brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
351 |
4. Check minimum number of eventsNone |
351 |
5. Include endpointsNone |
351 |
6. Filter based on genotype QC (FinnGen only) |
351 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of brain, other and unspecified
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4808 | 2024 | 2697 |
| Only index persons | 2930 | 1376 | 1554 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.08 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 48.81 | 47.92 | 49.20 |
| Only index persons | 41.61 | 43.17 | 40.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 351 | 153 | 198 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.09 |
| Median age at first event (years) | 47.34 | 42.25 | 51.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 323
- Matched controls
- 3228
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
69.3
64
*
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
64.8
60
*
34799
ICD-8 Finland
Other disease of brain, Other and unspecified
+∞
63.7
59
*
34798
ICD-8 Finland
Other disease of brain, Alii definiti
+∞
53.6
50
*
G93.90
ICD-10 Finland
Brain death
+∞
42.6
40
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.1
27.0
59
77
3489X
ICD-9 Finland
Other conditions of brain, Unspecified condition of brain
+∞
21.1
20
*
3488X
ICD-9 Finland
Other conditions of brain
+∞
20.0
19
*
YKA02
NOMESCO Finland
Excision of kidneys from cadaver donor
+∞
20.0
19
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
74.4
18.9
21
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.9
16.8
36
45
AA1AD
NOMESCO Finland
CT of head and brain
3.3
16.6
97
367
YJA10
NOMESCO Finland
Excision of liver from cadaver donor
+∞
12.6
12
*
G93.4
ICD-10 Finland
Encephalopathy, unspecified
124.2
11.5
12
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
11.3
66
243
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
11.2
39
93
TAB00
NOMESCO Finland
Lumbar puncture
6.9
11.1
27
42
N03AX14
ATC
levetiracetam; systemic
9.4
10.9
22
25
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
22.4
10.8
15
7
G93.9
ICD-10 Finland
Disorder of brain, unspecified
+∞
10.5
10
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
9.6
10.2
20
22
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.4
9.5
20
25
N05BA01
ATC
diazepam; systemic, rectal
2.9
9.4
58
223
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
9.2
39
113
R51.80
ICD-10 Finland
Headache
3.2
9.0
48
166
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
8.6
8.7
18
22
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
8.5
37
110
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
8.9
8.4
17
20
N03AF01
ATC
carbamazepine; oral, rectal
3.9
8.4
34
95
R42
ICD-10 Finland
Dizziness and giddiness
2.4
8.1
77
377
183
Kela drug reimbursment
Lamotrigin and topiramate
22.7
8.1
11
5
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
7.9
28
69
XA800
NOMESCO Finland
Neuropsychological investigation
5.0
7.8
24
51
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
12.2
7.6
13
11
N03AF02
ATC
oxcarbazepine; oral
5.8
7.5
20
36
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
7.3
7
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
7.2
28
76
R41.0
ICD-10 Finland
Disorientation, unspecified
5.7
7.0
19
35
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.3
6.9
33
106
WX892
NOMESCO Finland
Monitored bed care
3.2
6.8
34
113
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
6.8
92
522
N06AB04
ATC
citalopram; systemic
2.2
6.6
74
388
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.4
6.6
30
93
N03AX09
ATC
lamotrigine; oral
4.8
6.4
20
44
N05AH03
ATC
olanzapine; systemic
3.6
6.4
27
79
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.2
6.4
16
27
N03AG01
ATC
valproic acid; systemic, rectal
3.7
6.4
26
74
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
YFA50
NOMESCO Finland
Excision of heart for preparation of homograft
+∞
6.3
6
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
6.2
42
169
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISBROTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 3.99 [2.68, 5.94] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.697 |
During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 487 females with G6_DISBROTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 4.946 [3.66, 6.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 545 males with G6_DISBROTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISBROTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.44% | 0.838% |
| 5 | 2.171% | 5.642% |
| 10 | 6.164% | 14.249% |
| 15 | 11.626% | 26.237% |
| 20 | 20.3% | 41.219% |
Relationships between endpoints
↥Index endpoint: G6_DISBROTHUNS – Disorders of brain, other and unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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