No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
152 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified neuropathies
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1396 | 595 | 779 |
| Only index persons | 972 | 439 | 533 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.26 | 56.05 |
| Only index persons | 49.86 | 48.73 | 50.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 152 | 67 | 85 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 52.59 | 47.10 | 56.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 138
- Matched controls
- 1377
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G60.9
ICD-10 Finland
Hereditary and idiopathic neuropathy, unspecified
+∞
72.4
63
*
G60.8
ICD-10 Finland
Other hereditary and idiopathic neuropathies
+∞
58.6
52
*
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
47.7
43
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
121.0
46.4
48
6
3569X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Unspecified
+∞
24.7
23
*
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
14.8
14
*
3568X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Other specified idiopathic peripheral neuropathy
+∞
12.7
12
*
Z50.1
ICD-10 Finland
Other physical therapy
8.8
9.5
20
26
Z31.5
ICD-10 Finland
Genetic counselling
8.5
9.3
20
27
N03AE01
ATC
clonazepam; systemic
7.9
8.9
20
29
N03AX12
ATC
gabapentin; oral
4.1
8.8
37
114
R1250
NOMESCO Finland
Evaluation of functional capability
14.0
8.6
14
11
M60.8
ICD-10 Finland
Other myositis
84.4
7.5
8
*
TAB00
NOMESCO Finland
Lumbar puncture
10.2
7.5
14
15
A28
ICPC
Limited function/disability NOS
3.6
7.3
35
120
Z3226
NOMESCO Finland
Physiotherapist
3.4
7.2
38
137
N03AX16
ATC
pregabalin; oral
3.2
7.0
42
168
M60.9
ICD-10 Finland
Myositis, unspecified
42.2
6.8
8
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
73.0
6.5
7
*
R4110
NOMESCO Finland
Physiotherapy
2.9
6.5
45
199
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint G6_HERIPOTHUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.949 [1.41, 2.69] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.706 [1.3, 2.23] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_HERIPOTHUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.17% | 0.291% |
| 5 | 1.14% | 2.114% |
| 10 | 2.679% | 5.458% |
| 15 | 5.451% | 10.265% |
| 20 | 9.551% | 16.625% |
Relationships between endpoints
↥Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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