No definition available.
Generalized skin eruption due to drugs and medicaments
GENERALI_SKIN_ERUPT_DRUGS_MEDICAM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
1472 |
4. Check minimum number of eventsNone |
1472 |
5. Include endpointsNone |
1472 |
6. Filter based on genotype QC (FinnGen only) |
1472 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Generalized skin eruption due to drugs and medicaments
based on the number of shared cases.
Similar with more cases:
- Acute generalized exanthematous pustulosis
- Dermatitis due to substances taken internally
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11054 | 6550 | 4445 |
| Only index persons | 9672 | 5844 | 3828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.12 |
| Only index persons | 0.19 | 0.21 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.28 | 52.61 | 44.11 |
| Only index persons | 48.96 | 51.80 | 44.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1472 | 965 | 507 |
| Unadjusted period prevalence (%) | 0.29 | 0.33 | 0.22 |
| Median age at first event (years) | 55.46 | 52.24 | 61.60 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1320
- Matched controls
- 13197
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
4503599627370496.0
323.0
1318
22
H02AB06
ATC
prednisolone; systemic
4.3
132.7
876
4165
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
6.7
115.6
330
626
XQ800
NOMESCO Finland
Prick test
5.4
71.3
236
513
R06AE07
ATC
cetirizine; oral
2.8
66.6
739
4170
L50.0
ICD-10 Finland
Allergic urticaria
10.4
58.9
119
124
XQ802
NOMESCO Finland
Epicutan test
7.7
58.5
143
206
J01FF01
ATC
clindamycin; systemic
2.8
58.0
483
2233
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.3
55.8
229
613
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
55.2
661
3743
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
53.2
344
1331
XQ820
NOMESCO Finland
Exposure to medicinal substance
52.3
50.3
60
12
E0000UV
ATC
NA
2.4
48.7
644
3752
D07AB08
ATC
desonide; topical
3.6
47.3
238
755
D07AC01
ATC
betamethasone; topical
2.4
44.7
534
2917
R50.9
ICD-10 Finland
Fever, unspecified
3.1
44.3
283
1068
XQ899
NOMESCO Finland
Other assessment of skin
40.2
43.1
54
14
T78.4
ICD-10 Finland
Allergy, unspecified
5.1
41.0
136
289
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
37.2
198
649
L50.9
ICD-10 Finland
Urticaria, unspecified
6.1
37.1
105
184
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
8.9
35.5
77
91
D07AA02
ATC
hydrocortisone; topical
2.8
34.7
259
1066
A02BC02
ATC
pantoprazole; systemic
2.1
34.6
855
6195
J01MA12
ATC
levofloxacin; systemic
2.6
34.4
290
1282
E000001
ATC
NA
2.3
32.2
355
1803
XQ801
NOMESCO Finland
Intracutantest
35.2
32.0
41
12
A46
ICD-10 Finland
Erysipelas
2.8
31.1
221
878
C01CA24
ATC
epinephrine; parenteral
3.8
31.1
139
393
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
30.0
421
2374
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
29.3
470
2794
J01DB01
ATC
cefalexin; oral
2.2
28.7
1085
8948
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
28.5
337
1750
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
28.4
315
1588
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
9.5
27.1
56
61
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
26.8
193
770
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
25.0
220
980
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.9
24.6
163
616
L04AX01
ATC
azathioprine; systemic
4.2
23.8
94
238
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.0
23.8
98
258
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.1
23.7
96
249
D07AC13
ATC
mometasone; topical
1.9
22.5
400
2423
J01MA14
ATC
moxifloxacin; systemic
2.9
22.2
144
533
ZX120
NOMESCO Finland
Intravenous
2.7
22.1
158
622
N02AX02
ATC
tramadol; systemic, rectal
1.8
21.7
534
3609
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.6
21.6
76
172
J01MA02
ATC
ciprofloxacin; systemic
1.8
21.5
496
3278
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.0
21.5
89
235
N02AA05
ATC
oxycodone; systemic
2.4
21.5
200
912
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
21.1
377
2280
N03AG01
ATC
valproic acid; systemic, rectal
3.3
20.8
107
339
ZX108
NOMESCO Finland
Inhalation
13.2
20.7
36
28
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
20.7
207
978
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
13.8
20.6
35
26
H02AB07
ATC
prednisone; oral
2.3
20.4
210
1007
H02AB04
ATC
methylprednisolone; systemic
2.3
20.2
213
1032
P01BA02
ATC
hydroxychloroquine; oral
2.7
20.1
151
612
H02AB02
ATC
dexamethasone; systemic
2.5
20.0
165
705
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.0
20.0
121
430
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
19.5
117
413
N02BE01
ATC
paracetamol; systemic, rectal
1.9
19.3
1096
9464
L27.2
ICD-10 Finland
Dermatitis due to ingested food
8.9
19.0
40
46
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.0
18.8
114
405
L04AD01
ATC
ciclosporin; systemic
5.9
18.6
52
91
E000003
ATC
NA
3.4
18.5
93
289
C03CA01
ATC
furosemide; systemic
1.9
18.5
352
2157
N03AX16
ATC
pregabalin; oral
1.9
18.1
298
1730
R06AX27
ATC
desloratadine; oral
1.8
17.9
367
2302
D07AD01
ATC
clobetasol; topical
2.1
17.9
217
1117
J01DA01
ATC
[U] cefalexin; systemic
1.7
17.8
804
6371
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
17.7
119
452
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.9
17.5
109
391
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
17.4
293
1716
TQW80
NOMESCO Finland
Local dermatologic skincare
4.7
17.1
58
127
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
16.8
161
741
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
16.8
203
1041
L04AA06
ATC
mycophenolic acid; systemic
6.1
16.6
45
76
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
16.4
75
217
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
16.2
291
1738
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
16.0
96
338
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.3
16.0
59
141
J01FA06
ATC
roxithromycin; oral
1.7
15.9
501
3554
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.3
15.8
81
256
E000006
ATC
NA
2.6
15.8
123
509
R06.0
ICD-10 Finland
Dyspnoea
1.8
15.8
312
1923
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
15.7
268
1569
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.0
15.6
50
103
L04AX04
ATC
lenalidomide; oral
17.4
15.6
24
14
A04AA01
ATC
ondansetron; systemic, rectal
2.7
15.5
113
450
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
15.4
122
508
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
15.3
294
1792
J01FA09
ATC
clarithromycin; systemic
1.7
15.3
402
2704
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.3
15.3
153
719
P01AB01
ATC
metronidazole; oral, rectal
1.6
15.2
496
3541
M04AA01
ATC
allopurinol; systemic
2.2
14.9
161
785
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.4
14.9
72
218
J05AB01
ATC
aciclovir; systemic
1.8
14.9
279
1686
R03AC02
ATC
salbutamol; inhalant
1.6
14.8
656
5059
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.5
14.6
69
205
N03AF01
ATC
carbamazepine; oral, rectal
3.1
14.6
83
283
L27.1
ICD-10 Finland
Localized skin eruption due to drugs and medicaments
14.4
14.6
24
17
R03DC03
ATC
montelukast; oral
2.0
14.5
206
1124
J05AB11
ATC
valaciclovir; oral
2.1
14.4
184
960
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
14.4
267
1603
T88.6
ICD-10 Finland
Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
22.5
14.2
20
9
153
Kela drug reimbursment
Lenalidomid
13.6
14.2
24
18
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
14.1
501
3640
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
14.0
558
4171
J01AA02
ATC
doxycycline; systemic
1.6
13.9
941
8003
JN4BD
NOMESCO Finland
Extensive body CT
2.2
13.8
146
703
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
3.3
13.8
71
226
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
13.6
130
598
L51.0
ICD-10 Finland
Nonbullous erythema multiforme
34.4
13.5
17
5
L26
ICD-10 Finland
Exfoliative dermatitis
26.0
13.4
18
7
J01XX08
ATC
linezolid; systemic
21.4
13.3
19
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.8
13.2
89
337
L50.8
ICD-10 Finland
Other urticaria
5.2
13.1
40
79
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
13.1
114
500
R01AD08
ATC
fluticasone; nasal
1.7
13.1
353
2372
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.3
13.0
122
557
E000002
ATC
NA
2.0
13.0
172
913
A03
ICPC
Fever
1.9
13.0
216
1249
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
13.0
417
2936
SPAT1263
SPAT
Sampling
1.6
12.9
544
4095
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.8
12.9
55
151
N03AX09
ATC
lamotrigine; oral
3.1
12.9
73
247
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
12.8
120
546
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.8
12.8
42
90
R03BA02
ATC
budesonide; inhalant
1.8
12.8
229
1355
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
12.8
219
1278
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.7
442
3171
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.3
12.6
64
202
J01FA10
ATC
azithromycin; systemic
1.5
12.6
739
5995
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.0
12.5
50
130
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
12.5
96
395
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
12.5
154
793
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
12.5
225
1336
Z51.5
ICD-10 Finland
Palliative care
2.8
12.4
81
304
XQ848
NOMESCO Finland
Dermatological photography
4.1
12.3
47
117
L04AB04
ATC
adalimumab; parenteral
5.3
12.3
37
72
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
12.3
138
683
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.1
12.3
25
28
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
12.1
212
1242
NF1AA
NOMESCO Finland
Hip X-ray examination
2.3
12.1
120
561
N03AX12
ATC
gabapentin; oral
1.9
12.1
187
1051
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
12.0
532
4031
JN4AD
NOMESCO Finland
Body CT examination
2.4
12.0
101
434
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
12.0
352
2411
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
12.0
240
1473
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
11.9
120
567
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.2
11.9
119
559
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.4
11.8
100
434
R01AD09
ATC
mometasone; nasal
1.5
11.7
539
4111
XG410
NOMESCO Finland
Flow-volume spirometry
3.1
11.7
64
214
D02AX
ATC
Other emollients and protectives
3.0
11.7
67
230
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
16.6
11.7
18
11
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.3
11.6
42
100
N03AX14
ATC
levetiracetam; systemic
3.7
11.5
49
135
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.9
11.5
46
120
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
11.5
98
425
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.9
11.5
170
941
L03AA02
ATC
filgrastim; parenteral
3.8
11.4
48
131
WW500
NOMESCO Finland
Blood transfusion
3.1
11.4
62
207
L04AA01
ATC
[U] ciclosporin; systemic
5.7
11.2
31
55
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
11.2
219
1333
A92
ICPC
Allergy/allergic reaction NOS
3.6
10.9
48
137
D07XC01
ATC
betamethasone, combinations; topical
2.0
10.7
145
776
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.9
10.6
42
109
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
10.6
248
1587
A04AA02
ATC
granisetron; systemic, transdermal
2.5
10.6
84
351
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.6
10.6
47
135
H02AB09
ATC
hydrocortisone; systemic
3.8
10.5
44
120
R06AX22
ATC
ebastine; oral
1.8
10.5
205
1242
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.1
10.5
56
185
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
10.5
116
570
A02BC03
ATC
lansoprazole; oral
1.6
10.2
346
2439
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.5
10.2
46
134
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.2
10.2
53
172
A02BC05
ATC
esomeprazole; systemic
1.5
10.2
464
3502
N05BA04
ATC
oxazepam; oral
1.6
10.1
295
2004
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.8
10.0
41
110
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
10.0
158
892
ZXD05
NOMESCO Finland
Urgent procedure
1.5
10.0
382
2774
D05BB02
ATC
acitretin; oral
3.9
9.9
39
101
SPAT1254
SPAT
Administration of medicine
1.8
9.9
186
1113
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
9.8
497
3832
L20.0
ICD-10 Finland
Besnier prurigo
2.2
9.7
100
477
L27.9
ICD-10 Finland
Dermatitis due to unspecified substance taken internally
55.4
9.7
11
*
9940/3-C42.1
ICD-O-3
Hairy cell leukemia, NOS, of bone marrow
55.4
9.7
11
*
J02AC01
ATC
fluconazole; systemic
1.5
9.6
494
3814
R06AE09
ATC
levocetirizine; oral
1.8
9.6
189
1148
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
4.6
9.6
32
71
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.9
9.6
57
203
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
9.5
212
1335
C90.0
ICD-10 Finland
Multiple myeloma
6.0
9.5
25
42
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.0
9.5
128
682
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.9
9.5
55
192
Z88.1
ICD-10 Finland
Personal history of allergy to other antibiotic agents
100.7
9.4
10
*
A28
ICPC
Limited function/disability NOS
1.8
9.4
165
965
1CX01
NOMESCO Finland
NA
21.9
9.4
13
6
N03AF02
ATC
oxcarbazepine; oral
2.8
9.3
56
202
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.9
9.3
37
98
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
9.0
174
1047
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
15.7
9.0
14
9
SPAT1255
SPAT
Intravenous administration of medicine
2.3
9.0
85
389
N03AX18
ATC
lacosamide; systemic
10.1
9.0
17
17
C91.4
ICD-10 Finland
Hairy-cell leukaemia
36.9
9.0
11
*
M54.5
ICD-10 Finland
Low back pain
1.5
9.0
381
2814
WW200
NOMESCO Finland
Immunization
3.3
8.8
43
134
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.7
8.7
189
1179
C07AB07
ATC
bisoprolol; oral
1.4
8.6
506
3986
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
8.6
318
2277
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.6
8.6
62
248
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
8.6
165
995
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.6
265
1822
329
Kela drug reimbursment
Lenalidomide
16.4
8.6
13
8
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.3
8.6
80
367
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.1
8.5
100
503
ZYC01
NOMESCO Finland
Remote contact by phone
2.6
8.5
61
241
R51.80
ICD-10 Finland
Headache
1.7
8.5
174
1068
M05BX04
ATC
denosumab; parenteral
2.5
8.5
64
261
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.4
8.4
29
67
M25.5
ICD-10 Finland
Pain in joint
1.5
8.4
327
2365
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
12.8
8.4
14
11
S97
ICPC
Chronic ulcer skin
2.4
8.4
70
303
S88
ICPC
Dermatitis contact/allergic
3.4
8.3
38
113
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
5.3
8.3
24
46
D02AE01
ATC
carbamide; topical
2.1
8.3
92
454
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
9.5
8.3
16
17
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
3.8
8.3
33
88
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.0
8.3
98
497
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
8.2
92
457
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
8.2
77
353
R60.0
ICD-10 Finland
Localized oedema
1.9
8.2
127
712
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
8.1
609
5005
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.3
8.1
71
314
L30.3
ICD-10 Finland
Infective dermatitis
2.9
8.1
47
165
R53
ICD-10 Finland
Malaise and fatigue
1.6
8.1
242
1646
R11
ICD-10 Finland
Nausea and vomiting
2.0
8.1
107
566
L40.1
ICD-10 Finland
Generalized pustular psoriasis
33.6
8.1
10
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
8.1
79
370
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
8.0
157
951
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.5
8.0
36
106
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.9
8.0
46
160
S76
ICPC
Skin infection other
2.4
8.0
65
279
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.9
8.0
46
161
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.1
8.0
92
463
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
8.0
114
622
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
7.9
156
947
A41.9
ICD-10 Finland
Sepsis, unspecified
2.8
7.9
48
175
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.5
7.9
58
235
R03AC03
ATC
terbutaline; inhalant
1.7
7.9
170
1059
UJF32
NOMESCO Finland
Coloscopy
1.5
7.9
279
1974
S18
ICPC
Laceration/cut
1.4
7.9
473
3728
WZC30
NOMESCO Finland
Teaching
1.7
7.9
149
896
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
7.8
72
329
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
4.5
7.8
26
59
C08CA01
ATC
amlodipine; oral
1.5
7.8
366
2753
E66.01
ICD-10 Finland
Obesity due to excess calories
2.0
7.7
97
506
B01AB05
ATC
enoxaparin; parenteral
1.5
7.7
343
2548
127
Kela drug reimbursment
Transplant complication
4.1
7.7
28
69
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
7.7
154
942
R06AX13
ATC
loratadine; oral
1.7
7.7
182
1165
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
7.6
102
544
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
25.2
7.6
10
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
7.6
97
508
N05CF01
ATC
zopiclone; oral
1.5
7.5
352
2637
A07AA02
ATC
nystatin; oral
2.2
7.5
77
366
J47
ICD-10 Finland
Bronchiectasis
4.2
7.5
27
66
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
7.5
310
2267
L04AA13
ATC
leflunomide; oral
3.1
7.5
39
129
B01AB10
ATC
tinzaparin; parenteral
2.0
7.4
88
447
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
7.4
143
863
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.4
241
1671
B02.9
ICD-10 Finland
Zoster without complication
2.2
7.4
69
317
WX110
NOMESCO Finland
Local anesthesy
1.4
7.3
821
7174
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
7.3
338
2527
L93.0
ICD-10 Finland
Discoid lupus erythematosus
10.9
7.3
13
12
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.6
7.3
31
88
A02BC01
ATC
omeprazole; systemic
1.5
7.3
309
2271
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
7.3
7
*
N06AX21
ATC
duloxetine; oral
1.8
7.3
116
657
TGC00
NOMESCO Finland
Bronchial lavation
3.2
7.3
36
115
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.6
7.2
50
195
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.4
7.2
59
253
A07EA06
ATC
budesonide; oral, local oral
2.9
7.2
42
150
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
7.2
183
1195
M79.6
ICD-10 Finland
Pain in limb
1.4
7.2
403
3128
M05BA04
ATC
alendronic acid; oral
1.9
7.2
100
542
YNB10
NOMESCO Finland
Collection of stem cells for transplant
30.2
7.2
9
*
SPAT1325
SPAT
Vaccination
1.4
7.1
405
3144
L50
ICD-10 Finland
Urticaria
4.1
7.1
26
65
UDM02
NOMESCO Finland
Sinoscopy
3.7
7.1
29
80
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
7.1
373
2859
ZXE00
NOMESCO Finland
One hour or less
1.4
7.1
469
3745
NH3EA
NOMESCO Finland
Feet X-ray examination with load
3.4
7.1
32
96
C08CA13
ATC
lercanidipine; oral
1.7
7.0
135
815
Z3231
NOMESCO Finland
Registered nurse
1.5
7.0
314
2334
SPAT1301
SPAT
No procedures
1.4
7.0
367
2810
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
7.0
239
1675
GD1AD
NOMESCO Finland
Thorax CT examination
2.5
6.9
52
214
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.9
593
4936
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
6.9
24
57
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
6.9
73
354
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
6.9
165
1061
D07BC01
ATC
betamethasone and antiseptics; topical
1.7
6.9
133
803
J01FA01
ATC
erythromycin; systemic
1.6
6.9
168
1086
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
4.4
6.9
23
53
L40.5
ICD-10 Finland
Arthropathic psoriasis
4.0
6.8
25
63
R01AD12
ATC
fluticasone furoate; nasal
1.4
6.8
330
2485
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
6.1
6.8
17
28
J01CA04
ATC
amoxicillin; systemic
1.4
6.7
1007
9172
L04AB01
ATC
etanercept; parenteral
4.1
6.7
24
59
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.6
6.7
154
979
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
6.7
152
961
B01AC04
ATC
clopidogrel; oral
1.6
6.6
157
1006
L50.1
ICD-10 Finland
Idiopathic urticaria
6.5
6.6
16
25
M03BX02
ATC
tizanidine; oral
1.3
6.6
682
5834
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.6
6.6
176
1158
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
6.6
61
277
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.6
185
1238
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
6.6
64
300
ZX112
NOMESCO Finland
Subcutaneous
3.1
6.6
33
107
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
3.9
6.6
25
65
M13.9
ICD-10 Finland
Arthritis, unspecified
2.0
6.6
84
443
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
4.8
6.5
20
42
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.6
6.5
27
76
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
6.5
111
646
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
4.5
6.5
21
47
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.6
6.4
43
168
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.7
6.4
134
828
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.9
6.4
35
121
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
14.4
6.4
10
7
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
6.4
69
339
H05AA02
ATC
teriparatide; parenteral
8.2
6.3
13
16
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.2
6.3
59
270
L04AC05
ATC
ustekinumab; parenteral
11.1
6.3
11
10
R03AK08
ATC
formoterol and beclometasone; inhalant
2.5
6.3
45
182
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
18.1
6.3
9
5
L51.19
ICD-10 Finland
Other bullous erythema multiforme
+∞
6.3
6
*
R02
ICPC
Shortness of breath/dyspnoea
1.7
6.2
131
813
X57
ICD-10 Finland
Unspecified privation
3.1
6.2
31
101
XG466
NOMESCO Finland
Sleep oxymetry
2.8
6.2
37
135
D70.82
ICD-10 Finland
Drug-induced neutropenia
3.7
6.2
25
69
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
6.2
317
2408
Z71.8
ICD-10 Finland
Other specified counselling
1.4
6.1
275
2040
K07
ICPC
Swollen ankles/oedema
2.4
6.1
47
198
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
3.9
6.1
23
60
128
Kela drug reimbursment
Cancers of female genital organs
3.3
6.1
28
86
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.1
6.1
30
97
A06AD11
ATC
lactulose; oral
1.6
6.1
151
978
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
8.6
6.1
12
14
134
Kela drug reimbursment
General erythroderma
8.6
6.1
12
14
SPAT1153
SPAT
Removal of sutures
1.4
6.0
352
2736
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
6.7
6.0
14
21
WX002
NOMESCO Finland
Sedation and analgesia
1.5
6.0
219
1553
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
4.2
6.0
21
51
XG474
NOMESCO Finland
Exhalation nntrogen oxide
2.7
6.0
39
148
Mortality – FinRegistry
↥Association
Association between endpoint GENERALI_SKIN_ERUPT_DRUGS_MEDICAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GENERALI_SKIN_ERUPT_DRUGS_MEDICAM | 1.819 [1.6, 2.07] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.29 |
During the follow-up period (1.1.1998 — 31.12.2019), 1245 out of 5640 females with GENERALI_SKIN_ERUPT_DRUGS_MEDICAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GENERALI_SKIN_ERUPT_DRUGS_MEDICAM | 2.073 [1.77, 2.43] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 840 out of 3833 males with GENERALI_SKIN_ERUPT_DRUGS_MEDICAM died.
Mortality risk
Mortality risk for people of age
years, who have GENERALI_SKIN_ERUPT_DRUGS_MEDICAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | 0.399% |
| 5 | 0.945% | 2.288% |
| 10 | 2.696% | 5.745% |
| 15 | 5.097% | 10.828% |
| 20 | 8.893% | 17.877% |
Relationships between endpoints
↥Index endpoint: GENERALI_SKIN_ERUPT_DRUGS_MEDICAM – Generalized skin eruption due to drugs and medicaments
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data