temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1253 |
4. Check minimum number of eventsNone |
1253 |
5. Include endpointsNone |
1253 |
6. Filter based on genotype QC (FinnGen only) |
1253 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 5
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
- Name in latin
- Arteritis gigantocellularis cum polymyalgia reumatica
Similar endpoints
↥List of similar endpoints to
Temporal arteritis
based on the number of shared cases.
Similar with more cases:
- Giant cell arteritis with polymyalgia rheumatica
- Giant cell arteritis
- Other necrotizing vasculopathies (FG)
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7500 | 5041 | 2416 |
| Only index persons | 6755 | 4573 | 2182 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.07 |
| Only index persons | 0.14 | 0.17 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 72.49 | 72.98 | 71.41 |
| Only index persons | 71.88 | 72.38 | 70.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1253 | 779 | 474 |
| Unadjusted period prevalence (%) | 0.24 | 0.27 | 0.21 |
| Median age at first event (years) | 69.88 | 69.52 | 70.47 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1110
- Matched controls
- 11100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
4503599627370496.0
323.0
1108
*
M35.3
ICD-10 Finland
Polymyalgia rheumatica
74.1
323.0
422
91
PAW37
NOMESCO Finland
Biopsy of temporal artery
905.3
323.0
475
9
H02AB06
ATC
prednisolone; systemic
18.5
307.3
1006
3810
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.3
172.1
799
3216
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
10.2
156.7
343
466
M31.6
ICD-10 Finland
Other giant cell arteritis
1668.3
151.7
144
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
8.8
151.6
368
593
M05BA04
ATC
alendronic acid; oral
6.7
123.9
365
753
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.4
114.5
228
246
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
19.6
106.2
165
98
A02BC02
ATC
pantoprazole; systemic
4.5
91.0
934
6006
I77.6
ICD-10 Finland
Arteritis, unspecified
166.9
88.5
92
6
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
87.7
83
*
R51.80
ICD-10 Finland
Headache
5.2
86.2
311
776
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.8
73.9
203
356
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
55.7
672
3984
TPX00
NOMESCO Finland
Biopsy of artery or vein
542.6
52.9
52
*
R50.9
ICD-10 Finland
Fever, unspecified
3.7
52.0
266
876
H02AB07
ATC
prednisone; oral
3.4
48.7
277
986
L88
ICPC
Rheumatoid/seropositive arthritis
7.2
44.4
113
173
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
43.9
227
744
L04AX01
ATC
azathioprine; systemic
7.3
42.1
105
156
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.0
39.2
276
1119
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
36.7
35
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.4
35.8
140
355
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
34.6
33
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
30.3
29
*
N01
ICPC
Headache
3.6
29.1
139
419
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
28.7
210
854
AA1AD
NOMESCO Finland
CT of head and brain
2.2
28.7
378
2100
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
40.1
28.2
35
9
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.6
27.4
83
159
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
26.2
406
2401
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
26.1
25
*
G44.2
ICD-10 Finland
Tension-type headache
2.8
25.9
190
773
M05BA07
ATC
risedronic acid; oral
4.2
24.6
98
251
N02BE01
ATC
paracetamol; systemic, rectal
2.5
24.1
994
8554
J01DB01
ATC
cefalexin; oral
2.1
22.7
902
7463
P01BA02
ATC
hydroxychloroquine; oral
3.2
22.3
124
416
H57.1
ICD-10 Finland
Ocular pain
5.7
22.0
64
117
M13.9
ICD-10 Finland
Arthritis, unspecified
3.2
21.7
118
392
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
21.4
342
2012
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
21.3
151
597
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.2
21.2
84
214
ZX120
NOMESCO Finland
Intravenous
2.8
21.2
150
593
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
21.1
289
1594
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
21.1
457
3005
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.0
20.9
130
473
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
20.9
117
396
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
6.0
20.3
57
100
M25.5
ICD-10 Finland
Pain in joint
2.0
19.8
321
1887
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
19.4
235
1226
L04AA13
ATC
leflunomide; oral
5.4
18.8
57
110
A01
ICPC
Pain general/multiple sites
2.7
18.4
131
518
N03AX16
ATC
pregabalin; oral
2.0
18.1
297
1744
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.0
18.0
74
196
R53
ICD-10 Finland
Malaise and fatigue
2.0
17.9
271
1543
M79.6
ICD-10 Finland
Pain in limb
1.8
17.9
438
2954
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
14.1
17.3
29
21
M79.1
ICD-10 Finland
Myalgia
2.4
17.3
166
772
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
17.3
145
629
S18
ICPC
Laceration/cut
1.7
17.1
518
3719
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
19.6
16.9
25
13
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
6.0
16.8
46
79
WX110
NOMESCO Finland
Local anesthesy
1.7
16.6
694
5460
N02AX02
ATC
tramadol; systemic, rectal
1.7
16.4
501
3593
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
16.3
542
3980
M05BX04
ATC
denosumab; parenteral
2.9
16.2
105
390
R06.0
ICD-10 Finland
Dyspnoea
1.8
15.9
333
2118
N03AX12
ATC
gabapentin; oral
2.1
15.9
210
1126
A02BC05
ATC
esomeprazole; systemic
1.7
15.7
472
3354
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
15.7
15
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.2
15.6
59
145
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.0
15.5
90
313
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
15.3
507
3693
R03AC02
ATC
salbutamol; inhalant
1.7
15.1
551
4117
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.4
15.1
139
631
J01AA02
ATC
doxycycline; systemic
1.8
15.1
852
7217
R51
ICD-10 Finland
Headache
3.4
14.9
73
225
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
14.8
361
2398
A02BC01
ATC
omeprazole; systemic
1.8
14.8
355
2347
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
14.5
225
1280
H53.2
ICD-10 Finland
Diplopia
4.0
14.2
56
144
J01FA06
ATC
roxithromycin; oral
1.7
14.1
449
3215
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
14.0
94
358
C07AB07
ATC
bisoprolol; oral
1.6
14.0
609
4738
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
14.0
124
552
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
13.9
467
3388
UJF32
NOMESCO Finland
Coloscopy
1.7
13.8
330
2167
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
13.6
13
*
M54.5
ICD-10 Finland
Low back pain
1.7
13.5
344
2300
H34.1
ICD-10 Finland
Central retinal artery occlusion
11.1
13.5
25
23
J01FA10
ATC
azithromycin; systemic
1.6
13.4
547
4166
R51.81
ICD-10 Finland
Facial pain NOS
4.9
13.4
43
90
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.1
13.3
161
827
J01FF01
ATC
clindamycin; systemic
1.7
13.1
303
1966
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
13.1
250
1525
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
13.1
391
2736
L28
ICPC
Limited function/disability (L)
1.9
13.0
227
1346
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
13.0
99
408
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
12.9
337
2263
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
12.9
401
2829
J01CA04
ATC
amoxicillin; systemic
1.7
12.7
825
7038
M03BX02
ATC
tizanidine; oral
1.6
12.7
608
4794
L17
ICPC
Foot/toe symptom/complaint
1.7
12.7
303
1983
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
12.6
100
421
L04AC07
ATC
tocilizumab; parenteral
32.4
12.6
16
5
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
12.5
12
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
12.5
123
578
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
12.4
114
515
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.9
12.4
75
267
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
12.3
95
394
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.4
12.3
105
457
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.6
12.2
54
154
A03
ICPC
Fever
2.1
12.2
143
726
XCK00
NOMESCO Finland
Perimetry
2.3
12.2
111
502
A02BC03
ATC
lansoprazole; oral
1.7
12.2
358
2481
TAB00
NOMESCO Finland
Lumbar puncture
3.4
12.2
59
181
A04
ICPC
Weakness/tiredness general
2.0
11.7
167
917
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
12.7
11.6
20
16
M79.7
ICD-10 Finland
Fibromyalgia
4.1
11.6
44
110
H53.4
ICD-10 Finland
Visual field defects
4.6
11.5
39
87
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
11.5
244
1532
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
11.5
11
*
SPAT1263
SPAT
Sampling
1.6
11.4
470
3537
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
11.3
178
1014
J01MA02
ATC
ciprofloxacin; systemic
1.6
11.3
442
3284
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.8
11.2
206
1236
R05
ICD-10 Finland
Cough
1.8
11.1
219
1345
H26.3
ICD-10 Finland
Drug-induced cataract
11.3
11.1
20
18
5BA08
NOMESCO Finland
NA
10.2
11.0
21
21
SPAT1153
SPAT
Removal of sutures
1.6
11.0
391
2828
R52.9
ICD-10 Finland
Pain, unspecified
2.3
11.0
105
484
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
11.0
163
908
C03CA01
ATC
furosemide; systemic
1.6
10.9
410
3007
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
10.9
479
3649
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
10.9
95
421
N05CF01
ATC
zopiclone; oral
1.6
10.8
387
2804
L04AA06
ATC
mycophenolic acid; systemic
6.2
10.8
28
46
J01MA12
ATC
levofloxacin; systemic
1.8
10.7
225
1406
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
10.7
100
456
E0000UV
ATC
NA
1.6
10.5
414
3066
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
10.4
10
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
10.4
106
506
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.5
10.4
48
143
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
10.3
217
1358
H02AB09
ATC
hydrocortisone; systemic
4.8
10.2
33
71
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.7
10.0
33
72
A07EC01
ATC
sulfasalazine; oral, rectal
2.3
10.0
96
443
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
10.0
141
769
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
10.0
131
693
R02
ICPC
Shortness of breath/dyspnoea
1.9
10.0
157
890
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
10.0
354
2551
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
9.9
260
1731
J01MA14
ATC
moxifloxacin; systemic
2.1
9.9
111
551
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
9.8
259
1728
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
9.7
99
470
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
9.6
183
1108
G50.1
ICD-10 Finland
Atypical facial pain
4.4
9.6
33
76
A46
ICD-10 Finland
Erysipelas
1.8
9.5
174
1039
4AC0X
NOMESCO Finland
NA
+∞
9.4
9
*
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
9.4
9
*
L01AA01
ATC
cyclophosphamide; systemic
12.5
9.4
16
13
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.1
9.3
103
507
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
9.3
141
789
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
13.8
9.2
15
11
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.1
9.1
100
493
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
11.6
9.1
16
14
H47.1
ICD-10 Finland
Papilloedema, unspecified
15.7
9.0
14
9
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
9.0
118
626
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.9
9.0
140
788
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
9.0
190
1185
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
8.8
209
1351
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
8.7
127
699
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
8.7
164
988
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.7
8.7
21
32
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
8.6
87
413
SPAT1301
SPAT
No procedures
1.5
8.6
365
2719
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.4
8.6
39
116
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.4
8.5
69
296
JN4BD
NOMESCO Finland
Extensive body CT
1.8
8.5
140
807
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
8.4
644
5408
R52.2
ICD-10 Finland
Other chronic pain
3.1
8.4
44
145
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
8.4
101
517
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
8.4
107
563
G47.3
ICD-10 Finland
Sleep apnoea
1.7
8.3
196
1258
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
8.3
8
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
8.3
8
*
4AC07
NOMESCO Finland
NA
+∞
8.3
8
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
4.2
8.3
30
73
L03
ICPC
Low back symptom/complaint
1.6
8.3
253
1744
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.3
8.3
73
327
M01AE02
ATC
naproxen; oral, rectal
1.4
8.3
545
4436
H02AB04
ATC
methylprednisolone; systemic
1.7
8.3
169
1042
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
8.2
169
1045
L01
ICPC
Neck symptom/complaint
1.8
8.2
146
862
A02BA02
ATC
ranitidine; systemic
1.6
8.2
242
1650
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
8.2
164
1007
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
8.2
71
313
Z00.0
ICD-10 Finland
General medical examination
1.7
8.1
200
1299
L95
ICPC
Osteoporosis
2.6
8.1
57
227
R03BB04
ATC
tiotropium bromide; inhalant
1.9
8.1
126
713
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.0
8.1
99
512
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
8.1
68
297
NF1AA
NOMESCO Finland
Hip X-ray examination
1.9
8.0
123
689
Z3231
NOMESCO Finland
Registered nurse
1.5
8.0
302
2188
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
8.0
433
3385
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
7.9
507
4094
R63.4
ICD-10 Finland
Abnormal weight loss
2.7
7.9
51
193
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.9
7.9
111
604
NXL00
NOMESCO Finland
Biopsy of muscle
13.1
7.9
13
10
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
7.9
175
1107
H46
ICD-10 Finland
Optic neuritis
8.5
7.8
16
19
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
7.8
186
1201
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
7.7
161
997
M05.2
ICD-10 Finland
Rheumatoid vasculitis
45.3
7.7
9
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.6
7.7
33
94
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.7
269
1910
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.1
7.7
89
448
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.8
7.7
46
167
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
7.7
712
6150
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.6
7.6
53
209
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
7.6
308
2259
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
7.6
139
830
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
4.3
7.5
26
61
WZA90
NOMESCO Finland
Other doctors statement
1.6
7.5
213
1436
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
3.9
7.5
29
76
H15.1
ICD-10 Finland
Episcleritis
4.5
7.5
25
57
R03DC03
ATC
montelukast; oral
1.7
7.5
154
953
M01AH03
ATC
valdecoxib; oral
2.1
7.5
79
385
PAA99
NOMESCO Finland
Exploration of other arterial branch originating from aortic arch arteries
80.6
7.4
8
*
CS494
NOMESCO Finland
Other visual field testing
3.0
7.4
40
136
H26.4
ICD-10 Finland
After-cataract
1.7
7.4
145
882
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.8
7.4
45
166
R05
ICPC
Cough
1.6
7.3
226
1555
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.9
7.3
43
154
PA7BD
NOMESCO Finland
CT angiography of neck and brain
3.6
7.3
31
88
4AC0L
NOMESCO Finland
NA
+∞
7.3
7
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
7.3
7
*
J02AC01
ATC
fluconazole; systemic
1.5
7.3
370
2842
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
7.3
174
1122
C08CA01
ATC
amlodipine; oral
1.4
7.3
447
3562
B02.9
ICD-10 Finland
Zoster without complication
2.1
7.2
77
375
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.2
7.2
36
116
Z2221
NOMESCO Finland
Medical doctor
1.5
7.2
293
2149
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.1
409
3215
L08
ICPC
Shoulder symptom/complaint
1.6
7.0
205
1392
B01AF02
ATC
apixaban; oral
1.7
7.0
134
809
R60.0
ICD-10 Finland
Localized oedema
1.7
7.0
135
817
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.0
7.0
84
430
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.1
6.9
80
405
SPAT1310
SPAT
Counselling related to known health issue
1.5
6.9
337
2562
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
6.9
247
1757
M81.4
ICD-10 Finland
Drug-induced osteoporosis
13.9
6.9
11
8
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.8
6.9
41
149
N06AA09
ATC
amitriptyline; systemic
1.8
6.9
114
660
J05AB01
ATC
aciclovir; systemic
1.6
6.9
213
1469
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.5
6.9
52
217
R07.3
ICD-10 Finland
Other chest pain
1.8
6.8
108
612
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
6.8
190
1274
B01AC04
ATC
clopidogrel; oral
1.6
6.8
204
1391
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.8
181
1202
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
6.8
405
3198
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.7
209
1440
J37.0
ICD-10 Finland
Chronic laryngitis
2.8
6.7
40
145
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.6
6.7
167
1090
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.8
6.7
26
69
L60.0
ICD-10 Finland
Ingrowing nail
2.5
6.7
48
195
F29
ICPC
Eye symptom/complaint other
1.9
6.7
94
514
K04.1
ICD-10 Finland
Necrosis of pulp
2.0
6.7
88
469
ZXA00
NOMESCO Finland
Right side
1.4
6.7
319
2415
R01AD01
ATC
beclometasone; nasal
1.7
6.6
151
961
R01AD08
ATC
fluticasone; nasal
1.5
6.6
250
1803
R01AD09
ATC
mometasone; nasal
1.4
6.5
401
3179
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.6
6.5
44
173
D07AC01
ATC
betamethasone; topical
1.4
6.5
339
2605
C01CA24
ATC
epinephrine; parenteral
2.5
6.5
49
202
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
6.5
100
564
M05BA06
ATC
ibandronic acid; systemic
2.8
6.5
38
137
SPAT1254
SPAT
Administration of medicine
1.6
6.4
167
1101
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.3
6.4
30
93
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.4
223
1578
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.8
6.4
113
665
R06AE07
ATC
cetirizine; oral
1.4
6.4
407
3246
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
6.4
283
2106
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.4
6.4
49
207
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.4
6.4
28
83
M53.3
ICD-10 Finland
Sacrococcygeal disorders, not elsewhere classified
6.6
6.3
15
23
R04.2
ICD-10 Finland
Haemoptysis
2.5
6.3
45
181
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.5
6.3
45
181
PD5BD
NOMESCO Finland
Extensive CT of aorta
3.1
6.3
32
105
R03BA02
ATC
budesonide; inhalant
1.6
6.3
173
1153
C08CA05
ATC
nifedipine; systemic
2.0
6.3
81
428
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
6.3
6
*
S97
ICPC
Chronic ulcer skin
2.0
6.2
73
373
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
7.1
6.2
14
20
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
4.1
6.2
22
54
JN4AD
NOMESCO Finland
Body CT examination
1.9
6.2
88
482
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.3
6.1
55
248
M01AH02
ATC
rofecoxib; oral
1.6
6.1
164
1088
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.1
6.1
63
306
J01FA09
ATC
clarithromycin; systemic
1.4
6.1
291
2195
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.1
631
5445
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.4
6.0
49
211
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.2
6.0
57
264
Mortality – FinRegistry
↥Association
Association between endpoint M13_TEMPARTERIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TEMPARTERIT | 1.308 [1.18, 1.44] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.119 |
During the follow-up period (1.1.1998 — 31.12.2019), 1563 out of 4350 females with M13_TEMPARTERIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TEMPARTERIT | 1.385 [1.19, 1.61] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2033 males with M13_TEMPARTERIT died.
Mortality risk
Mortality risk for people of age
years, who have M13_TEMPARTERIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.275% |
| 5 | 0.736% | 1.533% |
| 10 | 1.731% | 3.506% |
| 15 | 3.541% | 6.783% |
| 20 | 6.176% | 11.54% |
Relationships between endpoints
↥Index endpoint: M13_TEMPARTERIT – Temporal arteritis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data