Recurrent and persistent haematuria

N14_RECURANDPERHEAMATUR

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N02# Cause of death: ICD-10 — N02# 2 out of 7 registries used, show all original rules.	299
4. Check minimum number of events None	299
5. Include endpoints None	299
6. Filter based on genotype QC (FinnGen only)	299

Control definitions (FinnGen only)

Control exclude: N14_GLOMERULAR

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: N00-N08
Name in latin: Haematuria recidiva et persistens

NAME	N14_RECURANDPERHEAMATUR
CONTROL_EXCLUDE	N14_GLOMERULAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N02
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N02
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Recurrent and persistent haematuria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2501	1150	1325
Only index persons	2128	1044	1084
Unadjusted period prevalence (%)
Whole population	0.04	0.03	0.04
Only index persons	0.04	0.04	0.04
Median age at first event (years)
Whole population	52.05	43.41	59.18
Only index persons	48.62	41.87	55.11

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	299	140	159
Unadjusted period prevalence (%)	0.06	0.05	0.07
Median age at first event (years)	51.75	43.14	59.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
274: Matched controls
2739

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N02.9

ICD-10 Finland

Recurrent and persistent haematuria, unspecified

+∞

152.8

132

R31

ICD-10 Finland

Unspecified haematuria

14.4

65.0

122

144

N08.2*D89.80

ICD-10 Finland

Immunoglobulin A (IgA) nephropathy

+∞

47.3

N02

ICD-10 Finland

Recurrent and persistent haematuria

+∞

31.9

UKC02

NOMESCO Finland

Cystoscopy

5.8

30.6

103

259

N02.0

ICD-10 Finland

Recurrent and persistent haematuria, minor glomerular abnormality

+∞

29.7

N02.8

ICD-10 Finland

Recurrent and persistent haematuria, other

+∞

29.7

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

29.9

24.2

N08.2

ICD-10 Finland

Glomerular disorders in blood diseases and disorders involving the immune mechanism

+∞

22.2

KA3AT

NOMESCO Finland

Biopsy of kidney with ultrasound guidance

87.4

22.0

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

29.3

21.8

A11CC03

ATC

alfacalcidol; systemic

23.9

21.3

D89.80

ICD-10 Finland

Immunoglobulin A (IgA) deposits in organisms

+∞

21.1

KA1AE

NOMESCO Finland

Kidney ultrasound examination

18.9

21.1

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

52.4

20.5

N18.8

ICD-10 Finland

Other chronic renal failure

21.4

20.0

B03XA01

ATC

erythropoietin; parenteral

71.5

18.0

N03.9

ICD-10 Finland

Chronic nephritic syndrome, unspecified

+∞

17.9

A12AA04

ATC

calcium carbonate; oral

45.3

17.5

N02.1

ICD-10 Finland

Recurrent and persistent haematuria, focal and segmental glomerular lesions

+∞

15.8

N02.2

ICD-10 Finland

Recurrent and persistent haematuria, diffuse membranous glomerulonephritis

+∞

15.8

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

6.9

15.7

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

7.7

15.3

Z94.0

ICD-10 Finland

Kidney transplant status

33.8

15.0

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

60.1

15.0

N02.3

ICD-10 Finland

Recurrent and persistent haematuria, diffuse mesangial proliferative glomerulonephritis

+∞

14.7

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

158.0

14.6

L04AA06

ATC

mycophenolic acid; systemic

20.5

14.5

137

Kela drug reimbursment

Uraemia requiring dialysis

79.2

13.7

Z49.1

ICD-10 Finland

Extracorporeal dialysis

22.5

12.2

R80

ICD-10 Finland

Isolated proteinuria

22.5

12.2

L04AD01

ATC

ciclosporin; systemic

21.1

11.3

B03XA02

ATC

darbepoetin alfa; parenteral

21.1

11.3

127

Kela drug reimbursment

Transplant complication

18.8

10.9

N18.0

ICD-10 Finland

End-stage renal disease

29.4

10.8

N02BE

ICD-10 Finland

+∞

10.5

N02.4

ICD-10 Finland

Recurrent and persistent haematuria, diffuse endocapillary proliferative glomerulonephritis

+∞

10.5

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.5

10.4

174

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

41.7

10.0

B05DA

ATC

Isotonic solutions

57.0

9.7

B05DB

ATC

Hypertonic solutions

57.0

9.7

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

103.4

9.5

TK800

NOMESCO Finland

Hemodialysis

11.2

9.4

J01MA02

ATC

ciprofloxacin; systemic

2.3

9.4

124

729

Z49.2

ICD-10 Finland

Other dialysis

38.0

9.1

C03CA01

ATC

furosemide; systemic

2.4

9.0

490

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

3.2

8.8

176

N39.1

ICD-10 Finland

Persistent proteinuria, unspecified

51.7

8.7

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

4.8

8.7

205

Kela drug reimbursment

Chronic hypertension

2.4

8.6

436

V03AE01

ATC

polystyrene sulfonate; oral

20.8

8.5

N03.3

ICD-10 Finland

Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis

+∞

8.4

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

34.4

8.1

L04AA01

ATC

[U] ciclosporin; systemic

13.6

8.0

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.2

7.4

482

C09AA02

ATC

enalapril; systemic

2.5

7.4

308

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.9

7.3

174

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

30.9

7.2

KH1BT

NOMESCO Finland

Urinary tract cathetrisation with X-ray guidance

20.7

7.2

C08CA01

ATC

amlodipine; oral

2.1

7.1

102

604

N13.3

ICD-10 Finland

Other and unspecified hydronephrosis

8.6

6.9

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.2

6.9

UKB02

NOMESCO Finland

Retrograde ureteroscopy

17.2

6.8

R60.0

ICD-10 Finland

Localized oedema

3.1

6.7

122

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.2

6.5

417

R33

ICD-10 Finland

Retention of urine

3.3

6.5

107

K65.0

ICD-10 Finland

Acute peritonitis

14.8

6.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.0

6.4

116

748

R50.9

ICD-10 Finland

Fever, unspecified

2.5

6.4

222

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.0

6.4

102

627

N30.0

ICD-10 Finland

Acute cystitis

2.7

6.3

183

J01DB01

ATC

cefalexin; oral

2.1

6.3

221

1811

M05BA04

ATC

alendronic acid; oral

3.4

6.3

N03.2

ICD-10 Finland

Chronic nephritic syndrome, diffuse membranous glomerulonephritis

+∞

6.3

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

+∞

6.3

N04.2

ICD-10 Finland

Nephrotic syndrome, diffuse membranous glomerulonephritis

+∞

6.3

A02BC02

ATC

pantoprazole; systemic

1.9

6.2

170

1265

C09CA01

ATC

losartan; oral

2.2

6.0

353

N02BE01

ATC

paracetamol; systemic, rectal

2.1

6.0

224

1859

Mortality – FinRegistry

↥

Association

Association between endpoint N14_RECURANDPERHEAMATUR and mortality.

Females

Parameter	HR [95% CI]	p-value
N14_RECURANDPERHEAMATUR	2.32 [1.83, 2.94]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.11

During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 1005 females with N14_RECURANDPERHEAMATUR died.

Males

Parameter	HR [95% CI]	p-value
N14_RECURANDPERHEAMATUR	2.256 [1.73, 2.94]	< 0.001
Birth year	0.985 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 422 out of 1118 males with N14_RECURANDPERHEAMATUR died.

Mortality risk

Mortality risk for people of age

years, who have N14_RECURANDPERHEAMATUR.

N-year risk	Females	Males
1	0.215%	0.347%
5	1.295%	2.358%
10	3.217%	5.811%
15	5.868%	11.113%
20	10.82%	18.533%

Relationships between endpoints

↥

Index endpoint: N14_RECURANDPERHEAMATUR – Recurrent and persistent haematuria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Recurrent and persistent haematuria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints