Risteys · G6_TETRAPLE

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G82.3, G82.4, G82.5 Hospital discharge: ICD-8 — 34403 Cause of death: ICD-10 — G82.3, G82.4, G82.5 Cause of death: ICD-8 — 34403 2 out of 7 registries used, show all original rules.	255
4. Check minimum number of events None	255
5. Include endpoints None	255
6. Filter based on genotype QC (FinnGen only)	255

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4087	1500	2554
Only index persons	3242	1232	2010
Unadjusted period prevalence (%)
Whole population	0.06	0.04	0.07
Only index persons	0.06	0.05	0.08
Median age at first event (years)
Whole population	50.34	49.30	50.77
Only index persons	48.83	47.36	49.72

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	255	97	158
Unadjusted period prevalence (%)	0.06	0.03	0.07
Median age at first event (years)	52.84	44.32	58.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
230: Matched controls
2299

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G82.5

ICD-10 Finland

Tetraplegia, unspecified

+∞

192.8

157

G82.4

ICD-10 Finland

Spastic tetraplegia

+∞

100.6

M03BX01

ATC

baclofen; systemic

121.4

77.1

T91.3

ICD-10 Finland

Sequelae of injury of spinal cord

894.3

69.9

G82.2

ICD-10 Finland

Paraplegia, unspecified

+∞

45.3

XKD06

NOMESCO Finland

Physiologic investigation of micturition

31.3

44.3

L89

ICD-10 Finland

Decubitus ulcer and pressure area

33.2

39.8

S14.0

ICD-10 Finland

Concussion and oedema of cervical spinal cord

447.6

39.3

Z46.8

ICD-10 Finland

Fitting and adjustment of other specified devices

34.1

37.8

N18

ICPC

Paralysis/weakness

35.2

37.4

N31.9

ICD-10 Finland

Neuromuscular dysfunction of bladder, unspecified

212.0

35.8

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

8.0

35.4

180

G95.8

ICD-10 Finland

Other specified diseases of spinal cord

+∞

34.2

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

13.1

33.6

S12.2

ICD-10 Finland

Fracture of other specified cervical vertebra

54.7

31.7

R4120

NOMESCO Finland

Occupational therapy

12.7

30.7

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

17.5

30.1

SPAT1229

SPAT

Assessment of need for aid

11.6

29.7

TKC10

NOMESCO Finland

Percutaneous puncture of bladder

34.6

29.6

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

13.4

29.5

R33

ICD-10 Finland

Retention of urine

8.1

27.7

113

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

6.9

27.7

159

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

31.4

26.7

ABC60

NOMESCO Finland

Decompression of cervical spinal cord

82.3

26.4

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

7.4

26.1

123

XKC03

NOMESCO Finland

Water cystometry

21.4

25.8

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

6.1

25.5

180

A28

ICPC

Limited function/disability NOS

6.5

25.4

156

L28

ICPC

Limited function/disability (L)

6.2

24.1

160

N03AX16

ATC

pregabalin; oral

4.7

23.0

302

N31.2

ICD-10 Finland

Flaccid neuropathic bladder, not elsewhere classified

69.6

22.3

R1250

NOMESCO Finland

Evaluation of functional capability

20.0

22.1

AA1AD

NOMESCO Finland

CT of head and brain

4.6

22.0

293

M47.1

ICD-10 Finland

Other spondylosis with myelopathy

29.9

21.9

A49.9

ICD-10 Finland

Bacterial infection, unspecified

6.8

21.9

114

G80.9

ICD-10 Finland

Cerebral palsy, unspecified

+∞

21.2

J01EA01

ATC

trimethoprim; systemic

4.4

20.9

319

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

5.8

20.9

145

N03AE01

ATC

clonazepam; systemic

9.1

20.6

UKC02

NOMESCO Finland

Cystoscopy

4.8

20.5

230

TKC20

NOMESCO Finland

Catheterisation of bladder

7.2

20.2

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

7.5

20.1

Z43.5

ICD-10 Finland

Attention to cystostomy

60.4

19.3

SPAT1167

SPAT

Insertion of urinary catheter

12.3

18.7

WX408

NOMESCO Finland

General anesthesy, balanced

3.8

18.7

104

408

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

6.5

18.2

J01MA02

ATC

ciprofloxacin; systemic

3.5

18.2

126

588

N31.1

ICD-10 Finland

Reflex neuropathic bladder, not elsewhere classified

194.2

17.8

J01MA12

ATC

levofloxacin; systemic

4.1

17.7

266

N03AX12

ATC

gabapentin; oral

4.5

17.6

207

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.6

17.2

101

408

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.3

16.9

220

NA1AD

NOMESCO Finland

Cervical spine CT examination

9.8

16.7

ZXD05

NOMESCO Finland

Urgent procedure

3.4

16.6

111

492

SPAT1148

SPAT

Treatment of chronic ulcer or burn

4.6

16.2

170

G82.3

ICD-10 Finland

Flaccid tetraplegia

+∞

15.8

G80.0

ICD-10 Finland

Spastic quadriplegic cerebral palsy

+∞

15.8

A46

ICD-10 Finland

Erysipelas

4.6

15.7

164

T91.1

ICD-10 Finland

Sequelae of fracture of spine

171.0

15.7

QBG10

NOMESCO Finland

Excision and repair of bedsore of trunk

171.0

15.7

N30.0

ICD-10 Finland

Acute cystitis

4.7

15.3

151

KCV12

NOMESCO Finland

Urinary bladder endoscopic botulin therapy

48.5

15.3

N28

ICPC

Limited function/disability (N)

22.9

14.9

S97

ICPC

Chronic ulcer skin

7.9

14.8

ABD40

NOMESCO Finland

Implantation of spinal injection device

+∞

14.7

S14.1

ICD-10 Finland

Other and unspecified injuries of cervical spinal cord

+∞

14.7

KA1AE

NOMESCO Finland

Kidney ultrasound examination

14.7

14.6

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

8.9

14.1

G99.2*M47.1

ICD-10 Finland

Spondylogenic compression of spinal cord

32.3

14.1

N99

ICPC

Neurological disease other

25.7

14.0

K59.09

ICD-10 Finland

Constipation, unspecified

7.0

14.0

N81

ICPC

Injury nervous system other

80.0

13.7

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.3

13.7

354

G82.0

ICD-10 Finland

Flaccid paraplegia

+∞

13.7

9072A

ICD-9 Finland

Late effects of injuries to the nervous system, Late effect of spinal cord injury

+∞

13.7

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.8

13.4

206

U05

ICPC

Urination problems other

8.0

13.3

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

4.9

13.1

109

J01MA06

ATC

norfloxacin; oral

4.3

13.1

146

J01XX05

ATC

methenamine; oral

53.1

13.0

Z3226

NOMESCO Finland

Physiotherapist

3.6

13.0

230

GBB00

NOMESCO Finland

Tracheostomy

16.7

12.9

U07

ICPC

Urine symptom/complaint other

7.9

12.8

X58

ICD-10 Finland

Exposure to other specified factors

3.9

12.7

178

NAJ10

NOMESCO Finland

Anterior reduction of fracture of cervical spine

74.0

12.7

XKD03

NOMESCO Finland

Urethral pressure profilometry

14.3

12.7

G82.1

ICD-10 Finland

Spastic paraplegia

+∞

12.6

N31.8

ICD-10 Finland

Other neuromuscular dysfunction of bladder

137.1

12.6

R4110

NOMESCO Finland

Physiotherapy

3.1

12.5

365

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

7.4

12.2

S12.7

ICD-10 Finland

Multiple fractures of cervical spine

68.5

11.7

U29

ICPC

Urinary symptom/complaint other

14.7

11.7

G80.1

ICD-10 Finland

Spastic diplegic cerebral palsy

+∞

11.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.9

11.5

406

Z3231

NOMESCO Finland

Registered nurse

2.9

11.5

406

N05BA01

ATC

diazepam; systemic, rectal

3.7

11.3

171

M48.0

ICD-10 Finland

Spinal stenosis

4.4

11.2

111

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.1

11.1

133

T90.5

ICD-10 Finland

Sequelae of intracranial injury

16.6

11.0

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

7.7

10.9

J01CA08

ATC

pivmecillinam; oral

2.8

10.8

395

A06AD11

ATC

lactulose; oral

3.5

10.8

183

QBG00

NOMESCO Finland

Debridement of bedsore of trunk

62.9

10.7

G95.0

ICD-10 Finland

Syringomyelia and syringobulbia

62.9

10.7

N02AX02

ATC

tramadol; systemic, rectal

2.6

10.6

115

639

TPH20

NOMESCO Finland

Insertion of central venous catheter through subclavian or brachiocephalic vein

12.9

10.5

W19

ICD-10 Finland

Unspecified fall

4.2

10.5

112

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

6.5

10.5

G80.3

ICD-10 Finland

Dyskinetic cerebral palsy

+∞

10.5

N06AX21

ATC

duloxetine; oral

4.0

10.2

126

SPAT1262

SPAT

Handing over of treatment supplies

3.2

10.1

231

R5140

NOMESCO Finland

Monitoring the use of the aid

4.0

10.1

122

W17

ICD-10 Finland

Other fall from one level to another

6.1

10.0

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

11.4

10.0

R25.2

ICD-10 Finland

Cramp and spasm

10.7

9.7

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

4.3

9.7

NFL22

NOMESCO Finland

Myotomy or tenotomy of hip or thigh

104.0

9.5

A08

ICPC

Swelling

7.8

9.5

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

10.2

9.5

G82

ICD-10 Finland

Paraplegia and tetraplegia

+∞

9.4

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

8.3

9.3

N02AA05

ATC

oxycodone; systemic

3.4

9.3

166

N32.82

ICD-10 Finland

Instability of the detrusor vesicae muscle

14.5

9.3

X59

ICD-10 Finland

Exposure to unspecified factor

3.0

9.3

248

G99.2*M50.0

ICD-10 Finland

Cervical disc disorder with myelopathy

38.3

9.1

ZZR10

NOMESCO Finland

Flap of skin and muscle

38.3

9.1

SPAT1296

SPAT

Other function in accordance with occupational therapy nomenclature

38.3

9.1

TAW99

NOMESCO Finland

Other minor neurosurgical procedure

38.3

9.1

R13

ICD-10 Finland

Dysphagia

5.0

9.1

J96.1

ICD-10 Finland

Chronic respiratory failure

8.5

9.0

M03BX02

ATC

tizanidine; oral

2.4

9.0

145

964

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

4.4

9.0

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

13.3

9.0

TPH04

NOMESCO Finland

Cathetrisation of vein

2.8

8.9

295

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

5.7

8.9

NF1AA

NOMESCO Finland

Hip X-ray examination

4.3

8.9

K59.0

ICD-10 Finland

Constipation

5.4

8.8

SPAT1231

SPAT

Assessment of adjustments needed in living environment

14.8

8.8

ZXE20

NOMESCO Finland

More than three and less than five hours

3.2

8.8

179

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.3

8.8

165

SPAT1215

SPAT

Assessment of need for medical rehabilitation

6.5

8.7

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

10.6

8.7

J01FF01

ATC

clindamycin; systemic

2.6

8.7

346

JDB10

NOMESCO Finland

Percutaneous gastrostomy

17.1

8.7

TAB00

NOMESCO Finland

Lumbar puncture

5.7

8.6

R53

ICD-10 Finland

Malaise and fatigue

2.9

8.6

232

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

5.0

8.5

JN4BD

NOMESCO Finland

Extensive body CT

3.6

8.5

123

SPAT1222

SPAT

Counselling/guidance promoting independent living

3.2

8.4

165

G81.9

ICD-10 Finland

Hemiplegia, unspecified

+∞

8.4

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

4.7

8.4

SPAT1216

SPAT

Assessment of functional ability

3.2

8.3

167

SPAT1295

SPAT

Other function in accordance with physical therapy nomenclature

5.3

8.2

RF120

NOMESCO Finland

18.0

8.2

N32.83

ICD-10 Finland

Nozzle synergy in the bladder neck

34.7

8.1

R1410

NOMESCO Finland

Drawing up a rehabilitation plan

34.7

8.1

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

5.6

8.1

NAG41

NOMESCO Finland

Anterior fusion of cervical spine with fixation

23.0

8.1

WX882

NOMESCO Finland

High dependency care

7.0

8.1

Z50.1

ICD-10 Finland

Other physical therapy

5.1

7.9

NAG42

NOMESCO Finland

Posterior fusion of cervical spine with or without fixation

46.5

7.8

N31.0

ICD-10 Finland

Uninhibited neuropathic bladder, not elsewhere classified

46.5

7.8

G99.2

ICD-10 Finland

Myelopathy in diseases classified elsewhere

46.5

7.8

K59.00

ICD-10 Finland

Constipation caused by slow bowel passage (SCT)

8.5

7.7

XG466

NOMESCO Finland

Sleep oxymetry

6.1

7.7

N06AA09

ATC

amitriptyline; systemic

3.7

7.7

104

ZXE10

NOMESCO Finland

More than one and less than three hours

2.3

7.7

527

S72.4

ICD-10 Finland

Fracture of lower end of femur

19.1

7.7

NA7BG

NOMESCO Finland

Spine and spinal cord MRI examination with high intensity magnet

26.0

7.6

WX872

NOMESCO Finland

Intensive care

4.5

7.6

TPH07

NOMESCO Finland

Cathetrisation of artery

3.4

7.6

123

R5130

NOMESCO Finland

Repair work or maintenance done on the aid

6.4

7.6

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.3

7.5

503

G99.2*M47.9

ICD-10 Finland

Myelopathy in spondylosis

82.6

7.5

R52.2

ICD-10 Finland

Other chronic pain

6.6

7.4

504

Kela drug reimbursment

Conditions requiring daily forced enteral nutrition

11.4

7.4

N30.9

ICD-10 Finland

Cystitis, unspecified

5.2

7.4

M41.4

ICD-10 Finland

Neuromuscular scoliosis

+∞

7.3

S13.1

ICD-10 Finland

Dislocation of cervical vertebra

+∞

7.3

80690

ICD-8 Finland

Fracture and fracture dislocation of vertebral column with spinal cord lesion, Cervicalis, Sequelae

+∞

7.3

34302

ICD-8 Finland

Cerebral spastic infantile paralysis, Tetraplegia spastica

+∞

7.3

W16

ICD-10 Finland

Diving or jumping into water causing injury other than drowning or submersion

+∞

7.3

KCJ00

NOMESCO Finland

Cystostomy

+∞

7.3

S24.0

ICD-10 Finland

Concussion and oedema of thoracic spinal cord

+∞

7.3

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

4.2

7.3

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

4.3

7.3

A41.9

ICD-10 Finland

Sepsis, unspecified

7.0

7.3

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

7.0

7.3

ZXE00

NOMESCO Finland

One hour or less

2.2

7.2

589

KCE02

NOMESCO Finland

Transluminal endoscopic extraction of calculus from bladder

20.8

7.2

G04AA01

ATC

20.8

7.2

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

12.6

7.2

H01BA02

ATC

desmopressin; nasal, systemic, sublingual

12.6

7.2

NE1AA

NOMESCO Finland

Pelvis X-ray examination

4.2

7.2

R5110

SPAT

7.4

7.1

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

4.1

7.1

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.5

7.0

274

TKC22

NOMESCO Finland

Catheterisation instruction

8.7

6.9

B01AB05

ATC

enoxaparin; parenteral

2.3

6.9

384

TNX92

NOMESCO Finland

Supporting bandage or orthosis of lower limb

9.8

6.9

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

9.8

6.9

R50.9

ICD-10 Finland

Fever, unspecified

2.8

6.8

181

TJD20

NOMESCO Finland

Change of gastrostomy tube

41.3

6.8

C03CA01

ATC

furosemide; systemic

2.3

6.8

411

J01MA14

ATC

moxifloxacin; systemic

3.5

6.8

ZXD10

NOMESCO Finland

Scheduled procedure

2.1

6.8

575

U04

ICPC

Incontinence urine

6.2

6.7

V89

ICD-10 Finland

Motor- or nonmotor-vehicle accident, type of vehicle unspecified

23.3

6.7

R4130

NOMESCO Finland

Speech therapy

8.2

6.7

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.1

6.6

135

G04BD07

ATC

tolterodine; oral

6.0

6.6

SPAT1211

SPAT

Application of soft bandage

3.2

6.5

113

NAJ12

NOMESCO Finland

Posterior reduction of fracture of cervical spine

71.7

6.5

NAG53

NOMESCO Finland

Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea

71.7

6.5

ZSA00

NOMESCO Finland

Procedure related to previous procedure classified in chapter A

71.7

6.5

NA2CG

NOMESCO Finland

Thoracal spine extensive MRI examination with high intensity magnet

14.8

6.5

U13

ICPC

Bladder symptom/complaint other

6.9

6.4

308

Kela drug reimbursment

Alprostadil, sildenafil and combination product containing aviptadil and phentolamine

6.9

6.4

XKD00

NOMESCO Finland

Uroflowmetry

2.5

6.4

238

N03AF02

ATC

oxcarbazepine; oral

5.8

6.4

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

8.5

6.4

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

4.4

6.4

R1210

NOMESCO Finland

Medical assessment of need and possibilities to rehabilitation

11.5

6.4

M50.1

ICD-10 Finland

Cervical disc disorder with radiculopathy

4.8

6.3

34403

ICD-8 Finland

Other cerebral paralysis, Laesia medullaris non traumatica, sequelae

+∞

6.3

3432A

ICD-9 Finland

Infantile cerebral palsy, Quadriplegic[CP-OIREYHTYMÄ,TETRAPLEGIA SPASTICA]

+∞

6.3

AWB00

NOMESCO Finland

Reoperation for superficial infection in surgery of the nervous system

+∞

6.3

NDT99

NOMESCO Finland

Other operation on wrist or hand

+∞

6.3

P21.0

ICD-10 Finland

Severe birth asphyxia

+∞

6.3

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

5.2

6.2

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

2.8

6.2

154

R56.8

ICD-10 Finland

Other and unspecified convulsions

4.2

6.2

N03AX09

ATC

lamotrigine; oral

4.2

6.2

Z2446

NOMESCO Finland

Social worker

3.8

6.1

ZXE17

NOMESCO Finland

Procedure duration 150 to 179 minutes

13.0

6.1

G47.3

ICD-10 Finland

Sleep apnoea

2.4

6.1

281

G04BD08

ATC

solifenacin; oral

4.0

6.1

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

4.2

6.1

S17

ICPC

Abrasion/scratch/blister

7.6

6.0

N29

ICPC

Neurological sympt/complt other

7.6

6.0

TQW11

NOMESCO Finland

Vacuum treatment of wound

7.6

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_TETRAPLE and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_TETRAPLE	4.524 [3.57, 5.73]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.319

During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1131 females with G6_TETRAPLE died.

Males

Parameter	HR [95% CI]	p-value
G6_TETRAPLE	4.224 [3.6, 4.96]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 782 out of 1973 males with G6_TETRAPLE died.

Mortality risk

Mortality risk for people of age

years, who have G6_TETRAPLE.

N-year risk	Females	Males
1	0.438%	0.861%
5	2.374%	5.06%
10	6.461%	12.798%
15	11.992%	21.439%
20	20.747%	34.276%

Relationships between endpoints

↥

Index endpoint: G6_TETRAPLE – Tetraplegia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_TETRAPLE
CONTROL_EXCLUDE	G6_CPETAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G82[3-5]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	34403
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G82[3-5]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	34403
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Tetraplegia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints