alcoholic neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
345 |
4. Check minimum number of eventsNone |
345 |
5. Include endpointsNone |
345 |
6. Filter based on genotype QC (FinnGen only) |
345 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G62
- Name in latin
- Polyneuropathia alcoholica
Similar endpoints
↥List of similar endpoints to
Alcohol induced polyneuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4609 | 835 | 3665 |
| Only index persons | 3095 | 628 | 2467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.02 | 0.10 |
| Only index persons | 0.08 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 56.02 | 57.32 |
| Only index persons | 57.57 | 57.05 | 57.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 345 | 68 | 277 |
| Unadjusted period prevalence (%) | 0.10 | 0.02 | 0.12 |
| Median age at first event (years) | 58.20 | 55.50 | 58.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 303
- Matched controls
- 3030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
4503599627370496.0
323.0
278
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
29.8
109.7
156
104
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
107.6
86.0
91
12
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
124.2
57.2
60
6
F10.25
ICD-10 Finland
Alcohol dependence continuous use
42.6
54.2
67
20
F10.20
ICD-10 Finland
Alcohol dependence currently independent
30.9
50.8
68
28
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
24.0
47.2
68
36
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
35.5
45.1
58
20
F10.24
ICD-10 Finland
Alcohol depence active use
42.6
35.8
44
12
P15
ICPC
Chronic alcohol abuse
18.5
34.6
54
35
N07BB01
ATC
disulfiram; oral
10.8
30.5
61
69
3575A
ICD-9 Finland
Inflammatory and toxic neuropathy, Alcoholic polyneuropathy
+∞
29.7
28
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
19.1
28.1
43
26
N05CD07
ATC
temazepam; oral
5.6
27.3
90
213
N05BA02
ATC
chlordiazepoxide; systemic
13.4
25.5
45
39
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.9
25.2
139
542
N05AH04
ATC
quetiapine; oral
5.1
25.2
91
236
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
24.6
25.0
35
16
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
23.8
24.1
34
16
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
15.4
22.5
37
27
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
31.9
22.3
29
10
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
17.0
22.1
35
23
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.4
22.1
93
278
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.2
22.0
47
59
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
18.4
21.5
33
20
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.8
21.2
64
133
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
20.9
131
547
N05CF01
ATC
zopiclone; oral
3.3
20.5
139
612
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
33.9
19.6
25
8
N06AX11
ATC
mirtazapine; oral
3.3
19.5
127
538
N06AB04
ATC
citalopram; systemic
3.7
19.1
98
343
N05BA04
ATC
oxazepam; oral
3.5
18.7
107
409
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
18.6
120
500
K70.1
ICD-10 Finland
Alcoholic hepatitis
27.1
18.5
25
10
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
21.7
18.1
26
13
N03AX12
ATC
gabapentin; oral
4.3
18.1
73
206
F10.09
ICD-10 Finland
Alcohol intoxication UNS
13.1
17.8
31
26
AA1AD
NOMESCO Finland
CT of head and brain
3.3
17.3
109
442
C03DA01
ATC
spironolactone; oral
4.6
16.9
63
163
A06AD11
ATC
lactulose; oral
3.7
16.4
82
278
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.8
15.8
34
43
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.9
15.6
71
221
N05AA02
ATC
levomepromazine; systemic
7.5
15.6
37
55
C03CA01
ATC
furosemide; systemic
2.9
15.4
124
586
R53
ICD-10 Finland
Malaise and fatigue
3.3
14.9
85
316
E87.6
ICD-10 Finland
Hypokalaemia
10.9
14.8
28
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
14.7
70
226
K70.4
ICD-10 Finland
Alcoholic hepatic failure
38.1
14.6
18
5
P16
ICPC
Acute alcohol abuse
13.6
14.2
24
19
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
18.7
14.0
21
12
A28
ICPC
Limited function/disability NOS
3.5
14.0
74
257
L28
ICPC
Limited function/disability (L)
3.4
13.6
73
257
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
22.4
13.5
19
9
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
13.5
61
188
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
13.9
13.1
22
17
K70.0
ICD-10 Finland
Alcoholic fatty liver
29.9
13.1
17
6
W19
ICD-10 Finland
Unspecified fall
4.3
13.1
51
137
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
52.4
13.0
15
*
K92.0
ICD-10 Finland
Haematemesis
7.6
12.9
30
43
N05BA01
ATC
diazepam; systemic, rectal
3.5
12.9
67
230
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.9
12.9
27
33
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
18.3
12.7
19
11
Z72.1
ICD-10 Finland
Alcohol use
21.2
12.6
18
9
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
135.4
12.5
13
*
G62.8
ICD-10 Finland
Other specified polyneuropathies
135.4
12.5
13
*
S72.0
ICD-10 Finland
Fracture of neck of femur
6.6
12.5
32
53
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
12.0
78
313
A46
ICD-10 Finland
Erysipelas
3.1
11.9
71
269
N06AB03
ATC
fluoxetine; oral
3.8
11.8
53
162
N06AB10
ATC
escitalopram; oral
3.0
11.6
74
291
S42.2
ICD-10 Finland
Fracture of upper end of humerus
7.6
11.3
26
37
N03AF01
ATC
carbamazepine; oral, rectal
5.3
11.1
34
71
Z2446
NOMESCO Finland
Social worker
4.7
11.1
38
90
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
12.6
11.0
19
16
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.4
11.0
56
189
V03AA01
ATC
NA
9.0
10.7
22
26
K85
ICD-10 Finland
Acute pancreatitis
11.8
10.7
19
17
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
6.2
10.6
28
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
10.5
96
467
S01.0
ICD-10 Finland
Open wound of scalp
4.0
10.5
42
116
N03AX16
ATC
pregabalin; oral
2.5
10.4
94
456
SPAT1265
SPAT
Breathalyser
19.6
10.4
15
8
N02AX02
ATC
tramadol; systemic, rectal
2.2
10.3
159
1003
N05AB01
ATC
dixyrazine; systemic
11.9
10.2
18
16
N06AA09
ATC
amitriptyline; systemic
3.7
10.0
44
132
Z3226
NOMESCO Finland
Physiotherapist
2.7
9.6
71
306
S22.3
ICD-10 Finland
Fracture of rib
3.9
9.5
39
110
ZXD05
NOMESCO Finland
Urgent procedure
2.3
9.5
109
595
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
9.2
71
312
R18
ICD-10 Finland
Ascites
8.7
9.2
19
23
L89
ICD-10 Finland
Decubitus ulcer and pressure area
12.0
9.2
16
14
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
6.9
9.1
22
34
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.1
9.1
35
93
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.7
9.1
40
120
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.7
9.0
30
69
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
24.9
9.0
12
5
N05AD03
ATC
melperone; systemic
13.1
9.0
15
12
N06AX16
ATC
venlafaxine; oral
3.2
8.9
49
172
R60.0
ICD-10 Finland
Localized oedema
3.2
8.9
47
163
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.3
8.8
32
81
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
8.7
27
58
A02BC01
ATC
omeprazole; systemic
2.3
8.7
97
518
F34.1
ICD-10 Finland
Dysthymia
6.3
8.6
22
37
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
+∞
8.4
8
*
C07AA05
ATC
propranolol; systemic
2.6
8.3
63
274
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
8.3
47
171
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
8.2
42
142
N05BE01
ATC
buspirone; oral
6.9
8.0
19
29
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
5.3
7.9
23
46
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.7
7.8
33
96
G63.2
ICD-10 Finland
Diabetic polyneuropathy
46.2
7.8
9
*
F10.23
ICD-10 Finland
Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication
46.2
7.8
9
*
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
46.2
7.8
9
*
N02AA05
ATC
oxycodone; systemic
2.6
7.7
57
244
Z02.7
ICD-10 Finland
Issue of medical certificate
3.8
7.7
32
92
V03AB30
ATC
NA
19.0
7.7
11
6
R4110
NOMESCO Finland
Physiotherapy
2.2
7.6
92
502
M04AA01
ATC
allopurinol; systemic
2.5
7.5
61
276
F10
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol
82.0
7.4
8
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
8.7
7.4
15
18
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
9.7
7.4
14
15
S06.0
ICD-10 Finland
Concussion
3.0
7.3
43
160
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
7.3
65
307
K29.2
ICD-10 Finland
Alcoholic gastritis
+∞
7.3
7
*
G72.8
ICD-10 Finland
Other specified myopathies
16.2
7.3
11
7
N06AX21
ATC
duloxetine; oral
3.1
7.3
40
140
N05AF03
ATC
chlorprothixene; systemic
6.3
7.2
18
30
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
20.6
7.2
10
5
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
7.2
54
233
SPAT1216
SPAT
Assessment of functional ability
2.6
7.1
56
247
A02BC02
ATC
pantoprazole; systemic
1.9
7.0
197
1483
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
7.0
40
146
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
7.0
56
251
X58
ICD-10 Finland
Exposure to other specified factors
2.6
7.0
53
230
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
7.0
6.9
16
24
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.9
6.9
21
45
M79.6
ICD-10 Finland
Pain in limb
2.0
6.8
109
663
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.9
6.8
27
75
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
41.0
6.8
8
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
5.0
6.7
20
42
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.1
6.7
37
131
JDB10
NOMESCO Finland
Percutaneous gastrostomy
12.6
6.6
11
9
N06AB06
ATC
sertraline; oral
3.2
6.6
34
116
N30.0
ICD-10 Finland
Acute cystitis
3.0
6.6
37
133
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
6.5
60
287
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
6.5
34
118
R27.0
ICD-10 Finland
Ataxia, unspecified
71.3
6.4
7
*
SPAT1240
SPAT
Therapeutic discussion
3.3
6.4
31
101
F61.0
ICD-10 Finland
Mixed personality disorders
11.4
6.3
11
10
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
11.4
6.3
11
10
K86.1
ICD-10 Finland
Other chronic pancreatitis
11.4
6.3
11
10
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
11.4
6.3
11
10
Z2221
NOMESCO Finland
Medical doctor
2.1
6.3
84
476
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
18.5
6.3
9
5
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.5
6.3
28
86
N05AX08
ATC
risperidone; systemic
3.2
6.3
32
109
S92
ICD-10 Finland
Fracture of foot, except ankle
+∞
6.3
6
*
E51.2
ICD-10 Finland
Wernicke encephalopathy
27.3
6.3
8
*
S82.6
ICD-10 Finland
Fracture of lateral malleolus
3.6
6.2
27
81
N03AX14
ATC
levetiracetam; systemic
7.9
6.2
13
17
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.7
6.2
25
71
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.7
6.2
25
71
A41.9
ICD-10 Finland
Sepsis, unspecified
4.6
6.2
20
46
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
6.2
42
170
S82.2
ICD-10 Finland
Fracture of shaft of tibia
12.9
6.1
10
8
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
8.9
6.1
12
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
6.1
62
313
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.8
6.1
24
67
N06AA12
ATC
doxepin; systemic
3.9
6.0
23
62
SPAT1254
SPAT
Administration of medicine
2.4
6.0
52
239
Mortality – FinRegistry
↥Association
Association between endpoint G6_ALCOPOLY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 6.471 [5.09, 8.24] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.275 |
During the follow-up period (1.1.1998 — 31.12.2019), 255 out of 596 females with G6_ALCOPOLY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ALCOPOLY | 5.295 [4.65, 6.04] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1346 out of 2491 males with G6_ALCOPOLY died.
Mortality risk
Mortality risk for people of age
years, who have G6_ALCOPOLY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.432% | 0.871% |
| 5 | 3.556% | 5.907% |
| 10 | 9.79% | 13.436% |
| 15 | 17.855% | 24.306% |
| 20 | 29.641% | 37.061% |
Relationships between endpoints
↥Index endpoint: G6_ALCOPOLY – Alcohol induced polyneuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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