photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.
Other disorders of skin and subcutaneous tissue related to radiation
DOID EFO Endpoint Browser PheWeb
L12_SKINRADIOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
59 |
4. Check minimum number of eventsNone |
59 |
5. Include endpoints |
59 |
6. Filter based on genotype QC (FinnGen only) |
59 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L55-L59
- Name in latin
- Aliae morbositates cutis et telae subcutaneae e radiatione
Similar endpoints
↥List of similar endpoints to
Other disorders of skin and subcutaneous tissue related to radiation
based on the number of shared cases.
Similar with more cases:
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Paracetamol of NSAID medication
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 422 | 251 | 168 |
| Only index persons | 350 | 224 | 126 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 56.02 | 58.38 | 52.65 |
| Only index persons | 54.89 | 57.35 | 50.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 59 | 46 | 13 |
| Unadjusted period prevalence (%) | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | 55.42 | 55.70 | 54.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 558
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L59.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue related to radiation, unspecified
+∞
29.9
26
*
L59.0
ICD-10 Finland
Erythema ab igne [dermatitis ab igne]
+∞
27.3
24
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.6
6.8
16
28
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
78.4
6.6
7
*
L59.8
ICD-10 Finland
Other specified disorders of skin and subcutaneous tissue related to radiation
+∞
6.4
6
*
Mortality – FinRegistry
↥Association
Association between endpoint L12_SKINRADIOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_SKINRADIOTH | 1.687 [1.14, 2.49] | 0.009 |
| Birth year | 0.999 [0.99, 1.01] | 0.785 |
During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 227 females with L12_SKINRADIOTH died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_SKINRADIOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | No data |
| 5 | 1.144% | No data |
| 10 | 2.755% | No data |
| 15 | 5.425% | No data |
| 20 | 9.691% | No data |
Relationships between endpoints
↥Index endpoint: L12_SKINRADIOTH – Other disorders of skin and subcutaneous tissue related to radiation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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