Other conditions related to polyarteritis nodosa

M13_POYARTOTH

Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M30.8 Hospital discharge: ICD-9 — 4460C Cause of death: ICD-10 — M30.8 Cause of death: ICD-9 — 4460C 2 out of 7 registries used, show all original rules.	87
4. Check minimum number of events None	87
5. Include endpoints None	87
6. Filter based on genotype QC (FinnGen only)	87

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M30
Name in latin: Aliae condiciones polyarteritidi nodosae cognatae

NAME	M13_POYARTOTH
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M308
HD_ICD_9	4460C
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M308
COD_ICD_9	4460C
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other conditions related to polyarteritis nodosa based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	581	336	240
Only index persons	484	287	197
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	64.23	64.19	64.15
Only index persons	62.10	63.01	60.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	87	54	33
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	57.75	54.01	63.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
82: Matched controls
821

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M30.8

ICD-10 Finland

Other conditions related to polyarteritis nodosa

+∞

112.5

H02AB06

ATC

prednisolone; systemic

21.3

24.9

274

L04AX01

ATC

azathioprine; systemic

33.8

20.2

M30.0

ICD-10 Finland

Polyarteritis nodosa

+∞

18.4

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

12.1

16.1

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

6.8

14.9

180

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

12.5

10.1

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

7.8

10.1

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.6

9.9

241

M05BA04

ATC

alendronic acid; oral

8.7

9.6

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

12.9

9.3

H02AB07

ATC

prednisone; oral

6.0

8.6

M30.1

ICD-10 Finland

Polyarteritis with lung involvement [Churg-Strauss]

+∞

8.5

M31.7

ICD-10 Finland

Microscopic polyangiitis

+∞

8.5

M31.9

ICD-10 Finland

Necrotizing vasculopathy, unspecified

+∞

8.5

PAW37

NOMESCO Finland

Biopsy of temporal artery

+∞

8.5

J18.9

ICD-10 Finland

Pneumonia, unspecified

4.5

8.4

116

H02AB09

ATC

hydrocortisone; systemic

25.1

8.3

A49.9

ICD-10 Finland

Bacterial infection, unspecified

6.1

7.3

N03AX16

ATC

pregabalin; oral

4.0

7.3

123

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

8.1

6.9

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

10.1

6.9

TAB00

NOMESCO Finland

Lumbar puncture

10.6

6.5

UDH02

NOMESCO Finland

Rhinopharyngoscopy

7.4

6.5

R50.9

ICD-10 Finland

Fever, unspecified

5.1

6.5

ZX120

NOMESCO Finland

Intravenous

5.1

6.5

D69.0

ICD-10 Finland

Allergic purpura

29.2

6.4

E27.3

ICD-10 Finland

Drug-induced adrenocortical insufficiency

+∞

6.3

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

+∞

6.3

L95.9

ICD-10 Finland

Vasculitis limited to skin, unspecified

+∞

6.3

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

16.6

6.1

Mortality – FinRegistry

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Association

Association between endpoint M13_POYARTOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_POYARTOTH	2.789 [2.0, 3.89]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.129

During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 272 females with M13_POYARTOTH died.

Males

Parameter	HR [95% CI]	p-value
M13_POYARTOTH	2.272 [1.53, 3.36]	< 0.001
Birth year	0.986 [0.97, 1.0]	0.026

During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 194 males with M13_POYARTOTH died.

Mortality risk

Mortality risk for people of age

years, who have M13_POYARTOTH.

N-year risk	Females	Males
1	0.244%	0.365%
5	1.567%	2.344%
10	4.319%	5.549%
15	7.846%	11.556%
20	13.131%	19.031%

Relationships between endpoints

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Index endpoint: M13_POYARTOTH – Other conditions related to polyarteritis nodosa

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other conditions related to polyarteritis nodosa

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints