Lewy body dementia: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.
Other and unspecified degenerative diseases of nervous system
DOID EFO Endpoint Browser PheWeb
G6_DEGENOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
819 |
4. Check minimum number of eventsNone |
819 |
5. Include endpointsNone |
819 |
6. Filter based on genotype QC (FinnGen only) |
819 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEURODEG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified degenerative diseases of nervous system
based on the number of shared cases.
Similar with more cases:
- Degenerative diseases of the nervous system
- Other degenerative diseases of the nervous system
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10790 | 5168 | 5413 |
| Only index persons | 7351 | 3692 | 3659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.15 | 0.15 |
| Only index persons | 0.14 | 0.14 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 74.25 | 75.65 | 72.93 |
| Only index persons | 74.27 | 75.65 | 72.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 819 | 326 | 493 |
| Unadjusted period prevalence (%) | 0.18 | 0.11 | 0.22 |
| Median age at first event (years) | 72.71 | 72.42 | 72.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 722
- Matched controls
- 7218
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
+∞
323.0
413
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
3526.8
280.0
252
*
N06DA03
ATC
rivastigmine; oral, transdermal
30.5
131.7
179
77
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
15.7
99.1
170
139
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
8.4
81.6
198
310
N05AH04
ATC
quetiapine; oral
6.9
80.9
230
455
F03
ICD-10 Finland
Unspecified dementia
10.1
70.1
148
179
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
23.2
68.0
99
49
TAB00
NOMESCO Finland
Lumbar puncture
15.8
61.5
103
75
N05AX08
ATC
risperidone; systemic
7.6
59.4
151
244
G31.0
ICD-10 Finland
Circumscribed brain atrophy
568.4
54.3
53
*
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
151.4
53.6
56
*
G30.1
ICD-10 Finland
Alzheimer disease with late onset
16.2
51.0
84
58
N06DA02
ATC
donepezil; oral
9.8
47.6
100
116
G20
ICD-10 Finland
Parkinson disease
9.0
46.5
103
131
N06DX01
ATC
memantine; oral
8.3
45.4
106
147
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
9.7
44.2
93
108
G30.8
ICD-10 Finland
Other Alzheimer disease
28.5
42.7
58
22
XA800
NOMESCO Finland
Neuropsychological investigation
9.4
36.3
77
90
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.4
34.8
112
237
P20
ICPC
Memory disturbance
3.5
33.7
184
642
AA1AD
NOMESCO Finland
CT of head and brain
2.9
32.9
269
1242
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.2
27.1
111
299
A28
ICPC
Limited function/disability NOS
2.8
27.1
206
890
N05AH03
ATC
olanzapine; systemic
6.8
26.3
68
108
R41.3
ICD-10 Finland
Other amnesia
8.1
26.1
60
80
N99
ICPC
Neurological disease other
18.3
26.0
40
23
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
+∞
25.1
24
*
3319X
ICD-9 Finland
Other cerebral degenerations, Cerebral degeneration, unspecified
+∞
25.1
24
*
R53
ICD-10 Finland
Malaise and fatigue
2.7
25.1
206
926
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
23.4
291
1621
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.5
23.3
87
214
N03AG01
ATC
valproic acid; systemic, rectal
5.3
22.1
70
144
F05.9
ICD-10 Finland
Delirium, unspecified
8.1
21.6
49
64
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
13.4
21.4
37
29
F0280, G318
ICD-10 Finland
NA
+∞
20.9
20
*
N03AE01
ATC
clonazepam; systemic
4.6
20.8
75
178
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
20.7
195
933
G30.0
ICD-10 Finland
Alzheimer disease with early onset
215.9
20.7
21
*
F05.1
ICD-10 Finland
Delirium superimposed on dementia
49.5
20.3
24
5
N06AX11
ATC
mirtazapine; oral
2.3
20.2
245
1326
SPAT1216
SPAT
Assessment of functional ability
2.5
20.2
183
856
F06.7
ICD-10 Finland
Mild cognitive disorder
6.7
19.8
51
81
N05BA04
ATC
oxazepam; oral
2.3
19.6
214
1097
P70
ICPC
Dementia
8.9
18.9
40
47
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
+∞
18.8
18
*
L28
ICPC
Limited function/disability (L)
2.5
18.7
174
819
N87
ICPC
Parkinsonism
9.1
18.1
38
44
R41.0
ICD-10 Finland
Disorientation, unspecified
4.6
17.9
63
146
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.9
17.6
75
208
R27.0
ICD-10 Finland
Ataxia, unspecified
21.5
17.4
25
12
N28
ICPC
Limited function/disability (N)
10.1
17.3
34
35
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.8
17.3
76
217
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
11.1
17.1
32
30
N29
ICPC
Neurological sympt/complt other
7.4
16.8
40
57
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
36.0
16.7
21
6
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
9.3
16.6
34
38
N05BA06
ATC
lorazepam; systemic, sublingual
3.8
16.2
70
197
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
16.0
256
1533
N05AD03
ATC
melperone; systemic
8.8
15.1
32
38
A06AD11
ATC
lactulose; oral
2.2
14.9
169
869
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
14.7
85
300
F0289, G318
ICD-10 Finland
NA
+∞
14.6
14
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.2
14.4
78
262
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.3
14.1
74
243
SPAT1229
SPAT
Assessment of need for aid
2.8
13.7
91
350
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
13.6
13
*
F0019, G301
ICD-10 Finland
NA
+∞
13.6
13
*
3318X
ICD-9 Finland
Other cerebral degenerations, Other cerebral degeneration
+∞
13.6
13
*
F0029, G308
ICD-10 Finland
NA
+∞
13.6
13
*
N05AD01
ATC
haloperidol; systemic
4.3
13.3
49
119
N06AB10
ATC
escitalopram; oral
2.4
13.3
122
562
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.6
13.0
33
52
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
28.9
13.0
17
6
G23.8
ICD-10 Finland
Other specified degenerative diseases of basal ganglia
50.9
12.9
15
*
S06.0
ICD-10 Finland
Concussion
2.7
12.7
92
372
N06AB04
ATC
citalopram; systemic
2.1
12.5
163
882
Z2445
NOMESCO Finland
Psychologist
5.1
12.5
39
80
I95.1
ICD-10 Finland
Orthostatic hypotension
3.6
12.5
56
163
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
7.6
12.3
28
38
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.5
11.9
56
170
R44.1
ICD-10 Finland
Visual hallucinations
15.0
11.8
19
13
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.3
11.8
43
104
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.9
11.8
38
81
R1250
NOMESCO Finland
Evaluation of functional capability
5.5
11.5
33
62
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
11.3
63
1321
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.6
11.2
50
145
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.2
11.2
34
68
R25.1
ICD-10 Finland
Tremor, unspecified
4.3
11.0
40
97
SPAT1053
SPAT
Memory test
2.0
10.9
150
828
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.1
10.7
58
196
F02.80
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without additional symptoms
60.9
10.6
12
*
G93.4
ICD-10 Finland
Encephalopathy, unspecified
60.9
10.6
12
*
N06DA04
ATC
galantamine; oral
7.2
10.6
25
36
F0282, G318
ICD-10 Finland
NA
+∞
10.4
10
*
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
10.4
10
*
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
16.3
10.4
16
10
A04
ICPC
Weakness/tiredness general
2.2
10.3
110
541
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
9.8
10.3
20
21
N04BD01
ATC
selegiline; oral
5.5
10.2
29
54
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
10.2
70
273
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
7.1
10.1
24
35
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.2
10.0
52
171
M03BX01
ATC
baclofen; systemic
6.4
9.9
25
40
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.1
9.9
37
93
N05AX12
ATC
aripiprazole; systemic
6.7
9.5
23
35
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
101.3
9.4
10
*
F02.89
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without information of additional symptoms
101.3
9.4
10
*
F009, G309
ICD-10 Finland
NA
+∞
9.4
9
*
F06.0
ICD-10 Finland
Organic hallucinosis
22.0
9.4
13
6
N19
ICPC
Speech disorder
7.1
9.4
22
32
K59.09
ICD-10 Finland
Constipation, unspecified
2.8
9.2
59
224
N03AX14
ATC
levetiracetam; systemic
4.7
9.0
29
63
SPAT1234
SPAT
Support of social functional capacity
2.7
8.7
60
237
R47.1
ICD-10 Finland
Dysarthria and anarthria
9.1
8.6
17
19
Z75.5
ICD-10 Finland
Holiday relief care
6.5
8.5
21
33
F01.9
ICD-10 Finland
Vascular dementia, unspecified
4.3
8.5
30
72
G32
ICD-10 Finland
Other degenerative disorders of nervous system in diseases classified elsewhere
+∞
8.3
8
*
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
+∞
8.3
8
*
F02.8
ICD-10 Finland
Dementia in other specified diseases classified elsewhere
+∞
8.3
8
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
8.2
83
400
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
8.2
59
240
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.1
8.1
30
75
N06AX16
ATC
venlafaxine; oral
2.3
8.1
73
333
F00
ICD-10 Finland
Dementia in Alzheimer disease
33.7
8.1
10
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
17.4
8.1
12
7
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.0
8.0
21
36
R42
ICD-10 Finland
Dizziness and giddiness
1.7
8.0
175
1122
R4130
NOMESCO Finland
Speech therapy
4.3
7.8
27
64
G11.2
ICD-10 Finland
Late-onset cerebellar ataxia
45.4
7.7
9
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
7.6
133
791
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.9
7.6
45
163
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.3
7.5
36
113
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
7.5
120
693
R35
ICD-10 Finland
Polyuria
2.4
7.4
61
267
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
7.4
66
300
N04BC05
ATC
pramipexole; oral
2.3
7.4
66
301
N05BA01
ATC
diazepam; systemic, rectal
1.9
7.4
104
576
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.4
7.2
16
22
R26.0
ICD-10 Finland
Ataxic gait
20.2
7.1
10
5
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
4.6
7.1
23
51
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
10.2
7.0
13
13
S01.0
ICD-10 Finland
Open wound of scalp
2.2
7.0
71
343
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.0
115
671
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
7.0
134
821
Z31.5
ICD-10 Finland
Genetic counselling
3.9
6.9
27
72
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
7.6
6.9
15
20
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.9
6.9
21
44
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
16.9
6.8
10
6
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
16.9
6.8
10
6
F22.0
ICD-10 Finland
Delusional disorder
6.5
6.7
16
25
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.7
6.6
21
46
G30
ICD-10 Finland
Alzheimer disease
12.4
6.6
11
9
N06AB06
ATC
sertraline; oral
2.3
6.6
60
274
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
6.9
6.5
15
22
R51.80
ICD-10 Finland
Headache
2.0
6.5
80
419
N04AA02
ATC
biperiden; systemic
5.1
6.5
19
38
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
70.4
6.4
7
*
F07.9
ICD-10 Finland
Unspecified organic personality and behavioural disorder due to brain disease, damage and dysfunction
70.4
6.4
7
*
R5110
SPAT
NA
3.9
6.3
24
63
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
11.1
6.3
11
10
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
6.3
6
*
F028, G318
ICD-10 Finland
NA
+∞
6.3
6
*
G31
ICD-10 Finland
Other degenerative diseases of nervous system, not elsewhere classified
+∞
6.3
6
*
F02.82
ICD-10 Finland
Dementia in other specified disease that is classified elsewhere other symptoms, mainly hallucinations
+∞
6.3
6
*
F07.0
ICD-10 Finland
Organic personality disorder
+∞
6.3
6
*
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
+∞
6.3
6
*
D21
ICPC
Swallowing problem
5.1
6.2
18
36
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
6.2
87
481
N05CD07
ATC
temazepam; oral
1.8
6.2
116
706
N06AX26
ATC
vortioxetine; oral
3.1
6.2
32
108
ZY000
NOMESCO Finland
Hospital inpatient
7.8
6.1
13
17
N05AB03
ATC
perphenazine; systemic, rectal
3.3
6.1
28
86
SPAT1254
SPAT
Administration of medicine
1.7
6.1
120
741
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.4
6.1
20
46
P29
ICPC
Psychological sympt/compl other
3.2
6.0
29
93
Mortality – FinRegistry
↥Association
Association between endpoint G6_DEGENOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENOTH | 3.447 [3.0, 3.96] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.576 |
During the follow-up period (1.1.1998 — 31.12.2019), 2005 out of 3191 females with G6_DEGENOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DEGENOTH | 3.577 [3.04, 4.2] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2129 out of 3230 males with G6_DEGENOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_DEGENOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.489% | 0.688% |
| 5 | 2.564% | 3.686% |
| 10 | 5.012% | 9.047% |
| 15 | 9.392% | 16.18% |
| 20 | 16.978% | 26.346% |
Relationships between endpoints
↥Index endpoint: G6_DEGENOTH – Other and unspecified degenerative diseases of nervous system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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