carpal tunnel syndrome: Entrapment of the median nerve in the wrist that is characterized by numbness, tingling and painful movement.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
32005 |
4. Check minimum number of eventsNone |
32005 |
5. Include endpointsNone |
32005 |
6. Filter based on genotype QC (FinnGen only) |
32005 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G56
- Name in latin
- Syndroma canalis carpi
Similar endpoints
↥List of similar endpoints to Carpal tunnel syndrome based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 197586 | 131488 | 65397 |
Only index persons | 188924 | 126663 | 62261 |
Unadjusted period prevalence (%) | |||
Whole population | 3.11 | 3.77 | 1.83 |
Only index persons | 3.91 | 4.66 | 2.38 |
Median age at first event (years) | |||
Whole population | 54.12 | 54.15 | 54.07 |
Only index persons | 53.75 | 53.79 | 53.69 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 32005 | 22029 | 9976 |
Unadjusted period prevalence (%) | 6.54 | 7.51 | 4.40 |
Median age at first event (years) | 53.85 | 52.77 | 56.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 28596
- Matched controls
- 260708
Mortality – FinRegistry
↥Association
Association between endpoint G6_CARPTU and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
G6_CARPTU | 0.916 [0.84, 0.99] | 0.037 |
Birth year | 0.992 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 11743 out of 105909 females with G6_CARPTU died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
G6_CARPTU | 0.864 [0.79, 0.94] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 7586 out of 53592 males with G6_CARPTU died.
Mortality risk
Mortality risk for people of age
years, who have G6_CARPTU.N-year risk | Females | Males |
---|---|---|
1 | 0.058% | 0.174% |
5 | 0.429% | 1.035% |
10 | 1.08% | 2.625% |
15 | 2.11% | 4.945% |
20 | 3.705% | 8.318% |
Relationships between endpoints
↥Index endpoint: G6_CARPTU – Carpal tunnel syndrome
GWS hits: 71