temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1421 |
4. Check minimum number of eventsNone |
1421 |
5. Include endpoints |
1421 |
6. Filter based on genotype QC (FinnGen only) |
1421 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Giant cell arteritis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9069 | 6071 | 2933 |
| Only index persons | 7652 | 5164 | 2488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.17 | 0.08 |
| Only index persons | 0.16 | 0.19 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 72.33 | 72.72 | 71.45 |
| Only index persons | 71.52 | 71.93 | 70.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1421 | 874 | 547 |
| Unadjusted period prevalence (%) | 0.28 | 0.30 | 0.24 |
| Median age at first event (years) | 69.81 | 69.42 | 70.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1248
- Matched controls
- 12481
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB06
ATC
prednisolone; systemic
16.3
323.0
1116
4266
M35.3
ICD-10 Finland
Polymyalgia rheumatica
73.6
323.0
445
93
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
4503599627370496.0
323.0
1111
*
PAW37
NOMESCO Finland
Biopsy of temporal artery
739.7
323.0
499
11
M31.6
ICD-10 Finland
Other giant cell arteritis
3117.4
282.1
262
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.8
179.9
874
3570
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
9.2
158.4
368
542
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
8.0
158.1
410
721
M05BA04
ATC
alendronic acid; oral
6.3
127.3
391
837
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
20.6
122.3
187
106
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.9
116.8
252
312
I77.6
ICD-10 Finland
Arteritis, unspecified
233.6
105.3
107
5
A02BC02
ATC
pantoprazole; systemic
4.1
93.9
1034
6724
R51.80
ICD-10 Finland
Headache
5.1
92.4
338
849
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
89.7
85
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
6.4
77.6
223
412
R50.9
ICD-10 Finland
Fever, unspecified
4.0
64.9
304
936
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
59.0
743
4442
TPX00
NOMESCO Finland
Biopsy of artery or vein
149.1
54.3
57
*
H02AB07
ATC
prednisone; oral
3.3
52.3
308
1118
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
44.2
248
857
L04AX01
ATC
azathioprine; systemic
6.9
43.5
113
177
L88
ICPC
Rheumatoid/seropositive arthritis
6.2
42.1
119
209
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
36.6
35
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
367.3
36.2
36
*
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
35.6
34
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.0
35.0
151
416
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.6
34.3
298
1345
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
31.2
229
930
N01
ICPC
Headache
3.6
30.9
149
450
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.9
30.1
87
157
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
46.2
29.7
36
8
AA1AD
NOMESCO Finland
CT of head and brain
2.1
29.2
421
2407
4465A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Giant cell arteritis
+∞
27.2
26
*
G44.2
ICD-10 Finland
Tension-type headache
2.7
26.6
203
836
M35.5
ICD-10 Finland
Multifocal fibrosclerosis
+∞
26.1
25
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
25.4
443
2704
N02BE01
ATC
paracetamol; systemic, rectal
2.3
23.2
1102
9550
M13.9
ICD-10 Finland
Arthritis, unspecified
3.3
23.2
126
416
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.1
23.2
94
244
M05BA07
ATC
risedronic acid; oral
3.8
22.8
101
284
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
22.3
319
1782
J01DB01
ATC
cefalexin; oral
2.0
22.2
1002
8376
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
22.2
503
3332
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
22.0
124
420
H57.1
ICD-10 Finland
Ocular pain
5.2
21.8
69
139
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
20.5
21.7
32
16
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
21.2
374
2257
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.7
20.9
61
112
M79.6
ICD-10 Finland
Pain in limb
1.8
20.5
479
3181
ZX120
NOMESCO Finland
Intravenous
2.6
20.3
164
695
M79.1
ICD-10 Finland
Myalgia
2.4
20.2
184
830
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
19.9
161
681
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.7
19.8
141
554
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
6.5
19.6
51
81
A01
ICPC
Pain general/multiple sites
2.7
19.3
142
570
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
19.1
259
1403
P01BA02
ATC
hydroxychloroquine; oral
2.8
19.1
131
505
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
18.8
597
4331
R06.0
ICD-10 Finland
Dyspnoea
1.8
18.4
370
2319
N03AX12
ATC
gabapentin; oral
2.1
18.3
229
1199
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.7
18.3
81
228
L04AA13
ATC
leflunomide; oral
4.7
18.0
62
138
M25.5
ICD-10 Finland
Pain in joint
1.9
17.8
345
2132
S18
ICPC
Laceration/cut
1.7
17.8
570
4122
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
17.7
565
4079
J01FF01
ATC
clindamycin; systemic
1.8
17.1
344
2145
M05BX04
ATC
denosumab; parenteral
2.9
17.1
111
412
N02AX02
ATC
tramadol; systemic, rectal
1.7
16.8
556
4037
N03AX16
ATC
pregabalin; oral
1.8
16.5
324
2001
J01CA04
ATC
amoxicillin; systemic
1.7
16.3
925
7779
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
16.2
404
2690
WX110
NOMESCO Finland
Local anesthesy
1.7
16.1
766
6114
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
16.0
155
717
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
16.0
105
393
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
10.6
15.7
30
29
R51
ICD-10 Finland
Headache
3.4
15.7
76
231
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
86.1
15.6
17
*
R03AC02
ATC
salbutamol; inhalant
1.6
15.4
610
4611
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.1
15.3
84
280
J01FA06
ATC
roxithromycin; oral
1.6
15.0
496
3563
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.5
15.0
124
531
R53
ICD-10 Finland
Malaise and fatigue
1.8
14.9
300
1859
R51.81
ICD-10 Finland
Facial pain NOS
4.9
14.8
48
101
A02BC05
ATC
esomeprazole; systemic
1.6
14.8
520
3796
M54.5
ICD-10 Finland
Low back pain
1.7
14.7
384
2577
A03
ICPC
Fever
2.2
14.7
161
791
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
14.7
429
2977
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
14.7
199
1069
XCK00
NOMESCO Finland
Perimetry
2.5
14.7
123
528
M03BX02
ATC
tizanidine; oral
1.6
14.6
674
5278
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
151.6
14.5
15
*
J01AA02
ATC
doxycycline; systemic
1.7
14.4
949
8144
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
14.1
276
1694
C07AB07
ATC
bisoprolol; oral
1.6
13.9
681
5378
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
13.9
105
429
L04AC07
ATC
tocilizumab; parenteral
24.1
13.8
19
8
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
13.8
245
1454
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.7
13.8
61
173
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.1
13.7
173
901
A02BC01
ATC
omeprazole; systemic
1.7
13.7
391
2682
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.4
13.7
117
507
M30.0
ICD-10 Finland
Polyarteritis nodosa
141.4
13.5
14
*
E0000UV
ATC
NA
1.6
13.4
462
3331
R02
ICPC
Shortness of breath/dyspnoea
2.0
13.3
172
904
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.5
13.3
63
189
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.0
13.3
177
942
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
13.1
537
4038
UJF32
NOMESCO Finland
Coloscopy
1.7
13.0
359
2433
SPAT1153
SPAT
Removal of sutures
1.6
12.9
430
3065
J01MA14
ATC
moxifloxacin; systemic
2.3
12.9
123
564
SPAT1263
SPAT
Sampling
1.6
12.9
525
3934
J01MA02
ATC
ciprofloxacin; systemic
1.6
12.9
494
3651
TAB00
NOMESCO Finland
Lumbar puncture
3.3
12.8
65
206
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
12.7
515
3853
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
12.5
12
*
H53.2
ICD-10 Finland
Diplopia
3.4
12.5
61
188
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.1
12.3
148
756
L17
ICPC
Foot/toe symptom/complaint
1.7
12.3
337
2277
A46
ICD-10 Finland
Erysipelas
1.9
12.2
200
1150
J01MA12
ATC
levofloxacin; systemic
1.8
12.2
249
1542
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.4
12.1
110
491
5BA08
NOMESCO Finland
NA
10.2
12.0
23
23
J01FA10
ATC
azithromycin; systemic
1.5
12.0
603
4726
C03CA01
ATC
furosemide; systemic
1.6
11.9
465
3432
NXL00
NOMESCO Finland
Biopsy of muscle
47.1
11.9
14
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
11.8
132
653
M79.7
ICD-10 Finland
Fibromyalgia
4.0
11.7
46
118
K07.63
ICD-10 Finland
Pain in the jaw joint UNS
6.4
11.7
30
48
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
11.7
402
2876
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
11.5
132
657
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.4
11.5
98
426
H02AB04
ATC
methylprednisolone; systemic
1.9
11.5
189
1086
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
11.5
11
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.0
11.5
162
882
M03BC01
ATC
orphenadrine (citrate); systemic
1.7
11.4
242
1514
R52.9
ICD-10 Finland
Pain, unspecified
2.2
11.3
115
545
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
11.3
113
533
H25.1
ICD-10 Finland
Senile nuclear cataract
1.6
11.2
438
3221
L01AA01
ATC
cyclophosphamide; systemic
12.8
11.1
19
15
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
11.1
206
1233
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
11.1
373
2646
H34.1
ICD-10 Finland
Central retinal artery occlusion
7.1
11.1
26
37
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
11.0
294
1962
G50.1
ICD-10 Finland
Atypical facial pain
4.6
10.9
37
83
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
15.6
10.8
17
11
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
9.7
10.8
21
22
H02AB09
ATC
hydrocortisone; systemic
4.5
10.7
37
85
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
10.6
111
534
L28
ICPC
Limited function/disability (L)
1.7
10.6
240
1527
A04
ICPC
Weakness/tiredness general
1.8
10.6
182
1062
N05CF01
ATC
zopiclone; oral
1.5
10.6
435
3228
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
10.5
718
5943
A02BC03
ATC
lansoprazole; oral
1.6
10.5
392
2842
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
10.4
104
487
4AC0X
NOMESCO Finland
NA
+∞
10.4
10
*
M05.2
ICD-10 Finland
Rheumatoid vasculitis
+∞
10.4
10
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
10.4
10
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
10.4
489
3733
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
10.4
140
747
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
10.3
149
816
Z3231
NOMESCO Finland
Registered nurse
1.6
10.3
341
2402
R63.4
ICD-10 Finland
Abnormal weight loss
3.0
10.2
59
206
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
10.2
190
1139
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
10.1
154
861
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.2
10.1
51
162
L04AA06
ATC
mycophenolic acid; systemic
5.4
10.0
29
55
JN4BD
NOMESCO Finland
Extensive body CT
1.9
10.0
158
896
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
10.0
214
1339
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
9.9
104
501
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.2
9.9
101
479
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
9.9
233
1493
H26.3
ICD-10 Finland
Drug-induced cataract
8.2
9.8
21
26
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
9.8
266
1775
A07EC01
ATC
sulfasalazine; oral, rectal
2.2
9.8
103
497
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
9.7
95
445
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
9.6
562
4472
R20.2
ICD-10 Finland
Paraesthesia of skin
2.4
9.5
80
346
R05
ICD-10 Finland
Cough
1.7
9.5
241
1576
L03
ICPC
Low back symptom/complaint
1.6
9.4
280
1912
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.3
9.4
88
403
PAA99
NOMESCO Finland
Exploration of other arterial branch originating from aortic arch arteries
+∞
9.4
9
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.1
9.3
112
569
C08CA01
ATC
amlodipine; oral
1.5
9.3
498
3882
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
9.3
118
615
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
9.2
180
1093
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
9.2
191
1180
L01
ICPC
Neck symptom/complaint
1.8
9.2
163
958
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.7
9.1
220
1420
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.1
9.1
48
158
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.4
9.1
42
126
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.0
9.0
116
606
SPAT1301
SPAT
No procedures
1.5
9.0
400
2998
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
8.9
127
691
H15.1
ICD-10 Finland
Episcleritis
5.5
8.9
25
46
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
8.9
123
661
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
12.6
8.9
15
12
R52.2
ICD-10 Finland
Other chronic pain
3.0
8.8
50
172
WZA90
NOMESCO Finland
Other doctors statement
1.6
8.7
235
1561
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
8.7
346
2527
G45.3
ICD-10 Finland
Amaurosis fugax
3.6
8.7
38
109
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
8.6
272
1881
CS494
NOMESCO Finland
Other visual field testing
3.2
8.6
43
137
Z71.8
ICD-10 Finland
Other specified counselling
1.6
8.6
252
1712
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
8.6
286
2001
XX9XE
NOMESCO Finland
Other ultrasound examination
11.7
8.6
15
13
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.3
8.6
79
358
M01AE02
ATC
naproxen; oral, rectal
1.4
8.5
604
4947
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
3.9
8.5
33
86
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.0
8.5
112
595
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.5
8.4
38
112
R03BB04
ATC
tiotropium bromide; inhalant
1.8
8.4
141
815
G47.3
ICD-10 Finland
Sleep apnoea
1.6
8.4
211
1378
Z2221
NOMESCO Finland
Medical doctor
1.5
8.4
324
2347
4AC0L
NOMESCO Finland
NA
+∞
8.3
8
*
4AC07
NOMESCO Finland
NA
+∞
8.3
8
*
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
8.3
8
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
8.3
8
*
H53.4
ICD-10 Finland
Visual field defects
3.2
8.3
41
130
ZXA00
NOMESCO Finland
Right side
1.5
8.2
359
2668
Z00.0
ICD-10 Finland
General medical examination
1.6
8.2
221
1466
L95
ICPC
Osteoporosis
2.5
8.2
64
269
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
8.2
84
400
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.2
202
1311
J02AC01
ATC
fluconazole; systemic
1.5
8.0
409
3133
R03DC03
ATC
montelukast; oral
1.7
8.0
174
1087
PA7BD
NOMESCO Finland
CT angiography of neck and brain
3.5
8.0
35
101
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
8.0
186
1189
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.2
8.0
78
366
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.0
7.9
94
480
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.9
149
896
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
5.2
7.9
23
45
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.0
7.8
43
147
R05
ICPC
Cough
1.6
7.8
249
1725
WZC30
NOMESCO Finland
Teaching
1.7
7.7
156
956
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.7
299
2161
XG410
NOMESCO Finland
Flow-volume spirometry
2.6
7.7
56
224
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
7.7
298
2154
R21
ICPC
Throat symptom/complaint
1.7
7.6
158
974
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.9
7.6
115
641
H26.4
ICD-10 Finland
After-cataract
1.7
7.6
159
982
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
7.6
136
802
J05AB01
ATC
aciclovir; systemic
1.6
7.6
233
1595
A02BA02
ATC
ranitidine; systemic
1.5
7.6
267
1888
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.6
95
494
H47.1
ICD-10 Finland
Papilloedema, unspecified
8.9
7.5
15
17
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.4
7.5
34
101
TNG10
NOMESCO Finland
Puncture of knee
5.5
7.5
21
39
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.2
7.5
77
368
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.4
7.5
64
280
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.8
7.4
117
661
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
7.4
164
1031
R07.3
ICD-10 Finland
Other chest pain
1.8
7.4
124
713
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
7.4
88
449
R01AD01
ATC
beclometasone; nasal
1.7
7.4
162
1014
B01AC04
ATC
clopidogrel; oral
1.6
7.4
228
1562
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
7.4
51
200
J01FA09
ATC
clarithromycin; systemic
1.5
7.4
324
2404
F29
ICPC
Eye symptom/complaint other
1.9
7.4
100
538
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.4
362
2747
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.0
7.3
91
470
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.4
7.3
61
266
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.7
7.3
48
184
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
7.3
197
1306
NF1AA
NOMESCO Finland
Hip X-ray examination
1.8
7.2
131
775
L99
ICPC
Musculoskeletal disease other
3.6
7.2
30
84
SPAT1310
SPAT
Counselling related to known health issue
1.4
7.2
372
2850
S97
ICPC
Chronic ulcer skin
2.1
7.2
75
363
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
7.2
792
6927
G43.9
ICD-10 Finland
Migraine, unspecified
2.9
7.1
41
144
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
8.0
7.1
15
19
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.6
7.1
49
191
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
7.0
230
1598
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
7.0
445
3532
M01AH02
ATC
rofecoxib; oral
1.6
7.0
180
1179
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.4
7.0
58
250
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.3
7.0
33
102
H46
ICD-10 Finland
Optic neuritis
6.4
6.9
17
27
R04.2
ICD-10 Finland
Haemoptysis
2.5
6.9
50
203
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
6.9
159
1009
L08
ICPC
Shoulder symptom/complaint
1.5
6.9
224
1552
ZXE00
NOMESCO Finland
One hour or less
1.4
6.9
443
3526
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.2
6.9
70
333
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
6.9
197
1324
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.8
700
6020
D69.0
ICD-10 Finland
Allergic purpura
8.3
6.8
14
17
XF402
NOMESCO Finland
ECG with work load test
1.7
6.7
151
954
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
6.7
447
3578
M01AH03
ATC
valdecoxib; oral
2.0
6.7
84
438
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
5.2
6.6
19
37
R60.0
ICD-10 Finland
Localized oedema
1.7
6.6
153
973
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
5.5
6.6
18
33
Z01.9
ICD-10 Finland
Special examination, unspecified
2.1
6.6
75
374
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.6
197
1336
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
6.6
148
937
L18
ICPC
Muscle pain
2.5
6.5
49
201
L60.0
ICD-10 Finland
Ingrowing nail
2.4
6.5
53
229
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.6
6.5
27
76
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.6
6.5
27
76
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.5
171
1127
R03BA05
ATC
fluticasone; inhalant
1.6
6.4
194
1319
C08CA05
ATC
nifedipine; systemic
1.9
6.4
94
517
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.5
6.4
46
186
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
70.2
6.4
7
*
ZXA05
NOMESCO Finland
Left side
1.4
6.3
328
2505
H92.0
ICD-10 Finland
Otalgia
2.2
6.3
57
260
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
3.2
6.3
31
100
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
6.3
6
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
6.3
6
*
R01AD09
ATC
mometasone; nasal
1.4
6.2
426
3410
M05BA06
ATC
ibandronic acid; systemic
2.6
6.2
41
158
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.3
6.2
21
49
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.1
6.2
70
349
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.2
6.2
59
276
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
5.4
6.2
17
32
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
6.1
466
3795
JN4AD
NOMESCO Finland
Body CT examination
1.8
6.1
104
606
D07AC01
ATC
betamethasone; topical
1.4
6.1
375
2950
M13.0
ICD-10 Finland
Polyarthritis, unspecified
4.9
6.1
18
37
PG1AE
NOMESCO Finland
Ultrasound examination of artery not elsewher classified
6.7
6.0
14
21
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.7
6.0
135
853
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.4
6.0
47
200
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
6.0
73
377
R06AE07
ATC
cetirizine; oral
1.4
6.0
444
3596
Mortality – FinRegistry
↥Association
Association between endpoint M13_GIANTCELL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_GIANTCELL | 1.291 [1.17, 1.42] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 1604 out of 4624 females with M13_GIANTCELL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_GIANTCELL | 1.32 [1.14, 1.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 859 out of 2239 males with M13_GIANTCELL died.
Mortality risk
Mortality risk for people of age
years, who have M13_GIANTCELL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | 0.217% |
| 5 | 0.717% | 1.508% |
| 10 | 1.759% | 3.57% |
| 15 | 3.324% | 7.161% |
| 20 | 5.818% | 12.419% |
Relationships between endpoints
↥Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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