No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
96 |
4. Check minimum number of eventsNone |
96 |
5. Include endpointsNone |
96 |
6. Filter based on genotype QC (FinnGen only) |
96 |
Control definitions (FinnGen only)
- Control exclude
- N14_GLOMERULAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N00-N08
- Name in latin
- Nephropathia hereditaria non alibi classificata
Similar endpoints
↥List of similar endpoints to
Hereditary nephropathy, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 696 | 397 | 292 |
| Only index persons | 604 | 359 | 245 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.77 | 56.15 | 57.22 |
| Only index persons | 54.59 | 53.86 | 55.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 96 | 51 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 57.20 | 54.87 | 59.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 87
- Matched controls
- 867
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N07.4
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, diffuse endocapillary proliferative glomerulonephritis
+∞
40.9
36
*
N07.3
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, diffuse mesangial proliferative glomerulonephritis
+∞
29.9
27
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
51.0
17.2
20
5
M07.3
ICD-10 Finland
Other psoriatic arthropathies
51.0
17.2
20
5
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
32.0
17.0
22
9
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
8.1
11.8
28
48
R07.4
ICD-10 Finland
Chest pain, unspecified
5.1
11.3
46
156
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
14.7
9.8
16
13
N07.9
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, unspecified
+∞
9.5
9
*
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
+∞
8.5
8
*
J01FF01
ATC
clindamycin; systemic
4.2
8.3
39
142
L40.0
ICD-10 Finland
Psoriasis vulgaris
9.1
7.8
16
21
E000001
ATC
NA
4.3
7.6
32
104
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.9
7.2
16
24
L04AA01
ATC
[U] ciclosporin; systemic
43.5
6.9
8
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
24.8
6.8
9
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
24.8
6.8
9
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.6
6.6
19
41
A02BC01
ATC
omeprazole; systemic
3.5
6.6
38
159
D05AX52
ATC
calcipotriol, combinations; topical
8.1
6.5
14
20
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
6.3
6
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.4
6.2
14
22
R50.9
ICD-10 Finland
Fever, unspecified
4.4
6.2
23
66
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHROPATHYHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 1.877 [1.41, 2.5] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.831 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 364 females with N14_NEPHROPATHYHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHROPATHYHER | 2.079 [1.56, 2.77] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 265 males with N14_NEPHROPATHYHER died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHROPATHYHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.338% |
| 5 | 1.2% | 2.306% |
| 10 | 3.01% | 5.455% |
| 15 | 5.937% | 10.541% |
| 20 | 10.864% | 17.371% |
Relationships between endpoints
↥Index endpoint: N14_NEPHROPATHYHER – Hereditary nephropathy, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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