autoimmune thyroid disease: Inflammatory disease of the thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. The clinical signs can range from hypothyroidism to thyrotoxicosis depending on the type of autoimmune thyroiditis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
706 |
4. Check minimum number of eventsNone |
706 |
5. Include endpointsNone |
706 |
6. Filter based on genotype QC (FinnGen only) |
706 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E06
- Name in latin
- Thyreoiditis autoimmunis
Similar endpoints
↥List of similar endpoints to
Autoimmune thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5469 | 4605 | 837 |
| Only index persons | 5134 | 4357 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.02 |
| Only index persons | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 38.53 | 38.87 | 36.49 |
| Only index persons | 38.30 | 38.64 | 36.40 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 706 | 614 | 92 |
| Unadjusted period prevalence (%) | 0.19 | 0.21 | 0.04 |
| Median age at first event (years) | 44.37 | 43.56 | 49.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 626
- Matched controls
- 6259
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
16384.0
323.0
581
*
H03AA01
ATC
levothyroxine sodium; systemic
351.6
323.0
495
66
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
800.3
270.0
247
5
104
Kela drug reimbursment
Thyroid insufficiency
2964.5
211.9
193
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
937.3
154.2
145
*
H03BB01
ATC
carbimazole; oral
151.9
98.3
102
8
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
93.1
87
*
E03
ICD-10 Finland
Other hypothyroidism
95.5
89.0
97
12
E03.89
ICD-10 Finland
Other specified hypothyroidism
771.5
71.6
69
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
199.7
69.6
71
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
58.2
55
*
T86
ICPC
Hypothyroidism/myxoedema
91.2
52.9
58
7
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
50.7
48
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
82.7
47.8
53
7
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
39.0
37
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
340.0
32.2
32
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.4
27.7
39
17
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
75.7
26.0
29
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
86.7
22.8
25
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
54.1
22.2
26
5
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.5
21.4
65
128
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
15.3
19.6
32
22
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
18.8
18
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
68.6
17.8
20
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
17.8
17
*
H02AB06
ATC
prednisolone; systemic
2.1
17.7
301
1903
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
19.1
16.1
24
13
E03.8
ICD-10 Finland
Other specified hypothyroidism
+∞
14.6
14
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
13.9
174
941
C07AB07
ATC
bisoprolol; oral
2.0
13.4
232
1432
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.6
13.1
45
103
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
17.2
13.1
20
12
A02BC02
ATC
pantoprazole; systemic
1.9
13.0
383
2853
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
12.5
12
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
21.8
12.1
17
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
11.5
247
1624
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
11.5
11
*
C07AA05
ATC
propranolol; systemic
2.1
11.3
142
763
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.8
11.0
47
132
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
44.1
11.0
13
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
61.0
10.7
12
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.6
10.1
25
39
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.7
9.7
32
71
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
9.6
32
72
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.6
9.5
32
73
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
101.5
9.4
10
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
9.4
9
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
9.4
9
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
9.1
51
175
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
37.2
9.0
11
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.5
8.8
25
47
H04AA01
ATC
glucagon; nasal, parenteral
4.8
8.8
28
60
R00.2
ICD-10 Finland
Palpitations
2.8
8.8
55
206
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.0
8.4
49
175
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
91.2
8.4
9
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
8.3
8
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
8.3
8
*
A10AE05
ATC
insulin detemir; parenteral
3.3
8.2
41
132
B03BA03
ATC
hydroxocobalamin; parenteral
3.9
8.2
32
85
N06AX21
ATC
duloxetine; oral
2.3
8.0
74
342
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.0
107
583
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
7.9
36
109
H02AB09
ATC
hydrocortisone; systemic
6.0
7.7
20
34
R06.0
ICD-10 Finland
Dyspnoea
1.9
7.7
133
796
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.8
7.7
31
85
2504
FHL
Unilateral resection or enucleation
81.0
7.4
8
*
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
7.3
7
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.1
164
1075
K90.0
ICD-10 Finland
Coeliac disease
3.8
7.0
28
76
A10AA01
ATC
NA
4.2
6.8
24
59
A02BC03
ATC
lansoprazole; oral
1.7
6.7
160
1057
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.1
6.6
74
374
TEA00
NOMESCO Finland
Biopsy of lip
10.2
6.6
12
12
N03AX12
ATC
gabapentin; oral
2.0
6.5
89
490
R03AC02
ATC
salbutamol; inhalant
1.5
6.5
327
2599
E06.0
ICD-10 Finland
Acute thyroiditis
70.5
6.4
7
*
107
Kela drug reimbursment
Pernicious anaemia
8.3
6.4
13
16
T89
ICPC
Diabetes insulin dependent
3.3
6.3
30
95
2448A
ICD-9 Finland
Acquired hypothyroidism, Other specified acquired hypothyroidism[HYPOTHYREOSIS POST THYREOIDITIDEM]
+∞
6.3
6
*
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
6.3
6
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
+∞
6.3
6
*
M79.1
ICD-10 Finland
Myalgia
1.9
6.2
89
497
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
6.2
58
271
N03AX16
ATC
pregabalin; oral
1.7
6.2
126
793
A10AA02
ATC
NA
3.8
6.1
24
65
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.1
110
663
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITAUTOIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYROIDITAUTOIM | 1.029 [0.88, 1.2] | 0.713 |
| Birth year | 0.996 [0.99, 1.0] | 0.367 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 3629 females with E4_THYROIDITAUTOIM died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITAUTOIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.497% | No data |
| 10 | 1.444% | No data |
| 15 | 2.964% | No data |
| 20 | 5.351% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITAUTOIM – Autoimmune thyroiditis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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