nonsyndromic deafness: An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
67 |
4. Check minimum number of eventsNone |
67 |
5. Include endpointsNone |
67 |
6. Filter based on genotype QC (FinnGen only) |
67 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H91
- Name in latin
- Hypacusis ototoxica
Similar endpoints
↥List of similar endpoints to
Ototoxic hearing loss
based on the number of shared cases.
Similar with more cases:
- Other hearing loss
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 494 | 281 | 211 |
| Only index persons | 427 | 248 | 179 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.06 | 68.61 | 62.66 |
| Only index persons | 65.57 | 67.99 | 62.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 67 | 39 | 28 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 59.57 | 59.43 | 59.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 57
- Matched controls
- 569
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H91.0
ICD-10 Finland
Ototoxic hearing loss
+∞
81.7
57
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
432.0
27.1
25
*
UDC00
NOMESCO Finland
Ear microscopy
41.1
10.9
13
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
8.5
8
*
H81.0
ICD-10 Finland
Ménière disease
91.5
7.6
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.7
7.5
15
20
DFF00
NOMESCO Finland
Pure tone audiometry
23.7
7.4
10
5
H91.1
ICD-10 Finland
Presbycusis
16.6
7.2
11
8
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
6.4
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3023368) Bacteria identified in Blood by Culture
25
144
2.17
2.27
4.4
4.1
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
36
246
2.00
2.03
11.3
8.0
mmol/l
1.2
1.2
0.64
27
201
(4010399)
9
34
2.90
1.95
1.3
1.3
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
10
40
2.76
1.94
9.4
3.2
e9/l
81.0
75.1
—
10
31
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
7
24
3.13
1.77
2.6
1.3
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
15
77
2.22
1.76
2.5
1.9
—
—
—
0
0
(3019225) pH of Specimen
10
43
2.56
1.69
11.1
5.6
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
5
14
3.77
1.64
1.4
1.7
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
7
27
2.77
1.56
3.3
7.5
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
5
16
3.29
1.46
1.2
2.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
29
201
1.78
1.45
17.0
10.1
inr
1.7
1.3
—
9
61
(3022145) Colonoscopy Study observation
10
47
2.33
1.42
1.0
1.3
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
5
17
3.09
1.38
1.8
2.2
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
5
18
2.91
1.31
1.8
2.4
—
—
—
0
0
(3003458) Phosphate [Moles/volume] in Serum or Plasma
13
74
1.94
1.17
13.5
6.9
mmol/l
1.1
1.1
0.06
13
67
(3026008) Bacteria identified in Urine by Culture
24
167
1.68
1.14
3.5
3.1
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
42
339
1.64
1.11
6.0
4.6
—
31.5
—
0
8
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
7
36
2.05
1.00
1.7
1.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
6
27
2.34
0.96
1.5
1.8
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
9
53
1.80
0.79
2.8
1.7
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
51
449
1.57
0.78
3.5
4.0
mmol/l
1.4
1.3
0.30
44
396
(3012544) pH of Venous blood
10
60
1.78
0.77
17.1
4.6
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
9
56
1.70
0.76
3.1
1.7
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
53
472
1.59
0.75
4.2
4.5
mmol/l
4.5
4.6
0.13
46
422
(3000494) Fungus identified in Specimen by Culture
9
57
1.67
0.75
1.1
1.5
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
11
163
0.61
0.72
3.5
3.1
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
41
349
1.45
0.71
5.9
4.7
—
—
—
0
0
(3000991) Gas panel - Venous blood
7
43
1.70
0.69
19.7
6.5
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
29
1.78
0.65
6.4
6.0
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
7
114
0.57
0.65
14.1
5.1
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
11
72
1.63
0.64
2.6
1.9
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
21
161
1.44
0.62
3.1
3.0
e6/l
20.2
44.6
0.52
16
125
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
20
0.00
0.61
0.0
3.2
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
20
0.00
0.61
0.0
3.2
—
3.8
—
0
15
(3043409) Potassium [Moles/volume] in Arterial blood
0
20
0.00
0.61
0.0
2.3
—
4.1
—
0
15
(3009445) Proteinase 3 Ab [Units/volume] in Serum
0
21
0.00
0.61
0.0
1.1
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
8
54
1.55
0.60
2.3
4.4
ug/l
8.2
14.7
—
8
44
(40768797) Stomach Pathology biopsy report
9
60
1.58
0.57
1.1
1.3
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
56
516
1.52
0.55
28.9
17.5
mmol/l
138.2
139.6
1.58
56
500
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
16
119
1.45
0.55
3.4
4.8
%
20.0
22.2
—
9
56
(3000850) Epithelial cells [#/volume] in Urine
15
111
1.45
0.52
2.3
2.5
e6/l
4.0
4.5
0.10
15
99
(3023103) Potassium [Moles/volume] in Serum or Plasma
56
518
1.49
0.51
29.8
17.5
mmol/l
4.0
4.0
0.09
56
501
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
25
204
1.36
0.51
1.8
2.0
pmol/l
102.3
96.9
0.19
14
102
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
10
68
1.55
0.50
1.3
1.6
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
15
112
1.44
0.50
2.7
2.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
20
158
1.38
0.49
2.9
2.4
—
—
—
0
0
(3022621) pH of Urine by Test strip
7
47
1.55
0.49
6.7
2.7
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
26
215
1.34
0.49
5.4
3.6
ng/l
29.7
37.9
0.21
17
148
(3009542) Hematocrit [Volume Fraction] of Blood
49
445
1.38
0.48
22.6
16.7
%
37.1
38.4
0.32
27
315
(3020564) Creatinine [Moles/volume] in Serum or Plasma
56
520
1.47
0.48
26.5
17.2
umol/l
88.3
78.2
0.60
56
520
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
31
1.66
0.44
1.4
2.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
22
180
1.33
0.43
2.7
1.9
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
54
502
1.39
0.42
24.6
15.3
mg/l
21.4
22.6
0.12
46
396
(3002256) Pathology report gross observation
8
60
1.38
0.42
1.4
1.1
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
18
144
1.34
0.41
4.6
3.0
mmol/l
5.6
7.6
1.07
13
116
(40761511) CBC panel - Blood by Automated count
55
514
1.39
0.40
19.1
14.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
11
81
1.43
0.39
2.1
1.7
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
5
75
0.64
0.38
2.2
1.8
ug/g
123.4
80.7
—
5
58
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
52
484
1.33
0.37
4.7
5.0
mmol/l
2.6
2.7
0.34
45
429
(36304419) Bacteria [Presence] in Urine
17
137
1.32
0.37
3.2
2.9
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
6
45
1.37
0.35
5.8
3.3
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
50
466
1.29
0.33
4.4
4.4
mmol/l
1.5
1.5
0.05
43
413
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
7
52
1.39
0.32
1.6
1.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
54
1.33
0.31
2.6
1.6
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
26
228
1.23
0.29
5.4
4.1
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
51
480
1.26
0.28
4.5
4.8
mmol/l
6.0
6.0
0.11
45
426
(3018095) Leukocytes [#/volume] in Urine
22
192
1.22
0.25
3.6
3.6
e6/l
58.8
62.9
0.04
16
137
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
26
290
0.83
0.25
3.7
3.0
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
5
37
1.38
0.24
1.4
1.6
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
5
38
1.34
0.24
2.0
1.2
—
—
—
0
0
(3020630) Protein [Mass/volume] in Serum or Plasma
5
42
1.21
0.22
15.0
2.4
g/l
63.3
64.8
—
5
37
(3024928) Oxygen saturation in Venous blood
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
48
1.27
0.21
1.0
1.5
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
1.2
—
35.8
—
0
13
(40768793) Breast Pathology biopsy report
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
(40768443) Skin Pathology biopsy report
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
12
142
0.81
0.20
1.5
1.5
—
—
—
0
0
(3035941) MCH [Entitic mass]
57
549
1.26
0.20
34.9
21.9
pg
29.8
30.2
0.86
57
537
(3000963) Hemoglobin [Mass/volume] in Blood
57
549
1.26
0.20
35.8
22.1
g/l
129.4
133.3
1.01
57
536
(3024731) MCV [Entitic volume]
57
549
1.26
0.20
34.9
22.0
fl
89.6
90.7
1.28
57
537
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
7
59
1.21
0.19
1.6
1.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
11
127
0.84
0.14
18.4
7.3
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
27
251
1.13
0.13
7.5
5.6
estimate
0.0
0.0
—
7
46
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
6
56
1.08
0.09
1.3
2.0
u/l
24.8
26.5
—
6
47
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
64
0.76
0.08
12.0
8.1
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
7
64
1.10
0.08
4.1
3.4
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
27
256
1.09
0.08
5.6
4.0
estimate
0.0
0.0
—
7
43
(3044889) 12 lead EKG panel
34
354
0.92
0.07
4.5
3.8
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
8
93
0.84
0.07
1.3
1.7
—
—
—
0
0
(3015736) pH of Urine
21
199
1.08
0.05
3.7
3.6
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
15
140
1.09
0.05
4.9
4.1
mg/mmol
7.2
9.8
—
8
90
(3035350) Ketones [Presence] in Urine by Test strip
26
251
1.06
0.03
5.7
3.9
estimate
0.0
0.0
—
7
46
(3011397) Hemoglobin [Presence] in Urine by Test strip
13
122
1.08
0.03
6.5
3.1
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
14
133
1.07
0.02
4.1
3.1
mg/l
63.3
64.0
—
8
87
(3013512) EKG study
15
143
1.06
0.02
5.7
4.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
19
183
1.05
0.01
4.3
3.1
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
14
142
0.98
0.00
6.5
3.5
estimate
0.0
0.0
—
7
42
(3002385) Erythrocyte distribution width [Ratio]
42
421
0.99
0.00
25.5
18.6
%
13.9
13.8
0.21
42
411
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
187
1.02
0.00
7.1
4.2
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
17
175
0.96
0.00
7.1
5.1
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
46
455
1.04
0.00
18.2
14.2
ml/min/173m2
68.1
78.3
1.73
38
350
(3041096) Erythrocytes [Presence] in Urine by Automated
14
135
1.05
0.00
4.4
4.2
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
28.6
—
0
5
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
2.0
—
90.1
—
0
5
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(4306422)
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3044941) Cell count panel - Synovial fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(4146454)
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
1.8
—
0
5
(3039443) Prostate specific Ag panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(21494890) Protein electrophoresis panel - 24 hour Urine
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3023511) Choriogonadotropin [Units/volume] in Urine
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3035947) Staphylolysin Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
6.2
—
199.3
—
0
5
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011648) Oxygen content in Venous blood
0
5
0.00
0.00
0.0
1.8
—
12.4
—
0
5
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(3024474) Albumin [Mass/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
207.8
—
0
5
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_HL_OTOTOX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_OTOTOX | 1.148 [0.87, 1.51] | 0.324 |
| Birth year | 0.997 [0.99, 1.01] | 0.517 |
During the follow-up period (1.1.1998 — 31.12.2019), 114 out of 265 females with H8_HL_OTOTOX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_HL_OTOTOX | 1.377 [0.94, 2.03] | 0.104 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 204 males with H8_HL_OTOTOX died.
Mortality risk
Mortality risk for people of age
years, who have H8_HL_OTOTOX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.281% |
| 5 | 0.764% | 1.75% |
| 10 | 1.721% | 4.524% |
| 15 | 3.425% | 8.169% |
| 20 | 5.855% | 13.591% |
Relationships between endpoints
↥Index endpoint: H8_HL_OTOTOX – Ototoxic hearing loss
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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