obsolete_alopecia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
336 |
4. Check minimum number of eventsNone |
336 |
5. Include endpoints |
336 |
6. Filter based on genotype QC (FinnGen only) |
336 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alia alopecia non cicatrisans
Similar endpoints
↥List of similar endpoints to
Other nonscarring hair loss
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2372 | 2134 | 224 |
| Only index persons | 2265 | 2061 | 204 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.01 |
| Only index persons | 0.07 | 0.08 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 38.44 | 40.23 | 21.33 |
| Only index persons | 39.24 | 40.85 | 22.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 336 | 324 | 12 |
| Unadjusted period prevalence (%) | 0.11 | 0.11 | 0.01 |
| Median age at first event (years) | 46.12 | 46.46 | 36.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 292
- Matched controls
- 2918
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
870.9
179.9
159
*
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
828.3
69.0
65
*
L65.0
ICD-10 Finland
Telogen effluvium
+∞
66.2
61
*
C03DA01
ATC
spironolactone; oral
9.1
34.9
79
114
L65
ICD-10 Finland
Other nonscarring hair loss
102.9
26.1
28
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.4
21.5
60
113
L63.9
ICD-10 Finland
Alopecia areata, unspecified
118.5
20.9
22
*
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
+∞
20.0
19
*
D07AC01
ATC
betamethasone; topical
3.3
19.5
136
611
D07AC13
ATC
mometasone; topical
3.3
19.0
129
564
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
12.9
102
466
L63.8
ICD-10 Finland
Other alopecia areata
135.6
12.5
13
*
L65.2
ICD-10 Finland
Alopecia mucinosa
67.7
11.7
13
*
E0000UV
ATC
NA
2.4
11.3
149
891
J01AA04
ATC
lymecycline; systemic
3.2
11.2
65
239
L70.0
ICD-10 Finland
Acne vulgaris
12.6
11.0
19
16
D07AD01
ATC
clobetasol; topical
3.1
11.0
68
264
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
10.7
107
553
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
9.0
65
276
S23
ICPC
Hair loss/baldness
19.4
9.0
13
7
H03AA01
ATC
levothyroxine sodium; systemic
2.3
8.9
98
523
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
8.4
133
827
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
8.4
8
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.2
8.3
31
81
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
8.2
46
166
L21.0
ICD-10 Finland
Seborrhoea capitis
19.0
7.7
11
6
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.7
7.6
32
93
D06BX01
ATC
metronidazole; topical
2.9
7.5
46
174
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
9.7
7.4
14
15
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.6
7.2
55
240
H02AB06
ATC
prednisolone; systemic
2.0
7.1
144
970
D07XC01
ATC
betamethasone, combinations; topical
2.9
6.9
41
155
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.2
6.8
74
386
J01DB01
ATC
cefalexin; oral
2.2
6.6
247
2072
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.9
6.5
38
141
WX002
NOMESCO Finland
Sedation and analgesia
2.3
6.5
64
319
L73.8
ICD-10 Finland
Other specified follicular disorders
71.3
6.5
7
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
6.4
79
436
Mortality – FinRegistry
↥Association
Association between endpoint L12_HAIRLOSSNONSCAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_HAIRLOSSNONSCAR | 1.293 [1.01, 1.66] | 0.046 |
| Birth year | 0.992 [0.98, 1.0] | 0.074 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 1581 females with L12_HAIRLOSSNONSCAR died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_HAIRLOSSNONSCAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | No data |
| 5 | 0.728% | No data |
| 10 | 1.747% | No data |
| 15 | 3.274% | No data |
| 20 | 5.749% | No data |
Relationships between endpoints
↥Index endpoint: L12_HAIRLOSSNONSCAR – Other nonscarring hair loss
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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