toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
73 |
4. Check minimum number of eventsNone |
73 |
5. Include endpointsNone |
73 |
6. Filter based on genotype QC (FinnGen only) |
73 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G90-G99
- Name in latin
- Encephalopathia toxica
Similar endpoints
↥List of similar endpoints to
Toxic encephalopathy
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 830 | 208 | 606 |
| Only index persons | 579 | 148 | 431 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.80 | 56.22 | 54.21 |
| Only index persons | 54.43 | 55.16 | 54.19 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 73 | 16 | 57 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 55.47 | 55.12 | 55.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 71
- Matched controls
- 711
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G92
ICD-10 Finland
Toxic encephalopathy
+∞
80.0
61
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
10.7
10.2
20
25
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.8
7.7
23
54
3498B
ICD-9 Finland
Other and unspecified disorders of the nervous system, Other specified disorders of nervous system[ENCEPHALOPATHIA TOXICA]
+∞
7.4
7
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
+∞
7.4
7
*
TK800
NOMESCO Finland
Hemodialysis
14.2
6.8
11
9
Z94.4
ICD-10 Finland
Liver transplant status
+∞
6.3
6
*
N06AX11
ATC
mirtazapine; oral
3.9
6.2
31
118
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
6.1
32
128
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPHTOX and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPHTOX | 3.789 [2.76, 5.19] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 333 males with G6_ENCEPHTOX died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPHTOX.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.655% |
| 5 | No data | 4.068% |
| 10 | No data | 10.518% |
| 15 | No data | 18.887% |
| 20 | No data | 30.332% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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