muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
103 |
4. Check minimum number of eventsNone |
103 |
5. Include endpointsNone |
103 |
6. Filter based on genotype QC (FinnGen only) |
103 |
Control definitions (FinnGen only)
- Control exclude
- G6_MYONEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G72
- Name in latin
- Myopathia medicamento provocata
Similar endpoints
↥List of similar endpoints to
Drug-induced myopathy
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1105 | 444 | 652 |
| Only index persons | 966 | 397 | 569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.92 | 70.20 | 61.21 |
| Only index persons | 64.72 | 69.67 | 61.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 103 | 39 | 64 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 61.87 | 59.54 | 63.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 93
- Matched controls
- 929
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G72.0
ICD-10 Finland
Drug-induced myopathy
+∞
134.0
93
*
G72.8
ICD-10 Finland
Other specified myopathies
+∞
34.5
31
*
G72.9
ICD-10 Finland
Myopathy, unspecified
+∞
21.7
20
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
4.3
9.4
45
166
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
8.8
8.1
17
23
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.4
8.0
16
20
N17.9
ICD-10 Finland
Acute renal failure, unspecified
12.4
7.6
13
12
N05BA01
ATC
diazepam; systemic, rectal
4.8
7.4
26
70
N03AG01
ATC
valproic acid; systemic, rectal
7.5
7.4
17
27
AA1AD
NOMESCO Finland
CT of head and brain
3.8
7.3
37
138
C07AB07
ATC
bisoprolol; oral
3.3
7.1
60
330
N05CF01
ATC
zopiclone; oral
3.4
7.0
42
179
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
6.6
40
171
G72.1
ICD-10 Finland
Alcoholic myopathy
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint G6_DRUGMYOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGMYOP | 2.524 [1.94, 3.28] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.681 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 406 females with G6_DRUGMYOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGMYOP | 3.526 [2.43, 5.11] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 603 males with G6_DRUGMYOP died.
Mortality risk
Mortality risk for people of age
years, who have G6_DRUGMYOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.338% | 0.656% |
| 5 | 1.617% | 3.793% |
| 10 | 4.124% | 9.144% |
| 15 | 7.844% | 16.717% |
| 20 | 13.534% | 27.041% |
Relationships between endpoints
↥Index endpoint: G6_DRUGMYOP – Drug-induced myopathy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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