peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
92 |
4. Check minimum number of eventsNone |
92 |
5. Include endpointsNone |
92 |
6. Filter based on genotype QC (FinnGen only) |
92 |
Control definitions (FinnGen only)
- Control exclude
- PAIN
Extra metadata
- First used in FinnGen datafreeze
- DF3
- Parent code in ICD-10
- G54
- Name in latin
- Syndroma phantomatis membri dolorosum
Similar endpoints
↥List of similar endpoints to
Phantom limb syndrome with pain
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Pain (limb, back, neck, head abdominally)
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 707 | 296 | 401 |
| Only index persons | 573 | 236 | 337 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.87 | 56.33 | 55.27 |
| Only index persons | 53.44 | 53.66 | 53.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 92 | 41 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 55.32 | 50.35 | 59.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 81
- Matched controls
- 810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.6
ICD-10 Finland
Phantom limb syndrome with pain
+∞
111.0
79
*
N03AX16
ATC
pregabalin; oral
26.8
35.3
56
62
N03AX12
ATC
gabapentin; oral
24.3
26.9
40
31
N02AA05
ATC
oxycodone; systemic
16.1
21.3
37
40
NGQ20
NOMESCO Finland
Amputation of lower leg
92.8
19.8
21
*
N02AX02
ATC
tramadol; systemic, rectal
8.5
17.7
55
161
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
16.4
17.0
28
25
N06AX21
ATC
duloxetine; oral
20.6
16.7
25
17
M79.6
ICD-10 Finland
Pain in limb
8.1
16.1
45
108
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
11.9
15.0
29
36
N06AA09
ATC
amitriptyline; systemic
18.3
14.9
23
17
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
27.0
14.1
19
9
C03CA01
ATC
furosemide; systemic
6.9
13.3
40
100
A46
ICD-10 Finland
Erysipelas
8.3
12.1
29
51
J01MA02
ATC
ciprofloxacin; systemic
5.6
12.0
48
166
J01FF01
ATC
clindamycin; systemic
6.0
12.0
41
118
NHQ40
NOMESCO Finland
Amputation of toe
30.1
11.6
15
6
L28
ICPC
Limited function/disability (L)
7.4
10.9
28
54
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
9.3
10.8
23
33
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
16.1
10.7
17
13
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
38.1
10.7
13
*
R52.2
ICD-10 Finland
Other chronic pain
46.2
10.3
12
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
10.2
10.1
20
25
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
62.7
9.9
11
*
NFQ20
NOMESCO Finland
Amputation of femur
112.5
9.6
10
*
G54.0
ICD-10 Finland
Brachial plexus disorders
112.5
9.6
10
*
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
+∞
9.6
9
*
N06AX16
ATC
venlafaxine; oral
7.5
9.1
22
38
L17
ICPC
Foot/toe symptom/complaint
5.0
9.1
34
102
SPAT1229
SPAT
Assessment of need for aid
9.2
9.1
19
26
SPAT1148
SPAT
Treatment of chronic ulcer or burn
7.0
9.0
23
43
N05CF01
ATC
zopiclone; oral
4.7
8.8
36
118
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
15.0
8.8
14
11
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.5
8.7
19
28
N06AX11
ATC
mirtazapine; oral
4.4
8.5
38
136
ZXE20
NOMESCO Finland
More than three and less than five hours
6.1
8.2
23
49
R10.1
ICD-10 Finland
Pain localized to upper abdomen
10.5
8.0
15
17
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
49.9
7.9
9
*
Z89.5
ICD-10 Finland
Acquired absence of leg at or below knee
87.7
7.5
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.1
7.5
21
44
N03AE01
ATC
clonazepam; systemic
10.3
7.4
14
16
S18
ICPC
Laceration/cut
3.7
7.4
43
188
M54.5
ICD-10 Finland
Low back pain
4.9
7.3
25
67
ZXD05
NOMESCO Finland
Urgent procedure
3.9
7.3
37
144
R06.0
ICD-10 Finland
Dyspnoea
4.5
7.1
27
80
A28
ICPC
Limited function/disability NOS
5.1
7.1
23
58
Z01.8
ICD-10 Finland
Other specified special examinations
4.9
7.0
24
64
S97
ICPC
Chronic ulcer skin
9.1
7.0
14
18
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.0
6.9
23
59
A41.9
ICD-10 Finland
Sepsis, unspecified
18.7
6.9
10
6
A01
ICPC
Pain general/multiple sites
10.1
6.9
13
15
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.6
6.7
14
19
A49.9
ICD-10 Finland
Bacterial infection, unspecified
6.1
6.7
18
36
ZXA00
NOMESCO Finland
Right side
4.0
6.7
30
104
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
6.7
25
73
WX306
NOMESCO Finland
Lumbar epidural anesthesy
8.9
6.4
13
17
J01MA12
ATC
levofloxacin; systemic
4.3
6.4
25
76
SPAT1301
SPAT
No procedures
3.5
6.4
38
163
TK800
NOMESCO Finland
Hemodialysis
29.2
6.4
8
*
N06AA10
ATC
nortriptyline; systemic
+∞
6.3
6
*
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
+∞
6.3
6
*
P06
ICPC
Sleep disturbance
6.4
6.2
16
30
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
6.2
45
222
N05CD07
ATC
temazepam; oral
5.2
6.1
19
45
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.3
6.1
41
190
M19.0
ICD-10 Finland
Primary arthrosis of other joints
9.2
6.1
12
15
Mortality – FinRegistry
↥Association
Association between endpoint PHANTOMLIMB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PHANTOMLIMB | 2.807 [1.79, 4.39] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 255 females with PHANTOMLIMB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| PHANTOMLIMB | 2.059 [1.54, 2.76] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 349 males with PHANTOMLIMB died.
Mortality risk
Mortality risk for people of age
years, who have PHANTOMLIMB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.332% |
| 5 | 1.62% | 1.938% |
| 10 | 4.051% | 5.199% |
| 15 | 7.699% | 10.008% |
| 20 | 12.73% | 16.672% |
Relationships between endpoints
↥Index endpoint: PHANTOMLIMB – Phantom limb syndrome with pain
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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