Risteys · G6

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G94.0, G94.1, G94.2* Cause of death: ICD-10 — G94.0, G94.1, G94.2* 2 out of 7 registries used, show all original rules.	190
4. Check minimum number of events None	190
5. Include endpoints None	190
6. Filter based on genotype QC (FinnGen only)	190

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1769	924	839
Only index persons	1488	795	693
Unadjusted period prevalence (%)
Whole population	0.02	0.03	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	56.83	58.92	54.41
Only index persons	57.38	58.88	55.66

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	190	120	70
Unadjusted period prevalence (%)	0.04	0.04	0.03
Median age at first event (years)	60.27	59.94	60.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
174: Matched controls
1737

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

1230.7

116.5

101

AAF00

NOMESCO Finland

Ventriculostomy

477.3

101.4

AA1AD

NOMESCO Finland

CT of head and brain

20.2

66.6

132

234

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

14.1

46.5

125

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

+∞

45.9

G94.2

ICD-10 Finland

Hydrocephalus in other diseases classified elsewhere

+∞

43.6

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

97.2

41.2

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

16.0

38.1

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

+∞

36.8

ZXD05

NOMESCO Finland

Urgent procedure

8.1

35.6

111

309

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

90.0

33.3

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

+∞

31.2

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

30.1

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

97.0

29.9

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

+∞

27.9

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

+∞

26.8

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

303.5

26.5

PA2LT

NOMESCO Finland

Endovascular closure of extensive brain aneurysm

303.5

26.5

PA3AC

NOMESCO Finland

Carotis angiography with X-ray

289.9

25.4

I60.2

ICD-10 Finland

Subarachnoid haemorrhage from anterior communicating artery

145.0

24.3

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

9.3

24.2

K90

ICPC

Stroke/cerebrovascular accident

35.9

23.7

PA2AD

NOMESCO Finland

CT angiography of brain

75.8

23.6

AA5PD

NOMESCO Finland

CT examination of brain pefusion

45.2

22.5

PA4AC

NOMESCO Finland

Vertebralis angiography with X-ray

250.1

22.1

N03AX14

ATC

levetiracetam; systemic

23.9

21.3

TAA40

NOMESCO Finland

Cathetrisation of cerebrospinal fluid through skin

+∞

20.2

WX404

NOMESCO Finland

Intravenous generell anesthesy

4.9

19.9

278

WX730

NOMESCO Finland

Conventional respirator

39.4

19.5

G942, I602

ICD-10 Finland

+∞

19.1

I60.1

ICD-10 Finland

Subarachnoid haemorrhage from middle cerebral artery

211.9

18.9

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

18.1

18.8

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

18.0

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

5.9

17.6

127

WX872

NOMESCO Finland

Intensive care

11.2

16.3

AA1AA

NOMESCO Finland

Head X-ray examination

66.4

16.1

AAF50

NOMESCO Finland

Third ventriculostomy

+∞

14.8

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

19.2

14.7

I61.5

ICD-10 Finland

Intracerebral haemorrhage, intraventricular

163.1

14.7

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

10.3

14.7

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

20.3

13.7

XX3DW

NOMESCO Finland

Time consuming IT work

5.9

13.5

H02AB02

ATC

dexamethasone; systemic

5.5

13.4

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

26.7

12.7

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

12.4

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

12.4

11.9

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

20.7

11.8

R51.80

ICD-10 Finland

Headache

4.2

11.7

149

I61.0

ICD-10 Finland

Intracerebral haemorrhage in hemisphere, subcortical

16.6

11.6

G942, I615

ICD-10 Finland

+∞

11.6

G91.8

ICD-10 Finland

Other hydrocephalus

+∞

11.6

I60.6

ICD-10 Finland

Subarachnoid haemorrhage from other intracranial arteries

+∞

11.6

I60.7

ICD-10 Finland

Subarachnoid haemorrhage from intracranial artery, unspecified

128.1

11.6

PA2KT

NOMESCO Finland

Endovascular closure of brain aneurysm

128.1

11.6

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

21.9

11.4

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

19.4

11.0

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

17.5

10.6

G942, I601

ICD-10 Finland

+∞

10.5

G97.2

ICD-10 Finland

Intracranial hypotension following ventricular shunting

+∞

10.5

G94.1

ICD-10 Finland

Hydrocephalus in neoplastic disease

+∞

10.5

SPAT1215

SPAT

Assessment of need for medical rehabilitation

7.3

10.2

N18

ICPC

Paralysis/weakness

13.3

10.1

AAC00

NOMESCO Finland

Ligature of intracranial aneurysm

18.1

10.1

PA2AC

NOMESCO Finland

Cerebral angiography with X-ray

105.5

9.5

XX1ZW

NOMESCO Finland

Very extensive written report from radiologist

105.5

9.5

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

+∞

9.5

PA2MT

NOMESCO Finland

Endovascular closure of very extensive brain aneurysm

+∞

9.5

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

+∞

9.5

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

14.8

9.4

Y83.1

ICD-10 Finland

Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

16.8

9.2

SPAT1229

SPAT

Assessment of need for aid

5.1

9.1

WX408

NOMESCO Finland

General anesthesy, balanced

2.9

9.1

322

I60.0

ICD-10 Finland

Subarachnoid haemorrhage from carotid siphon and bifurcation

25.6

9.0

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

5.0

8.4

I60.8

ICD-10 Finland

Other subarachnoid haemorrhage

+∞

8.4

I61.9

ICD-10 Finland

Intracerebral haemorrhage, unspecified

15.5

8.3

SPAT1224

SPAT

Implementation of speech therapy rehabilitation plan

12.7

7.7

PA7BD

NOMESCO Finland

CT angiography of neck and brain

10.8

7.7

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

10.8

7.7

D43.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Brain, supratentorial

26.3

7.7

PA2YT

NOMESCO Finland

Cerebral artery PTA with stent

26.3

7.7

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.2

7.6

163

N29

ICPC

Neurological sympt/complt other

14.2

7.5

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

11.6

7.4

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

4.3

7.4

G941, D431

ICD-10 Finland

+∞

7.3

G942, I690

ICD-10 Finland

+∞

7.3

G00.9

ICD-10 Finland

Bacterial meningitis, unspecified

+∞

7.3

G942, I600

ICD-10 Finland

+∞

7.3

G942, I609

ICD-10 Finland

+∞

7.3

AAB30

NOMESCO Finland

Evacuation of spontaneous intracranial haematoma

+∞

7.3

N03AF02

ATC

oxcarbazepine; oral

8.5

7.3

G40.9

ICD-10 Finland

Epilepsy, unspecified

8.5

7.3

ZXC86

NOMESCO Finland

Use of endoscopic device

31.4

7.2

D21

ICPC

Swallowing problem

12.8

7.2

WX882

NOMESCO Finland

High dependency care

6.9

7.1

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.6

7.1

336

SPAT1231

SPAT

Assessment of adjustments needed in living environment

14.6

7.0

Z2221

NOMESCO Finland

Medical doctor

0.2

6.9

363

ZXE10

NOMESCO Finland

More than one and less than three hours

2.4

6.9

484

D33.30

ICD-10 Finland

Acoustic neuroma

41.7

6.8

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

23.6

6.7

WF049

NOMESCO Finland

Radiotherapy of metastasis

9.3

6.7

SPAT1216

SPAT

Assessment of functional ability

3.1

6.6

145

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

15.0

6.5

NK6AI

NOMESCO Finland

Other cone beam scan

72.4

6.5

C79.31

ICD-10 Finland

Secondary malignant tumor of the cerebellum

72.4

6.5

G41.9

ICD-10 Finland

Status epilepticus, unspecified

72.4

6.5

K91

ICPC

Cerebrovascular disease

18.9

6.3

C71.90

ICD-10 Finland

Malignant tumor in unspecified localization in the brain without histology

+∞

6.3

G942, I606

ICD-10 Finland

+∞

6.3

L01AX03

ATC

temozolomide; systemic

+∞

6.3

I60.5

ICD-10 Finland

Subarachnoid haemorrhage from vertebral artery

+∞

6.3

I60.4

ICD-10 Finland

Subarachnoid haemorrhage from basilar artery

+∞

6.3

L28

ICPC

Limited function/disability (L)

2.9

6.1

164

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

7.7

6.0

Z3231

NOMESCO Finland

Registered nurse

0.2

6.0

326

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HCINOTH	5.144 [3.85, 6.87]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.055

During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 716 females with G6_HCINOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_HCINOTH	5.443 [3.94, 7.52]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.055

During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 639 males with G6_HCINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCINOTH.

N-year risk	Females	Males
1	0.386%	0.987%
5	3.0%	6.198%
10	6.745%	15.626%
15	12.709%	27.03%
20	20.651%	42.374%

Relationships between endpoints

↥

Index endpoint: G6_HCINOTH – Hydrocephalus in other diseases

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_HCINOTH
CONTROL_EXCLUDE	G6_HYDROCEPH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G94[0-2]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G94[0-2]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Hydrocephalus in other diseases

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints