Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
249 |
4. Check minimum number of eventsNone |
249 |
5. Include endpointsNone |
249 |
6. Filter based on genotype QC (FinnGen only) |
249 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M30
- Name in latin
- Polyarteritis nodosa
Similar endpoints
↥List of similar endpoints to
Polyarteritis nodosa
based on the number of shared cases.
Similar with more cases:
- Polyarteritis nodosa and related conditions
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2412 | 1441 | 939 |
| Only index persons | 1633 | 982 | 651 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.80 | 70.69 | 60.69 |
| Only index persons | 61.28 | 64.65 | 56.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 249 | 140 | 109 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 59.70 | 59.01 | 60.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 217
- Matched controls
- 2170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
220.0
172
*
L04AX01
ATC
azathioprine; systemic
25.0
38.7
55
29
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
36.5
34
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
9.5
35.3
81
128
L04AA06
ATC
mycophenolic acid; systemic
48.2
27.7
33
8
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
25.5
24
*
H02AB06
ATC
prednisolone; systemic
3.9
20.3
141
696
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
19.0
18
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
19.0
18
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
18.9
115
496
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
18.0
17
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
18.0
17
*
M05BA04
ATC
alendronic acid; oral
6.4
17.3
48
92
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
7.2
16.0
40
66
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
15.8
15
*
L01AA01
ATC
cyclophosphamide; systemic
48.8
15.3
18
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.6
14.8
56
152
4460A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Polyarteritis nodosa[POLYARTERITIS NODOSA (CLASSICA)]
+∞
14.7
14
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
45.9
14.3
17
*
C03CA01
ATC
furosemide; systemic
3.1
13.5
105
507
A11CC03
ATC
alfacalcidol; systemic
13.4
13.5
23
19
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
12.9
45
111
N085, M318
ICD-10 Finland
NA
+∞
12.6
12
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
11.5
12.6
23
22
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
5.0
12.1
40
93
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.4
12.1
37
79
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.6
12.0
31
53
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
20.3
11.8
17
9
F02.89*M30.0
ICD-10 Finland
Dementia in polyarteritis nodosa
+∞
11.6
11
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
11.6
11
*
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
11.6
11
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
16.2
11.5
18
12
Z94.0
ICD-10 Finland
Kidney transplant status
26.7
11.3
15
6
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
10.6
48
151
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.9
10.6
22
27
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
10.5
10
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
10.5
10
*
P01BA02
ATC
hydroxychloroquine; oral
5.0
10.2
33
75
L04AD01
ATC
ciclosporin; systemic
17.8
10.0
15
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
9.9
113
649
44600
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Polyarteritis nodosa
+∞
9.4
9
*
M30.3
ICD-10 Finland
Mucocutaneous lymph node syndrome [Kawasaki]
+∞
9.4
9
*
J01MA12
ATC
levofloxacin; systemic
3.0
9.3
62
258
TK800
NOMESCO Finland
Hemodialysis
9.7
9.2
18
20
127
Kela drug reimbursment
Transplant complication
16.5
9.2
14
9
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.1
9.1
36
100
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.9
9.1
22
35
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
8.9
76
368
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
8.4
8
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
8.4
8
*
TGC00
NOMESCO Finland
Bronchial lavation
10.6
8.2
15
15
H02AB07
ATC
prednisone; oral
3.2
8.1
45
164
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
23.0
8.1
11
5
A12AA04
ATC
calcium carbonate; oral
9.0
8.0
16
19
A02BC01
ATC
omeprazole; systemic
2.5
7.9
78
401
R50.9
ICD-10 Finland
Fever, unspecified
3.1
7.8
45
169
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
46.7
7.8
9
*
L04AA01
ATC
[U] ciclosporin; systemic
19.2
7.7
11
6
H02AB04
ATC
methylprednisolone; systemic
2.9
7.6
49
196
N03AX16
ATC
pregabalin; oral
2.5
7.6
65
312
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
7.4
25
60
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
7.3
7
*
I77.6
ICD-10 Finland
Arteritis, unspecified
+∞
7.3
7
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.1
7.3
28
76
Z2446
NOMESCO Finland
Social worker
4.5
7.3
25
61
N30.0
ICD-10 Finland
Acute cystitis
2.9
7.2
45
178
D69.0
ICD-10 Finland
Allergic purpura
31.1
7.2
9
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.9
7.2
29
83
C08CA01
ATC
amlodipine; oral
2.2
7.0
94
554
S97
ICPC
Chronic ulcer skin
4.9
7.0
22
49
A12BA01
ATC
potassium chloride; oral
4.3
7.0
25
64
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.7
7.0
19
36
J01FF01
ATC
clindamycin; systemic
2.4
6.8
70
363
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.9
6.8
21
46
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
41.4
6.8
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
6.7
48
206
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
6.7
75
408
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.8
6.7
11
9
N18.0
ICD-10 Finland
End-stage renal disease
10.5
6.6
12
12
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
6.4
68
360
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
6.4
46
198
ZX120
NOMESCO Finland
Intravenous
3.2
6.3
32
110
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
6.3
6
*
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
6.3
6
*
L52
ICD-10 Finland
Erythema nodosum
27.5
6.3
8
*
B03XA02
ATC
darbepoetin alfa; parenteral
8.1
6.2
13
17
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.6
6.1
26
78
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.1
6.1
18
38
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.0
6.0
23
63
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLNODOSA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.456 [2.03, 2.97] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.939 |
During the follow-up period (1.1.1998 — 31.12.2019), 585 out of 1085 females with M13_POLNODOSA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.422 [1.81, 3.24] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 625 males with M13_POLNODOSA died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLNODOSA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.36% | 0.392% |
| 5 | 1.66% | 3.074% |
| 10 | 4.388% | 7.997% |
| 15 | 8.081% | 15.044% |
| 20 | 13.718% | 24.31% |
Relationships between endpoints
↥Index endpoint: M13_POLNODOSA – Polyarteritis nodosa
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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