cerebral palsy: A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
659 |
4. Check minimum number of eventsNone |
659 |
5. Include endpointsNone |
659 |
6. Filter based on genotype QC (FinnGen only) |
659 |
Control definitions (FinnGen only)
- Control exclude
- G6_CPETAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G80-G83
- Name in latin
- Paralysis cerebralis infantilis
Similar endpoints
↥List of similar endpoints to
Cerebral palsy
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13423 | 5771 | 7608 |
| Only index persons | 10731 | 4719 | 6012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.17 | 0.21 |
| Only index persons | 0.20 | 0.17 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 4.66 | 4.71 | 4.29 |
| Only index persons | 4.37 | 4.68 | 4.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 659 | 344 | 315 |
| Unadjusted period prevalence (%) | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | 4.97 | 5.57 | 4.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 611
- Matched controls
- 6109
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
+∞
178.1
162
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
+∞
174.6
159
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
+∞
128.8
119
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
103.1
96
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
14.7
94.0
167
152
3430A
ICD-9 Finland
Infantile cerebral palsy, Diplegic
+∞
75.6
71
*
M03BX01
ATC
baclofen; systemic
45.6
73.5
90
23
3431A
ICD-9 Finland
Infantile cerebral palsy, Hemiplegic
+∞
70.2
66
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
15.5
65.9
112
87
34300
ICD-8 Finland
Cerebral spastic infantile paralysis, Hemiplegia spastica
+∞
65.8
62
*
34301
ICD-8 Finland
Cerebral spastic infantile paralysis, Diplegia spastica
+∞
61.5
58
*
34309
ICD-8 Finland
Cerebral spastic infantile paralysis, Unspecified
+∞
58.3
55
*
N03AG01
ATC
valproic acid; systemic, rectal
8.0
51.9
126
191
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
51.8
49
*
N05BA01
ATC
diazepam; systemic, rectal
6.3
51.7
154
312
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
45.4
43
*
SPAT1229
SPAT
Assessment of need for aid
9.6
45.3
97
118
34308
ICD-8 Finland
Cerebral spastic infantile paralysis, Alia definita
+∞
44.3
42
*
G80.8
ICD-10 Finland
Other cerebral palsy
+∞
44.3
42
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.3
43.8
112
181
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
13.6
42.4
75
62
N99
ICPC
Neurological disease other
55.1
39.1
46
9
N05BA09
ATC
clobazam; oral
19.9
38.3
58
32
G80.3
ICD-10 Finland
Dyskinetic cerebral palsy
+∞
37.9
36
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.2
37.8
128
294
N03AX14
ATC
levetiracetam; systemic
10.6
36.6
73
77
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
5.0
36.4
128
305
N03AF02
ATC
oxcarbazepine; oral
9.3
35.4
76
92
L28
ICPC
Limited function/disability (L)
5.1
34.8
121
284
N18
ICPC
Paralysis/weakness
40.8
33.8
42
11
183
Kela drug reimbursment
Lamotrigin and topiramate
18.8
33.8
52
30
A28
ICPC
Limited function/disability NOS
5.4
33.2
107
230
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
16.9
33.2
53
34
N28
ICPC
Limited function/disability (N)
32.1
32.1
42
14
3438X
ICD-9 Finland
Infantile cerebral palsy, Other specified infantile cerebral palsy[PARESIS CEREBRALIS INFANTILIS ALIA DEFINITA]
+∞
31.5
30
*
34302
ICD-8 Finland
Cerebral spastic infantile paralysis, Tetraplegia spastica
+∞
30.5
29
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
23.0
30.0
43
20
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
13.4
29.6
52
42
G82.4
ICD-10 Finland
Spastic tetraplegia
+∞
29.4
28
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
24.3
29.1
41
18
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
25.1
28.7
40
17
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.2
27.8
49
40
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.2
27.7
92
203
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.1
27.5
117
332
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.4
26.9
85
177
NFL22
NOMESCO Finland
Myotomy or tenotomy of hip or thigh
97.7
25.9
28
*
N03AF01
ATC
carbamazepine; oral, rectal
7.6
25.4
61
88
G80
ICD-10 Finland
Cerebral palsy
+∞
25.2
24
*
N03AX09
ATC
lamotrigine; oral
5.5
24.7
76
153
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
21.2
24.6
36
18
R4110
NOMESCO Finland
Physiotherapy
2.8
23.3
188
848
N03AE01
ATC
clonazepam; systemic
6.3
23.1
63
109
G40.10
ICD-10 Finland
Simple partial seizures
19.9
22.8
34
18
H47.2
ICD-10 Finland
Optic atrophy
238.5
22.8
23
*
9375
FHL
Achilles tendon dissection or extension
238.5
22.8
23
*
N05CD08
ATC
midazolam; nasal, systemic
9.5
22.2
46
52
Z3226
NOMESCO Finland
Physiotherapist
2.9
22.0
158
659
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
21.3
195
938
3AX01
NOMESCO Finland
NA
29.3
21.1
28
10
RT150
NOMESCO Finland
NA
14.8
21.1
35
25
ZX114
NOMESCO Finland
Intramuscular
10.6
20.7
40
40
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
26.6
20.6
28
11
N03AG04
ATC
vigabatrin; oral
33.9
20.3
26
8
G91.1
ICD-10 Finland
Obstructive hydrocephalus
49.8
20.3
24
5
G40.89
ICD-10 Finland
Other epilepsy
32.5
19.4
25
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
19.4
122
463
P85
ICPC
Mental retardation
19.0
19.3
29
16
G80.4
ICD-10 Finland
Ataxic cerebral palsy
+∞
18.8
18
*
3439X
ICD-9 Finland
Infantile cerebral palsy, unspecified
+∞
18.8
18
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
24.6
18.8
26
11
37300
ICD-8 Finland
Strabismus, Concomitans convergens
21.7
18.8
27
13
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
18.7
92
291
A06AD11
ATC
lactulose; oral
3.7
18.6
86
258
R4120
NOMESCO Finland
Occupational therapy
4.7
18.4
65
152
F82
ICD-10 Finland
Specific developmental disorder of motor function
10.8
18.4
35
34
TJD20
NOMESCO Finland
Change of gastrostomy tube
22.6
18.3
26
12
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
9.1
18.2
38
44
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
18.1
222
1221
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
18.0
158
728
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
29.8
17.5
23
8
N03AX11
ATC
topiramate; oral
6.5
17.5
46
76
N29
ICPC
Neurological sympt/complt other
13.1
17.3
30
24
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.5
17.1
86
276
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
65.2
16.8
19
*
G81.0
ICD-10 Finland
Flaccid hemiplegia
+∞
16.7
16
*
3432A
ICD-9 Finland
Infantile cerebral palsy, Quadriplegic[CP-OIREYHTYMÄ,TETRAPLEGIA SPASTICA]
+∞
16.7
16
*
34409
ICD-8 Finland
Other cerebral paralysis, Unspecified
+∞
16.7
16
*
34304
ICD-8 Finland
Cerebral spastic infantile paralysis, Dystonia tetraplegica. Tonusväxlingssyndrom
+∞
16.7
16
*
M41.4
ICD-10 Finland
Neuromuscular scoliosis
92.6
16.6
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
16.6
131
568
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
41.3
16.4
20
5
RS142
NOMESCO Finland
NA
31.0
16.2
21
7
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
7.8
16.2
37
50
3454A
ICD-9 Finland
Epilepsy, Partial epilepsy, with impairment of consciousness[EPILEPSIA GENERALISATA SECUNDARIA]
48.9
16.1
19
*
RT274
NOMESCO Finland
NA
48.9
16.1
19
*
R1250
NOMESCO Finland
Evaluation of functional capability
7.7
16.0
37
51
Z2445
NOMESCO Finland
Psychologist
3.6
15.9
76
234
F80.1
ICD-10 Finland
Expressive language disorder
8.3
15.5
34
43
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
5.8
15.4
44
81
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.2
15.3
59
151
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
15.2
131
594
AA1AD
NOMESCO Finland
CT of head and brain
2.7
15.2
114
478
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
46.2
15.1
18
*
H50.30
ICD-10 Finland
Intermittent esotropy
12.9
15.0
26
21
XA800
NOMESCO Finland
Neuropsychological investigation
4.0
15.0
62
169
EBA15
NOMESCO Finland
Extraction of large number of teeth
6.2
14.9
40
68
H50.31
ICD-10 Finland
Intermittent exotropia
9.0
14.9
31
36
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
13.7
14.8
25
19
181
Kela drug reimbursment
Retigabine and vigabatrin
25.8
14.8
20
8
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
21.7
14.7
21
10
Z2446
NOMESCO Finland
Social worker
3.0
14.6
92
346
3459X
ICD-9 Finland
Epilepsy, unspecified
153.5
14.5
15
*
XKC03
NOMESCO Finland
Water cystometry
7.7
14.4
33
45
RT490
NOMESCO Finland
NA
17.5
14.4
22
13
G91.0
ICD-10 Finland
Communicating hydrocephalus
27.9
14.3
19
7
NF1DA
NOMESCO Finland
X-ray of hips
10.1
14.3
28
29
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
43.6
14.2
17
*
R1260
NOMESCO Finland
Evaluation of communicative skills
9.2
14.1
29
33
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
13.1
14.0
24
19
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
14.0
87
323
RT190
NOMESCO Finland
NA
24.4
13.9
19
8
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.8
13.8
46
102
H50.1
ICD-10 Finland
Divergent concomitant strabismus
15.2
13.7
22
15
3432B
ICD-9 Finland
Infantile cerebral palsy, Quadriplegic[CP-OIREYHTYMÄ,DYSTONIA TETRAPLEGICA]
+∞
13.6
13
*
G82.1
ICD-10 Finland
Spastic paraplegia
+∞
13.6
13
*
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
143.0
13.5
14
*
9362
FHL
Adductorotomy
143.0
13.5
14
*
F83
ICD-10 Finland
Mixed specific developmental disorders
6.6
13.4
34
54
G40
ICD-10 Finland
Epilepsy
10.8
13.3
25
24
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.8
13.3
91
358
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
13.2
94
380
G40.00
ICD-10 Finland
Benign childhood epilepsy with centrotemporal EEG spikes
41.0
13.2
16
*
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
17.2
13.1
20
12
U04
ICPC
Incontinence urine
6.4
12.7
33
54
H53.0
ICD-10 Finland
Amblyopia ex anopsia
8.1
12.7
28
36
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.5
12.6
61
190
34400
ICD-8 Finland
Other cerebral paralysis, Hemiplegia NUD
+∞
12.5
12
*
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
24.9
12.5
17
7
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
20.6
12.5
18
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
12.5
121
579
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
12.4
72
256
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
12.3
65
216
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
16.3
12.2
19
12
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
7.5
12.1
28
39
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
4.4
12.0
43
103
RS222
NOMESCO Finland
NA
8.2
12.0
26
33
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
11.9
74
275
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
4.4
11.9
43
104
JDB10
NOMESCO Finland
Percutaneous gastrostomy
9.2
11.8
24
27
RL140
NOMESCO Finland
NA
10.8
11.8
22
21
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.6
11.8
53
156
R33
ICD-10 Finland
Retention of urine
4.9
11.7
38
82
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.1
11.7
164
924
SPAT1234
SPAT
Support of social functional capacity
5.0
11.7
37
78
L89
ICD-10 Finland
Decubitus ulcer and pressure area
19.4
11.6
17
9
N03AX18
ATC
lacosamide; systemic
8.9
11.6
24
28
R62.0
ICD-10 Finland
Delayed milestone
5.1
11.6
36
74
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.7
11.5
26
35
G82.2
ICD-10 Finland
Paraplegia, unspecified
+∞
11.5
11
*
R11
ICD-10 Finland
Nausea and vomiting
3.0
11.4
67
240
7803A
ICD-9 Finland
General symptoms, Convulsions
8.6
11.4
24
29
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.5
11.4
40
94
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
11.2
76
297
37301
ICD-8 Finland
Strabismus, Concomitans divergens
17.4
11.2
17
10
SPAT1231
SPAT
Assessment of adjustments needed in living environment
13.0
11.2
19
15
SPAT1262
SPAT
Handing over of treatment supplies
2.5
11.2
94
418
Z02.7
ICD-10 Finland
Issue of medical certificate
3.7
11.1
48
137
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.2
11.1
59
198
N03AX12
ATC
gabapentin; oral
2.6
11.1
82
339
SPAT1216
SPAT
Assessment of functional ability
2.8
11.0
71
270
N85
ICPC
Congenital anomaly neurological
44.1
11.0
13
*
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
8.5
10.9
23
28
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.5
10.9
38
89
Z50.1
ICD-10 Finland
Other physical therapy
4.4
10.8
39
94
H54.7
ICD-10 Finland
Unspecified visual loss
18.2
10.8
16
9
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
18.2
10.8
16
9
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
28.6
10.8
14
5
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
21.9
10.7
15
7
K03.66
ICD-10 Finland
Tooth plaque
2.8
10.7
69
262
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.9
10.7
66
245
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
61.1
10.7
12
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.6
10.6
48
142
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
3.7
10.6
46
132
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.9
10.6
65
240
N05AX08
ATC
risperidone; systemic
3.1
10.6
60
210
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.0
10.5
62
223
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
7.0
10.5
25
37
G82.5
ICD-10 Finland
Tetraplegia, unspecified
+∞
10.4
10
*
34305
ICD-8 Finland
Cerebral spastic infantile paralysis, Ataxia
+∞
10.4
10
*
N88
ICPC
Epilepsy
10.9
10.3
19
18
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
10.3
65
245
RS211
NOMESCO Finland
NA
8.7
10.1
21
25
602
Kela drug reimbursment
Children's severe malnutrition
6.3
10.1
26
43
P21.0
ICD-10 Finland
Severe birth asphyxia
40.8
10.0
12
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
6.5
9.9
25
40
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
20.4
9.8
14
7
R47.1
ICD-10 Finland
Dysarthria and anarthria
20.4
9.8
14
7
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
10.9
9.8
18
17
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.9
9.8
39
104
H50.0
ICD-10 Finland
Convergent concomitant strabismus
7.6
9.8
22
30
WX704
NOMESCO Finland
Intubation
3.1
9.8
53
181
R5120
NOMESCO Finland
Preparation of an aid
7.0
9.7
23
34
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
55.9
9.7
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
9.6
44
132
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
15.3
9.6
15
10
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.7
9.5
31
68
R5110
SPAT
NA
7.7
9.5
21
28
RT320
NOMESCO Finland
NA
101.5
9.4
10
*
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
17.9
9.4
14
8
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
30.5
9.4
12
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.1
9.4
53
184
P91.02
ICD-10 Finland
Neonatal hypoxic-ischaemic encephalopathy, severe
+∞
9.4
9
*
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
22.1
9.4
13
6
NHG22
NOMESCO Finland
Fusion of subtalar joint
22.1
9.4
13
6
K59.09
ICD-10 Finland
Constipation, unspecified
3.6
9.4
41
119
R60.0
ICD-10 Finland
Localized oedema
3.1
9.3
52
180
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
9.2
75
327
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
9.2
45
142
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
13.9
9.2
15
11
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
6.9
9.2
22
33
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
9.1
73
314
Z3231
NOMESCO Finland
Registered nurse
1.8
9.1
176
1102
WX892
NOMESCO Finland
Monitored bed care
3.0
9.1
52
183
ZXA05
NOMESCO Finland
Left side
2.1
9.1
113
598
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
15.9
9.1
14
9
34599
ICD-8 Finland
Epilepsy, Other and unspecified
37.3
9.0
11
*
R4130
NOMESCO Finland
Speech therapy
4.8
9.0
29
63
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
6.2
9.0
23
38
TKC20
NOMESCO Finland
Catheterisation of bladder
3.9
9.0
36
97
JDB00
NOMESCO Finland
Gastrostomy
24.4
8.9
12
5
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
8.9
67
280
U07
ICPC
Urine symptom/complaint other
3.6
8.8
38
109
K59.0
ICD-10 Finland
Constipation
3.6
8.7
38
110
G04BD04
ATC
oxybutynin; oral, transdermal
4.5
8.7
30
70
3781B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]
50.7
8.7
10
*
3451A
ICD-9 Finland
Epilepsy, Generalised convulsive epilepsy
50.7
8.7
10
*
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
5.3
8.6
25
49
N03AX23
ATC
brivaracetam; systemic
27.9
8.5
11
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
27.9
8.5
11
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
7.5
8.5
19
26
A46
ICD-10 Finland
Erysipelas
2.6
8.4
60
242
N05AH04
ATC
quetiapine; oral
2.0
8.4
112
609
N03AB02
ATC
phenytoin; systemic
13.0
8.4
14
11
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
8.4
90
446
G04BD08
ATC
solifenacin; oral
4.1
8.4
31
78
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
8.3
8
*
34401
ICD-8 Finland
Other cerebral paralysis, Diplegia NUD
+∞
8.3
8
*
Q04.8
ICD-10 Finland
Other specified congenital malformations of brain
+∞
8.3
8
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
8.3
204
1371
N05CD07
ATC
temazepam; oral
3.0
8.3
47
165
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.8
8.2
53
203
SPAT1301
SPAT
No procedures
1.8
8.2
173
1108
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.7
8.2
53
204
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.8
8.2
33
90
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
8.3
8.1
17
21
N03AA02
ATC
phenobarbital; systemic
33.8
8.1
10
*
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
9.1
8.1
16
18
SPAT1260
SPAT
Consultation of another employee
2.1
8.0
96
501
L17
ICPC
Foot/toe symptom/complaint
1.9
8.0
133
787
L16
ICPC
Ankle symptom/complaint
2.3
7.9
78
371
ZXA00
NOMESCO Finland
Right side
1.9
7.9
119
679
N03AX15
ATC
zonisamide; oral
13.2
7.9
13
10
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
4.6
7.8
26
59
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
11.0
7.8
14
13
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.8
97
515
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
7.8
53
209
A03FA02
ATC
cisapride; oral, rectal
3.1
7.7
40
133
3503
FHL
Single muscle retroposition
15.3
7.7
12
8
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
15.3
7.7
12
8
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
45.6
7.7
9
*
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
45.6
7.7
9
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
7.7
56
230
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
7.7
92
481
H52.2
ICD-10 Finland
Astigmatism
4.1
7.7
28
70
H53.4
ICD-10 Finland
Visual field defects
6.8
7.6
18
27
AAF00
NOMESCO Finland
Ventriculostomy
18.6
7.6
11
6
P07.2
ICD-10 Finland
Extreme immaturity
25.4
7.6
10
*
P07.3
ICD-10 Finland
Other preterm infants
5.5
7.6
21
39
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
4.8
7.6
24
52
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
7.6
41
141
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
10.2
7.6
14
14
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
7.3
7.5
17
24
N03AX16
ATC
pregabalin; oral
2.0
7.5
100
544
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.3
7.5
26
62
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.9
7.5
29
77
N05AH03
ATC
olanzapine; systemic
2.7
7.5
51
202
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.4
186
1252
9480
FHL
Tendon shortening and extension
81.0
7.4
8
*
34532
ICD-8 Finland
Epilepsy, Partialis (focalis) generalisata
81.0
7.4
8
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
81.0
7.4
8
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
81.0
7.4
8
*
Z93.1
ICD-10 Finland
Gastrostomy status
81.0
7.4
8
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.8
7.4
16
21
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
7.4
65
294
34408
ICD-8 Finland
Other cerebral paralysis, Alia definita
+∞
7.3
7
*
Z99.8
ICD-10 Finland
Dependence on other enabling machines and devices
+∞
7.3
7
*
2133
FHL
Suntin revisio
+∞
7.3
7
*
H47.6
ICD-10 Finland
Disorders of visual cortex
+∞
7.3
7
*
9372
FHL
Measures for knee flexors
+∞
7.3
7
*
WX882
NOMESCO Finland
High dependency care
3.2
7.3
37
122
ZXE00
NOMESCO Finland
One hour or less
1.6
7.3
222
1574
G41.9
ICD-10 Finland
Status epilepticus, unspecified
16.0
7.2
11
7
S06.0
ICD-10 Finland
Concussion
2.2
7.2
74
363
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.9
7.2
42
152
H51.9
ICD-10 Finland
Disorder of binocular movement, unspecified
30.4
7.2
9
*
N03AX22
ATC
perampanel; oral
20.3
7.1
10
5
WX002
NOMESCO Finland
Sedation and analgesia
2.0
7.1
88
467
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.1
7.0
85
446
SPAT1240
SPAT
Therapeutic discussion
2.0
7.0
85
447
C03CA01
ATC
furosemide; systemic
2.1
7.0
76
380
N06AA12
ATC
doxepin; systemic
3.9
6.9
27
72
K90
ICPC
Stroke/cerebrovascular accident
7.7
6.9
15
20
RT130
NOMESCO Finland
NA
14.0
6.9
11
8
ZXD05
NOMESCO Finland
Urgent procedure
1.7
6.9
171
1144
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
6.8
50
205
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
4.4
6.8
23
54
M79.6
ICD-10 Finland
Pain in limb
1.7
6.8
173
1163
NEK20
NOMESCO Finland
Fenestration or forage of bone of pelvis
40.5
6.8
8
*
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
16.9
6.8
10
6
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
22.8
6.7
9
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.9
6.6
92
510
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
7.0
6.5
15
22
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.7
6.5
43
169
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.4
6.5
52
227
H52.0
ICD-10 Finland
Hypermetropia
3.8
6.4
25
67
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.4
59
273
SPAT1153
SPAT
Removal of sutures
1.8
6.4
127
793
H35.1
ICD-10 Finland
Retinopathy of prematurity
70.6
6.4
7
*
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
70.6
6.4
7
*
R51
NOMESCO Finland
Aids services
70.6
6.4
7
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
70.6
6.4
7
*
G40.0
ICD-10 Finland
Localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset
70.6
6.4
7
*
N05AA02
ATC
levomepromazine; systemic
3.5
6.4
28
83
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.2
6.4
31
100
WX725
NOMESCO Finland
Noninvasive ventilation
3.4
6.4
29
89
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.9
6.3
36
127
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.5
6.3
53
978
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
11.2
6.3
11
10
ADB00
NOMESCO Finland
Implantation of vagus nerve stimulating device
18.2
6.3
9
5
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
18.2
6.3
9
5
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
18.2
6.3
9
5
RK321
NOMESCO Finland
NA
+∞
6.3
6
*
31599
ICD-8 Finland
Unspecified mental retardation, Other and unspecified
+∞
6.3
6
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
6.3
25
69
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
6.2
94
534
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.9
6.2
24
64
3159X
ICD-9 Finland
Specific delays in development, Unspecified delay in development
27.0
6.2
8
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.2
81
435
S17
ICPC
Abrasion/scratch/blister
3.6
6.2
26
75
Z2221
NOMESCO Finland
Medical doctor
1.7
6.1
156
1049
TNH32
NOMESCO Finland
Custom moulded split, ankle or foot
10.2
6.0
11
11
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.5
6.0
54
978
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.0
109
658
TNH33
NOMESCO Finland
Custom moulded brace, ankle or foot
5.6
6.0
16
29
K05.18
ICD-10 Finland
Chronic gingivitis
2.6
6.0
42
168
G04BD12
ATC
mirabegron; oral
2.9
6.0
35
127
Mortality – FinRegistry
↥Association
Association between endpoint G6_CP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CP | 3.963 [3.08, 5.1] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.391 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 2065 females with G6_CP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CP | 4.157 [3.3, 5.24] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 321 out of 2713 males with G6_CP died.
Mortality risk
Mortality risk for people of age
years, who have G6_CP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.503% | 0.856% |
| 5 | 2.212% | 4.649% |
| 10 | 5.788% | 11.035% |
| 15 | 11.207% | 20.602% |
| 20 | 18.459% | 32.662% |
Relationships between endpoints
↥Index endpoint: G6_CP – Cerebral palsy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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