Dermatopolymyositis, unspecified

M13_DERMATOPOLYNAS

dermatomyositis: Dermatomyositis (DM) is a type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M33.9 Cause of death: ICD-10 — M33.9 2 out of 7 registries used, show all original rules.	181
4. Check minimum number of events None	181
5. Include endpoints None	181
6. Filter based on genotype QC (FinnGen only)	181

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M33
Name in latin: Dermato[poly]myositis non specificata

NAME	M13_DERMATOPOLYNAS
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M339
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M339
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dermatopolymyositis, unspecified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	919	568	346
Only index persons	811	503	308
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	59.15	58.28	60.73
Only index persons	57.73	56.78	59.29

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	181	105	76
Unadjusted period prevalence (%)	0.03	0.04	0.03
Median age at first event (years)	56.65	52.96	61.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
170: Matched controls
1697

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M33.9

ICD-10 Finland

Dermatopolymyositis, unspecified

+∞

239.7

168

M33.1

ICD-10 Finland

Other dermatomyositis

+∞

74.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

22.4

60.3

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

11.1

44.6

121

309

M33.2

ICD-10 Finland

Polymyositis

+∞

43.6

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

14.3

41.0

H02AB06

ATC

prednisolone; systemic

11.5

40.2

144

551

L04AX01

ATC

azathioprine; systemic

36.7

39.2

P01BA02

ATC

hydroxychloroquine; oral

16.0

37.6

M60.9

ICD-10 Finland

Myositis, unspecified

378.8

32.0

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

+∞

29.0

M05BA04

ATC

alendronic acid; oral

14.1

27.1

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

13.1

25.7

NJ3CG

NOMESCO Finland

Extensive MRI examination of extremities with median high magnet

+∞

25.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

12.4

25.5

G72.9

ICD-10 Finland

Myopathy, unspecified

97.2

23.4

NJ3BG

NOMESCO Finland

MRI examination of extremities with high intensity magnet

251.0

22.1

NXL00

NOMESCO Finland

Biopsy of muscle

+∞

21.3

L04AA06

ATC

mycophenolic acid; systemic

48.5

21.1

J99.1*M33.9

ICD-10 Finland

Respiratory disorders in dermatopolymyositis

+∞

20.2

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

13.1

19.6

M60.8

ICD-10 Finland

Other myositis

+∞

17.0

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

6.3

14.6

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.6

14.2

104

519

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

+∞

12.7

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

6.6

12.5

L04AD01

ATC

ciclosporin; systemic

19.9

12.3

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

+∞

11.6

M05BA07

ATC

risedronic acid; oral

18.7

11.5

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.2

11.0

320

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

12.4

10.9

XA402

NOMESCO Finland

ENMG

17.5

10.6

M33.0

ICD-10 Finland

Juvenile dermatomyositis

+∞

10.5

J99.1

ICD-10 Finland

Respiratory disorders in other diffuse connective tissue disorders

+∞

10.5

J99.1*M33.2

ICD-10 Finland

Respiratory disorders in polymyositis

+∞

10.5

M35.1

ICD-10 Finland

Other overlap syndromes

+∞

10.5

H02AB07

ATC

prednisone; oral

4.1

10.2

130

J84.1

ICD-10 Finland

Other interstitial pulmonary diseases with fibrosis

15.9

10.2

L04AA01

ATC

[U] ciclosporin; systemic

21.6

10.0

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

7.7

9.7

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.2

9.1

218

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.0

9.1

114

A02BC02

ATC

pantoprazole; systemic

2.9

9.0

125

838

ZX120

NOMESCO Finland

Intravenous

4.5

8.8

M33

ICD-10 Finland

Dermatopolymyositis

+∞

8.4

NGA20

NOMESCO Finland

Exploration of soft tissue knee or lower leg, open

+∞

8.4

JN4BD

NOMESCO Finland

Extensive body CT

4.1

8.3

XG410

NOMESCO Finland

Flow-volume spirometry

6.3

8.1

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

6.5

8.0

R50.9

ICD-10 Finland

Fever, unspecified

3.6

7.7

118

R13

ICD-10 Finland

Dysphagia

5.8

7.7

1XC02

NOMESCO Finland

83.6

7.5

D07AB08

ATC

desonide; topical

3.6

7.2

107

M05BB03

ATC

alendronic acid and colecalciferol; oral

17.6

6.8

D07AC01

ATC

betamethasone; topical

2.5

6.8

384

M79.0

ICD-10 Finland

Rheumatism, unspecified

9.3

6.7

L99

ICPC

Musculoskeletal disease other

13.0

6.7

J84.8

ICD-10 Finland

Other specified interstitial pulmonary diseases

13.0

6.7

R06.0

ICD-10 Finland

Dyspnoea

2.6

6.6

263

N03AX16

ATC

pregabalin; oral

2.7

6.5

213

E0000UV

ATC

2.3

6.5

435

L88

ICPC

Rheumatoid/seropositive arthritis

6.4

6.5

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.6

6.4

NJ3DG

NOMESCO Finland

Very extensive MRI examination of extremities with high intensity magnet

+∞

6.3

TPH04

NOMESCO Finland

Cathetrisation of vein

2.7

6.1

193

J84.9

ICD-10 Finland

Interstitial pulmonary disease, unspecified

7.7

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint M13_DERMATOPOLYNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_DERMATOPOLYNAS	2.848 [2.14, 3.79]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.207

During the follow-up period (1.1.1998 — 31.12.2019), 130 out of 495 females with M13_DERMATOPOLYNAS died.

Males

Parameter	HR [95% CI]	p-value
M13_DERMATOPOLYNAS	2.483 [1.74, 3.55]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.017

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 295 males with M13_DERMATOPOLYNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_DERMATOPOLYNAS.

N-year risk	Females	Males
1	0.296%	0.595%
5	1.603%	3.498%
10	4.077%	7.608%
15	7.333%	14.038%
20	12.719%	22.408%

Relationships between endpoints

↥

Index endpoint: M13_DERMATOPOLYNAS – Dermatopolymyositis, unspecified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Dermatopolymyositis, unspecified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints