No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
706 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control conditions
- not E4_THYROIDITAUTOIM
Extra metadata
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Hypothyroidism, autoimmune, DX-based
based on the number of shared cases.
Similar with more cases:
- Autoimmune thyroiditis
- Thyroiditis
- Thyroiditis, ILD-related definition
- Disorders of thyroid, IBD co-morbidities
- Autoimmune diseases related-to ILD
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1013 | 858 | 154 |
| Only index persons | 972 | 826 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.77 | 27.49 | 15.90 |
| Only index persons | 26.47 | 28.23 | 16.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 125 | 13 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | 40.89 | 40.78 | 41.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 125
- Matched controls
- 1248
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.3
ICD-10 Finland
Autoimmune thyroiditis
9971.0
163.2
120
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
8490.9
157.7
124
15
H03AA01
ATC
levothyroxine sodium; systemic
300.3
80.6
123
211
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
13.3
34.0
70
109
104
Kela drug reimbursment
Thyroid insufficiency
18.2
30.6
50
44
E03.89
ICD-10 Finland
Other specified hypothyroidism
14.5
14.3
24
20
E03
ICD-10 Finland
Other hypothyroidism
7.4
10.7
26
43
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.9
10.5
17
13
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
12.0
9.1
16
15
T86
ICPC
Hypothyroidism/myxoedema
9.6
8.6
17
20
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
7.2
8.4
20
32
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
23.9
8.2
11
5
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.5
8.0
15
16
XCK10
NOMESCO Finland
Photography of fundus of eye
6.1
7.5
20
38
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
9.7
7.3
14
16
H3600, E103
ICD-10 Finland
NA
42.4
6.8
8
*
A10AA01
ATC
NA
13.2
6.7
11
9
A10AE05
ATC
insulin detemir; parenteral
5.8
6.6
18
35
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
15.4
6.5
10
7
A10AA02
ATC
NA
11.9
6.4
11
10
A10AE04
ATC
insulin glargine; parenteral
5.1
6.3
19
42
2452A
ICD-9 Finland
Thyroiditis, Chronic lymphocytic thyroiditis
+∞
6.3
6
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
5.0
6.2
19
43
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHY_AI_DX and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_HYTHY_AI_DX.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_HYTHY_AI_DX – Hypothyroidism, autoimmune, DX-based
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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