Other disorders of peripheral nervous system

G6_PERIPHOTH

peripheral nervous system disease: A disease involving the peripheral nervous system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G64 Cause of death: ICD-10 — G64 2 out of 7 registries used, show all original rules.	213
4. Check minimum number of events None	213
5. Include endpoints None	213
6. Filter based on genotype QC (FinnGen only)	213

Control definitions (FinnGen only)

Control exclude: G6_POLYNEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G60-G64
Name in latin: Aliae morbositates systematis nervosi peripherici

NAME	G6_PERIPHOTH
CONTROL_EXCLUDE	G6_POLYNEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G64
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G64
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other disorders of peripheral nervous system based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1252	584	661
Only index persons	1109	536	573
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	59.48	59.38	59.73
Only index persons	57.53	58.02	57.07

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	213	116	97
Unadjusted period prevalence (%)	0.04	0.04	0.04
Median age at first event (years)	58.80	56.40	61.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
194: Matched controls
1941

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G64

ICD-10 Finland

Other disorders of peripheral nervous system

+∞

277.5

193

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

226.9

37.2

N03AX12

ATC

gabapentin; oral

5.9

21.2

163

N03AX16

ATC

pregabalin; oral

4.6

18.9

255

G62.8

ICD-10 Finland

Other specified polyneuropathies

+∞

13.7

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

6.2

12.0

TAB00

NOMESCO Finland

Lumbar puncture

8.7

11.3

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

6.1

10.6

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.6

8.9

477

N02AX02

ATC

tramadol; systemic, rectal

2.5

8.8

557

N06AX21

ATC

duloxetine; oral

3.9

8.5

107

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

4.3

8.5

N03AE01

ATC

clonazepam; systemic

5.8

8.3

M48.0

ICD-10 Finland

Spinal stenosis

3.8

7.5

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

14.1

7.5

R20.2

ICD-10 Finland

Paraesthesia of skin

4.8

7.5

M54.2

ICD-10 Finland

Cervicalgia

4.7

7.3

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

5.3

7.2

L28

ICPC

Limited function/disability (L)

3.1

7.2

164

JN3BD

NOMESCO Finland

Extensive abdominal CT

3.4

7.1

119

M79.6

ICD-10 Finland

Pain in limb

2.3

6.8

444

N06AA09

ATC

amitriptyline; systemic

3.4

6.7

106

N06AX11

ATC

mirtazapine; oral

2.3

6.4

395

G60.0

ICD-10 Finland

Hereditary motor and sensory neuropathy

+∞

6.3

NA7DG

NOMESCO Finland

Spine and spinal cord very extensive MRI examination with high intensity magnet

27.6

6.3

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

3.7

6.2

R52.9

ICD-10 Finland

Pain, unspecified

3.6

6.1

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.7

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_PERIPHOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_PERIPHOTH	1.811 [1.42, 2.32]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.162

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 508 females with G6_PERIPHOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_PERIPHOTH	2.226 [1.7, 2.91]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 563 males with G6_PERIPHOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_PERIPHOTH.

N-year risk	Females	Males
1	0.178%	0.322%
5	0.962%	2.451%
10	2.551%	6.395%
15	4.571%	12.048%
20	7.489%	19.046%

Relationships between endpoints

↥

Index endpoint: G6_PERIPHOTH – Other disorders of peripheral nervous system

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other disorders of peripheral nervous system

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints