nephritis: Inflammation of renal tissue. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
820 |
4. Check minimum number of eventsNone |
820 |
5. Include endpointsNone |
820 |
6. Filter based on genotype QC (FinnGen only) |
820 |
Control definitions (FinnGen only)
- Control exclude
- N14_GLOMERULAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N00-N08
- Name in latin
- Syndroma nephriticum non specificatum
Similar endpoints
↥List of similar endpoints to
Unspecified nephritic syndrome
based on the number of shared cases.
Similar with more cases:
- Glomerulonephritis
- Glomerular diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8239 | 3572 | 4519 |
| Only index persons | 5566 | 2532 | 3034 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.13 |
| Only index persons | 0.11 | 0.09 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 45.73 | 49.89 | 41.98 |
| Only index persons | 36.87 | 40.89 | 33.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 820 | 364 | 456 |
| Unadjusted period prevalence (%) | 0.17 | 0.12 | 0.20 |
| Median age at first event (years) | 37.79 | 37.66 | 37.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 738
- Matched controls
- 7381
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
58399
ICD-8 Finland
Nephritis, unqualified
+∞
247.2
223
*
N05.9
ICD-10 Finland
Unspecified nephritic syndrome, unspecified
+∞
188.9
173
*
5839X
ICD-9 Finland
Nephritis and nephropathy, not specified as acute or chronic, With unspecified pathological lesion in kidney
+∞
146.9
136
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
90.8
138.9
152
21
Z94.0
ICD-10 Finland
Kidney transplant status
166.8
121.4
125
9
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
94.0
121.0
132
17
A12AA04
ATC
calcium carbonate; oral
100.2
108.8
118
14
A11CC03
ATC
alfacalcidol; systemic
50.8
105.7
127
30
127
Kela drug reimbursment
Transplant complication
57.7
103.0
121
25
L04AA06
ATC
mycophenolic acid; systemic
53.9
102.6
122
27
N05.8
ICD-10 Finland
Unspecified nephritic syndrome, other
1060.2
97.3
93
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
343.1
91.0
90
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
13.7
89.3
162
148
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
93.0
88.6
97
12
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
132.7
88.2
93
8
137
Kela drug reimbursment
Uraemia requiring dialysis
189.1
82.0
84
5
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
80.7
76
*
L04AA01
ATC
[U] ciclosporin; systemic
29.7
77.4
105
41
Z49.1
ICD-10 Finland
Extracorporeal dialysis
64.7
70.4
81
14
TK800
NOMESCO Finland
Hemodialysis
29.4
68.5
93
36
L04AX01
ATC
azathioprine; systemic
10.8
65.2
132
146
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
64.5
61
*
L04AD01
ATC
ciclosporin; systemic
22.0
62.9
93
48
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
53.0
60.5
72
15
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
90.5
60.0
66
8
N18.8
ICD-10 Finland
Other chronic renal failure
16.7
59.4
97
66
B03XA02
ATC
darbepoetin alfa; parenteral
36.7
59.3
76
23
Z49.0
ICD-10 Finland
Preparatory care for dialysis
108.7
55.7
60
6
B05DA
ATC
Isotonic solutions
201.6
54.8
56
*
C03CA01
ATC
furosemide; systemic
3.7
54.6
328
1319
H02AB04
ATC
methylprednisolone; systemic
4.7
53.7
211
575
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
57.2
53.7
63
12
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
148.3
52.6
55
*
B03XA01
ATC
erythropoietin; parenteral
71.0
52.0
59
9
N18.0
ICD-10 Finland
End-stage renal disease
36.8
47.8
61
18
KA1AE
NOMESCO Finland
Kidney ultrasound examination
17.2
47.3
76
49
V03AE01
ATC
polystyrene sulfonate; oral
33.1
46.6
61
20
B05DB
ATC
Hypertonic solutions
239.2
44.4
45
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.7
44.2
170
444
Z49.2
ICD-10 Finland
Other dialysis
122.4
43.3
46
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
441.8
42.6
42
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
98.0
42.3
46
5
R80
ICD-10 Finland
Isolated proteinuria
39.8
41.5
52
14
205
Kela drug reimbursment
Chronic hypertension
3.1
39.8
295
1308
M04AA01
ATC
allopurinol; systemic
4.1
39.7
175
516
7151
FHL
Kidney transplantation
408.1
39.5
39
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
38.9
171
503
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.3
38.5
109
198
H05BX01
ATC
cinacalcet; oral
140.7
38.1
40
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.2
37.5
107
196
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
6.3
35.8
101
182
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
34.6
33
*
N03.8
ICD-10 Finland
Chronic nephritic syndrome, other
+∞
34.6
33
*
58209
ICD-8 Finland
Chronic nephritis, Unspecified
+∞
33.6
32
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
32.5
31
*
N05.0
ICD-10 Finland
Unspecified nephritic syndrome, minor glomerular abnormality
+∞
32.5
31
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
91.8
32.0
35
*
5838X
ICD-9 Finland
Nephritis and nephropathy, not specified as acute or chronic, With other specified pathological lesion in kidney[NEPHRITIS INTERSTITIALIS CHRONICA ALIA DEFINITA]
+∞
31.5
30
*
V03AE02
ATC
sevelamer; oral
71.0
30.1
34
5
TK820
NOMESCO Finland
Peritoneal dialysis
161.5
29.9
31
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
29.7
282
1400
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
83.6
29.0
32
*
M05BA04
ATC
alendronic acid; oral
4.7
28.9
104
247
L01BB01
ATC
NA
150.7
27.8
29
*
C02AC05
ATC
moxonidine; oral
6.4
26.8
73
125
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.0
26.3
75
136
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
269.5
25.9
26
*
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
46.1
25.7
31
7
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
25.1
24
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
134.5
24.7
26
*
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
15.6
24.5
40
27
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
9.7
24.4
50
55
58099
ICD-8 Finland
Acute nephritis
+∞
24.1
23
*
58200
ICD-8 Finland
Chronic nephritis, Cum uraemia
+∞
24.1
23
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
69.8
24.0
27
*
P01BA02
ATC
hydroxychloroquine; oral
4.0
23.9
102
284
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
129.2
23.7
25
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.8
23.7
82
186
B07.9
ICD-10 Finland
Verruca simplex
7.4
23.1
56
81
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
+∞
23.0
22
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
23.0
22
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
123.8
22.7
24
*
C08CA02
ATC
felodipine; oral
3.7
22.6
107
326
C09AA02
ATC
enalapril; systemic
2.6
22.3
191
870
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
22.2
118
394
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
5.3
21.7
68
138
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.0
21.0
59
105
5828A
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,EI NEFR SDR]
+∞
20.9
20
*
C07AB02
ATC
metoprolol; systemic
2.5
20.6
197
948
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.6
20.4
74
176
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
19.9
347
2199
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
19.9
19
*
L04AA05
ATC
[U] tacrolimus; systemic
+∞
19.9
19
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
18.8
18
*
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
102.7
18.6
20
*
C02CA01
ATC
prazosin; oral
9.9
18.6
37
39
Z2446
NOMESCO Finland
Social worker
4.1
18.5
75
199
ZX120
NOMESCO Finland
Intravenous
3.3
18.4
101
342
L04AA13
ATC
leflunomide; oral
6.7
18.1
46
72
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.6
17.9
46
73
N04.2
ICD-10 Finland
Nephrotic syndrome, diffuse membranous glomerulonephritis
+∞
17.8
17
*
5838C
ICD-9 Finland
Nephritis and nephropathy, not specified as acute or chronic, With other specified pathological lesion in kidney[NEPHRITIS INTERSTITIALIS CHRONICA INFECTIOSA]
+∞
17.8
17
*
N04.0
ICD-10 Finland
Nephrotic syndrome, minor glomerular abnormality
+∞
17.8
17
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.3
17.7
95
317
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
184.2
17.6
18
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.9
17.6
35
37
R50.9
ICD-10 Finland
Fever, unspecified
2.7
17.2
125
510
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
17.2
134
570
C08CA01
ATC
amlodipine; oral
2.0
16.9
288
1772
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
16.9
119
477
78900
ICD-8 Finland
Abnormal urinary constituents of unspecified cause, Albuminuria
64.9
16.8
19
*
187
Kela drug reimbursment
MPA
+∞
16.7
16
*
N03.0
ICD-10 Finland
Chronic nephritic syndrome, minor glomerular abnormality
+∞
16.7
16
*
N04.1
ICD-10 Finland
Nephrotic syndrome, focal and segmental glomerular lesions
+∞
16.7
16
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
92.2
16.6
18
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.5
16.2
48
92
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
15.8
286
1791
5602
FHL
Internal fistula (eg Cimino)
+∞
15.7
15
*
N03.1
ICD-10 Finland
Chronic nephritic syndrome, focal and segmental glomerular lesions
+∞
15.7
15
*
A07EC01
ATC
sulfasalazine; oral, rectal
3.2
15.7
87
296
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
15.6
182
950
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
163.3
15.5
16
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
163.3
15.5
16
*
A02BC01
ATC
omeprazole; systemic
2.1
15.4
226
1300
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
46.0
15.1
18
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
15.0
93
340
H02AB06
ATC
prednisolone; systemic
1.9
15.0
354
2428
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.5
14.9
44
84
M10.3
ICD-10 Finland
Gout due to impairment of renal function
32.4
14.9
19
6
5829A
ICD-9 Finland
Chronic glomerulonephritis with unspecified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA NUD ,EI NEFR SDR]
+∞
14.6
14
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
14.6
330
2226
H05BX02
ATC
paricalcitol; systemic
152.9
14.5
15
*
ZXD05
NOMESCO Finland
Urgent procedure
2.0
14.5
249
1520
K65.0
ICD-10 Finland
Acute peritonitis
11.7
14.4
26
23
C09CA01
ATC
losartan; oral
2.1
14.3
193
1067
RS220
NOMESCO Finland
NA
12.3
14.2
25
21
C08CA13
ATC
lercanidipine; oral
2.6
14.1
113
486
M10.9
ICD-10 Finland
Gout, unspecified
3.4
14.0
70
222
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
13.9
138
662
ZXA05
NOMESCO Finland
Left side
2.0
13.8
203
1160
N19
ICD-10 Finland
Unspecified kidney failure
4.9
13.7
45
97
H26.3
ICD-10 Finland
Drug-induced cataract
15.1
13.6
22
15
J01FF01
ATC
clindamycin; systemic
2.0
13.6
218
1285
4059B
ICD-9 Finland
Secondary hypertension, Unspecified[HYPERTONIA SECUNDARIA ALIA DEFINITA]
+∞
13.6
13
*
A46
ICD-10 Finland
Erysipelas
2.4
13.6
124
569
C07AG02
ATC
carvedilol; oral
3.4
13.6
68
216
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
142.5
13.5
14
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
142.5
13.5
14
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.1
13.4
75
256
J01MA12
ATC
levofloxacin; systemic
2.2
13.3
161
847
C02EA02
ATC
NA
4.2
13.1
50
126
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.8
13.0
43
94
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
50.9
12.9
15
*
N05.2
ICD-10 Finland
Unspecified nephritic syndrome, diffuse membranous glomerulonephritis
+∞
12.5
12
*
40399
ICD-8 Finland
Hypertensive renal disease
+∞
12.5
12
*
N05.3
ICD-10 Finland
Unspecified nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
+∞
12.5
12
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
+∞
12.5
12
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
12.5
12
*
5850B
ICD-9 Finland
Chronic renal failure[INSUFFICIENTIA RENIS CHRONICA CUM URAEMIA]
+∞
12.5
12
*
T86.1
ICD-10 Finland
Kidney transplant failure and rejection
+∞
12.5
12
*
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
12.4
70
241
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
12.4
190
1096
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.8
12.3
52
144
M01CB01
ATC
sodium aurothiomalate; parenteral
7.6
12.3
28
38
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.1
12.2
68
231
78930
ICD-8 Finland
Abnormal urinary constituents of unspecified cause, Haematuria
12.7
12.2
21
17
U14
ICPC
Kidney symptom/complaint
8.9
12.1
25
29
L01AA01
ATC
cyclophosphamide; systemic
27.2
12.1
16
6
JN4AD
NOMESCO Finland
Body CT examination
3.1
12.0
68
235
212
Kela drug reimbursment
Gout
5.8
11.9
33
59
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.4
11.8
35
68
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.6
11.7
89
370
ZXA00
NOMESCO Finland
Right side
1.9
11.7
207
1260
RD210
NOMESCO Finland
NA
7.3
11.6
27
38
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.8
11.6
32
57
Z3231
NOMESCO Finland
Registered nurse
1.9
11.6
209
1277
7910X
ICD-9 Finland
Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]
+∞
11.5
11
*
PC6DE
NOMESCO Finland
NA
+∞
11.5
11
*
N03.5
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangiocapillary glomerulonephritis
+∞
11.5
11
*
KAS40
NOMESCO Finland
Excision of transplanted kidney
121.8
11.5
12
*
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
11.4
47
128
TK810
NOMESCO Finland
Hemofiltration
15.3
11.3
18
12
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
11.3
477
5645
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
13.0
11.2
19
15
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
11.1
167
950
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
11.0
83
344
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.6
11.0
37
83
N25.0
ICD-10 Finland
Renal osteodystrophy
44.0
10.9
13
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
10.9
294
2042
A41.9
ICD-10 Finland
Sepsis, unspecified
4.1
10.9
42
108
J01MA02
ATC
ciprofloxacin; systemic
1.7
10.7
285
1965
J01MA14
ATC
moxifloxacin; systemic
2.5
10.7
83
350
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
10.2
10.6
20
20
BBA50
NOMESCO Finland
Total parathyroidectomy
111.5
10.4
11
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
+∞
10.4
10
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
10.4
10
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
10.4
10
*
N03.2
ICD-10 Finland
Chronic nephritic syndrome, diffuse membranous glomerulonephritis
+∞
10.4
10
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
10.3
77
316
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.1
10.1
39
100
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
10.1
126
665
A02BA02
ATC
ranitidine; systemic
1.9
10.1
160
928
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
26.4
9.8
13
5
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
20.3
9.8
14
7
C02DE02
ATC
NA
6.3
9.7
25
41
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.6
9.7
33
75
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.0
9.7
56
198
H02AB07
ATC
prednisone; oral
2.1
9.6
116
604
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.5
9.6
44
132
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
9.6
206
1323
R4110
NOMESCO Finland
Physiotherapy
1.8
9.5
194
1224
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
9.5
107
541
L88
ICPC
Rheumatoid/seropositive arthritis
3.7
9.5
40
112
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.0
9.4
37
97
28700
ICD-8 Finland
Purpura and other haemorrhagic conditions, Allergic purpura
101.3
9.4
10
*
TK824
NOMESCO Finland
Replacement of peritoneal dialysis catheter extension tube
101.3
9.4
10
*
6119
FHL
Other measure in this category
101.3
9.4
10
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.8
9.4
30
64
7101
FHL
Needle biopsy in the operating room
+∞
9.4
9
*
N05.1
ICD-10 Finland
Unspecified nephritic syndrome, focal and segmental glomerular lesions
+∞
9.4
9
*
N06.9
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, unspecified
+∞
9.4
9
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.8
9.4
60
227
WW200
NOMESCO Finland
Immunization
4.2
9.4
34
83
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
9.2
46
148
C07AB07
ATC
bisoprolol; oral
1.6
9.1
335
2503
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
9.0
197
1267
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
9.0
88
415
K65.9
ICD-10 Finland
Peritonitis, unspecified
18.9
9.0
13
7
M31.3
ICD-10 Finland
Wegener granulomatosis
24.3
8.9
12
5
R31
ICD-10 Finland
Unspecified haematuria
2.3
8.8
85
400
40199
ICD-8 Finland
Essential benign hypertension
6.1
8.8
23
39
WW400
NOMESCO Finland
Plasmaferesis
50.6
8.7
10
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
20.3
8.5
12
6
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
+∞
8.3
8
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
+∞
8.3
8
*
7158
FHL
Graft removal
+∞
8.3
8
*
5820A
ICD-9 Finland
Chronic glomerulonephritis, With lesion of proliferative glomerulonephritis[GLOMERULONEPHRITIS CHRONICA PROLIF,EI NEFR SDR]
+∞
8.3
8
*
79299
ICD-8 Finland
Uraemia
+∞
8.3
8
*
N03.7
ICD-10 Finland
Chronic nephritic syndrome, diffuse crescentic glomerulonephritis
+∞
8.3
8
*
5828B
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,NEFR SDR]
+∞
8.3
8
*
Q87.80
ICD-10 Finland
Alport syndrome
+∞
8.3
8
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
8.3
395
3114
J01DB01
ATC
cefalexin; oral
1.7
8.3
576
5004
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
8.3
137
800
A02BC02
ATC
pantoprazole; systemic
1.6
8.3
447
3637
B01AA03
ATC
warfarin; systemic
1.8
8.2
148
893
J01DA01
ATC
[U] cefalexin; systemic
1.6
8.2
438
3548
J01FA06
ATC
roxithromycin; oral
1.6
8.1
288
2107
2740A
ICD-9 Finland
Gouty arthropathy
33.7
8.1
10
*
PB1DE
NOMESCO Finland
Upper extremity arteries ultrasound examination with Doppler method
33.7
8.1
10
*
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
10.2
8.1
15
15
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
10.2
8.1
15
15
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.7
7.9
33
92
A12BA01
ATC
potassium chloride; oral
3.2
7.9
40
130
C02DE10
ATC
NA
7.9
7.9
17
22
Z3226
NOMESCO Finland
Physiotherapist
1.8
7.8
136
810
H02AB08
ATC
triamcinolone; systemic
15.2
7.7
12
8
5997A
ICD-9 Finland
Other disorders of urethra and urinary tract, Haematuria
15.2
7.7
12
8
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
45.5
7.7
9
*
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
45.5
7.7
9
*
L04AB01
ATC
etanercept; parenteral
5.7
7.7
21
38
L04AA17
ATC
[U] adalimumab; parenteral
18.6
7.6
11
6
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
7.6
41
140
C08CA03
ATC
isradipine; systemic
5.5
7.6
21
39
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
7.6
76
363
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.3
7.5
69
318
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.3
7.5
26
62
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
6.6
7.4
18
28
306
Kela drug reimbursment
Erythropoietin and darbepoetin
80.9
7.4
8
*
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
80.9
7.4
8
*
5850A
ICD-9 Finland
Chronic renal failure[INSUFFICIENTIA RENIS CHRONICA SINE URAEMIA]
80.9
7.4
8
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
13.5
7.4
12
9
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
13.5
7.4
12
9
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
7.3
58
249
RS222
NOMESCO Finland
NA
6.9
7.3
17
25
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.3
7.3
35
110
GD1UN
NOMESCO Finland
Lung circulation SPECT
9.5
7.3
14
15
ZX108
NOMESCO Finland
Inhalation
9.5
7.3
14
15
Z99.2
ICD-10 Finland
Dependence on renal dialysis
+∞
7.3
7
*
B05D
ATC
PERITONEAL DIALYTICS
+∞
7.3
7
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
7.3
7
*
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
+∞
7.3
7
*
58199
ICD-8 Finland
Nephrotic syndrome
+∞
7.3
7
*
KAS96
NOMESCO Finland
Other transplantation of kidney or related procedure
+∞
7.3
7
*
N03.4
ICD-10 Finland
Chronic nephritic syndrome, diffuse endocapillary proliferative glomerulonephritis
+∞
7.3
7
*
C10AX09
ATC
ezetimibe; oral
2.1
7.3
85
434
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
7.3
62
275
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
3.9
7.2
28
74
N02AA05
ATC
oxycodone; systemic
1.9
7.2
102
563
NFA20
NOMESCO Finland
Exploration of hip joint or femur
30.3
7.2
9
*
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
7.1
41
145
WX203
NOMESCO Finland
Infraclavicular plexus blockade
4.1
7.1
26
65
RS221
NOMESCO Finland
NA
5.4
7.1
20
38
KBV00
NOMESCO Finland
Insertion of stent into ureter
8.9
7.1
14
16
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
5.9
6.9
18
31
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.2
6.9
34
109
204
Kela drug reimbursment
Leukemia lymphatica
3.4
6.9
31
93
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
13.9
6.9
11
8
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.5
6.9
30
88
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.9
144
906
M01CB03
ATC
auranofin; oral
8.4
6.8
14
17
GD2SN
NOMESCO Finland
Lung ventilation SPECT
8.4
6.8
14
17
J01CF02
ATC
cloxacillin; systemic
3.8
6.8
27
73
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.9
6.8
39
138
R11
ICD-10 Finland
Nausea and vomiting
2.4
6.8
56
244
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
40.4
6.8
8
*
K06.18
ICD-10 Finland
Another gingival hyperplasia
16.9
6.8
10
6
M13.9
ICD-10 Finland
Arthritis, unspecified
2.4
6.8
56
245
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.0
6.7
25
64
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
6.7
87
465
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
22.7
6.7
9
*
QDH05
NOMESCO Finland
Correction of deformity of toe nail
22.7
6.7
9
*
UJF32
NOMESCO Finland
Coloscopy
1.6
6.6
174
1166
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
6.6
105
605
N05AA02
ATC
levomepromazine; systemic
2.7
6.6
42
159
L05.0
ICD-10 Finland
Pilonidal cyst with abscess
10.1
6.5
12
12
NG4AA
NOMESCO Finland
Lower leg X-ray examination
3.6
6.5
27
76
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
6.5
32
103
WX202
NOMESCO Finland
Supraclavicular plexus blockade
5.4
6.5
18
34
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.7
6.4
26
72
4029B
ICD-9 Finland
Hypertensive heart disease, Unspecified[CUM DECOMPENSATIONE CORDIS (WHO III)]
70.4
6.4
7
*
9527
FHL
Alloarthroplasty, implant or endoprosthesis
70.4
6.4
7
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
6.4
220
1578
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
6.4
60
281
L04AA11
ATC
[U] etanercept; parenteral
14.5
6.4
10
7
C08DB01
ATC
diltiazem; oral
2.6
6.4
43
170
R4180
NOMESCO Finland
Podiatric therapy
6.6
6.4
15
23
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
6.3
186
1283
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
11.1
6.3
11
10
WX610
NOMESCO Finland
Patient controlled analgesia
11.1
6.3
11
10
I15.0
ICD-10 Finland
Renovascular hypertension
11.1
6.3
11
10
WX204
NOMESCO Finland
Axillary plexus blockaced
3.4
6.3
28
84
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
18.2
6.3
9
5
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
18.2
6.3
9
5
K65.8
ICD-10 Finland
Other peritonitis
18.2
6.3
9
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.3
112
670
N00.9
ICD-10 Finland
Acute nephritic syndrome, Unspecified
+∞
6.3
6
*
D638, N188
ICD-10 Finland
NA
+∞
6.3
6
*
N05
ICD-10 Finland
Unspecified nephritic syndrome
+∞
6.3
6
*
59329
ICD-8 Finland
Other diseases of kidney and ureter, Morbi renis NUD
+∞
6.3
6
*
2859A
ICD-9 Finland
Other and unspecified anaemias, Anaemia, unspecified[ANAEMIA SECUNDARIA]
+∞
6.3
6
*
N04.89
ICD-10 Finland
Nephrotic syndrome, other
+∞
6.3
6
*
305
Kela drug reimbursment
MPA
+∞
6.3
6
*
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
+∞
6.3
6
*
5824A
ICD-9 Finland
Chronic glomerulonephritis, With lesion of rapidly progressive glomerulonephritis[CRESCENT GLOMERULONEPHRITIS ,EI NEFR SDR]
+∞
6.3
6
*
5819X
ICD-9 Finland
Nephrotic syndrome with unspecified pathological lesion in kidney
+∞
6.3
6
*
B01AB10
ATC
tinzaparin; parenteral
2.3
6.2
53
236
H65.2
ICD-10 Finland
Chronic serous otitis media
7.1
6.2
14
20
C07AG01
ATC
labetalol; systemic
7.1
6.2
14
20
M35.1
ICD-10 Finland
Other overlap syndromes
26.9
6.2
8
*
NDB60
NOMESCO Finland
Prosthetic replacement of MCP joint of finger
26.9
6.2
8
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
6.2
228
1660
4019X
ICD-9 Finland
Essential hypertension, Unspecified
3.4
6.2
28
85
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.2
164
1105
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
6.1
151
995
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
7.8
6.1
13
17
C10AA04
ATC
fluvastatin; oral
2.1
6.1
67
336
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
6.1
39
147
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
12.6
6.1
10
8
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
6.8
6.1
14
21
ZZA00
NOMESCO Finland
Split skin graft
3.3
6.0
28
87
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
10.1
6.0
11
11
C10AA05
ATC
atorvastatin; oral
1.5
6.0
254
1906
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.0
6.0
22
56
L05.9
ICD-10 Finland
Pilonidal cyst without abscess
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint N14_NEPHRITICNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHRITICNAS | 3.223 [2.74, 3.79] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 1505 females with N14_NEPHRITICNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_NEPHRITICNAS | 3.306 [2.74, 3.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 460 out of 1344 males with N14_NEPHRITICNAS died.
Mortality risk
Mortality risk for people of age
years, who have N14_NEPHRITICNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.254% | 0.593% |
| 5 | 1.766% | 3.965% |
| 10 | 4.829% | 9.347% |
| 15 | 9.355% | 16.734% |
| 20 | 15.551% | 27.301% |
Relationships between endpoints
↥Index endpoint: N14_NEPHRITICNAS – Unspecified nephritic syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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