obsolete_alopecia:
Other and unspecified nonscarring hair loss
DOID EFO Endpoint Browser PheWeb
L12_HAIRLOSS_NONSCARNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
247 |
4. Check minimum number of eventsNone |
247 |
5. Include endpointsNone |
247 |
6. Filter based on genotype QC (FinnGen only) |
247 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified nonscarring hair loss
based on the number of shared cases.
Similar with more cases:
- Other nonscarring hair loss
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1676 | 1527 | 142 |
| Only index persons | 1591 | 1465 | 126 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.00 |
| Only index persons | 0.05 | 0.05 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 38.60 | 40.48 | 18.66 |
| Only index persons | 39.71 | 41.33 | 20.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 247 | 242 | 5 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.00 |
| Median age at first event (years) | 45.95 | 46.30 | 28.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 212
- Matched controls
- 2118
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
2824.3
192.8
157
*
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
904.4
69.1
64
*
C03DA01
ATC
spironolactone; oral
12.0
33.4
65
75
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.2
20.1
47
71
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
+∞
18.0
17
*
L63.9
ICD-10 Finland
Alopecia areata, unspecified
69.2
17.0
19
*
D07AC13
ATC
mometasone; topical
3.7
16.9
99
406
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
12.7
81
339
D07AB02
ATC
hydrocortisone butyrate; topical
3.1
12.3
88
396
D07AC01
ATC
betamethasone; topical
3.0
12.3
98
473
L63.8
ICD-10 Finland
Other alopecia areata
+∞
11.6
11
*
J01AA04
ATC
lymecycline; systemic
3.7
11.3
53
173
D07AD01
ATC
clobetasol; topical
3.5
10.0
51
177
E0000UV
ATC
NA
2.4
8.4
110
660
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.3
8.0
98
569
L65.0
ICD-10 Finland
Telogen effluvium
46.7
7.8
9
*
S23
ICPC
Hair loss/baldness
16.5
7.3
11
7
L65
ICD-10 Finland
Other nonscarring hair loss
31.2
7.2
9
*
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
12.6
7.2
12
10
D07XC01
ATC
betamethasone, combinations; topical
3.8
7.1
30
89
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
6.2
7.1
18
31
H03AA01
ATC
levothyroxine sodium; systemic
2.4
7.0
73
384
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.6
7.0
57
265
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.5
7.0
24
59
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
6.9
35
120
D10AX03
ATC
azelaic acid; topical
3.3
6.6
33
112
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
3.5
6.6
30
95
L70.0
ICD-10 Finland
Acne vulgaris
8.6
6.4
13
16
L68.0
ICD-10 Finland
Hirsutism
+∞
6.3
6
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
6.0
60
307
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSS_NONSCARNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HAIRLOSS_NONSCARNAS | 1.264 [0.93, 1.72] | 0.139 |
| Birth year | 0.996 [0.99, 1.0] | 0.376 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1161 females with L12_HAIRLOSS_NONSCARNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSS_NONSCARNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.148% | No data |
| 5 | 0.788% | No data |
| 10 | 1.975% | No data |
| 15 | 3.802% | No data |
| 20 | 6.515% | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSS_NONSCARNAS – Other and unspecified nonscarring hair loss
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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