Female pelvic inflammatory disorders in diseases classified elsewhere

N14_FEMPELINFINOTH

Pelvic Inflammatory Disease: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N74*
  • Cause of death: ICD-10 N74*

2 out of 7 registries used, show all original rules.

127

4. Check minimum number of events

None

127

5. Include endpoints

None

127

6. Filter based on genotype QC (FinnGen only)

122

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1114 1114 -
Only index persons 1099 1099 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.04 0.04 -
Median age at first event (years)
Whole population - 23.59 -
Only index persons - 23.53 -

-FinnGen-

Key figures

All Female Male
Number of individuals 122 122 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 24.74 24.74 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
127
Matched controls
1269
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N74.4*A56.1
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
132.6
103
*
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
153.1
33.5
34
*
A56.1
ICD-10 Finland
Chlamydial infection of pelviperitoneum and other genitourinary organs
221.3
19.1
19
*
P01AB01
ATC
metronidazole; oral, rectal
5.7
18.7
87
352
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
5.7
15.5
52
137
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
21.3
13.9
20
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.1
12.9
80
373
N70.0
ICD-10 Finland
Acute salpingitis and oophoritis
+∞
12.7
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
4.1
12.7
71
301
J01AA02
ATC
doxycycline; systemic
4.9
11.5
109
704
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
+∞
10.6
10
*
N74.4
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
9.5
9
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.1
8.8
77
418
N76.0
ICD-10 Finland
Acute vaginitis
5.3
8.7
27
61
N71.9
ICD-10 Finland
Inflammatory disease of uterus, unspecified
21.9
8.6
12
6
R51.80
ICD-10 Finland
Headache
3.8
8.6
40
136
N02AX02
ATC
tramadol; systemic, rectal
3.1
7.6
52
233
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
+∞
7.4
7
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.5
7.1
37
134
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.4
6.9
36
131
J01DB01
ATC
cefalexin; oral
4.1
6.8
115
892
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.3
6.8
38
147
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.7
6.6
30
99
M77.1
ICD-10 Finland
Lateral epicondylitis
4.5
6.4
22
56
N70.9
ICD-10 Finland
Salpingitis and oophoritis, unspecified
+∞
6.3
6
*
M03BX02
ATC
tizanidine; oral
2.7
6.2
90
604
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
3.6
6.2
28
92

Mortality – FinRegistry

Association

Association between endpoint N14_FEMPELINFINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMPELINFINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_FEMPELINFINOTH – Female pelvic inflammatory disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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