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Juvenile dermatomyositis

M13_JUVDERMATOMYO

juvenile dermatomyositis: Juvenile dermatomyositis (JDM) is the early-onset form of dermatomyositis (DM, see this term), a systemic, autoimmune inflammatory muscle disorder, characterized by proximal muscle weakness, evocative skin lesion, and systemic manifestations.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M33.0
  • Hospital discharge: ICD-9 7103A
  • Cause of death: ICD-10 M33.0
  • Cause of death: ICD-9 7103A

2 out of 7 registries used, show all original rules.

43

4. Check minimum number of events

None

43

5. Include endpoints

None

43

6. Filter based on genotype QC (FinnGen only)

42

Control definitions (FinnGen only)

Control exclude
M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M33
Name in latin
Dermatomyositis juvenilis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 274 169 105
Only index persons 232 146 86
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.01 0.00
Median age at first event (years)
Whole population - 14.41 14.08
Only index persons 14.40 14.59 14.09

-FinnGen-

Key figures

All Female Male
Number of individuals 42 26 16
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 23.94 14.38 39.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

Association

Association between endpoint M13_JUVDERMATOMYO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_JUVDERMATOMYO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: M13_JUVDERMATOMYO – Juvenile dermatomyositis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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