Risteys · G6

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G91.0 Hospital discharge: ICD-9 — 3313 Cause of death: ICD-10 — G91.0 Cause of death: ICD-9 — 3313 2 out of 7 registries used, show all original rules.	769
4. Check minimum number of events None	769
5. Include endpoints None	769
6. Filter based on genotype QC (FinnGen only)	769

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	6750	3351	3305
Only index persons	4677	2460	2217
Unadjusted period prevalence (%)
Whole population	0.09	0.10	0.09
Only index persons	0.09	0.09	0.08
Median age at first event (years)
Whole population	59.21	61.43	56.68
Only index persons	55.27	58.24	51.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	769	403	366
Unadjusted period prevalence (%)	0.15	0.14	0.16
Median age at first event (years)	60.46	59.84	61.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
696: Matched controls
6960

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

1904.2

323.0

366

G91.0

ICD-10 Finland

Communicating hydrocephalus

+∞

323.0

626

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

+∞

273.5

244

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

+∞

209.2

190

AAF00

NOMESCO Finland

Ventriculostomy

502.2

191.9

183

G91.1

ICD-10 Finland

Obstructive hydrocephalus

+∞

163.1

150

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

129.0

159.5

167

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

+∞

149.5

138

AA1AD

NOMESCO Finland

CT of head and brain

7.6

127.4

404

1070

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

61.7

116.4

135

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

16.6

108.8

183

146

AAF15

NOMESCO Finland

Ventriculoatrial shunt

+∞

101.6

AA1AA

NOMESCO Finland

Head X-ray examination

116.0

101.3

108

3313A

ICD-9 Finland

Other cerebral degenerations, Communicating hydrocephalus

+∞

98.3

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

1003.6

92.0

AAF25

NOMESCO Finland

Removal of shunt of ventricle of brain

977.5

89.8

T85.0

ICD-10 Finland

Mechanical complication of ventricular intracranial (communicating) shunt

+∞

77.6

AAC00

NOMESCO Finland

Ligature of intracranial aneurysm

52.9

70.5

ZXD05

NOMESCO Finland

Urgent procedure

4.3

67.2

357

1376

AAF99

NOMESCO Finland

Other shunt operation on ventricle of brain or intracerebral cyst

677.2

63.9

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

52.4

62.9

AAA20

NOMESCO Finland

Insertion of intraventricular pressure monitoring device

+∞

58.1

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

56.9

57.1

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

9.1

54.8

122

159

I60.2

ICD-10 Finland

Subarachnoid haemorrhage from anterior communicating artery

81.7

53.9

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

23.9

50.9

2132

FHL

Ventricular operators sunt

274.6

50.8

I60.7

ICD-10 Finland

Subarachnoid haemorrhage from intracranial artery, unspecified

109.9

47.5

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

6.6

47.0

131

237

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

35.0

44.9

G91.8

ICD-10 Finland

Other hydrocephalus

+∞

43.2

I60.1

ICD-10 Finland

Subarachnoid haemorrhage from middle cerebral artery

49.8

42.6

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

6.1

42.1

124

239

R51.80

ICD-10 Finland

Headache

4.1

37.0

164

487

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.6

36.9

195

673

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.7

36.7

187

626

XA800

NOMESCO Finland

Neuropsychological investigation

8.1

36.2

118

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.5

36.1

200

713

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

9.8

36.0

ZXE10

NOMESCO Finland

More than one and less than three hours

2.8

35.2

331

1698

AAL00

NOMESCO Finland

Endovascular occlusion of intracranial aneurysm

58.9

33.6

N03AX14

ATC

levetiracetam; systemic

10.2

33.1

PA2LT

NOMESCO Finland

Endovascular closure of extensive brain aneurysm

51.5

32.8

K90

ICPC

Stroke/cerebrovascular accident

8.9

31.1

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

11.6

30.8

N03AG01

ATC

valproic acid; systemic, rectal

6.0

30.5

167

N03AB02

ATC

phenytoin; systemic

18.8

30.0

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

12.6

29.9

I60.0

ICD-10 Finland

Subarachnoid haemorrhage from carotid siphon and bifurcation

28.2

29.6

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

11.2

29.3

K91

ICPC

Cerebrovascular disease

18.0

28.3

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

11.2

28.2

G40.9

ICD-10 Finland

Epilepsy, unspecified

7.4

28.1

102

Z2445

NOMESCO Finland

Psychologist

7.0

25.6

101

I61.9

ICD-10 Finland

Intracerebral haemorrhage, unspecified

12.5

25.6

3314A

ICD-9 Finland

Other cerebral degenerations, Obstructive hydrocephalus

+∞

25.2

2133

FHL

Suntin revisio

258.9

24.8

I60.6

ICD-10 Finland

Subarachnoid haemorrhage from other intracranial arteries

93.5

24.8

G91.3

ICD-10 Finland

Post-traumatic hydrocephalus, unspecified

+∞

24.1

TAB00

NOMESCO Finland

Lumbar puncture

5.6

23.1

137

N18

ICPC

Paralysis/weakness

10.2

22.6

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.7

21.6

102

310

N03AF02

ATC

oxcarbazepine; oral

6.8

21.1

I62.0

ICD-10 Finland

Nontraumatic subdural haemorrhage

15.5

20.9

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

3.8

20.8

281

4300A

ICD-9 Finland

Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOID. POST ANEURYSMA SACCULARE]

33.7

20.3

ZXD35

NOMESCO Finland

Usual procedure

5.9

20.1

103

I60.3

ICD-10 Finland

Subarachnoid haemorrhage from posterior communicating artery

59.3

20.0

ZSA00

NOMESCO Finland

Procedure related to previous procedure classified in chapter A

59.3

20.0

N03AF01

ATC

carbamazepine; oral, rectal

4.6

19.8

172

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.2

19.8

263

1490

ZXA00

NOMESCO Finland

Right side

2.3

19.7

234

1256

XXA00

NOMESCO Finland

Clinical examination requiring general anaesthesia

20.1

19.6

R4150

NOMESCO Finland

Neuropsychological rehabilitation

32.3

19.4

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

14.5

19.2

SPAT1216

SPAT

Assessment of functional ability

2.6

19.2

159

705

SPAT1229

SPAT

Assessment of need for aid

3.5

19.1

306

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

3.8

19.1

251

AAF50

NOMESCO Finland

Third ventriculostomy

+∞

18.8

G91

ICD-10 Finland

Hydrocephalus

+∞

18.8

H47.2

ICD-10 Finland

Optic atrophy

28.7

18.8

2161

FHL

Neck ligation, big brain

28.7

18.8

R56.8

ICD-10 Finland

Other and unspecified convulsions

4.7

18.6

149

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.7

18.2

250

R26.8

ICD-10 Finland

Other and unspecified abnormalities of gait and mobility

6.9

18.0

R42

ICD-10 Finland

Dizziness and giddiness

2.3

18.0

194

989

A28

ICPC

Limited function/disability NOS

2.5

17.8

155

706

N28

ICPC

Limited function/disability (N)

9.6

17.3

L28

ICPC

Limited function/disability (L)

2.5

17.2

155

717

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

3.4

17.2

285

A06AD11

ATC

lactulose; oral

2.5

16.7

150

690

ICD-10 Finland

7.3

16.6

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

6.4

16.6

Z98.2

ICD-10 Finland

Presence of cerebrospinal fluid drainage device

174.0

16.6

H53.4

ICD-10 Finland

Visual field defects

8.1

16.5

183

Kela drug reimbursment

Lamotrigin and topiramate

14.7

16.4

PA2KT

NOMESCO Finland

Endovascular closure of brain aneurysm

41.1

16.4

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

5.2

16.2

105

XCK00

NOMESCO Finland

Perimetry

3.4

16.0

260

PA2MT

NOMESCO Finland

Endovascular closure of very extensive brain aneurysm

61.5

15.8

2130

FHL

Ventricular atrial shunt

+∞

15.7

2124

FHL

Intracranial pressure measurement, intraventricular

+∞

15.7

N06AB04

ATC

citalopram; systemic

2.2

15.5

177

917

G44.2

ICD-10 Finland

Tension-type headache

2.9

15.5

101

386

R53

ICD-10 Finland

Malaise and fatigue

2.3

15.5

173

889

N05BA09

ATC

clobazam; oral

20.6

15.2

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.9

15.1

361

R1250

NOMESCO Finland

Evaluation of functional capability

7.9

15.1

N29

ICPC

Neurological sympt/complt other

7.5

14.9

N05AH04

ATC

quetiapine; oral

2.5

14.8

124

547

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

12.2

14.7

ZXD10

NOMESCO Finland

Scheduled procedure

1.9

14.7

285

1831

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

3.1

14.6

295

AAD10

NOMESCO Finland

Evacuation of chronic subdural haematoma

10.4

14.6

P20

ICPC

Memory disturbance

2.5

14.3

119

525

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.3

14.3

236

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

2.9

14.1

357

I61.0

ICD-10 Finland

Intracerebral haemorrhage in hemisphere, subcortical

7.3

14.0

9530/0-C70.0

ICD-O-3

Meningioma, NOS, of cerebral meninges

18.0

13.9

WX408

NOMESCO Finland

General anesthesy, balanced

2.0

13.9

209

1211

G40.12

ICD-10 Finland

Simple partial seizures with secondary generalization

20.5

13.8

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

7.9

13.8

AAD05

NOMESCO Finland

Evacuation of acute subdural haematoma

34.8

13.6

M03BX01

ATC

baclofen; systemic

9.3

13.3

R4120

NOMESCO Finland

Occupational therapy

3.4

13.3

203

ZXE20

NOMESCO Finland

More than three and less than five hours

2.4

12.8

118

547

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.3

12.7

135

671

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

2.8

12.7

321

S06.0

ICD-10 Finland

Concussion

2.6

12.6

395

N99

ICPC

Neurological disease other

11.3

12.6

2139

FHL

Other measure in this category

+∞

12.5

G81.1

ICD-10 Finland

Spastic hemiplegia

+∞

12.5

I60.4

ICD-10 Finland

Subarachnoid haemorrhage from basilar artery

132.3

12.5

N03AX09

ATC

lamotrigine; oral

4.5

12.3

100

F03

ICD-10 Finland

Unspecified dementia

3.3

11.8

194

PA2YT

NOMESCO Finland

Cerebral artery PTA with stent

30.6

11.7

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.3

11.7

115

551

T90.5

ICD-10 Finland

Sequelae of intracranial injury

10.3

11.6

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

3.0

11.6

237

I60.5

ICD-10 Finland

Subarachnoid haemorrhage from vertebral artery

+∞

11.5

AAF10

NOMESCO Finland

Lumboperitoneal shunt

+∞

11.5

AAK00

NOMESCO Finland

Cranioplasty

121.9

11.5

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

4.3

11.3

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

13.0

11.2

G40.20

ICD-10 Finland

Complex partial seizures with only alteration of consciousness

9.4

11.1

G41.9

ICD-10 Finland

Status epilepticus, unspecified

14.2

11.0

I61.1

ICD-10 Finland

Intracerebral haemorrhage in hemisphere, cortical

14.2

11.0

G04BD07

ATC

tolterodine; oral

3.0

11.0

221

R51

ICD-10 Finland

Headache

3.9

11.0

122

TAA40

NOMESCO Finland

Cathetrisation of cerebrospinal fluid through skin

44.0

10.9

G03.9

ICD-10 Finland

Meningitis, unspecified

44.0

10.9

I60.8

ICD-10 Finland

Other subarachnoid haemorrhage

44.0

10.9

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.1

10.9

142

766

N02BE01

ATC

paracetamol; systemic, rectal

1.9

10.8

572

4907

SPAT1234

SPAT

Support of social functional capacity

3.2

10.8

184

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.1

10.7

129

675

N05AX08

ATC

risperidone; systemic

2.7

10.6

294

AA1BD

NOMESCO Finland

Extensive CT of head and brain

5.0

10.6

Q03.9

ICD-10 Finland

Congenital hydrocephalus, unspecified

+∞

10.4

AAK80

NOMESCO Finland

Partial excision of skull cap

+∞

10.4

Z3229

NOMESCO Finland

Other healthcare associate professional

2.6

10.3

336

PA2AC

NOMESCO Finland

Cerebral angiography with X-ray

23.8

10.3

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

3.0

10.2

203

G40.2

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

11.5

10.1

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.5

10.0

357

ZXC86

NOMESCO Finland

Use of endoscopic device

17.0

9.9

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

3.4

9.7

142

N05BA01

ATC

diazepam; systemic, rectal

2.2

9.6

107

538

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

3.9

9.6

101

2127

FHL

Ventriculostomy

101.4

9.4

D32.0

ICD-10 Finland

Benign neoplasm: Cerebral meninges

30.5

9.4

G97.2

ICD-10 Finland

Intracranial hypotension following ventricular shunting

+∞

9.4

Z3231

NOMESCO Finland

Registered nurse

1.8

9.4

192

1215

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

2.2

9.3

473

AA5BD

NOMESCO Finland

CT of cerebral ischaemia

5.6

9.3

AA1AG

NOMESCO Finland

Short MRI examination of brain with median intensity magnet

6.0

9.1

N03AX18

ATC

lacosamide; systemic

11.7

9.1

I69.2

ICD-10 Finland

Sequelae of other nontraumatic intracranial haemorrhage

37.2

9.0

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

3.6

9.0

117

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

5.9

9.0

G00.9

ICD-10 Finland

Bacterial meningitis, unspecified

24.4

8.9

AA5PD

NOMESCO Finland

CT examination of brain pefusion

10.9

8.8

H47.1

ICD-10 Finland

Papilloedema, unspecified

16.5

8.6

R1100

NOMESCO Finland

General evaluation of the need for rehabilitation

6.5

8.5

WX704

NOMESCO Finland

Intubation

2.8

8.5

210

2152

FHL

Extraction, big brain

91.1

8.4

N06AB10

ATC

escitalopram; oral

2.0

8.4

122

682

Z75.5

ICD-10 Finland

Holiday relief care

8.0

8.4

AAK85

NOMESCO Finland

Replantation of previously excised part of skull cap

+∞

8.3

T85.7

ICD-10 Finland

Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts

+∞

8.3

AAB30

NOMESCO Finland

Evacuation of spontaneous intracranial haematoma

+∞

8.3

34793

ICD-8 Finland

Other disease of brain, Hydrocephalus acquisitus NUD

+∞

8.3

Q03.0

ICD-10 Finland

Malformations of aqueduct of Sylvius

+∞

8.3

Z03

ICPC

Housing/neighbourhood problem

10.9

8.3

WYA20

NOMESCO Finland

Home visit

5.5

8.2

PA2BG

NOMESCO Finland

MRI examination of vessels in the head with high intensity magnet

11.9

8.1

AA9CW

NOMESCO Finland

33.8

8.1

D32.02

ICD-10 Finland

Benign tumor of the meninges at the base of the brain

10.2

8.1

G40.19

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures

10.2

8.1

RT150

NOMESCO Finland

22.3

8.0

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.2

8.0

377

N05CD08

ATC

midazolam; nasal, systemic

4.3

8.0

NA7BG

NOMESCO Finland

Spine and spinal cord MRI examination with high intensity magnet

13.2

7.9

4380A

ICD-9 Finland

Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]

11.0

7.8

U04

ICPC

Incontinence urine

2.8

7.8

184

SPAT1053

SPAT

Memory test

1.9

7.7

122

705

R11

ICD-10 Finland

Nausea and vomiting

2.3

7.6

323

G40.10

ICD-10 Finland

Simple partial seizures

8.2

7.6

RS313

NOMESCO Finland

25.3

7.6

Y83.1

ICD-10 Finland

Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

6.3

7.6

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.9

7.6

112

631

N05AH03

ATC

olanzapine; systemic

3.2

7.5

124

ZXM00

NOMESCO Finland

Intraoperative use of ultrasonographic imaging

7.2

7.5

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

3.2

7.5

125

R5599

NOMESCO Finland

Other rehabilitation service

4.0

7.4

I60

ICD-10 Finland

Subarachnoid haemorrhage

80.9

7.4

R55

ICD-10 Finland

Syncope and collapse

2.1

7.4

439

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

4.4

7.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.7

7.4

183

1219

G40

ICD-10 Finland

Epilepsy

8.5

7.3

S06.6

ICD-10 Finland

Traumatic subarachnoid haemorrhage

9.5

7.3

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

9.5

7.3

74200

ICD-8 Finland

Congenital hydrocephalus, Communicans

+∞

7.3

GBB03

NOMESCO Finland

Percutaneous tracheostomy

+∞

7.3

G94.2

ICD-10 Finland

Hydrocephalus in other diseases classified elsewhere

+∞

7.3

OAB43

SPAT

0.2

7.3

378

AA1BM

NOMESCO Finland

MRI examination of brain with 3 Tesla magnet

7.4

7.2

JDB10

NOMESCO Finland

Percutaneous gastrostomy

5.4

7.1

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

2.6

7.1

194

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

8.9

7.1

T36

ICD-10 Finland

Poisoning by systemic antibiotics

3.5

7.0

GBB00

NOMESCO Finland

Tracheostomy

5.9

6.9

N05AD01

ATC

haloperidol; systemic

3.5

6.9

ZXE15

NOMESCO Finland

Procedure duration 120 to 149 minutes

5.1

6.8

SPAT1252

SPAT

Overall medication plan or its review

2.3

6.8

273

D43.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Brain, infratentorial

40.4

6.8

G80.2

ICD-10 Finland

Spastic hemiplegic cerebral palsy

40.4

6.8

F79.0

ICD-10 Finland

Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour

40.4

6.8

RL140

NOMESCO Finland

16.9

6.8

XX4AW

NOMESCO Finland

16.9

6.8

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

3.4

6.7

SPAT1301

SPAT

No procedures

1.6

6.7

219

1561

F54

ICD-10 Finland

Psychological and behavioural factors associated with disorders or diseases classified elsewhere

22.8

6.7

4309X

ICD-9 Finland

Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOIDALIS NUD]

22.8

6.7

N05BA04

ATC

oxazepam; oral

1.7

6.6

162

1071

G40.89

ICD-10 Finland

Other epilepsy

12.4

6.6

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.0

6.6

417

F06.7

ICD-10 Finland

Mild cognitive disorder

3.6

6.6

A04

ICPC

Weakness/tiredness general

1.9

6.4

541

G40.11

ICD-10 Finland

Simple partial epileptic seizure that develops into a complex partial seizure

70.5

6.4

G90.1

ICD-10 Finland

Familial dysautonomia [Riley-Day]

70.5

6.4

RT490

NOMESCO Finland

70.5

6.4

L01AX03

ATC

temozolomide; systemic

14.5

6.4

G41.0

ICD-10 Finland

Grand mal status epilepticus

14.5

6.4

D33.30

ICD-10 Finland

Acoustic neuroma

14.5

6.4

WX882

NOMESCO Finland

High dependency care

3.3

6.4

ZXA05

NOMESCO Finland

Left side

1.6

6.4

179

1225

N05AD03

ATC

melperone; systemic

5.3

6.4

D32.00

ICD-10 Finland

Benign tumor of the meninges on the outer surface of the cerebrum

5.6

6.3

WW200

SPAT

2.2

6.3

289

SPAT1245

SPAT

Provision of support and information to patient’s family members

2.6

6.3

176

N30.0

ICD-10 Finland

Acute cystitis

1.9

6.3

100

578

RS122

NOMESCO Finland

+∞

6.3

I62.9

ICD-10 Finland

Intracranial haemorrhage (nontraumatic), unspecified

+∞

6.3

Q05.2

ICD-10 Finland

Lumbar spina bifida with hydrocephalus

+∞

6.3

7423A

ICD-9 Finland

Other congenital anomalies of nervous system, Congenital hydrocephalus

+∞

6.3

P52.2

ICD-10 Finland

Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn

+∞

6.3

74209

ICD-8 Finland

Congenital hydrocephalus, Unspecified

+∞

6.3

RP120

NOMESCO Finland

+∞

6.3

AAA27

NOMESCO Finland

Insertion of intracerebral pressure monitoring device

26.9

6.2

Z3226

NOMESCO Finland

Physiotherapist

1.7

6.2

130

821

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.7

6.1

134

859

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

0.3

6.1

410

Z08

ICPC

Social welfare problem

6.8

6.1

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

0.5

6.0

1030

N39.4

ICD-10 Finland

Other specified urinary incontinence

2.1

6.0

304

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCCOMM and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_HCCOMM	3.207 [2.83, 3.63]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.446

During the follow-up period (1.1.1998 — 31.12.2019), 862 out of 2207 females with G6_HCCOMM died.

Males

Parameter	HR [95% CI]	p-value
G6_HCCOMM	3.268 [2.82, 3.79]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 835 out of 2089 males with G6_HCCOMM died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCCOMM.

N-year risk	Females	Males
1	0.237%	0.734%
5	1.673%	3.6%
10	4.418%	9.74%
15	9.011%	17.976%
20	15.437%	29.439%

NAME	G6_HCCOMM
CONTROL_EXCLUDE	G6_HYDROCEPH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G910
HD_ICD_9	3313
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G910
COD_ICD_9	3313
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Communicating hydrocephalus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints