| Only index persons | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 74.05 | 74.92 | 73.17 |
| Only index persons | 73.83 | 74.66 | 72.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1722 | 809 | 913 |
| Unadjusted period prevalence (%) | 0.34 | 0.28 | 0.40 |
| Median age at first event (years) | 73.21 | 73.36 | 73.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1593
- Matched controls
- 15927
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
16384.0
323.0
944
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
20.7
323.0
561
408
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
323.0
1593
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
3265.3
302.9
283
*
AA1AD
NOMESCO Finland
CT of head and brain
7.1
279.7
1014
3161
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
255.2
238
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
237.6
222
*
AA1AA
NOMESCO Finland
Head X-ray examination
90.9
236.2
260
34
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
205.8
193
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
626.9
173.8
169
*
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
+∞
167.7
158
*
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
19.7
160.7
250
149
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
131.1
124
*
AAF00
NOMESCO Finland
Ventriculostomy
161.0
127.4
133
9
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
118.2
112
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
108.7
325
635
P20
ICPC
Memory disturbance
3.8
107.0
567
2004
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
490.8
94.4
93
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.8
89.3
277
557
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
235.4
87.4
89
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
740.9
72.7
71
*
SPAT1053
SPAT
Memory test
2.9
71.4
568
2550
R42
ICD-10 Finland
Dizziness and giddiness
2.8
68.7
605
2881
SPAT1216
SPAT
Assessment of functional ability
2.9
66.3
506
2192
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.6
63.3
332
1095
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
5.8
61.5
186
355
L28
ICPC
Limited function/disability (L)
2.7
58.8
494
2243
SPAT1229
SPAT
Assessment of need for aid
3.5
57.6
305
1006
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.4
54.7
303
1031
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.7
54.4
201
478
R53
ICD-10 Finland
Malaise and fatigue
2.6
53.1
506
2442
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
50.7
443
2027
F03
ICD-10 Finland
Unspecified dementia
4.0
50.5
221
617
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.5
50.4
263
851
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
4.8
50.4
178
403
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
3.3
49.1
281
974
A28
ICPC
Limited function/disability NOS
2.5
47.8
490
2433
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
47.8
446
2106
N05AX08
ATC
risperidone; systemic
3.4
46.7
249
816
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
46.4
670
3923
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
45.5
482
2424
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
45.0
190
511
N99
ICPC
Neurological disease other
13.4
44.1
78
61
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
418.0
41.3
41
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.4
41.3
221
723
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.7
40.7
191
562
N05AH04
ATC
quetiapine; oral
2.8
40.1
295
1195
N06DX01
ATC
memantine; oral
2.9
39.7
271
1050
N06DA02
ATC
donepezil; oral
3.1
39.6
240
856
U04
ICPC
Incontinence urine
3.7
38.7
181
530
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
13.7
37.9
66
50
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
37.9
237
864
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
36.1
265
1069
SPAT1234
SPAT
Support of social functional capacity
3.4
35.7
188
605
TAB00
NOMESCO Finland
Lumbar puncture
5.4
35.5
110
214
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
35.3
579
3472
S06.0
ICD-10 Finland
Concussion
2.9
35.2
242
936
N03AG01
ATC
valproic acid; systemic, rectal
4.0
35.0
147
391
G04BD08
ATC
solifenacin; oral
3.0
34.1
213
774
G04BD07
ATC
tolterodine; oral
3.3
33.9
181
587
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
33.4
32
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
2.8
32.7
235
933
N02BE01
ATC
paracetamol; systemic, rectal
2.4
32.5
1394
11920
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.3
32.0
176
583
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
32.0
344
1696
SPAT1254
SPAT
Administration of medicine
2.2
31.1
359
1830
N28
ICPC
Limited function/disability (N)
6.8
30.7
79
121
N06AB10
ATC
escitalopram; oral
2.4
30.7
285
1304
G04BD12
ATC
mirabegron; oral
2.5
30.6
279
1263
N06AB04
ATC
citalopram; systemic
2.2
30.1
381
2020
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
29.3
28
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
29.1
338
1720
N06DA03
ATC
rivastigmine; oral, transdermal
3.2
29.0
162
541
G20
ICD-10 Finland
Parkinson disease
3.9
28.3
123
337
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.3
28.2
152
495
P70
ICPC
Dementia
4.4
28.0
106
256
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
27.2
26
*
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
6.3
27.0
73
120
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.1
26.8
109
281
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
26.1
25
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.2
25.6
140
461
M48.0
ICD-10 Finland
Spinal stenosis
2.2
25.0
303
1563
R51.80
ICD-10 Finland
Headache
2.4
24.6
220
980
SPAT1301
SPAT
No procedures
1.8
24.3
599
4018
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.2
24.0
277
1394
A04
ICPC
Weakness/tiredness general
2.1
23.9
291
1500
R1250
NOMESCO Finland
Evaluation of functional capability
5.9
23.6
67
118
N30.0
ICD-10 Finland
Acute cystitis
2.1
23.2
298
1571
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.2
23.1
130
436
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.3
23.1
124
403
N05AH03
ATC
olanzapine; systemic
3.7
22.7
104
298
F06.7
ICD-10 Finland
Mild cognitive disorder
3.6
22.7
106
309
SPAT1101
SPAT
Orthostatic test
2.8
22.4
150
564
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
6.5
21.7
57
91
K90
ICPC
Stroke/cerebrovascular accident
3.6
21.1
97
279
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
9.2
20.6
43
48
R41.0
ICD-10 Finland
Disorientation, unspecified
3.3
20.0
104
330
N29
ICPC
Neurological sympt/complt other
4.9
19.8
65
136
G04BD04
ATC
oxybutynin; oral, transdermal
2.6
19.7
155
641
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.2
19.5
105
342
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
19.1
618
4407
SPAT1252
SPAT
Overall medication plan or its review
2.3
19.0
182
835
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
18.9
159
681
WX320
NOMESCO Finland
Spinalanesthesy
0.5
18.8
142
2731
Z03
ICPC
Housing/neighbourhood problem
11.2
18.7
35
32
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
19.0
18.7
28
15
R32
ICD-10 Finland
Unspecified urinary incontinence
3.6
18.6
86
249
N06AX16
ATC
venlafaxine; oral
2.4
18.1
165
735
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
17.9
69
171
N06AX11
ATC
mirtazapine; oral
1.7
17.6
498
3402
A06AD11
ATC
lactulose; oral
1.8
17.4
345
2114
J01CA08
ATC
pivmecillinam; oral
1.6
17.4
597
4293
N05BA04
ATC
oxazepam; oral
1.7
17.0
409
2660
N05AB03
ATC
perphenazine; systemic, rectal
4.0
16.9
69
180
W19
ICD-10 Finland
Unspecified fall
2.1
16.9
197
985
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
3.6
16.8
77
222
N18
ICPC
Paralysis/weakness
4.1
16.6
66
168
G30.8
ICD-10 Finland
Other Alzheimer disease
3.3
16.6
84
262
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.5
16.5
78
231
R55
ICD-10 Finland
Syncope and collapse
1.9
16.2
245
1361
R26.0
ICD-10 Finland
Ataxic gait
21.2
16.0
23
11
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
3.1
15.8
90
304
R26.2
ICD-10 Finland
Difficulty in walking, not elsewhere classified
5.0
15.7
50
102
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
15.6
15
*
N06AB06
ATC
sertraline; oral
2.4
15.5
141
629
WYA20
NOMESCO Finland
Home visit
3.9
15.4
63
165
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.1
15.4
60
151
N03AX09
ATC
lamotrigine; oral
4.6
15.2
52
115
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
9.3
15.2
31
34
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.6
15.2
44
81
ZXD05
NOMESCO Finland
Urgent procedure
1.6
15.1
503
3559
SPAT1251
SPAT
Organisation of medication
2.7
15.1
104
396
Z00.0
ICD-10 Finland
General medical examination
1.8
14.8
307
1898
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.9
14.8
258
1505
N04AA02
ATC
biperiden; systemic
5.2
14.6
45
89
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.8
14.6
48
102
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
14.5
91
330
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
14.5
214
3420
Z75.5
ICD-10 Finland
Holiday relief care
5.2
14.4
44
86
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
12.7
14.4
25
20
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
7.2
14.3
34
48
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.8
14.3
47
100
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.3
14.3
52
123
G04CA02
ATC
tamsulosin; oral
1.6
14.1
496
3546
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
13.9
288
1776
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
13.9
524
3805
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
20.2
13.8
20
10
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
2.1
13.7
162
816
L99
ICPC
Musculoskeletal disease other
4.2
13.5
51
125
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.0
13.5
189
1019
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.9
13.5
43
89
N03AB02
ATC
phenytoin; systemic
5.4
13.2
39
74
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
13.2
156
786
SPAT1042
SPAT
Guidance concerning balance maintenance
7.6
13.2
30
40
Z2445
NOMESCO Finland
Psychologist
4.1
13.0
50
125
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
12.9
287
1803
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.0
12.9
75
259
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
7.6
12.7
29
39
J01EA01
ATC
trimethoprim; systemic
1.6
12.6
440
3125
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
12.5
487
3545
2132
FHL
Ventricular operators sunt
131.0
12.4
13
*
N03AX14
ATC
levetiracetam; systemic
3.6
12.3
55
157
N05AX12
ATC
aripiprazole; systemic
5.0
12.2
38
77
A29
ICPC
General symptom/complaint other
1.8
12.1
215
1260
SPAT1262
SPAT
Handing over of treatment supplies
1.6
12.1
329
2190
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.6
12.0
30
46
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.6
12.0
210
3240
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
3.9
12.0
48
125
G04BD09
ATC
trospium; oral
2.8
11.8
75
276
188
Kela drug reimbursment
Psychosis requiring demanding treatment
9.7
11.7
23
24
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.0
11.7
164
884
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.2
11.6
60
193
SPAT1304
SPAT
Counselling and guidance related to ageing
1.9
11.5
179
1001
AXX01
SPAT
NA
4.0
11.5
45
115
2133
FHL
Suntin revisio
+∞
11.5
11
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
11.5
11
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
11.5
11
*
N06AB03
ATC
fluoxetine; oral
1.9
11.5
169
928
N87
ICPC
Parkinsonism
3.7
11.4
48
131
F05.9
ICD-10 Finland
Delirium, unspecified
3.3
11.4
57
179
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.5
11.2
51
149
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
11.2
11.0
20
18
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
2.2
11.0
108
500
T90.5
ICD-10 Finland
Sequelae of intracranial injury
6.9
10.9
26
38
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.7
10.7
72
275
N05AC02
ATC
thioridazine; oral
4.6
10.7
36
80
N05AA02
ATC
levomepromazine; systemic
2.8
10.6
66
238
N05BA01
ATC
diazepam; systemic, rectal
1.7
10.6
222
1369
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
10.6
581
4515
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
10.6
217
1331
N05AH02
ATC
clozapine; systemic
7.5
10.2
23
31
SPAT1139
SPAT
Nutrition survey
2.6
10.1
71
276
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
10.1
137
729
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.5
10.1
34
76
183
Kela drug reimbursment
Lamotrigin and topiramate
11.4
10.1
18
16
R27.0
ICD-10 Finland
Ataxia, unspecified
8.5
10.1
21
25
SPAT1167
SPAT
Insertion of urinary catheter
2.3
10.0
89
395
SPAT1307
SPAT
Psychosocial counselling and guidance
3.1
9.9
53
175
R26
ICD-10 Finland
Abnormalities of gait and mobility
7.7
9.9
22
29
S01.0
ICD-10 Finland
Open wound of scalp
2.0
9.8
135
721
N80
ICPC
Head injury other
3.7
9.8
41
112
N05AF03
ATC
chlorprothixene; systemic
3.9
9.8
39
102
S72.0
ICD-10 Finland
Fracture of neck of femur
2.1
9.7
107
523
Z11
ICPC
Compliance/being ill problem
6.6
9.7
24
37
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.2
9.7
50
161
ZXA00
NOMESCO Finland
Right side
1.5
9.7
469
3541
N03AF01
ATC
carbamazepine; oral, rectal
2.3
9.7
92
420
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.6
9.7
151
2409
130
Kela drug reimbursment
Malignant tumour
0.4
9.5
40
958
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.5
636
5106
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.4
9.5
45
137
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
9.4
492
3767
2124
FHL
Intracranial pressure measurement, intraventricular
+∞
9.4
9
*
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
21.8
9.4
13
6
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
9.6
9.3
18
19
J01DB01
ATC
cefalexin; oral
1.4
9.2
1150
10283
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
9.0
245
1620
Z2221
NOMESCO Finland
Medical doctor
0.6
9.0
210
3066
SPAT1279
SPAT
Preparation of immediate hospitalisation
3.6
8.9
38
106
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.6
8.9
38
106
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
7.5
8.9
20
27
G30.0
ICD-10 Finland
Alzheimer disease with early onset
4.4
8.9
31
72
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.1
8.9
101
503
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
2.0
8.9
105
530
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
8.8
168
1003
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
10.8
8.8
16
15
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
6.4
8.8
22
35
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.3
8.8
82
375
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.7
8.7
28
60
G04BD11
ATC
fesoterodine; oral
2.4
8.7
72
309
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
4.1
8.7
32
79
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.3
8.6
80
362
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
0.5
8.5
51
1075
N30.9
ICD-10 Finland
Cystitis, unspecified
2.0
8.5
109
570
AAA10
NOMESCO Finland
Biopsy through craniotomy
20.1
8.5
12
6
L29
ICPC
Musculoskeletal sympt/complt other
1.9
8.4
122
664
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.7
8.4
27
58
Z02.7
ICD-10 Finland
Issue of medical certificate
2.0
8.4
104
536
N06AX21
ATC
duloxetine; oral
1.9
8.4
131
733
G91
ICD-10 Finland
Hydrocephalus
+∞
8.3
8
*
N06AX03
ATC
mianserin; oral
2.2
8.3
81
377
N05AN01
ATC
lithium; oral
3.6
8.3
35
98
N17
ICPC
Vertigo/dizziness
1.6
8.2
202
1299
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
6.5
8.2
20
31
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.8
8.1
147
865
N06DA04
ATC
galantamine; oral
2.6
8.1
59
236
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
8.0
256
1758
K91
ICPC
Cerebrovascular disease
3.4
8.0
37
111
R11
ICD-10 Finland
Nausea and vomiting
1.8
8.0
128
721
F22.0
ICD-10 Finland
Delusional disorder
3.7
8.0
33
91
SPAT1276
SPAT
Outlining of treatment with patient or their family members
2.6
8.0
55
215
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
5.0
7.9
24
49
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.9
7.9
120
668
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
4.5
7.9
26
58
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
7.9
247
1689
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
2.9
7.8
45
157
N06AX26
ATC
vortioxetine; oral
2.5
7.7
60
249
SPAT1244
SPAT
Occupational therapy
4.3
7.7
27
64
C91.2
ICD-10 Finland
Subacute lymphocytic leukemia
45.2
7.7
9
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.6
7.7
53
207
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
4.8
7.6
24
51
359
Kela drug reimbursment
Mirabegroni
4.5
7.6
25
56
S06.3
ICD-10 Finland
Focal brain injury
3.7
7.6
31
85
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
7.5
221
1489
XF402
NOMESCO Finland
ECG with work load test
0.5
7.4
72
1306
G41.2
ICD-10 Finland
Complex partial status epilepticus
13.4
7.4
12
9
A10BH01
ATC
sitagliptin; oral
1.6
7.4
171
1085
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
7.3
1166
10595
Z08
ICPC
Social welfare problem
4.2
7.3
26
63
G04BD10
ATC
darifenacin; oral
4.2
7.3
26
63
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.9
7.3
42
147
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.7
7.2
47
178
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
3.4
7.2
33
99
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
15.8
7.2
11
7
G21.8
ICD-10 Finland
Other secondary parkinsonism
15.8
7.2
11
7
SPAT1014
SPAT
Treatment of eyes
2.8
7.2
43
155
N03AF02
ATC
oxcarbazepine; oral
2.7
7.2
47
179
ZYC01
SPAT
NA
2.3
7.2
65
292
SPAT1263
SPAT
Sampling
1.3
7.1
621
5135
G72.8
ICD-10 Finland
Other specified myopathies
3.1
7.1
37
123
R50.9
ICD-10 Finland
Fever, unspecified
1.6
7.1
201
1342
-
ICD-10 Finland
NA
2.7
7.1
46
175
SPAT1050
SPAT
Extensive neurological examination
2.6
7.1
49
192
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.7
7.0
191
2717
E0000UV
ATC
NA
1.4
7.0
524
4227
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.3
6.9
62
280
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
3.5
6.8
29
83
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.2
6.8
65
301
SPAT1153
SPAT
Removal of sutures
1.4
6.7
488
3912
S82
ICPC
Naevus/mole
0.5
6.7
55
1049
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
22.6
6.7
9
*
A10BA02
ATC
metformin; oral
1.4
6.7
480
3845
F01.9
ICD-10 Finland
Vascular dementia, unspecified
2.7
6.7
41
152
R21
ICPC
Throat symptom/complaint
0.5
6.6
62
1138
Z60.8
ICD-10 Finland
Other problems related to social environment
7.8
6.6
14
18
WW200
SPAT
NA
1.8
6.6
111
641
T90
ICPC
Diabetes non-insulin dependent
1.4
6.5
383
2961
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
3.2
6.5
31
97
XJH00
NOMESCO Finland
Transanal ultrasonography
1.7
6.5
127
765
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.7
6.5
122
727
R33
ICD-10 Finland
Retention of urine
1.6
6.5
159
1022
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.1
6.5
32
103
G41.9
ICD-10 Finland
Status epilepticus, unspecified
6.2
6.5
16
26
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.8
6.5
39
143
R60.0
ICD-10 Finland
Localized oedema
1.5
6.4
194
1312
2139
FHL
Other measure in this category
70.1
6.4
7
*
2130
FHL
Ventricular atrial shunt
70.1
6.4
7
*
S70.0
ICD-10 Finland
Contusion of hip
2.0
6.4
74
373
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.4
6.4
52
225
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
6.4
459
3670
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.1
6.4
67
325
N05BA06
ATC
lorazepam; systemic, sublingual
1.9
6.3
94
520
C03CA01
ATC
furosemide; systemic
1.3
6.3
627
5260
P72
ICPC
Schizophrenia
4.2
6.3
22
53
F0019, G301
ICD-10 Finland
NA
3.2
6.3
30
94
Y96.9
ICD-10 Finland
Unspecified type of accident
3.2
6.3
30
94
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
6.3
555
4576
F31
ICD-10 Finland
Bipolar affective disorder
6.0
6.3
16
27
G90.2
ICD-10 Finland
Horner syndrome
9.3
6.3
12
13
M54.5
ICD-10 Finland
Low back pain
1.4
6.3
394
3080
P29
ICPC
Psychological sympt/compl other
2.4
6.3
48
201
DJA10
NOMESCO Finland
Biopsy of septum of nose
26.8
6.2
8
*
R41.3
ICD-10 Finland
Other amnesia
2.1
6.2
66
321
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.3
6.2
54
242
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.3
6.2
54
243
H25.8
ICD-10 Finland
Other senile cataract
0.6
6.2
116
1780
XKD00
NOMESCO Finland
Uroflowmetry
1.4
6.1
301
2255
N03AX18
ATC
lacosamide; systemic
7.7
6.1
13
17
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
6.1
149
959
A10AE04
ATC
insulin glargine; parenteral
1.6
6.1
150
968
ZXC86
NOMESCO Finland
Use of endoscopic device
6.7
6.0
14
21
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
2.5
6.0
44
181
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCNP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCNP | 2.238 [2.01, 2.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.32 |
During the follow-up period (1.1.1998 — 31.12.2019), 1631 out of 3345 females with G6_HCNP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCNP | 2.381 [2.07, 2.74] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1722 out of 3293 males with G6_HCNP died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCNP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.473% |
| 5 | 1.38% | 2.537% |
| 10 | 3.1% | 6.356% |
| 15 | 6.083% | 11.522% |
| 20 | 11.154% | 18.816% |
Relationships between endpoints
↥Index endpoint: G6_HCNP – Normal-pressure hydrocephalus
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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