pseudotumor cerebri: Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
358 |
4. Check minimum number of eventsNone |
358 |
5. Include endpointsNone |
358 |
6. Filter based on genotype QC (FinnGen only) |
358 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Hypertensio intracranialis benigna
Similar endpoints
↥List of similar endpoints to
Benign intracranial hypertension
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1710 | 1314 | 380 |
| Only index persons | 1612 | 1273 | 339 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 31.63 | 30.53 | 35.22 |
| Only index persons | 31.49 | 30.53 | 35.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 358 | 300 | 58 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.03 |
| Median age at first event (years) | 34.03 | 32.91 | 39.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 328
- Matched controls
- 3280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.2
ICD-10 Finland
Benign intracranial hypertension
+∞
323.0
317
*
S01EC01
ATC
acetazolamide; systemic
842.4
265.8
228
9
H47.1
ICD-10 Finland
Papilloedema, unspecified
953.6
173.3
155
*
TAB00
NOMESCO Finland
Lumbar puncture
52.1
120.9
145
49
Z01.0
ICD-10 Finland
Examination of eyes and vision
16.7
98.3
181
225
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
23.6
71.8
106
65
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
27.9
71.0
99
50
XCK00
NOMESCO Finland
Perimetry
23.9
68.2
100
59
R51.80
ICD-10 Finland
Headache
9.5
68.2
172
340
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
14.0
60.9
112
117
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
44.1
57.0
70
20
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
60.8
55.4
64
13
XCW99
NOMESCO Finland
Other investigative procedure of eye
11.8
48.3
95
109
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
+∞
44.8
42
*
CS494
NOMESCO Finland
Other visual field testing
52.1
41.4
49
11
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
57.7
38.7
45
9
AA1AD
NOMESCO Finland
CT of head and brain
6.1
34.2
106
237
E66.01
ICD-10 Finland
Obesity due to excess calories
6.9
32.2
88
165
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
8.3
31.0
73
109
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
50.3
30.3
36
8
N03AX11
ATC
topiramate; oral
13.8
29.7
52
44
XCK10
NOMESCO Finland
Photography of fundus of eye
9.7
28.4
60
74
H53.1
ICD-10 Finland
Subjective visual disturbances
9.8
27.2
57
69
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
15.2
26.9
45
34
C03CA01
ATC
furosemide; systemic
6.3
26.0
75
148
E66.8
ICD-10 Finland
Other obesity
7.9
25.5
61
92
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
111.8
19.8
21
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
17.9
17
*
H47.3
ICD-10 Finland
Other disorders of optic disc
178.7
16.7
17
*
G44.2
ICD-10 Finland
Tension-type headache
3.5
15.8
84
295
A02BC02
ATC
pantoprazole; systemic
2.6
15.5
207
1298
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.9
15.2
52
122
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
26.5
14.9
20
8
G47.3
ICD-10 Finland
Sleep apnoea
3.7
14.7
69
218
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
14.7
14
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.4
14.4
44
91
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.6
13.9
36
60
XCD10
NOMESCO Finland
Electrophysiological examination of eye
14.4
13.9
23
17
R42
ICD-10 Finland
Dizziness and giddiness
3.3
13.8
77
278
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
13.6
13
*
N02BE01
ATC
paracetamol; systemic, rectal
3.1
13.4
284
2217
H02AB06
ATC
prednisolone; systemic
2.4
13.0
156
892
E66.9
ICD-10 Finland
Obesity, unspecified
6.1
12.8
35
63
H53.4
ICD-10 Finland
Visual field defects
21.1
12.6
18
9
3482A
ICD-9 Finland
Other conditions of brain, Benign intracranial hypertension
+∞
12.6
12
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
12.6
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
12.3
117
587
N02AX02
ATC
tramadol; systemic, rectal
2.5
12.2
120
610
H53.9
ICD-10 Finland
Visual disturbance, unspecified
11.1
12.0
22
21
R4190
NOMESCO Finland
Nutritional therapy
7.0
11.9
29
45
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
67.4
11.7
13
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
11.5
11
*
E23.06
ICD-10 Finland
Empty sella
124.2
11.5
12
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
3.5
11.4
55
177
T82
ICPC
Obesity
6.0
11.4
31
56
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
11.1
103
506
H57.1
ICD-10 Finland
Ocular pain
8.4
10.8
23
29
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
9.0
10.7
22
26
N03AX16
ATC
pregabalin; oral
2.8
10.6
74
308
N03AX12
ATC
gabapentin; oral
3.2
10.4
58
207
R03AC02
ATC
salbutamol; inhalant
2.1
9.9
194
1331
A10BA02
ATC
metformin; oral
3.0
9.8
60
229
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.4
9.5
89
434
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
9.4
9
*
ZXA10
NOMESCO Finland
Bilateral
2.9
9.3
60
236
H47.2
ICD-10 Finland
Optic atrophy
37.8
9.1
11
*
C09CA06
ATC
candesartan; oral
2.8
9.0
64
265
J01FF01
ATC
clindamycin; systemic
2.4
9.0
88
437
SPAT1153
SPAT
Removal of sutures
2.3
8.7
96
504
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
8.6
63
268
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
28.4
8.5
11
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
28.4
8.5
11
*
H53.2
ICD-10 Finland
Diplopia
8.2
8.5
18
23
G43.9
ICD-10 Finland
Migraine, unspecified
3.3
8.4
43
145
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
8.4
8
*
C08CA01
ATC
amlodipine; oral
2.7
8.3
61
258
M01AE02
ATC
naproxen; oral, rectal
2.0
8.1
205
1498
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
8.1
75
362
H02AB04
ATC
methylprednisolone; systemic
2.9
8.0
50
192
SPAT1249
SPAT
Treatment-related counselling outside office
2.0
8.0
160
1072
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
46.1
7.7
9
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
7.7
60
262
M79.6
ICD-10 Finland
Pain in limb
2.1
7.7
113
667
Z3229
NOMESCO Finland
Other healthcare associate professional
4.1
7.7
29
76
R53
ICD-10 Finland
Malaise and fatigue
2.3
7.6
78
396
J35.1
ICD-10 Finland
Hypertrophy of tonsils
5.8
7.5
20
36
C09AA05
ATC
ramipril; oral
3.1
7.5
42
150
C09CA01
ATC
losartan; oral
2.9
7.4
46
175
N05CF01
ATC
zopiclone; oral
2.2
7.4
86
458
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
6.5
7.3
18
29
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
7.3
7
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
7.3
122
758
R01AD09
ATC
mometasone; nasal
1.9
7.2
170
1193
N06AX16
ATC
venlafaxine; oral
2.4
7.1
64
301
SPAT1260
SPAT
Consultation of another employee
2.4
7.1
64
301
KH1AD
NOMESCO Finland
CT of urinary organs
6.6
7.0
17
27
N06AX21
ATC
duloxetine; oral
2.8
7.0
47
187
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.3
6.9
20
40
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.8
6.9
44
172
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
8.5
6.9
14
17
H02AB09
ATC
hydrocortisone; systemic
6.3
6.9
17
28
R51
ICD-10 Finland
Headache
3.2
6.8
34
113
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
6.6
68
343
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.4
6.6
58
269
M03BX02
ATC
tizanidine; oral
1.8
6.6
196
1470
N06AX11
ATC
mirtazapine; oral
1.9
6.6
108
660
N20.1
ICD-10 Finland
Calculus of ureter
6.4
6.5
16
26
H93.1
ICD-10 Finland
Tinnitus
4.1
6.5
24
62
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
14.7
6.4
10
7
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.4
6.4
18
35
SPAT1310
SPAT
Counselling related to known health issue
1.9
6.4
121
775
C07AB07
ATC
bisoprolol; oral
2.0
6.3
86
488
C10AA05
ATC
atorvastatin; oral
2.4
6.3
55
256
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
6.3
41
163
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
6.3
6
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
6.3
6
*
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
+∞
6.3
6
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
6.2
67
345
N05BA04
ATC
oxazepam; oral
2.0
6.1
84
476
N01
ICPC
Headache
2.2
6.1
66
340
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
6.1
45
192
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
6.0
92
544
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
6.0
107
668
N05AH04
ATC
quetiapine; oral
2.1
6.0
70
373
Mortality – FinRegistry
↥Association
Association between endpoint G6_BENINTRAHYP and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have G6_BENINTRAHYP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: G6_BENINTRAHYP – Benign intracranial hypertension
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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