Guillain-Barre syndrome

G6_GUILBAR

Guillain-Barre syndrome: Guillain-BarrC) syndrome (GBS) is the term used to describe a spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS; see these terms) and some other regional variants.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G61.0
  • Hospital discharge: ICD-9 3570
  • Hospital discharge: ICD-8 35401
  • Cause of death: ICD-10 G61.0
  • Cause of death: ICD-9 3570
  • Cause of death: ICD-8 35401

2 out of 7 registries used, show all original rules.

510

4. Check minimum number of events

None

510

5. Include endpoints

None

510

6. Filter based on genotype QC (FinnGen only)

489

Control definitions (FinnGen only)

Control exclude
G6_POLYNEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G61
Name in latin
Syndroma Guillain-Barré

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4635 2063 2535
Only index persons 3894 1777 2117
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.07
Only index persons 0.07 0.07 0.08
Median age at first event (years)
Whole population 50.92 49.00 52.39
Only index persons 48.14 46.19 49.78

-FinnGen-

Key figures

All Female Male
Number of individuals 489 223 266
Unadjusted period prevalence (%) 0.11 0.09 0.13
Median age at first event (years) 51.52 48.16 54.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
510
Matched controls
5102
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G61.0
ICD-10 Finland
Guillain-Barré syndrome
+∞
323.0
425
*
TAB00
NOMESCO Finland
Lumbar puncture
15.2
69.4
120
101
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
62.0
68.3
79
15
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
+∞
55.2
52
*
35401
ICD-8 Finland
Polyneuritis and polyradiculitis, Polyradicultitis Guillain-Barré
+∞
53.0
50
*
3570A
ICD-9 Finland
Inflammatory and toxic neuropathy, Acute infective polyneuritis
+∞
48.7
46
*
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
+∞
45.5
43
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
23.5
37.0
53
25
6BA02
NOMESCO Finland
NA
82.1
34.3
38
5
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.8
32.5
99
202
N03AX12
ATC
gabapentin; oral
4.1
28.5
127
384
WW400
NOMESCO Finland
Plasmaferesis
285.3
27.0
27
*
R20.2
ICD-10 Finland
Paraesthesia of skin
5.6
25.2
78
160
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
27.9
25.2
34
13
ZX120
NOMESCO Finland
Intravenous
4.2
22.3
91
249
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
22.0
21
*
N99
ICPC
Neurological disease other
27.8
21.6
29
11
R4120
NOMESCO Finland
Occupational therapy
5.5
20.8
64
130
N03AX16
ATC
pregabalin; oral
2.8
20.3
157
695
N28
ICPC
Limited function/disability (N)
13.9
17.2
29
22
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.9
17.0
74
213
G82.2
ICD-10 Finland
Paraplegia, unspecified
31.2
16.2
21
7
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.5
14.9
54
131
N29
ICPC
Neurological sympt/complt other
9.0
14.4
30
35
AA1AD
NOMESCO Finland
CT of head and brain
2.4
14.1
148
753
N94
ICPC
Peripheral neuritis/neuropathy
+∞
13.6
13
*
G35
ICD-10 Finland
Multiple sclerosis
12.6
13.2
23
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
13.0
101
435
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
13.0
103
447
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
9.6
12.1
24
26
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
8.7
11.9
25
30
R1250
NOMESCO Finland
Evaluation of functional capability
8.1
11.0
24
31
G51.0
ICD-10 Finland
Bell palsy
6.1
10.9
29
50
Z3226
NOMESCO Finland
Physiotherapist
2.3
10.2
103
504
N18
ICPC
Paralysis/weakness
8.1
9.7
21
27
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.9
9.7
59
218
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
5.9
9.6
26
46
L28
ICPC
Limited function/disability (L)
2.4
9.6
89
419
R4110
NOMESCO Finland
Physiotherapy
2.0
9.1
140
818
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.9
8.7
27
57
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
8.6
44
145
H02AB06
ATC
prednisolone; systemic
1.8
8.6
237
1685
N06AA09
ATC
amitriptyline; systemic
2.8
8.5
56
217
N06AX21
ATC
duloxetine; oral
2.6
8.4
60
246
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
8.2
115
648
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
8.0
217
1524
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.2
7.9
41
137
GBB00
NOMESCO Finland
Tracheostomy
9.6
7.8
15
16
2AB04
NOMESCO Finland
NA
45.7
7.7
9
*
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
45.7
7.7
9
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
7.7
85
432
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
7.7
78
381
H02AB07
ATC
prednisone; oral
2.2
7.5
77
377
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
81.2
7.4
8
*
Z3231
NOMESCO Finland
Registered nurse
1.8
7.4
142
888
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
13.6
7.4
12
9
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
13.6
7.4
12
9
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.5
7.4
57
243
L04AX01
ATC
azathioprine; systemic
3.6
7.4
32
94
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
7.3
7
*
M48.0
ICD-10 Finland
Spinal stenosis
2.3
7.2
64
294
XA402
NOMESCO Finland
ENMG
5.2
7.2
21
42
109
Kela drug reimbursment
Multiple sclerosis
9.0
7.1
14
16
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.4
7.0
33
103
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
14.0
6.9
11
8
A28
ICPC
Limited function/disability NOS
2.2
6.9
73
364
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
11.1
6.8
12
11
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
9.5
6.8
13
14
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
6.8
50
209
Z2446
NOMESCO Finland
Social worker
2.9
6.7
39
141
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.3
6.7
19
37
R53
ICD-10 Finland
Malaise and fatigue
1.9
6.5
99
572
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
6.5
43
170
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
9.4
6.3
12
13
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
9.4
6.3
12
13
G61
ICD-10 Finland
Inflammatory polyneuropathy
+∞
6.3
6
*
NA7DM
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
6.1
35
125
N03AE01
ATC
clonazepam; systemic
3.0
6.1
32
110
C03CA01
ATC
furosemide; systemic
1.7
6.1
135
878
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
6.0
139
913

Mortality – FinRegistry

Association

Association between endpoint G6_GUILBAR and mortality.

Females

Parameter HR [95% CI] p-value
G6_GUILBAR 2.186 [1.81, 2.63] < 0.001
Birth year 0.997 [0.99, 1.01] 0.473

During the follow-up period (1.1.1998 — 31.12.2019), 256 out of 1332 females with G6_GUILBAR died.

Males

Parameter HR [95% CI] p-value
G6_GUILBAR 1.876 [1.59, 2.21] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 391 out of 1622 males with G6_GUILBAR died.

Mortality risk

Mortality risk for people of age

years, who have G6_GUILBAR.

N-year risk Females Males
1 0.24% 0.382%
5 1.313% 1.977%
10 3.35% 4.535%
15 6.366% 8.683%
20 11.367% 14.611%

Relationships between endpoints

Index endpoint: G6_GUILBAR – Guillain-Barre syndrome

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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