Risteys · N14_ISOLPROTEINURIA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — N06# Cause of death: ICD-10 — N06# 2 out of 7 registries used, show all original rules.	395
4. Check minimum number of events None	395
5. Include endpoints None	395
6. Filter based on genotype QC (FinnGen only)	395

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2409	1167	1221
Only index persons	2118	1030	1088
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.04	0.04	0.04
Median age at first event (years)
Whole population	57.83	56.49	59.16
Only index persons	55.61	53.58	57.53

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	395	193	202
Unadjusted period prevalence (%)	0.08	0.07	0.09
Median age at first event (years)	55.99	50.34	61.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
358: Matched controls
3578

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N06.9

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, unspecified

+∞

217.6

186

N06.0

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, minor glomerular abnormality

+∞

76.9

KA3AT

NOMESCO Finland

Biopsy of kidney with ultrasound guidance

309.6

75.5

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

58.9

64.5

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

17.9

64.4

105

R80

ICD-10 Finland

Isolated proteinuria

134.3

63.3

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

43.8

52.9

I15.1

ICD-10 Finland

Hypertension secondary to other renal disorders

129.5

52.4

N18.8

ICD-10 Finland

Other chronic renal failure

26.6

52.3

A11CC03

ATC

alfacalcidol; systemic

39.1

49.3

L04AA06

ATC

mycophenolic acid; systemic

53.9

46.6

C03CA01

ATC

furosemide; systemic

5.3

45.5

190

629

N04.9

ICD-10 Finland

Nephrotic syndrome, unspecified

+∞

44.7

Z94.0

ICD-10 Finland

Kidney transplant status

107.9

44.0

127

Kela drug reimbursment

Transplant complication

59.8

40.6

N06.1

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, focal and segmental glomerular lesions

+∞

40.4

A12AA04

ATC

calcium carbonate; oral

38.5

39.7

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

118.5

39.7

N39.1

ICD-10 Finland

Persistent proteinuria, unspecified

205.6

36.5

TK800

NOMESCO Finland

Hemodialysis

34.9

35.8

Z49.0

ICD-10 Finland

Preparatory care for dialysis

87.4

35.6

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

72.6

34.8

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

99.8

33.4

L04AD01

ATC

ciclosporin; systemic

32.4

32.9

N08.2*D89.80

ICD-10 Finland

Immunoglobulin A (IgA) nephropathy

+∞

32.8

N04.1

ICD-10 Finland

Nephrotic syndrome, focal and segmental glomerular lesions

+∞

32.8

137

Kela drug reimbursment

Uraemia requiring dialysis

79.6

32.5

Z49.1

ICD-10 Finland

Extracorporeal dialysis

58.7

32.0

L04AA01

ATC

[U] ciclosporin; systemic

32.9

31.5

C08CA01

ATC

amlodipine; oral

3.8

31.0

197

868

N18.0

ICD-10 Finland

End-stage renal disease

74.8

30.5

205

Kela drug reimbursment

Chronic hypertension

3.9

30.3

167

651

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.4

29.9

102

247

N04.0

ICD-10 Finland

Nephrotic syndrome, minor glomerular abnormality

+∞

29.6

N08.39*E11.2

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic nephropathy

+∞

29.6

B03XA02

ATC

darbepoetin alfa; parenteral

32.5

29.2

C09AA02

ATC

enalapril; systemic

4.4

28.9

127

399

N03.9

ICD-10 Finland

Chronic nephritic syndrome, unspecified

+∞

28.5

B05DA

ATC

Isotonic solutions

84.7

28.2

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

58.3

27.7

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.6

26.9

166

692

N06.8

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, other

+∞

26.4

N06.2

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, diffuse membranous glomerulonephritis

+∞

26.4

KA1AE

NOMESCO Finland

Kidney ultrasound examination

22.2

26.3

V03AE01

ATC

polystyrene sulfonate; oral

36.2

26.0

Z49.2

ICD-10 Finland

Other dialysis

101.0

26.0

B05DB

ATC

Hypertonic solutions

145.5

26.0

320

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

267.9

25.0

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

7.4

23.8

M04AA01

ATC

allopurinol; systemic

4.4

22.2

254

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.5

21.1

216

KA2AE

NOMESCO Finland

Ultrasound examination transplanted kidney

116.8

20.8

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

7.7

20.6

N03.1

ICD-10 Finland

Chronic nephritic syndrome, focal and segmental glomerular lesions

+∞

20.0

JAK10

NOMESCO Finland

Laparotomy and insertion of peritoneal dialysis catheter

111.2

19.8

N06.3

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, diffuse mesangial proliferative glomerulonephritis

+∞

18.9

N19

ICD-10 Finland

Unspecified kidney failure

10.4

18.4

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

6.2

18.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.7

18.0

195

1096

N03.2

ICD-10 Finland

Chronic nephritic syndrome, diffuse membranous glomerulonephritis

+∞

17.9

N03.8

ICD-10 Finland

Chronic nephritic syndrome, other

+∞

17.9

N04.2

ICD-10 Finland

Nephrotic syndrome, diffuse membranous glomerulonephritis

+∞

17.9

KA2AT

NOMESCO Finland

Biopsy of transplanted kidney with ultrasound guidance

188.9

17.7

N03.0

ICD-10 Finland

Chronic nephritic syndrome, minor glomerular abnormality

+∞

16.8

N25.8

ICD-10 Finland

Other disorders resulting from impaired renal tubular function

94.5

16.7

TJA35

NOMESCO Finland

Removal of peritoneal dialysis catheter

94.5

16.7

H02AB04

ATC

methylprednisolone; systemic

3.4

16.6

319

C10AA05

ATC

atorvastatin; oral

2.6

16.3

170

917

P01BA02

ATC

hydroxychloroquine; oral

4.5

16.2

152

B03XA01

ATC

erythropoietin; parenteral

49.9

16.2

C08CA13

ATC

lercanidipine; oral

3.6

15.9

255

N17.9

ICD-10 Finland

Acute renal failure, unspecified

9.6

15.8

WW200

NOMESCO Finland

Immunization

10.2

15.8

C08CA02

ATC

felodipine; oral

4.2

15.7

172

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

+∞

15.7

I10

ICD-10 Finland

Essential (primary) hypertension

2.5

15.7

237

1557

TK820

NOMESCO Finland

Peritoneal dialysis

89.0

15.7

V03AE02

ATC

sevelamer; oral

89.0

15.7

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

5.8

15.5

C02AC05

ATC

moxonidine; oral

6.1

14.9

N03.3

ICD-10 Finland

Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis

+∞

14.7

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

4.3

14.6

147

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

8.6

14.4

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

5.5

13.4

C09CA01

ATC

losartan; oral

2.6

13.2

117

561

H02AB06

ATC

prednisolone; systemic

2.3

13.0

193

1208

C10AA01

ATC

simvastatin; oral

2.3

12.7

180

1095

RD210

NOMESCO Finland

11.6

12.7

ZX120

NOMESCO Finland

Intravenous

3.9

12.7

161

K65.0

ICD-10 Finland

Acute peritonitis

18.1

12.6

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

5.8

12.6

N08.2

ICD-10 Finland

Glomerular disorders in blood diseases and disorders involving the immune mechanism

+∞

12.6

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

7.0

12.3

H05BX01

ATC

cinacalcet; oral

39.0

12.3

B03XA03

ATC

methoxy polyethylene glycol-epoetin beta; parenteral

39.0

12.3

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.4

12.2

126

653

M10.9

ICD-10 Finland

Gout, unspecified

4.6

12.1

104

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.0

12.1

140

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

5.8

12.0

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.0

11.9

303

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

4.4

11.8

107

V03AE03

ATC

lanthanum carbonate; oral

67.2

11.7

L04AX01

ATC

azathioprine; systemic

5.8

11.7

N03.5

ICD-10 Finland

Chronic nephritic syndrome, diffuse mesangiocapillary glomerulonephritis

+∞

11.5

N08.39

ICD-10 Finland

Glomerular disorders in diabetes mellitus microalbuminuria

123.8

11.5

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

5.6

11.4

TPH90

NOMESCO Finland

Removal of fixed intravenous catheter

17.8

11.3

E11.2

ICD-10 Finland

Type 2 diabetes mellitus, with renal complications

8.0

10.9

196

Kela drug reimbursment

Paricalcitol and cinacalcet

29.0

10.8

O12.1

ICD-10 Finland

Gestational proteinuria

113.2

10.5

C07AB07

ATC

bisoprolol; oral

2.1

10.2

180

1170

321

Kela drug reimbursment

Paricalcitol and cinacalcet

41.3

10.0

M01CB01

ATC

sodium aurothiomalate; parenteral

10.5

9.6

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.6

9.6

334

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.3

9.6

102

524

TPX10

NOMESCO Finland

Implantation of vascular injection port

7.9

9.6

7910X

ICD-9 Finland

Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]

102.6

9.5

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

4.4

9.4

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.3

9.3

481

I12.0

ICD-10 Finland

Hypertensive renal disease with renal failure

14.2

9.3

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

3.2

9.2

179

WX202

NOMESCO Finland

Supraclavicular plexus blockade

9.4

9.1

N18.5

ICD-10 Finland

Chronic kidney disease, stage 5

37.7

9.1

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

3.2

9.0

165

OAB74

NOMESCO Finland

Nutritional guidance related to treatment and rehabilitation for medical condition

24.7

9.0

Z3231

NOMESCO Finland

Registered nurse

2.2

8.9

116

652

A07EC01

ATC

sulfasalazine; oral, rectal

3.3

8.8

145

TJA33

NOMESCO Finland

Percutaneous introduction of peritoneal dialysis catheter

51.3

8.7

J01FF01

ATC

clindamycin; systemic

2.2

8.7

109

601

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.1

8.7

111

620

J01MA02

ATC

ciprofloxacin; systemic

2.0

8.6

152

966

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

28.3

8.5

L04AA13

ATC

leflunomide; oral

5.5

8.5

N04.5

ICD-10 Finland

Nephrotic syndrome, diffuse mesangiocapillary glomerulonephritis

+∞

8.4

D89.80

ICD-10 Finland

Immunoglobulin A (IgA) deposits in organisms

+∞

8.4

N06.4

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, diffuse endocapillary proliferative glomerulonephritis

+∞

8.4

58209

ICD-8 Finland

Chronic nephritis, Unspecified

+∞

8.4

N05.9

ICD-10 Finland

Unspecified nephritic syndrome, unspecified

+∞

8.4

N06.5

ICD-10 Finland

Isolated proteinuria with specified morphological lesion, diffuse mesangiocapillary glomerulonephritis

+∞

8.4

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

3.0

8.3

181

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

2.3

8.0

404

C02CA01

ATC

prazosin; oral

8.1

8.0

N18

ICD-10 Finland

Chronic kidney disease

13.4

7.9

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.3

7.9

133

ZXD05

NOMESCO Finland

Urgent procedure

2.0

7.9

123

738

U14

ICPC

Kidney symptom/complaint

9.7

7.9

WX204

NOMESCO Finland

Axillary plexus blockaced

6.2

7.8

R06.0

ICD-10 Finland

Dyspnoea

2.1

7.8

537

J01MA14

ATC

moxifloxacin; systemic

3.1

7.7

151

M06.8

ICD-10 Finland

Other specified rheumatoid arthritis

18.8

7.6

D47.2

ICD-10 Finland

Monoclonal gammopathy of undetermined significance (MGUS)

12.2

7.6

XW000

NOMESCO Finland

Bone marrow biopsy

5.0

7.6

306

Kela drug reimbursment

Erythropoietin and darbepoetin

81.7

7.4

M13.9

ICD-10 Finland

Arthritis, unspecified

3.4

7.4

111

R50.9

ICD-10 Finland

Fever, unspecified

2.5

7.4

274

Z01.8

ICD-10 Finland

Other specified special examinations

2.2

7.4

435

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

3.4

7.3

112

N00.0

ICD-10 Finland

Acute nephritic syndrome, Minor glomerular abnormality

+∞

7.3

N04.3

ICD-10 Finland

Nephrotic syndrome, diffuse mesangial proliferative glomerulonephritis

+∞

7.3

N05.8

ICD-10 Finland

Unspecified nephritic syndrome, other

+∞

7.3

U88

ICPC

Glomerulonephritis/nephrosis

+∞

7.3

N06

ICD-10 Finland

Isolated proteinuria with specified morphological lesion

+∞

7.3

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

5.0

7.3

WW500

NOMESCO Finland

Blood transfusion

4.4

7.3

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.3

7.3

355

C09CA06

ATC

candesartan; oral

2.2

7.2

445

M10.3

ICD-10 Finland

Gout due to impairment of renal function

30.7

7.2

RS221

NOMESCO Finland

8.2

7.2

R4110

NOMESCO Finland

Physiotherapy

2.0

7.2

563

E66.8

ICD-10 Finland

Other obesity

4.0

7.1

XPX08

NOMESCO Finland

Intraoperative flow measurement

12.4

7.1

ZXE10

NOMESCO Finland

More than one and less than three hours

1.9

7.1

133

849

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

2.3

7.0

359

J01MA12

ATC

levofloxacin; systemic

2.2

6.9

407

C07AG02

ATC

carvedilol; oral

3.6

6.9

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

6.3

6.9

212

Kela drug reimbursment

Gout

7.4

6.8

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

3.9

6.7

H26.3

ICD-10 Finland

Drug-induced cataract

23.0

6.7

SPAT1262

SPAT

Handing over of treatment supplies

2.2

6.7

398

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

5.0

6.6

H02AB07

ATC

prednisone; oral

2.4

6.6

287

C08CA03

ATC

isradipine; systemic

12.6

6.6

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.2

6.6

110

RF420

NOMESCO Finland

10.3

6.6

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

3.0

6.5

133

ZXE20

NOMESCO Finland

More than three and less than five hours

2.4

6.5

271

C10AA03

ATC

pravastatin; oral

3.3

6.5

100

ZXA05

NOMESCO Finland

Left side

2.0

6.5

584

A12AA12

ATC

[U] calcium acetate anhydrous; systemic

71.0

6.4

B25.8

ICD-10 Finland

Other cytomegaloviral diseases

71.0

6.4

KBV00

NOMESCO Finland

Insertion of stent into ureter

14.6

6.4

3AC01

NOMESCO Finland

14.6

6.4

TPH04

NOMESCO Finland

Cathetrisation of vein

2.1

6.4

434

Z3229

NOMESCO Finland

Other healthcare associate professional

2.8

6.4

153

N02AX02

ATC

tramadol; systemic, rectal

1.8

6.3

156

1081

RF410

NOMESCO Finland

11.3

6.3

WX002

NOMESCO Finland

Sedation and analgesia

2.1

6.3

377

N04.4

ICD-10 Finland

Nephrotic syndrome, diffuse endocapillary proliferative glomerulonephritis

+∞

6.3

5828A

ICD-9 Finland

Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,EI NEFR SDR]

+∞

6.3

JN3AD

NOMESCO Finland

Abdominal CT examination

3.0

6.2

124

E66.00

ICD-10 Finland

Metabolic syndrome

3.2

6.2

104

B01AB05

ATC

enoxaparin; parenteral

1.9

6.1

112

704

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.5

6.1

198

M01AE01

ATC

ibuprofen; systemic, rectal

0.5

6.1

238

2807

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

5.7

6.1

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

3.0

6.0

121

C10AA04

ATC

fluvastatin; oral

2.8

6.0

146

Mortality – FinRegistry

↥

Association

Association between endpoint N14_ISOLPROTEINURIA and mortality.

Females

Parameter	HR [95% CI]	p-value
N14_ISOLPROTEINURIA	2.374 [1.89, 2.99]	< 0.001
Birth year	0.997 [0.99, 1.01]	0.498

During the follow-up period (1.1.1998 — 31.12.2019), 298 out of 1035 females with N14_ISOLPROTEINURIA died.

Males

Parameter	HR [95% CI]	p-value
N14_ISOLPROTEINURIA	2.47 [2.05, 2.98]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.007

During the follow-up period (1.1.1998 — 31.12.2019), 335 out of 1068 males with N14_ISOLPROTEINURIA died.

Mortality risk

Mortality risk for people of age

years, who have N14_ISOLPROTEINURIA.

N-year risk	Females	Males
1	0.206%	0.406%
5	1.226%	2.37%
10	3.842%	6.592%
15	7.307%	12.895%
20	13.146%	21.264%

Relationships between endpoints

↥

Index endpoint: N14_ISOLPROTEINURIA – Isolated proteinuria with specified morphological lesion

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	N14_ISOLPROTEINURIA
CONTROL_EXCLUDE	N14_GLOMERULAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	N06
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	N06
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Isolated proteinuria with specified morphological lesion

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints