Cauda equina syndrome: Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. Signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; ' foot drop '; problems with bowel and/or bladder control; and sexual dysfunction. Cauda equina syndrome may be caused by a herniated disk , tumor , infection, fracture, or spinal stenosis . Treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. Physical therapy , occupational therapy , and/or other services may be required if symptoms persist following surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
454 |
4. Check minimum number of eventsNone |
454 |
5. Include endpointsNone |
454 |
6. Filter based on genotype QC (FinnGen only) |
454 |
Control definitions (FinnGen only)
- Control exclude
- G6_CPETAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G83
- Name in latin
- Syndroma caudae equinae
Similar endpoints
↥List of similar endpoints to
Cauda equina syndrome
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3048 | 1653 | 1377 |
| Only index persons | 2805 | 1572 | 1233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 54.69 | 54.54 | 54.67 |
| Only index persons | 53.39 | 53.76 | 52.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 454 | 279 | 175 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | 52.29 | 50.05 | 55.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 395
- Matched controls
- 3951
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G83.4
ICD-10 Finland
Cauda equina syndrome
4503599627370496.0
323.0
386
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
14.8
117.2
239
371
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
15.1
93.5
172
192
M54.4
ICD-10 Finland
Lumbago with sciatica
7.8
64.3
179
379
N03AX12
ATC
gabapentin; oral
7.9
63.7
174
357
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
10.4
60.1
129
175
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
18.3
60.0
96
68
N03AX16
ATC
pregabalin; oral
6.4
59.8
209
591
N02AX02
ATC
tramadol; systemic, rectal
5.7
56.6
276
1138
M48.0
ICD-10 Finland
Spinal stenosis
8.0
53.5
138
249
R33
ICD-10 Finland
Retention of urine
12.1
52.3
101
109
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
7.9
49.2
126
221
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.3
47.7
150
349
M54.5
ICD-10 Finland
Low back pain
4.8
46.7
229
875
N02AA05
ATC
oxycodone; systemic
6.3
41.2
125
270
ZXD05
NOMESCO Finland
Urgent procedure
4.4
40.4
207
791
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
19.8
40.0
61
36
M54.3
ICD-10 Finland
Sciatica
9.5
37.8
82
106
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
11.5
37.2
72
75
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
10.0
37.1
78
95
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
6.9
35.4
96
175
N06AX21
ATC
duloxetine; oral
6.0
34.7
107
230
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
17.2
33.8
54
36
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.8
33.3
105
231
L03
ICPC
Low back symptom/complaint
4.0
32.0
168
618
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
35.0
32.0
41
13
ZXD35
NOMESCO Finland
Usual procedure
13.1
29.7
53
46
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.4
29.6
98
226
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
15.9
29.3
48
34
L86
ICPC
Back syndrome with radiating pain
7.5
28.2
70
110
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
19.1
28.2
43
25
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
27.4
168
684
G04CA02
ATC
tamsulosin; oral
4.1
25.6
116
363
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
25.2
130
454
M54.1
ICD-10 Finland
Radiculopathy
8.1
24.6
57
80
A06AD11
ATC
lactulose; oral
4.5
24.3
95
257
XKD00
NOMESCO Finland
Uroflowmetry
4.2
22.5
95
276
N06AA09
ATC
amitriptyline; systemic
4.5
22.1
85
225
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
22.1
232
1312
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.0
21.6
97
297
WX704
NOMESCO Finland
Intubation
5.7
21.5
65
132
R15
ICD-10 Finland
Faecal incontinence
11.6
20.9
39
37
N05AH04
ATC
quetiapine; oral
3.6
20.8
109
377
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
27.2
20.7
28
11
WX725
NOMESCO Finland
Noninvasive ventilation
7.9
20.2
47
66
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
9.0
20.1
43
53
M79.6
ICD-10 Finland
Pain in limb
2.8
20.1
187
961
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.9
20.0
91
280
R51.80
ICD-10 Finland
Headache
3.7
20.0
100
334
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
26.2
19.8
27
11
UKC02
NOMESCO Finland
Cystoscopy
3.7
19.8
99
330
N06AX16
ATC
venlafaxine; oral
3.7
19.0
94
309
XKC03
NOMESCO Finland
Water cystometry
9.1
19.0
40
48
N03AX09
ATC
lamotrigine; oral
6.8
18.9
49
81
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
8.3
18.7
42
56
TKC20
NOMESCO Finland
Catheterisation of bladder
5.2
18.2
59
129
N06AX11
ATC
mirtazapine; oral
2.7
17.9
166
835
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
17.9
175
910
G82.2
ICD-10 Finland
Paraplegia, unspecified
188.0
17.7
18
*
M03BX02
ATC
tizanidine; oral
2.6
17.5
280
1901
TKC22
NOMESCO Finland
Catheterisation instruction
13.4
17.4
30
24
J01MA02
ATC
ciprofloxacin; systemic
2.6
17.2
187
1024
N06AB04
ATC
citalopram; systemic
2.9
16.9
124
536
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
16.9
120
510
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
12.4
16.8
30
26
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.8
16.8
58
136
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
16.7
186
1027
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
177.1
16.6
17
*
N05CF01
ATC
zopiclone; oral
2.6
16.5
160
818
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.9
16.4
47
89
M03BC01
ATC
orphenadrine (citrate); systemic
2.8
16.3
131
598
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.6
16.3
49
98
L28
ICPC
Limited function/disability (L)
3.3
16.3
90
320
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
25.8
16.2
22
9
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.1
16.1
67
188
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
16.1
180
992
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
16.0
146
717
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
35.0
15.9
20
6
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
27.6
15.7
21
8
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
15.6
79
262
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.1
15.5
43
78
AA1AD
NOMESCO Finland
CT of head and brain
2.8
15.4
122
549
XKD06
NOMESCO Finland
Physiologic investigation of micturition
9.1
15.3
32
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
15.1
195
1146
WX402
NOMESCO Finland
General anaesthesia
3.1
14.8
93
359
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
14.6
124
580
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
37.6
14.6
18
5
ZXE20
NOMESCO Finland
More than three and less than five hours
3.2
14.5
84
306
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.1
14.5
59
162
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
28.4
14.4
19
7
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
20.1
14.4
21
11
A02BC02
ATC
pantoprazole; systemic
2.4
14.3
275
1941
N03AE01
ATC
clonazepam; systemic
4.9
14.3
48
109
R4110
NOMESCO Finland
Physiotherapy
2.5
14.3
135
669
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
14.0
139
702
A28
ICPC
Limited function/disability NOS
3.3
14.0
77
270
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
14.0
70
229
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.7
14.0
112
504
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
12.0
14.0
25
22
G55.1
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders
18.4
14.0
21
12
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
7.4
14.0
33
48
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.2
13.9
55
147
G43.9
ICD-10 Finland
Migraine, unspecified
5.2
13.8
43
90
UJF32
NOMESCO Finland
Coloscopy
2.5
13.7
126
614
G81.9
ICD-10 Finland
Hemiplegia, unspecified
+∞
13.6
13
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
13.4
63
196
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
7.2
13.3
32
48
N02BE01
ATC
paracetamol; systemic, rectal
3.1
13.3
355
2921
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.3
13.2
50
128
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.2
13.2
75
270
J01EA01
ATC
trimethoprim; systemic
2.5
13.2
123
601
A01
ICPC
Pain general/multiple sites
3.9
13.0
55
156
Z3226
NOMESCO Finland
Physiotherapist
2.7
12.9
101
445
N05AH03
ATC
olanzapine; systemic
4.4
12.9
48
121
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.3
12.9
71
249
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
12.8
96
413
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
12.8
51
137
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.2
12.8
40
84
K59.0
ICD-10 Finland
Constipation
5.2
12.8
40
84
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.7
12.8
59
181
P76
ICPC
Depressive disorder
4.3
12.6
47
119
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
13.8
12.6
21
16
M54.2
ICD-10 Finland
Cervicalgia
4.2
12.5
49
130
U05
ICPC
Urination problems other
5.5
12.5
37
73
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
12.4
96
420
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
10.1
12.4
24
25
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
10.1
12.4
24
25
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.4
12.3
64
215
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
12.2
108
508
M47.82
ICD-10 Finland
Other spondylosis, cervical region
5.5
12.0
35
68
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
8.8
12.0
25
30
SPAT1229
SPAT
Assessment of need for aid
3.9
12.0
51
146
M25.5
ICD-10 Finland
Pain in joint
2.3
11.9
138
746
P03
ICPC
Feeling depressed
3.6
11.9
55
169
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.8
11.8
33
61
N05BA04
ATC
oxazepam; oral
2.4
11.8
121
617
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
17.1
11.8
18
11
N30.0
ICD-10 Finland
Acute cystitis
3.0
11.8
74
284
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.2
11.7
45
117
A04
ICPC
Weakness/tiredness general
3.1
11.7
67
242
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.5
11.7
41
98
R52.2
ICD-10 Finland
Other chronic pain
5.7
11.6
33
62
M01AH05
ATC
etoricoxib; oral
2.1
11.5
258
1854
C03CA01
ATC
furosemide; systemic
2.4
11.5
119
607
SPAT1167
SPAT
Insertion of urinary catheter
8.7
11.5
24
29
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.8
11.5
32
59
K59.09
ICD-10 Finland
Constipation, unspecified
4.4
11.4
42
105
SPAT1263
SPAT
Sampling
2.1
11.4
191
1213
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
11.4
87
376
SPAT1153
SPAT
Removal of sutures
2.2
11.4
146
824
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.7
11.3
85
364
L17
ICPC
Foot/toe symptom/complaint
2.3
11.2
121
627
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
11.2
176
1086
R20.2
ICD-10 Finland
Paraesthesia of skin
3.9
11.2
46
128
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
11.1
120
623
M01AB05
ATC
diclofenac; systemic, rectal
2.1
11.0
283
2136
RF210
NOMESCO Finland
NA
6.5
11.0
28
46
R53
ICD-10 Finland
Malaise and fatigue
2.4
10.9
104
507
S06.0
ICD-10 Finland
Concussion
3.2
10.9
60
208
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
9.2
10.9
22
25
9211
FHL
Exploration or removal of diskusprolapse
9.2
10.9
22
25
N05BA01
ATC
diazepam; systemic, rectal
2.8
10.9
73
291
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.6
10.9
51
158
M03BX01
ATC
baclofen; systemic
11.0
10.9
20
19
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
10.8
47
137
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
5.0
10.7
34
73
R32
ICD-10 Finland
Unspecified urinary incontinence
6.9
10.7
26
40
SPAT1262
SPAT
Handing over of treatment supplies
2.6
10.7
88
395
N07BC02
ATC
methadone; systemic
61.7
10.7
12
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.2
10.6
59
207
H02AB06
ATC
prednisolone; systemic
2.0
10.5
199
1312
ZXA05
NOMESCO Finland
Left side
2.3
10.5
120
638
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.3
10.5
39
99
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
12.5
10.4
18
15
TAB00
NOMESCO Finland
Lumbar puncture
4.8
10.3
34
76
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
10.2
84
378
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.1
10.2
59
214
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
11.7
10.2
18
16
N18
ICPC
Paralysis/weakness
11.7
10.2
18
16
R39.1
ICD-10 Finland
Other difficulties with micturition
7.6
10.1
23
32
J01FF01
ATC
clindamycin; systemic
2.2
10.1
123
671
J01CA08
ATC
pivmecillinam; oral
2.0
10.1
174
1102
Z02.7
ICD-10 Finland
Issue of medical certificate
4.1
10.0
39
103
ABC66
NOMESCO Finland
Decompression of lumbal spinal channel
41.2
10.0
12
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
9.9
132
747
J01DB01
ATC
cefalexin; oral
2.4
9.9
335
2771
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.0
9.9
31
66
N05CD07
ATC
temazepam; oral
2.8
9.9
68
276
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.6
9.8
44
132
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
13.8
9.7
16
12
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.3
9.7
49
161
N05AX12
ATC
aripiprazole; systemic
5.5
9.7
28
54
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.6
9.7
44
133
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.2
9.7
51
173
Z2446
NOMESCO Finland
Social worker
3.5
9.7
45
139
S93.4
ICD-10 Finland
Sprain and strain of ankle
3.0
9.6
58
214
U07
ICPC
Urine symptom/complaint other
4.0
9.6
38
102
P29
ICPC
Psychological sympt/compl other
4.0
9.6
38
102
N05AA02
ATC
levomepromazine; systemic
4.3
9.6
35
87
ZXA00
NOMESCO Finland
Right side
2.2
9.6
125
699
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
9.6
98
492
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
15.5
9.6
15
10
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.4
9.5
34
83
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.1
9.5
37
98
Z71.8
ICD-10 Finland
Other specified counselling
2.2
9.5
114
615
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.7
9.5
41
119
NA7BT
NOMESCO Finland
Injection to spinal facet joint with radiological guidance
30.8
9.4
12
*
F34.1
ICD-10 Finland
Dysthymia
5.3
9.4
28
56
X58
ICD-10 Finland
Exposure to other specified factors
2.7
9.4
69
290
3534B
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral root lesions, not elsewhere classified[SYNDROMA CAUDAE EQUINAE]
+∞
9.4
9
*
C07AA05
ATC
propranolol; systemic
2.3
9.4
96
480
A02BC01
ATC
omeprazole; systemic
2.1
9.4
122
683
S18
ICPC
Laceration/cut
2.0
9.4
172
1106
SPAT1240
SPAT
Therapeutic discussion
2.9
9.3
60
230
M54.8
ICD-10 Finland
Other dorsalgia
4.5
9.2
32
76
B01AB05
ATC
enoxaparin; parenteral
2.1
9.2
129
743
U13
ICPC
Bladder symptom/complaint other
6.5
9.2
23
37
NF3AA
NOMESCO Finland
Femur X-ray examination
8.6
9.2
19
23
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
16.1
9.1
14
9
A02BC05
ATC
esomeprazole; systemic
2.0
9.1
171
1106
P01AB01
ATC
metronidazole; oral, rectal
1.9
9.0
180
1190
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
19.1
9.0
13
7
SPAT1254
SPAT
Administration of medicine
2.5
9.0
74
332
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.0
109
591
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
8.9
41
126
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.7
8.9
65
273
N06AB10
ATC
escitalopram; oral
2.2
8.8
96
493
Z3231
NOMESCO Finland
Registered nurse
2.1
8.8
126
732
R52.1
ICD-10 Finland
Chronic intractable pain
14.5
8.7
14
10
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
8.7
62
256
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
5.0
8.7
27
57
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
8.7
66
281
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
8.6
83
402
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.6
8.6
38
113
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.9
8.6
23
41
M70.6
ICD-10 Finland
Trochanteric bursitis
2.7
8.5
60
246
G99.2*M51.0
ICD-10 Finland
Lumbar and other intervertebral disc disorders with myelopathy
28.2
8.5
11
*
Z50.1
ICD-10 Finland
Other physical therapy
3.7
8.3
35
100
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
5.4
8.3
24
47
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
4.9
8.3
26
56
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
8.3
81
396
M89.0
ICD-10 Finland
Algoneurodystrophy
14.9
8.3
13
9
M47.9
ICD-10 Finland
Spondylosis, unspecified
5.1
8.2
25
52
F61.0
ICD-10 Finland
Mixed personality disorders
7.1
8.2
19
28
R42
ICD-10 Finland
Dizziness and giddiness
2.2
8.1
96
510
A02BA02
ATC
ranitidine; systemic
2.3
8.1
86
433
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
12.0
8.1
14
12
U08
ICPC
Urinary retention
9.2
8.1
16
18
F60.9
ICD-10 Finland
Personality disorder, unspecified
9.2
8.1
16
18
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
9.2
8.1
16
18
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
22.6
8.1
11
5
P80
ICPC
Personality disorder
22.6
8.1
11
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
8.0
65
286
N06AB06
ATC
sertraline; oral
2.6
8.0
58
242
N06AX03
ATC
mianserin; oral
3.7
8.0
34
98
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.0
8.0
130
788
N05AX08
ATC
risperidone; systemic
3.1
8.0
43
149
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
8.0
8.0
17
22
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
7.9
45
161
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
7.9
49
185
G44.8
ICD-10 Finland
Other specified headache syndromes
8.7
7.9
16
19
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.2
7.9
18
26
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
11.1
7.8
14
13
K07
ICPC
Swollen ankles/oedema
4.1
7.8
29
74
M01AC06
ATC
meloxicam; systemic, rectal
1.9
7.7
155
1011
N06AB03
ATC
fluoxetine; oral
2.5
7.7
61
266
R60.0
ICD-10 Finland
Localized oedema
2.7
7.7
52
207
NA3CM
NOMESCO Finland
Lumbar spine extensive MRI examination with 3 Tesla magnet
45.9
7.7
9
*
J01MA12
ATC
levofloxacin; systemic
2.3
7.7
79
394
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
4.3
7.6
27
66
A02BC03
ATC
lansoprazole; oral
2.0
7.6
124
747
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.3
7.6
37
119
D17
ICPC
Incontinence of bowel
12.2
7.6
13
11
WX110
NOMESCO Finland
Local anesthesy
1.9
7.6
276
2188
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
7.6
101
562
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
5.0
7.6
23
48
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
7.6
40
137
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.9
7.5
44
161
M01AE01
ATC
ibuprofen; systemic, rectal
2.5
7.5
360
3178
R35
ICD-10 Finland
Polyuria
3.4
7.5
35
109
R4120
NOMESCO Finland
Occupational therapy
3.2
7.5
38
126
W19
ICD-10 Finland
Unspecified fall
2.8
7.5
48
186
P01
ICPC
Feeling anxious/nervous/tense
2.7
7.5
51
205
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
6.2
7.5
19
32
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
7.5
46
172
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
7.4
89
473
N03AF02
ATC
oxcarbazepine; oral
4.7
7.4
24
54
N06AX12
ATC
bupropion; oral
3.2
7.4
37
122
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
7.3
157
1042
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.6
7.3
20
37
G83.9
ICD-10 Finland
Paralytic syndrome, unspecified
+∞
7.3
7
*
NAW00
NOMESCO Finland
Repair of wound dehiscence in surgery of spine or neck
+∞
7.3
7
*
N06AA10
ATC
nortriptyline; systemic
6.0
7.3
19
33
R31
ICD-10 Finland
Unspecified haematuria
2.9
7.3
45
168
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
16.1
7.3
11
7
K59.1
ICD-10 Finland
Functional diarrhoea
3.7
7.3
30
85
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
7.5
7.3
16
22
A03
ICPC
Fever
2.2
7.2
74
368
WX290
NOMESCO Finland
Other blockade of nerve
1.8
7.2
186
1313
N81
ICPC
Injury nervous system other
30.6
7.2
9
*
Z43.5
ICD-10 Finland
Attention to cystostomy
30.6
7.2
9
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
8.2
7.2
15
19
G44.2
ICD-10 Finland
Tension-type headache
2.4
7.1
62
284
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
7.1
69
334
H01
ICPC
Ear pain/earache
2.6
7.1
51
211
RS221
NOMESCO Finland
NA
7.2
7.1
16
23
R4110
SPAT
NA
5.3
7.0
20
39
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
5.3
7.0
20
39
N07BB01
ATC
disulfiram; oral
3.8
7.0
28
77
N03AG01
ATC
valproic acid; systemic, rectal
3.2
7.0
36
121
N04BC05
ATC
pramipexole; oral
3.2
7.0
36
121
R02
ICPC
Shortness of breath/dyspnoea
2.5
6.9
56
247
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.8
6.8
43
164
D12
ICPC
Constipation
4.5
6.8
23
54
S49.9
ICD-10 Finland
Unspecified injury of shoulder and upper arm
9.6
6.8
13
14
WX400
NOMESCO Finland
Inhalation anesthesy
3.8
6.8
27
74
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.9
6.8
115
699
N05AD01
ATC
haloperidol; systemic
4.9
6.8
21
45
M01AH01
ATC
celecoxib; oral (coxibs)
2.1
6.8
83
445
R06AE07
ATC
cetirizine; oral
1.8
6.7
182
1291
SPAT1301
SPAT
No procedures
1.8
6.7
129
821
F43.1
ICD-10 Finland
Post-traumatic stress disorder
6.6
6.7
16
25
M51.2
ICD-10 Finland
Other specified intervertebral disc displacement
23.0
6.7
9
*
SPAT1216
SPAT
Assessment of functional ability
2.3
6.7
64
307
ZXE00
NOMESCO Finland
One hour or less
1.8
6.7
157
1068
L02
ICPC
Back symptom/complaint
2.6
6.7
47
194
N30.9
ICD-10 Finland
Cystitis, unspecified
3.3
6.7
32
103
M13.9
ICD-10 Finland
Arthritis, unspecified
3.0
6.6
38
137
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
3.4
6.6
30
93
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.0
6.5
37
132
G04BD08
ATC
solifenacin; oral
3.0
6.5
37
132
F32.8
ICD-10 Finland
Other depressive episodes
7.6
6.5
14
19
S80.0
ICD-10 Finland
Contusion of knee
3.1
6.5
34
117
TAD08
NOMESCO Finland
Sympathetic block on sacral Level
70.9
6.4
7
*
T91.3
ICD-10 Finland
Sequelae of injury of spinal cord
70.9
6.4
7
*
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
6.4
217
1639
L12
ICPC
Hand/finger symptom/complaint
2.2
6.4
63
307
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
6.4
48
204
TAB20
NOMESCO Finland
Epidural puncture
14.6
6.4
10
7
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.3
6.4
22
53
XF600
NOMESCO Finland
Bloodpressure measurement
3.1
6.4
33
112
SPAT1307
SPAT
Psychosocial counselling and guidance
3.1
6.4
33
112
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.3
6.4
18
35
N06AX22
ATC
agomelatine; oral
5.3
6.4
18
35
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.4
6.4
55
249
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
5.7
6.4
17
31
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.2
6.3
32
107
D11
ICPC
Diarrhoea
2.4
6.3
55
252
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
11.3
6.3
11
10
N03AX11
ATC
topiramate; oral
4.5
6.3
21
49
N83.1
ICD-10 Finland
Corpus luteum cyst
9.5
6.3
12
13
G56.4
ICD-10 Finland
Causalgia
18.4
6.3
9
5
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.5
6.3
27
80
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
5.2
6.3
18
36
ABD99
NOMESCO Finland
Other operation on spinal cord or nerve for pain or impaired function
27.1
6.2
8
*
J01XX08
ATC
linezolid; systemic
27.1
6.2
8
*
A46
ICD-10 Finland
Erysipelas
2.3
6.2
57
270
N02AC04
ATC
dextropropoxyphene; oral
4.2
6.2
22
55
N76.0
ICD-10 Finland
Acute vaginitis
3.3
6.2
29
92
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.7
6.2
41
164
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.9
6.1
35
126
R13
ICD-10 Finland
Dysphagia
3.1
6.1
31
104
C01CA24
ATC
epinephrine; parenteral
3.1
6.1
32
110
ZZH31
NOMESCO Finland
Bone allograft, small pieces
12.8
6.1
10
8
N05AF03
ATC
chlorprothixene; systemic
4.3
6.1
21
51
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.3
6.1
29
93
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.5
6.1
27
82
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
8.8
6.1
12
14
RF220
NOMESCO Finland
NA
6.9
6.1
14
21
E66.8
ICD-10 Finland
Other obesity
3.2
6.1
30
99
Y69
ICD-10 Finland
Unspecified misadventure during surgical and medical care
10.2
6.1
11
11
R11
ICD-10 Finland
Nausea and vomiting
2.7
6.1
39
152
F32.1
ICD-10 Finland
Moderate depressive episode
3.2
6.0
29
94
Mortality – FinRegistry
↥Association
Association between endpoint G6_CAUDA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUDA | 1.674 [1.35, 2.08] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.302 |
During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 1360 females with G6_CAUDA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUDA | 2.282 [1.82, 2.85] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 1078 males with G6_CAUDA died.
Mortality risk
Mortality risk for people of age
years, who have G6_CAUDA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.472% |
| 5 | 0.849% | 2.728% |
| 10 | 2.433% | 6.745% |
| 15 | 5.003% | 13.023% |
| 20 | 8.671% | 21.312% |
Relationships between endpoints
↥Index endpoint: G6_CAUDA – Cauda equina syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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