Risteys · SFN

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G60.8, G62.8, G63.3* Cause of death: ICD-10 — G60.8, G62.8, G63.3* 2 out of 7 registries used, show all original rules.	926
4. Check minimum number of events None	926
5. Include endpoints None	926
6. Filter based on genotype QC (FinnGen only)	926

	All	Female	Male
Number of individuals
Whole population	4420	1835	2568
Only index persons	4164	1744	2420
Unadjusted period prevalence (%)
Whole population	0.06	0.05	0.07
Only index persons	0.08	0.06	0.09
Median age at first event (years)
Whole population	63.93	64.22	63.77
Only index persons	63.81	64.02	63.66

	All	Female	Male
Number of individuals	926	406	520
Unadjusted period prevalence (%)	0.19	0.14	0.23
Median age at first event (years)	64.11	62.03	65.73

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
815: Matched controls
8151

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

247.2

323.0

368

G62.8

ICD-10 Finland

Other specified polyneuropathies

4503599627370496.0

323.0

761

N03AX12

ATC

gabapentin; oral

7.9

125.8

343

686

N03AX16

ATC

pregabalin; oral

5.5

100.4

396

1203

N06AX21

ATC

duloxetine; oral

5.5

57.7

192

434

G60.8

ICD-10 Finland

Other hereditary and idiopathic neuropathies

+∞

55.9

R20.2

ICD-10 Finland

Paraesthesia of skin

7.5

52.3

131

202

TAB00

NOMESCO Finland

Lumbar puncture

8.4

47.3

109

147

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.4

46.0

187

512

TAW99

NOMESCO Finland

Other minor neurosurgical procedure

36.2

39.9

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

5.7

38.5

118

235

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.7

35.9

321

1559

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.5

34.5

134

344

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

33.6

454

2744

AA1AD

NOMESCO Finland

CT of head and brain

2.7

32.7

284

1339

G60.0

ICD-10 Finland

Hereditary motor and sensory neuropathy

+∞

31.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.9

31.0

139

406

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

5.9

30.6

169

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.2

30.1

180

660

L28

ICPC

Limited function/disability (L)

3.0

28.6

190

747

N06AA09

ATC

amitriptyline; systemic

3.7

28.3

135

414

G61.8

ICD-10 Finland

Other inflammatory polyneuropathies

+∞

27.2

N29

ICPC

Neurological sympt/complt other

10.6

26.1

G63.2*E11.4

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy

34.3

25.7

N04BC05

ATC

pramipexole; oral

4.0

25.5

109

303

N03AE01

ATC

clonazepam; systemic

4.6

24.7

210

M48.0

ICD-10 Finland

Spinal stenosis

3.1

24.6

154

576

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.8

24.5

187

795

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.3

24.0

311

1747

N02AX02

ATC

tramadol; systemic, rectal

2.1

23.8

404

2559

A02BC02

ATC

pantoprazole; systemic

2.2

23.8

568

4171

R52.2

ICD-10 Finland

Other chronic pain

6.3

22.8

105

R26.8

ICD-10 Finland

Other and unspecified abnormalities of gait and mobility

9.7

22.6

N06AX16

ATC

venlafaxine; oral

3.0

22.1

144

549

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.7

22.0

101

298

N03AX09

ATC

lamotrigine; oral

5.7

21.8

120

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

3.7

21.8

100

295

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.4

21.6

112

364

N28

ICPC

Limited function/disability (N)

10.5

21.6

ZX120

NOMESCO Finland

Intravenous

3.3

21.5

119

405

Z01.8

ICD-10 Finland

Other specified special examinations

2.4

21.5

216

1058

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.6

21.3

181

811

M79.6

ICD-10 Finland

Pain in limb

2.1

21.1

328

1969

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.2

21.1

278

1552

G61.0

ICD-10 Finland

Guillain-Barré syndrome

+∞

20.9

N99

ICPC

Neurological disease other

12.9

20.5

C03CA01

ATC

furosemide; systemic

2.2

20.4

274

1539

N02BE01

ATC

paracetamol; systemic, rectal

2.6

20.3

719

6056

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

9.4

20.3

A28

ICPC

Limited function/disability NOS

2.6

19.9

166

735

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.6

19.8

279

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.6

19.5

277

G64

ICD-10 Finland

Other disorders of peripheral nervous system

+∞

18.8

N02AA05

ATC

oxycodone; systemic

2.5

18.5

163

741

TPH04

NOMESCO Finland

Cathetrisation of vein

2.2

18.3

214

1117

H02AB06

ATC

prednisolone; systemic

1.9

18.3

406

2757

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

4.7

18.0

144

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.9

18.0

122

474

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

4.0

17.9

199

G61.9

ICD-10 Finland

Inflammatory polyneuropathy, unspecified

97.2

17.6

Z50.1

ICD-10 Finland

Other physical therapy

4.0

17.2

191

L17

ICPC

Foot/toe symptom/complaint

2.1

17.2

234

1305

N18

ICPC

Paralysis/weakness

8.7

16.9

XA402

NOMESCO Finland

ENMG

6.6

16.8

G72.9

ICD-10 Finland

Myopathy, unspecified

13.8

16.6

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.8

16.4

110

424

R50.9

ICD-10 Finland

Fever, unspecified

2.5

16.4

143

644

UJF32

NOMESCO Finland

Coloscopy

2.0

16.0

249

1457

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.6

15.7

122

514

R53

ICD-10 Finland

Malaise and fatigue

2.2

15.6

187

977

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

2.0

15.6

261

1567

M25.5

ICD-10 Finland

Pain in joint

2.0

15.5

239

1392

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

8.2

15.4

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.5

15.4

134

600

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

2.3

15.1

151

726

TK800

NOMESCO Finland

Hemodialysis

6.0

15.0

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

2.8

15.0

103

404

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.7

14.9

105

417

R4110

NOMESCO Finland

Physiotherapy

2.0

14.9

253

1524

A01

ICPC

Pain general/multiple sites

3.1

14.8

296

D47.2

ICD-10 Finland

Monoclonal gammopathy of undetermined significance (MGUS)

10.0

14.8

E11.4

ICD-10 Finland

Type 2 diabetes mellitus, with neurological complications

5.3

14.8

R42

ICD-10 Finland

Dizziness and giddiness

2.1

14.7

198

1088

H04.10

ICD-10 Finland

Dry eye syndrome

2.8

14.7

103

406

A41.9

ICD-10 Finland

Sepsis, unspecified

4.7

14.7

112

N06AX11

ATC

mirtazapine; oral

1.9

14.6

269

1668

G63.2*E10.4

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic polyneuropathy

81.6

14.6

Z03.89

ICD-10 Finland

Observation for other suspected diseases and conditions

2.5

14.6

126

559

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.0

14.6

219

1254

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.4

14.5

226

R35

ICD-10 Finland

Polyuria

3.1

14.3

279

N05BA04

ATC

oxazepam; oral

2.0

14.3

214

1225

SPAT1215

SPAT

Assessment of need for medical rehabilitation

4.3

14.3

129

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.9

14.2

290

1859

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.8

14.2

338

2285

L04AX01

ATC

azathioprine; systemic

3.9

14.2

160

R52.9

ICD-10 Finland

Pain, unspecified

2.9

14.0

314

N03AF01

ATC

carbamazepine; oral, rectal

3.5

13.9

195

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.8

13.5

337

R13

ICD-10 Finland

Dysphagia

3.0

13.2

288

J01DB01

ATC

cefalexin; oral

1.9

13.2

661

5614

R51.80

ICD-10 Finland

Headache

2.3

13.0

124

580

G63.2

ICD-10 Finland

Diabetic polyneuropathy

28.9

13.0

H02AB07

ATC

prednisone; oral

2.3

12.9

135

659

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

3.1

12.9

252

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

5.4

12.9

H02AB04

ATC

methylprednisolone; systemic

2.2

12.8

136

668

R60.0

ICD-10 Finland

Localized oedema

2.4

12.8

110

488

A02BC05

ATC

esomeprazole; systemic

1.8

12.8

340

2359

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.4

12.7

113

511

SPAT1229

SPAT

Assessment of need for aid

2.8

12.7

334

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.2

12.6

138

689

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.9

12.6

292

N05AH04

ATC

quetiapine; oral

2.2

12.6

139

696

H02AB09

ATC

hydrocortisone; systemic

5.8

12.5

G62.0

ICD-10 Finland

Drug-induced polyneuropathy

131.9

12.5

SPAT1216

SPAT

Assessment of functional ability

2.2

12.4

144

734

J01FF01

ATC

clindamycin; systemic

1.8

12.4

243

1523

A07AA02

ATC

nystatin; oral

3.0

12.4

254

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

4.1

12.3

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

5.0

12.3

UKC02

NOMESCO Finland

Cystoscopy

2.1

12.3

163

884

S18

ICPC

Laceration/cut

1.7

12.3

365

2609

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.1

12.2

160

861

R07.4

ICD-10 Finland

Chest pain, unspecified

1.8

12.0

243

1535

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.1

12.0

227

R4120

NOMESCO Finland

Occupational therapy

2.9

12.0

265

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

4.0

11.9

127

N02AJ06

ATC

codeine and paracetamol; systemic

1.7

11.8

300

2038

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.8

11.8

226

1400

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.0

11.8

157

851

M54.1

ICD-10 Finland

Radiculopathy

3.9

11.6

125

J01MA02

ATC

ciprofloxacin; systemic

1.7

11.6

329

2307

E0000UV

ATC

1.7

11.6

302

2063

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

3.0

11.5

231

B03XA02

ATC

darbepoetin alfa; parenteral

5.7

11.4

Z49.1

ICD-10 Finland

Extracorporeal dialysis

7.4

11.3

JN3AD

NOMESCO Finland

Abdominal CT examination

2.7

11.3

317

J01EA01

ATC

trimethoprim; systemic

1.9

11.3

196

1174

SPAT1295

SPAT

Other function in accordance with physical therapy nomenclature

3.1

11.1

201

L04AA06

ATC

mycophenolic acid; systemic

5.5

11.1

Z3226

NOMESCO Finland

Physiotherapist

1.9

11.1

173

993

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

2.1

11.0

133

691

A03FA01

ATC

metoclopramide; systemic, rectal

1.9

11.0

181

1059

127

Kela drug reimbursment

Transplant complication

6.4

11.0

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.5

10.9

358

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.7

10.9

326

2309

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.7

10.8

376

2778

N06AB04

ATC

citalopram; systemic

1.9

10.8

173

1005

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

5.2

10.7

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.1

10.7

190

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.2

10.6

108

520

SPAT1301

SPAT

No procedures

1.7

10.6

256

1703

NJ3CG

NOMESCO Finland

Extensive MRI examination of extremities with median high magnet

14.4

10.5

M54.5

ICD-10 Finland

Low back pain

1.7

10.5

258

1724

A02BA02

ATC

ranitidine; systemic

1.9

10.5

165

950

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.6

10.4

308

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.1

10.4

132

697

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

10.4

200

1235

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

2.3

10.4

100

468

N06AB10

ATC

escitalopram; oral

2.0

10.4

149

830

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

3.1

10.3

189

N06

ICPC

Sensation disturbance other

13.3

10.2

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.0

10.1

152

857

S97

ICPC

Chronic ulcer skin

2.9

10.1

224

C07AB07

ATC

bisoprolol; oral

1.6

10.1

394

2983

WX002

NOMESCO Finland

Sedation and analgesia

1.9

10.1

172

1019

R52.1

ICD-10 Finland

Chronic intractable pain

9.3

10.1

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

5.4

10.1

A04AA01

ATC

ondansetron; systemic, rectal

2.8

10.0

252

JN4BD

NOMESCO Finland

Extensive body CT

2.1

10.0

115

583

Z3231

NOMESCO Finland

Registered nurse

1.7

10.0

234

1535

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

12.4

9.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.0

9.8

143

799

Z2446

NOMESCO Finland

Social worker

2.8

9.8

238

SPAT1231

SPAT

Assessment of adjustments needed in living environment

4.7

9.8

ZXD05

NOMESCO Finland

Urgent procedure

1.7

9.8

261

1779

B81

ICPC

Anaemia vit B12/folate deficiency

3.5

9.7

130

R06.0

ICD-10 Finland

Dyspnoea

1.8

9.7

210

1343

G62.1

ICD-10 Finland

Alcoholic polyneuropathy

55.7

9.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

2.7

9.6

263

TK810

NOMESCO Finland

Hemofiltration

10.2

9.5

JN4AD

NOMESCO Finland

Body CT examination

2.4

9.5

342

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

3.2

9.5

154

R11

ICD-10 Finland

Nausea and vomiting

2.6

9.5

284

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.0

9.5

133

730

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

3.7

9.4

112

R27.0

ICD-10 Finland

Ataxia, unspecified

17.8

9.4

6BA02

NOMESCO Finland

30.4

9.4

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

3.0

9.4

189

TPX10

NOMESCO Finland

Implantation of vascular injection port

4.0

9.3

ZXA05

NOMESCO Finland

Left side

1.7

9.3

213

1384

N05CF01

ATC

zopiclone; oral

1.7

9.2

264

1830

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

3.1

9.2

164

NA7BG

NOMESCO Finland

Spine and spinal cord MRI examination with high intensity magnet

13.9

9.2

R20.1

ICD-10 Finland

Hypoaesthesia of skin

13.9

9.2

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

2.6

9.2

277

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.1

9.2

108

555

H53.2

ICD-10 Finland

Diplopia

3.8

9.1

100

XKD00

NOMESCO Finland

Uroflowmetry

1.8

9.1

164

984

C08CA05

ATC

nifedipine; systemic

2.6

9.1

280

GD1AD

NOMESCO Finland

Thorax CT examination

3.2

9.1

154

WX408

NOMESCO Finland

General anesthesy, balanced

1.7

9.1

233

1561

V03AE01

ATC

polystyrene sulfonate; oral

7.2

9.1

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

10.2

9.0

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

9.0

266

1851

A06AD11

ATC

lactulose; oral

1.9

9.0

131

731

NXL00

NOMESCO Finland

Biopsy of muscle

18.8

8.9

H03AA01

ATC

levothyroxine sodium; systemic

1.8

8.9

171

1050

Z03.5

ICD-10 Finland

Observation for other suspected cardiovascular diseases

2.5

8.9

296

N94

ICPC

Peripheral neuritis/neuropathy

24.3

8.9

NA3EA

NOMESCO Finland

Lumbar spine X-ray examination with flexion

3.8

8.9

G04CA02

ATC

tamsulosin; oral

1.7

8.9

218

1443

G44.2

ICD-10 Finland

Tension-type headache

2.1

8.9

105

538

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

5.2

8.8

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

1.9

8.8

139

799

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

3.4

8.8

125

R39.1

ICD-10 Finland

Other difficulties with micturition

3.6

8.7

110

A11CC03

ATC

alfacalcidol; systemic

4.3

8.7

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

2.4

8.6

340

P01AB01

ATC

metronidazole; oral, rectal

1.6

8.6

290

2090

D64.9

ICD-10 Finland

Anaemia, unspecified

2.2

8.6

460

K59.0

ICD-10 Finland

Constipation

2.8

8.6

208

XW000

NOMESCO Finland

Bone marrow biopsy

3.0

8.6

161

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

2.5

8.5

283

J02AC01

ATC

fluconazole; systemic

1.6

8.5

271

1921

TPH07

NOMESCO Finland

Cathetrisation of artery

2.1

8.5

507

R25.1

ICD-10 Finland

Tremor, unspecified

4.3

8.5

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.6

8.5

242

1666

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.1

8.4

102

527

M04AA01

ATC

allopurinol; systemic

1.9

8.4

123

684

R1250

NOMESCO Finland

Evaluation of functional capability

4.1

8.4

JN1CG

NOMESCO Finland

Extensive MRI examination of upper part of abdomen with high intensity magnet

4.6

8.4

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.2

8.4

388

R5599

NOMESCO Finland

Other rehabilitation service

4.1

8.3

XKD06

NOMESCO Finland

Physiologic investigation of micturition

3.4

8.3

114

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

4.0

8.3

ZXA00

NOMESCO Finland

Right side

1.7

8.3

226

1537

J01MA14

ATC

moxifloxacin; systemic

2.2

8.3

377

B03BA03

ATC

hydroxocobalamin; parenteral

2.7

8.3

218

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

3.6

8.3

104

PD4CG

NOMESCO Finland

Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet

6.6

8.2

TQW40

NOMESCO Finland

Remowal of suture of skin

2.4

8.2

295

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

5.5

8.2

M79.0

ICD-10 Finland

Rheumatism, unspecified

3.5

8.2

105

A46

ICD-10 Finland

Erysipelas

1.9

8.2

128

730

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

4.1

8.1

E86

ICD-10 Finland

Volume depletion

4.5

8.1

NJ3BG

NOMESCO Finland

MRI examination of extremities with high intensity magnet

17.4

8.1

N06AA10

ATC

nortriptyline; systemic

4.7

8.0

K59.09

ICD-10 Finland

Constipation, unspecified

2.5

8.0

242

P01BA02

ATC

hydroxychloroquine; oral

2.3

8.0

348

R01AD08

ATC

fluticasone; nasal

1.7

8.0

209

1403

Z3229

NOMESCO Finland

Other healthcare associate professional

2.2

8.0

374

B01AB05

ATC

enoxaparin; parenteral

1.6

8.0

249

1753

M79.1

ICD-10 Finland

Myalgia

2.0

7.9

521

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

6.7

7.9

XG412

NOMESCO Finland

Flow-volume spirometry with bronchospasmolysis

2.5

7.9

249

G56.2

ICD-10 Finland

Lesion of ulnar nerve

3.3

7.8

120

L04AD01

ATC

ciclosporin; systemic

4.9

7.8

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

3.5

7.8

104

R06AE07

ATC

cetirizine; oral

1.6

7.8

307

2285

M14.6

ICD-10 Finland

Neuropathic arthropathy

45.4

7.7

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

2.4

7.7

286

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.0

7.7

101

542

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.8

7.7

141

849

Z04.9

ICD-10 Finland

Examination and observation for unspecified reason

3.1

7.7

133

A02BC01

ATC

omeprazole; systemic

1.6

7.7

220

1512

ZXE10

NOMESCO Finland

More than one and less than three hours

1.6

7.7

291

2142

TKC20

NOMESCO Finland

Catheterisation of bladder

2.3

7.6

300

D07AC01

ATC

betamethasone; topical

1.6

7.6

266

1922

R26.2

ICD-10 Finland

Difficulty in walking, not elsewhere classified

6.2

7.6

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.7

7.5

188

Z71.8

ICD-10 Finland

Other specified counselling

1.7

7.5

176

1143

133

Kela drug reimbursment

Severe chronic pancreatic insufficiency

5.1

7.5

M01AB55

ATC

diclofenac, combinations; oral

2.4

7.4

276

JC2KB

NOMESCO Finland

Functional X-ray examination of swallowing

6.5

7.4

G12.8

ICD-10 Finland

Other spinal muscular atrophies and related syndromes

80.8

7.4

G58.7

ICD-10 Finland

Mononeuritis multiplex

80.8

7.4

C88.0

ICD-10 Finland

Waldenström macroglobulinaemia

80.8

7.4

SHA03

NOMESCO Finland

Correction of physiology of bite - demanding therapy visit

4.0

7.4

PH1AE

NOMESCO Finland

Ultrasound examination of upper extremity veins

5.4

7.4

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

2.3

7.4

320

G60.9

ICD-10 Finland

Hereditary and idiopathic neuropathy, unspecified

+∞

7.3

L16

ICPC

Ankle symptom/complaint

2.1

7.3

442

X59

ICD-10 Finland

Exposure to unspecified factor

1.8

7.3

144

888

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.2

7.3

377

N12

ICD-10 Finland

Tubulo-interstitial nephritis, not specified as acute or chronic

5.2

7.3

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.9

7.3

149

N05CD07

ATC

temazepam; oral

1.9

7.3

103

566

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

4.3

7.3

R03AC02

ATC

salbutamol; inhalant

1.5

7.3

381

3008

N06CA01

ATC

amitriptyline and psycholeptics; systemic

2.0

7.3

444

R33

ICD-10 Finland

Retention of urine

2.2

7.2

342

S01GX01

ATC

cromoglicic acid; ophthalmic

1.8

7.2

131

788

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

2.5

7.2

235

A12AA04

ATC

calcium carbonate; oral

4.9

7.2

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.3

7.2

311

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.8

7.1

140

863

M54.4

ICD-10 Finland

Lumbago with sciatica

1.8

7.1

125

742

XG410

NOMESCO Finland

Flow-volume spirometry

2.8

7.1

167

Z09.4

ICD-10 Finland

Follow-up examination after treatment of fracture

2.9

7.1

145

M05BA04

ATC

alendronic acid; oral

2.3

7.1

291

XF400

NOMESCO Finland

ECG with 12 standard connections

1.7

7.1

144

894

N18.8

ICD-10 Finland

Other chronic renal failure

3.5

7.1

Z94.8

ICD-10 Finland

Other transplanted organ and tissue status

10.1

7.0

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.7

7.0

166

1076

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

2.9

7.0

147

A09AA02

ATC

multienzymes (lipase, protease etc.)

4.0

7.0

ZY010

NOMESCO Finland

Hospital outpatient

3.0

7.0

140

J01CF05

ATC

flucloxacillin; systemic

3.0

7.0

131

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

3.5

7.0

M01AX05

ATC

glucosamine; oral

1.7

7.0

158

1015

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

2.2

6.9

336

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

7.6

6.9

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

2.2

6.9

351

SPAT1260

SPAT

Consultation of another employee

1.7

6.9

142

887

Z31.5

ICD-10 Finland

Genetic counselling

3.1

6.9

121

K07.60

ICD-10 Finland

Snapping jaw

3.1

6.9

121

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

1.7

6.9

145

912

WW500

NOMESCO Finland

Blood transfusion

2.8

6.9

150

SBA10

NOMESCO Finland

Measurement of excretion of saliva

8.4

6.8

G04BD12

ATC

mirabegron; oral

1.9

6.8

511

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

3.8

6.8

XPX04

NOMESCO Finland

Angioscopy

11.0

6.8

J01MA12

ATC

levofloxacin; systemic

1.7

6.8

149

948

137

Kela drug reimbursment

Uraemia requiring dialysis

6.2

6.8

AA1AG

NOMESCO Finland

Short MRI examination of brain with median intensity magnet

6.2

6.8

TNX50

NOMESCO Finland

Removal of cutom molded cast and internal stretch

2.7

6.8

169

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.5

6.8

325

2509

M01AE03

ATC

ketoprofen; systemic, rectal

1.5

6.7

292

2202

SAA03

NOMESCO Finland

Extended examination of mouth

1.5

6.7

269

1992

R56.8

ICD-10 Finland

Other and unspecified convulsions

2.7

6.7

170

SPAT1254

SPAT

Administration of medicine

1.8

6.7

118

700

F32.11

ICD-10 Finland

Moderate depressive episode with somatic syndrome

3.4

6.7

WX882

NOMESCO Finland

High dependency care

3.3

6.7

101

UJF30

NOMESCO Finland

Ileoscopy through colon

2.1

6.7

391

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

2.3

6.7

280

N18.0

ICD-10 Finland

End-stage renal disease

5.2

6.7

C03DA01

ATC

spironolactone; oral

2.0

6.7

480

SPAT1296

SPAT

Other function in accordance with occupational therapy nomenclature

5.6

6.6

ZZH40

NOMESCO Finland

Substitute of bone

7.9

6.6

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

3.9

6.6

C07AA05

ATC

propranolol; systemic

1.7

6.6

135

840

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

2.3

6.6

249

JAH00

NOMESCO Finland

Laparotomy

3.4

6.6

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.7

6.6

144

912

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

2.2

6.6

295

SPAT1167

SPAT

Insertion of urinary catheter

3.0

6.6

125

WX892

NOMESCO Finland

Monitored bed care

2.1

6.6

358

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

2.0

6.6

411

N05BA01

ATC

diazepam; systemic, rectal

1.8

6.6

107

622

ABD30

NOMESCO Finland

Implantation of spinal stimulation device

10.1

6.5

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

2.1

6.5

360

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

3.7

6.5

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

1.9

6.5

477

SAA04

NOMESCO Finland

Special inverstigation of mouth

2.4

6.5

212

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

2.3

6.5

256

Z2221

NOMESCO Finland

Medical doctor

1.6

6.5

209

1473

SPAT1153

SPAT

Removal of sutures

1.5

6.4

256

1892

G25.8

ICD-10 Finland

Other specified extrapyramidal and movement disorders

3.6

6.4

M03BX01

ATC

baclofen; systemic

4.7

6.4

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

2.4

6.4

217

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.9

6.4

472

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.5

6.4

259

1922

GBB00

NOMESCO Finland

Tracheostomy

5.0

6.4

K58.9

ICD-10 Finland

Irritable bowel syndrome without diarrhoea

3.1

6.4

105

SPAT1211

SPAT

Application of soft bandage

2.0

6.4

400

NE1AA

NOMESCO Finland

Pelvis X-ray examination

2.2

6.4

295

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

8.2

6.3

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

5.2

6.3

TQW11

NOMESCO Finland

Vacuum treatment of wound

4.1

6.3

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

3.8

6.3

G12.2

ICD-10 Finland

Motor neuron disease

9.3

6.3

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.5

6.3

361

2878

SPAT1225

SPAT

Implementation of podiatry rehabilitation plan

3.5

6.3

SPAT1104

SPAT

Monitoring of emergency patient

2.2

6.2

290

WW200

NOMESCO Finland

Immunization

3.2

6.2

101

WX722

NOMESCO Finland

PEEP

2.6

6.2

166

G62

ICD-10 Finland

Other polyneuropathies

26.9

6.2

NGA20

NOMESCO Finland

Exploration of soft tissue knee or lower leg, open

26.9

6.2

SPAT1263

SPAT

Sampling

1.5

6.2

321

2499

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.1

6.2

316

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

2.5

6.2

196

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.1

6.2

317

J01CA08

ATC

pivmecillinam; oral

1.5

6.2

237

1731

N03AG01

ATC

valproic acid; systemic, rectal

2.4

6.2

216

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

6.2

399

3252

N04BC04

ATC

ropinirole; oral

6.3

6.2

R52.0

ICD-10 Finland

Acute pain

3.5

6.2

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

1.9

6.2

510

K56.6

ICD-10 Finland

Other and unspecified intestinal obstruction

3.0

6.2

122

NF1AA

NOMESCO Finland

Hip X-ray examination

2.1

6.1

361

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

2.4

6.1

229

SBB10

NOMESCO Finland

Teeth copy

2.5

6.1

180

SPAT1172

SPAT

Guidance concerning hydration

3.8

6.1

RJ411

NOMESCO Finland

12.6

6.1

E87.6

ICD-10 Finland

Hypokalaemia

3.2

6.1

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

2.4

6.1

220

F43.22

ICD-10 Finland

Adaptation disorder with mixed anxiety and depression

3.0

6.1

109

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

2.9

6.1

125

T89

ICPC

Diabetes insulin dependent

2.8

6.1

132

G97.0

ICD-10 Finland

Cerebrospinal fluid leak from spinal puncture

6.8

6.1

S29

ICPC

Skin symptom/complaint other

1.7

6.0

130

822

A10AE05

ATC

insulin detemir; parenteral

2.3

6.0

221

Z03.8

ICD-10 Finland

Observation for other suspected diseases and conditions

2.7

6.0

149

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

2.5

6.0

194

R20.8

ICD-10 Finland

Other and unspecified disturbances of skin sensation

6.1

6.0

I73.0

ICD-10 Finland

Raynaud syndrome

4.6

6.0

NAME	SFN
CONTROL_EXCLUDE	G6_POLYNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G608\|G628\|G633
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G608\|G628\|G633
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
SFN	2.127 [1.75, 2.58]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.556

Parameter	HR [95% CI]	p-value
SFN	1.787 [1.5, 2.13]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.059

N-year risk	Females	Males
1	0.152%	0.371%
5	1.346%	2.018%
10	3.672%	4.985%
15	6.693%	9.373%
20	10.957%	15.86%

Small fibre neuropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints