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Toxic encephalopathy

DOID EFO Endpoint Browser PheWeb

G6_ENCEPHTOX

toxic encephalopathy: A group of neurologic disorders caused by damage to the nervous system following exposure to pharmacologic, biologic, and chemical agents. Examples of neurotoxins include chemotherapy agents, radiation treatment, heavy metals, pesticides, and food additives.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G92
  • Hospital discharge: ICD-9 — 3498B
  • Hospital discharge: ICD-8 — 32302
  • Cause of death: ICD-10 — G92
  • Cause of death: ICD-9 — 3498B
  • Cause of death: ICD-8 — 32302

2 out of 7 registries used, show all original rules.

73

4. Check minimum number of events

None

73

5. Include endpoints

None

73

6. Filter based on genotype QC (FinnGen only)

73

Control definitions (FinnGen only)

Control exclude
G6_OTHNEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Encephalopathia toxica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 830 208 606
Only index persons 579 148 431
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.01 0.01 0.02
Median age at first event (years)
Whole population 54.80 56.22 54.21
Only index persons 54.43 55.16 54.19

-FinnGen-

Key figures

All Female Male
Number of individuals 73 16 57
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 55.47 55.12 55.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
71
Matched controls
711
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G92
ICD-10 Finland
Toxic encephalopathy
+∞
80.0
61
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
10.7
10.2
20
25
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.8
7.7
23
54
3498B
ICD-9 Finland
Other and unspecified disorders of the nervous system, Other specified disorders of nervous system[ENCEPHALOPATHIA TOXICA]
+∞
7.4
7
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
+∞
7.4
7
*
TK800
NOMESCO Finland
Hemodialysis
14.2
6.8
11
9
Z94.4
ICD-10 Finland
Liver transplant status
+∞
6.3
6
*
N06AX11
ATC
mirtazapine; oral
3.9
6.2
31
118
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
6.1
32
128

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3009508) Creatinine [Moles/volume] in Urine
43
211
3.53
6.52
4.6
3.0
mmol/l
8.2
8.1
0.02
33
169
(3022145) Colonoscopy Study observation
21
64
4.20
6.46
1.7
1.3
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
30
122
3.48
6.05
2.0
1.8
pmol/l
575.1
439.7
0.48
25
103
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
49
279
3.30
5.51
9.6
7.4
mmol/l
1.2
1.2
0.01
41
232
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
47
264
3.19
5.36
7.7
6.7
mmol/l
1.2
1.2
0.31
42
239
(3012544) pH of Venous blood
18
56
3.94
5.32
2.6
5.1
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
28
118
3.23
5.23
2.2
1.8
nmol/l
1350.8
1295.7
0.07
21
92
(3024561) Albumin [Mass/volume] in Serum or Plasma
44
251
2.90
4.67
12.6
5.2
g/l
33.6
35.4
1.40
44
239
(3020682) Albumin/Creatinine [Ratio] in Urine
40
218
2.85
4.61
5.2
3.8
mg/mmol
5.8
9.2
0.40
26
136
(3027945) Reticulocytes/100 erythrocytes in Blood
18
63
3.46
4.44
1.6
2.8
%
1.6
2.0
1.97
18
57
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
14
43
3.79
4.15
5.4
2.1
kpa
4.7
5.1
1.11
14
38
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
43
255
2.67
4.04
4.7
4.1
ng/l
61.2
54.1
0.09
38
191
(3012516) Albumin [Mass/volume] in Urine
37
205
2.63
3.98
4.2
3.2
mg/l
38.8
382.6
0.54
25
132
(3044640) Blood type and Crossmatch panel - Blood
36
199
2.60
3.86
3.1
2.6
—
—
—
0
0
(3019225) pH of Specimen
15
51
3.44
3.84
5.7
4.5
—
—
—
0
0
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
6
5
12.89
3.83
1.0
1.6
—
—
—
0
0
(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma
6
5
12.89
3.83
7.8
2.0
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
44
270
2.58
3.77
15.7
7.3
inr
1.3
1.2
0.35
14
77
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
23
103
2.80
3.71
1.1
1.2
u/ml
1.5
0.8
—
5
28
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
21
90
2.87
3.67
6.6
4.4
%
35.4
30.2
1.23
16
55
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
6
6
10.74
3.56
2.0
2.8
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
16
60
3.13
3.50
3.7
2.2
ug/g
124.5
225.9
0.67
11
51
(4035726)
14
49
3.30
3.41
1.2
1.3
—
—
—
0
0
(3000991) Gas panel - Venous blood
15
57
3.05
3.20
5.5
11.0
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
56
403
2.67
3.20
7.7
3.9
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
22
104
2.60
3.16
1.2
1.4
g/l
4.4
2.5
1.01
13
59
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
8
16
5.47
3.15
1.5
1.7
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
8
16
5.47
3.15
1.1
1.1
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
10
30
3.70
3.03
1.4
1.0
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
19
85
2.67
3.03
1.7
1.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
42
272
2.28
2.95
5.2
4.4
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
7
14
5.40
2.80
1.0
1.4
—
—
—
0
0
(3022313) Gas panel - Capillary blood
10
32
3.46
2.76
4.8
2.0
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
33
199
2.20
2.70
6.6
5.9
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
46
317
2.22
2.69
19.2
7.7
umol/l
15.0
12.0
0.52
46
304
(3003694) ABO and Rh group [Type] in Blood
27
150
2.27
2.69
1.5
1.3
—
—
—
0
0
(3013512) EKG study
33
201
2.17
2.62
5.0
4.1
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
5
7
7.56
2.59
4.8
1.7
g/l
0.8
1.0
—
5
7
(3022948) Iron [Moles/volume] in Serum or Plasma
20
99
2.41
2.57
2.5
2.3
umol/l
14.3
13.7
0.11
20
88
(3026493) Urate [Moles/volume] in Serum or Plasma
30
177
2.18
2.57
4.8
3.1
umol/l
384.9
5754.6
0.78
23
149
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
55
412
2.36
2.56
4.1
3.4
pmol/l
15.2
15.0
0.21
47
364
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
32
196
2.13
2.47
3.9
3.5
ng/l
1679.6
1317.9
0.19
25
168
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
36
231
2.10
2.46
4.9
2.9
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
6
12
5.34
2.45
1.0
1.1
—
—
—
0
0
(3022621) pH of Urine by Test strip
10
35
3.15
2.41
4.9
2.2
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
9
28
3.52
2.40
3.8
2.6
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
6
13
4.92
2.32
4.3
2.2
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
6
13
4.92
2.32
1.2
1.9
—
—
—
0
0
(1616796) Gas panel - Central venous blood
6
13
4.92
2.32
3.8
3.8
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
6
14
4.57
2.20
1.2
1.9
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
6
14
4.57
2.20
1.3
1.8
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
14
63
2.51
2.17
2.2
1.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
16
77
2.38
2.16
1.9
1.6
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
22
123
2.13
2.10
1.5
1.7
mg/l
6.1
1.3
0.85
14
101
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
25
149
2.03
2.01
3.0
2.5
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
5
11
4.79
1.97
1.8
1.8
%
163.8
241.8
—
5
11
(4146454)
5
11
4.79
1.97
1.8
2.8
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
29
184
1.96
1.96
6.0
4.6
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
15
74
2.29
1.91
2.3
1.8
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
6
17
3.75
1.88
1.8
1.2
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
15
75
2.26
1.86
1.4
1.2
u/ml
1.1
5.6
—
6
26
(3029937) Albumin [Presence] in Urine by Test strip
25
153
1.96
1.86
6.0
3.9
estimate
0.0
0.0
—
9
54
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
12
4.39
1.85
1.0
1.3
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
6
18
3.53
1.78
1.5
1.2
—
—
—
0
0
(3018418) pH of Serum or Plasma
27
173
1.89
1.74
6.2
5.0
ph
7.4
7.4
—
7
37
(3030981) Hyaline casts [#/volume] in Urine by Automated count
8
31
2.77
1.71
3.0
2.7
e6/l
0.1
0.0
—
8
31
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
7
25
2.98
1.69
1.3
1.0
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
14
3.75
1.64
1.2
1.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
16
87
2.07
1.61
2.1
1.4
—
—
—
0
0
(3002256) Pathology report gross observation
14
73
2.14
1.56
1.1
1.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
45
0.00
1.56
0.0
2.2
—
—
—
0
0
(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma
7
27
2.76
1.56
2.7
3.8
u/ml
30.0
337.5
—
7
22
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
5
15
3.50
1.55
2.8
1.7
%
50.4
80.4
—
5
15
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
21
3.02
1.54
1.3
1.3
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
9
39
2.49
1.49
1.7
1.7
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
6
22
2.88
1.46
1.5
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
13
68
2.11
1.44
2.2
1.6
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
37
274
1.71
1.42
4.9
4.8
estimate
0.0
0.0
—
8
61
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
14
76
2.04
1.41
4.9
8.2
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
12
205
0.50
1.34
4.4
3.0
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
14
78
1.98
1.32
6.3
3.5
—
—
—
0
0
(3036489) Thrombin time
5
18
2.90
1.30
1.6
1.7
s
28.8
20.4
—
5
18
(3026008) Bacteria identified in Urine by Culture
24
161
1.73
1.29
3.8
2.8
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
17
103
1.85
1.27
2.2
1.9
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
35
0.00
1.19
0.0
1.2
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
8
41
2.07
1.13
1.4
1.6
g/l
1.4
1.1
—
8
35
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
5
21
2.48
1.11
1.8
2.7
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
5
21
2.48
1.11
2.2
2.1
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
9
45
2.14
1.10
5.0
1.7
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
9
46
2.09
1.08
1.7
2.5
g/l
13.2
9.2
—
9
38
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
32
242
1.57
1.06
2.8
2.0
pmol/l
89.7
92.3
0.16
20
134
(36304419) Bacteria [Presence] in Urine
26
187
1.61
1.06
4.8
2.7
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
36
280
1.56
1.05
4.6
3.6
estimate
0.0
0.0
—
9
54
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
60
527
1.78
1.05
5.9
4.0
mu/l
2.1
1.9
0.28
52
463
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
29
0.00
1.00
0.0
1.9
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
7
36
2.04
1.00
1.1
1.2
—
—
—
0
0
(3036481) Cortisol [Moles/volume] in Serum or Plasma
9
51
1.87
0.99
1.3
1.7
nmol/l
314.2
349.8
—
9
45
(4010399)
10
55
1.95
0.97
1.6
1.5
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
65
593
1.88
0.95
30.3
15.6
mg/l
16.5
25.3
2.59
56
468
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
6
28
2.24
0.94
3.0
2.1
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
15
96
1.71
0.93
1.7
2.0
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
6
29
2.16
0.91
1.8
2.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
28
213
1.51
0.87
5.8
3.9
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
6
32
1.95
0.84
5.0
3.4
mmol/l
27.0
25.4
—
6
32
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
8
48
1.75
0.82
6.8
3.1
u/l
42.3
28.3
—
8
43
(1761482) Bacteria [#/volume] in Urine by Culture
0
24
0.00
0.81
0.0
5.5
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
34
273
1.46
0.80
5.0
3.6
estimate
0.0
0.0
—
8
57
(3039443) Prostate specific Ag panel - Serum or Plasma
0
26
0.00
0.80
0.0
1.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
25
317
0.68
0.78
2.4
2.5
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
5
23
2.26
0.78
1.2
1.2
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
29
229
1.44
0.73
2.8
2.2
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
27
1.91
0.70
1.4
1.3
—
—
—
0
0
(3000492) Spirometry study
7
44
1.65
0.67
2.0
1.7
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
25
310
0.71
0.66
3.2
4.6
%
18.7
21.7
0.89
11
163
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
30
1.71
0.62
1.4
1.5
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
6
35
1.78
0.59
1.5
1.6
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
6
35
1.78
0.59
1.0
1.3
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
20
153
1.42
0.59
5.8
3.3
—
—
—
0
0
(40758558) Short blood count panel - Blood
19
148
1.38
0.50
9.9
6.5
—
—
—
0
0
(3020630) Protein [Mass/volume] in Serum or Plasma
7
46
1.58
0.50
1.3
1.6
g/l
63.8
66.7
—
7
41
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
10
69
1.52
0.47
1.7
1.7
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
31
1.66
0.44
2.0
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
10
71
1.47
0.42
1.7
1.8
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
16
0.00
0.41
0.0
3.4
—
1.6
—
0
16
(3038515) Glucose [Moles/volume] in Venous blood
0
16
0.00
0.41
0.0
3.4
—
7.4
—
0
16
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
61
573
1.39
0.41
31.2
14.9
ml/min/173m2
70.4
79.1
1.44
50
468
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
62
584
1.41
0.41
7.1
4.8
mmol/l
6.3
6.1
0.55
55
525
(3009542) Hematocrit [Volume Fraction] of Blood
49
529
0.78
0.39
29.6
16.2
%
37.4
39.8
1.02
26
363
(3002385) Erythrocyte distribution width [Ratio]
44
479
0.80
0.36
40.9
19.3
%
14.3
13.8
2.05
44
473
(3044889) 12 lead EKG panel
39
430
0.80
0.36
5.0
4.3
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
6
44
1.40
0.35
4.7
2.8
g/l
144.8
125.6
—
6
44
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
60
570
1.30
0.30
10.7
6.2
mmol/mol
42.6
40.5
0.63
54
534
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
5
37
1.38
0.24
1.8
1.6
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
12
0.00
0.21
0.0
3.4
—
4.0
—
0
12
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
12
0.00
0.21
0.0
3.4
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
12
0.00
0.21
0.0
3.4
—
105.9
—
0
12
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
6
47
1.30
0.21
3.3
3.6
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
63
609
1.25
0.19
32.9
15.0
—
—
—
0
0
(3015736) pH of Urine
23
206
1.17
0.19
4.6
3.5
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
60
583
1.16
0.13
6.6
4.1
mmol/l
1.2
1.3
0.38
50
529
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
41
392
1.10
0.11
5.0
4.9
ug/l
1.8
3.1
0.91
35
351
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
45
1.12
0.10
7.2
6.8
mmol/l
23.9
24.1
—
5
45
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
61
596
1.14
0.09
7.2
4.6
mmol/l
4.1
4.5
2.14
53
549
(40761536) Microorganisms panel - Urine sediment
6
54
1.12
0.09
5.5
4.1
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
6
58
1.04
0.08
1.3
1.6
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
61
597
1.13
0.08
7.4
4.6
mmol/l
1.3
1.4
0.46
52
545
(3011397) Hemoglobin [Presence] in Urine by Test strip
14
128
1.12
0.07
3.4
3.6
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
62
612
1.09
0.03
7.6
5.2
mmol/l
2.4
2.6
1.88
55
559
(3021788) Differential panel - Synovial fluid
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
8
0.00
0.00
0.0
1.3
—
180.3
—
0
8
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3035880) pH of Pleural fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.7
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
14.3
—
0
5
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(21494815) CD4 cells/100 lymphocytes in Specimen
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
15.3
—
0
6
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3003434) Protein [Mass/volume] in Pleural fluid
0
9
0.00
0.00
0.0
1.2
—
28.2
—
0
9
(40760892) CBC W Ordered Manual Differential panel - Blood
13
130
1.00
0.00
7.3
6.3
—
—
—
0
0
(3000012) Reticulocyte production index
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.3
—
3.1
—
0
7
(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
65
644
1.08
0.00
36.9
18.4
umol/l
99.8
84.1
1.46
65
644
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.5
—
21.3
—
0
6
(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.2
—
14.3
—
0
6
(3036782) Glucose [Moles/volume] in Pleural fluid
0
8
0.00
0.00
0.0
1.0
—
6.8
—
0
8
(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose
0
6
0.00
0.00
0.0
1.2
—
8.0
—
0
6
(3003181) Sodium [Moles/volume] in Urine
0
9
0.00
0.00
0.0
1.3
—
65.7
—
0
9
(3004451) EKG impression Narrative
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3011985) Renin [Units/volume] in Plasma
0
5
0.00
0.00
0.0
1.6
—
10.5
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ENCEPHTOX and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
G6_ENCEPHTOX 3.789 [2.76, 5.19] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 140 out of 333 males with G6_ENCEPHTOX died.

Mortality risk

Mortality risk for people of age

years, who have G6_ENCEPHTOX.

N-year risk Females Males
1 No data 0.655%
5 No data 4.068%
10 No data 10.518%
15 No data 18.887%
20 No data 30.332%

Relationships between endpoints

↥

Index endpoint: G6_ENCEPHTOX – Toxic encephalopathy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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