Risteys · G6_ALCODEGEN

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G31.2 Cause of death: ICD-10 — G31.2 2 out of 7 registries used, show all original rules.	778
4. Check minimum number of events None	778
5. Include endpoints None	778
6. Filter based on genotype QC (FinnGen only)	778

	All	Female	Male
Number of individuals
Whole population	12921	2765	9998
Only index persons	10336	2353	7983
Unadjusted period prevalence (%)
Whole population	0.24	0.08	0.28
Only index persons	0.26	0.09	0.30
Median age at first event (years)
Whole population	58.75	58.87	58.62
Only index persons	58.94	59.19	58.87

	All	Female	Male
Number of individuals	778	127	651
Unadjusted period prevalence (%)	0.25	0.04	0.29
Median age at first event (years)	59.68	57.78	60.05

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
721: Matched controls
7209

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G31.2

ICD-10 Finland

Degeneration of nervous system due to alcohol

+∞

323.0

721

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

32.8

290.9

409

277

F10.29

ICD-10 Finland

Addiction caused by alcohol UNS

31.7

143.3

193

F10.25

ICD-10 Finland

Alcohol dependence continuous use

30.7

110.9

150

F10.20

ICD-10 Finland

Alcohol dependence currently independent

29.3

110.9

152

P15

ICPC

Chronic alcohol abuse

23.8

104.1

152

F10.40

ICD-10 Finland

Withdrawal symptoms and delirium caused by alcohol without seizures

38.3

93.3

119

R56.8

ICD-10 Finland

Other and unspecified convulsions

13.4

90.9

167

158

N07BB01

ATC

disulfiram; oral

12.4

88.5

169

173

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

5.0

85.1

380

1308

F10.26

ICD-10 Finland

Alcohol dependence periodic alcoholism

25.7

75.0

106

F10.00

ICD-10 Finland

Alcohol-related acute intoxication uncomplicated

22.5

73.2

108

F10.31

ICD-10 Finland

Withdrawal symptoms caused by alcohol with seizures

50.5

70.8

F10.9

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder

37.9

70.6

K70.3

ICD-10 Finland

Alcoholic cirrhosis of liver

23.2

68.0

N05AH04

ATC

quetiapine; oral

5.7

67.9

227

537

AA1AD

NOMESCO Finland

CT of head and brain

4.4

66.2

314

1075

F10.24

ICD-10 Finland

Alcohol depence active use

25.6

65.1

F10.39

ICD-10 Finland

Withdrawal symptoms caused by alcohol UNS

24.6

65.1

N05BA02

ATC

chlordiazepoxide; systemic

14.2

62.7

110

F10.49

ICD-10 Finland

Withdrawal symptoms and delirium caused by alcohol without information about seizures

39.6

61.9

F10.21

ICD-10 Finland

Alcohol dependence currently abstinent, but staying in restrictive environment

31.3

57.1

G62.1

ICD-10 Finland

Alcoholic polyneuropathy

91.7

53.8

F10.2

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Dependence syndrome

25.6

52.6

S01.0

ICD-10 Finland

Open wound of scalp

6.5

52.1

147

272

3039X

ICD-9 Finland

Alcohol dependence syndrome, Other and unspecified alcohol dependence

16.2

51.0

N06AX11

ATC

mirtazapine; oral

3.5

50.2

319

1325

N06AB04

ATC

citalopram; systemic

4.0

49.9

242

803

F10.09

ICD-10 Finland

Alcohol intoxication UNS

14.4

49.7

P16

ICPC

Acute alcohol abuse

20.7

48.6

N05CD07

ATC

temazepam; oral

4.4

45.0

188

535

F10.30

ICD-10 Finland

Withdrawal symptoms caused by alcohol uncomplicated

19.6

44.6

C07AA05

ATC

propranolol; systemic

4.2

44.5

200

610

N05BA04

ATC

oxazepam; oral

3.6

44.3

256

966

K70.1

ICD-10 Finland

Alcoholic hepatitis

37.1

43.2

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.8

42.3

216

733

E87.1

ICD-10 Finland

Hypo-osmolality and hyponatraemia

10.2

42.2

N05BA01

ATC

diazepam; systemic, rectal

4.2

41.8

180

524

J18.9

ICD-10 Finland

Pneumonia, unspecified

3.3

41.4

279

1168

K92.0

ICD-10 Finland

Haematemesis

11.5

39.3

F32.9

ICD-10 Finland

Depressive episode, unspecified

5.2

39.0

133

303

T36

ICD-10 Finland

Poisoning by systemic antibiotics

8.6

38.9

115

N05CF01

ATC

zopiclone; oral

3.0

38.8

319

1517

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

10.9

37.7

A28

ICPC

Limited function/disability NOS

3.8

36.8

179

574

F05.9

ICD-10 Finland

Delirium, unspecified

14.6

36.5

A06AD11

ATC

lactulose; oral

3.7

36.1

180

588

Z72.1

ICD-10 Finland

Alcohol use

16.2

35.0

R53

ICD-10 Finland

Malaise and fatigue

3.5

35.0

196

701

L28

ICPC

Limited function/disability (L)

3.7

34.3

171

556

SPAT1309

SPAT

Guidance related to psychoactive substances / risk behaviour

11.2

33.8

S06.0

ICD-10 Finland

Concussion

4.4

32.8

129

338

W19

ICD-10 Finland

Unspecified fall

4.5

32.5

126

325

E87.6

ICD-10 Finland

Hypokalaemia

11.2

32.3

F03

ICD-10 Finland

Unspecified dementia

10.5

31.8

K70.4

ICD-10 Finland

Alcoholic hepatic failure

44.4

31.2

F10.73

ICD-10 Finland

Residual or late-onset psychosis caused by alcohol dementia

167.1

30.9

N05AB01

ATC

dixyrazine; systemic

18.8

30.0

N05AX08

ATC

risperidone; systemic

5.4

29.8

198

N05AA02

ATC

levomepromazine; systemic

6.5

29.0

131

F10.03

ICD-10 Finland

Alcohol-related acute intoxication with delirium

57.5

28.4

K86.00

ICD-10 Finland

Acute pancreatitis caused by alcohol

10.7

27.7

R27.0

ICD-10 Finland

Ataxia, unspecified

49.2

27.7

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

4.5

27.1

102

253

G40.9

ICD-10 Finland

Epilepsy, unspecified

7.5

26.9

S42.2

ICD-10 Finland

Fracture of upper end of humerus

7.1

26.2

101

N05AD01

ATC

haloperidol; systemic

7.6

25.9

N05AD03

ATC

melperone; systemic

16.6

25.7

K70.9

ICD-10 Finland

Alcoholic liver disease, unspecified

40.4

25.1

V03AA01

ATC

7.7

25.0

SPAT1265

SPAT

Breathalyser

14.3

24.8

R41.0

ICD-10 Finland

Disorientation, unspecified

7.4

24.8

F10.41

ICD-10 Finland

Withdrawal symptoms and delirium caused by alcohol with seizures

50.2

24.4

SPAT1222

SPAT

Counselling/guidance promoting independent living

3.2

23.8

144

528

F10.8

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Other mental and behavioural disorders

129.3

23.7

3050A

ICD-9 Finland

Nondependent abuse of drugs, Alcohol abuse

16.0

23.5

N03AF01

ATC

carbamazepine; oral, rectal

4.8

23.4

184

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

5.9

23.1

120

N03AG01

ATC

valproic acid; systemic, rectal

5.1

23.1

159

E51.2

ICD-10 Finland

Wernicke encephalopathy

86.3

22.8

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

4.9

22.7

171

N06AB03

ATC

fluoxetine; oral

3.4

22.3

118

393

P20

ICPC

Memory disturbance

3.4

21.7

112

365

SPAT1254

SPAT

Administration of medicine

3.0

21.7

138

523

G72.8

ICD-10 Finland

Other specified myopathies

9.0

21.7

SPAT1227

SPAT

Substance abuse rehabilitation

32.3

21.6

SPAT1216

SPAT

Assessment of functional ability

2.9

21.4

144

566

G40.51

ICD-10 Finland

Epileptic seizures related to alcohol

61.9

21.0

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.3

21.0

255

1389

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

4.3

20.7

208

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.0

20.7

239

S06.5

ICD-10 Finland

Traumatic subdural haemorrhage

5.6

20.3

118

C03CA01

ATC

furosemide; systemic

2.2

20.3

261

1455

N05AH03

ATC

olanzapine; systemic

5.0

20.2

145

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

3.9

20.1

240

R26.0

ICD-10 Finland

Ataxic gait

29.9

19.7

S72.0

ICD-10 Finland

Fracture of neck of femur

5.7

19.5

107

F10

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol

47.4

19.3

D64.9

ICD-10 Finland

Anaemia, unspecified

3.1

19.0

111

394

N06AB10

ATC

escitalopram; oral

2.7

18.9

146

621

F10.74

ICD-10 Finland

Residual or late-onset psychosis caused by alcohol otherwise permanently impaired intelligence

+∞

18.8

S82.6

ICD-10 Finland

Fracture of lateral malleolus

4.3

18.6

178

SPAT1234

SPAT

Support of social functional capacity

5.0

18.4

128

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

4.8

18.3

142

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

4.1

18.1

193

SPAT1137

SPAT

Taking care of patient’s/customer’s hygiene

4.6

18.1

149

2910A

ICD-9 Finland

Alcoholic psychoses, Alcohol withdrawal delirium

53.9

18.0

EBA15

NOMESCO Finland

Extraction of large number of teeth

4.4

17.9

160

K86.08

ICD-10 Finland

Alcohol-induced chronic pancreatitis

18.6

17.9

N03AX14

ATC

levetiracetam; systemic

6.5

17.9

S22.3

ICD-10 Finland

Fracture of rib

3.5

17.8

282

V03AB30

ATC

12.9

17.8

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.0

17.4

108

400

K85

ICD-10 Finland

Acute pancreatitis

7.2

16.9

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

7.7

16.9

K70.0

ICD-10 Finland

Alcoholic fatty liver

13.1

16.8

F10.6

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Amnesic syndrome

+∞

16.7

G31.0

ICD-10 Finland

Circumscribed brain atrophy

+∞

16.7

F10.4

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium

92.2

16.6

S01.1

ICD-10 Finland

Open wound of eyelid and periocular area

7.1

16.4

F10.23

ICD-10 Finland

Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication

21.5

16.1

N06AB06

ATC

sertraline; oral

3.3

16.0

271

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

4.0

15.9

174

F10.01

ICD-10 Finland

Alcohol-related acute intoxication with permanent or other somatic damage

16.1

15.8

J15.9

ICD-10 Finland

Bacterial pneumonia, unspecified

3.0

15.8

362

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.6

15.7

124

530

S82.8

ICD-10 Finland

Fractures of other parts of lower leg

5.7

15.7

A98

ICPC

Health maint/preventive medicine

0.5

15.0

508

6000

N06AX16

ATC

venlafaxine; oral

2.7

14.7

104

417

SPAT1229

SPAT

Assessment of need for aid

3.3

14.6

242

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.5

14.6

123

544

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

6.4

14.6

G31.9

ICD-10 Finland

Degenerative disease of nervous system, unspecified

152.9

14.5

F10.59

ICD-10 Finland

Alcohol psychosis, mixed type

152.9

14.5

ZXD05

NOMESCO Finland

Urgent procedure

2.0

14.2

243

1480

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.2

13.8

156

798

R18

ICD-10 Finland

Ascites

7.8

13.8

N05BE01

ATC

buspirone; oral

5.5

13.7

F10.06

ICD-10 Finland

Alcohol-related acute intoxication with seizures

76.6

13.6

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.6

13.6

109

468

J69.0

ICD-10 Finland

Pneumonitis due to food and vomit

7.0

13.6

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

34.7

13.5

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.1

13.5

274

X59

ICD-10 Finland

Exposure to unspecified factor

2.2

13.5

158

820

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.3

13.2

136

666

A09AA02

ATC

multienzymes (lipase, protease etc.)

7.3

13.2

G40

ICD-10 Finland

Epilepsy

17.1

13.0

E87.2

ICD-10 Finland

Acidosis

17.1

13.0

SPAT1247

SPAT

Outpatient detoxication and monitoring

19.5

13.0

Z2446

NOMESCO Finland

Social worker

3.4

12.7

199

R11

ICD-10 Finland

Nausea and vomiting

3.4

12.6

200

SPAT1307

SPAT

Psychosocial counselling and guidance

4.8

12.5

R42

ICD-10 Finland

Dizziness and giddiness

2.1

12.2

159

862

N05AF03

ATC

chlorprothixene; systemic

5.1

12.2

K92.1

ICD-10 Finland

Melaena

3.3

12.2

200

L89

ICD-10 Finland

Decubitus ulcer and pressure area

6.8

12.1

133

Kela drug reimbursment

Severe chronic pancreatic insufficiency

8.9

12.1

NHJ10

NOMESCO Finland

Internal fixation of fracture of ankle using wire, rod, cerclage or pin

4.0

12.1

126

N05BA06

ATC

lorazepam; systemic, sublingual

3.7

12.1

152

G41.9

ICD-10 Finland

Status epilepticus, unspecified

13.7

12.0

OAB43

SPAT

0.1

11.9

403

XF400

NOMESCO Finland

ECG with 12 standard connections

2.1

11.8

149

795

A04

ICPC

Weakness/tiredness general

2.5

11.8

396

C03DA01

ATC

spironolactone; oral

2.4

11.8

103

462

7803A

ICD-9 Finland

General symptoms, Convulsions

12.1

11.4

R26.8

ICD-10 Finland

Other and unspecified abnormalities of gait and mobility

5.8

11.3

K29.2

ICD-10 Finland

Alcoholic gastritis

17.4

11.2

TAB00

NOMESCO Finland

Lumbar puncture

4.4

11.2

N03AF02

ATC

oxcarbazepine; oral

5.2

11.2

F10.02

ICD-10 Finland

Alcohol-related acute intoxication with other acute clinical complications

25.5

11.2

30300

ICD-8 Finland

Alcoholism, Episodic excessive drinking

7.2

11.1

W00

ICD-10 Finland

Fall on same level involving ice and snow

2.5

11.1

375

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.9

11.0

243

Z03

ICPC

Housing/neighbourhood problem

14.2

11.0

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.6

11.0

357

X44

ICD-10 Finland

Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

8.0

10.9

SPAT1240

SPAT

Therapeutic discussion

2.9

10.9

246

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

2.5

10.9

393

N03AB02

ATC

phenytoin; systemic

10.8

N06AX03

ATC

mianserin; oral

3.3

10.8

167

N06AA12

ATC

doxepin; systemic

3.4

10.8

156

F29

ICD-10 Finland

Unspecified nonorganic psychosis

5.1

10.8

S43.0

ICD-10 Finland

Dislocation of shoulder joint

3.9

10.8

114

F10.3

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Withdrawal state

18.1

10.8

M01AH05

ATC

etoricoxib; oral

0.6

10.7

219

3110

2918A

ICD-9 Finland

Alcoholic psychoses, Other specified alcoholic psychosis

21.8

10.7

A29

ICPC

General symptom/complaint other

2.5

10.7

369

R55

ICD-10 Finland

Syncope and collapse

2.4

10.6

438

R01AD58

ATC

fluticasone, combinations; inhalant, nasal

0.3

10.6

670

W10

ICD-10 Finland

Fall on and from stairs and steps

3.4

10.5

159

S42.0

ICD-10 Finland

Fracture of clavicle

4.7

10.5

TKC20

NOMESCO Finland

Catheterisation of bladder

2.7

10.4

301

N28

ICPC

Limited function/disability (N)

7.9

10.4

N10

ICD-10 Finland

Acute tubulo-interstitial nephritis

2.3

10.4

100

470

SPAT1231

SPAT

Assessment of adjustments needed in living environment

7.3

10.3

P29

ICPC

Psychological sympt/compl other

4.2

10.3

309

Kela drug reimbursment

Nalmefene and naltrexone

23.7

10.3

F32.00

ICD-10 Finland

Mild depressive episode without somatic syndrome

3.9

10.2

110

G40.22

ICD-10 Finland

Complex partial epileptic seizure with secondary generalization

5.1

10.1

NBJ62

NOMESCO Finland

Internal fixation of fracture of shoulder or upper arm using plate and screws, humerus

9.3

10.1

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

3.2

10.0

177

SPAT1053

SPAT

Memory test

2.1

9.9

116

596

A02BC02

ATC

pantoprazole; systemic

1.7

9.9

447

3562

E86

ICD-10 Finland

Volume depletion

4.6

9.9

Z08

ICPC

Social welfare problem

8.9

9.8

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

2.8

9.8

250

I85.9

ICD-10 Finland

Oesophageal varices without bleeding

9.7

9.8

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.8

9.7

192

1201

N17.9

ICD-10 Finland

Acute renal failure, unspecified

3.3

9.5

144

G93.4

ICD-10 Finland

Encephalopathy, unspecified

17.8

9.4

EBA00

NOMESCO Finland

Extraction of tooth

1.7

9.4

231

1546

G37.2

ICD-10 Finland

Central pontine myelinolysis

+∞

9.4

N05BA12

ATC

alprazolam; oral

2.4

9.4

362

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

2.9

9.2

209

Z02.7

ICD-10 Finland

Issue of medical certificate

2.9

9.2

193

T74.1

ICD-10 Finland

Physical abuse

6.4

9.1

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

3.0

9.1

182

S42.3

ICD-10 Finland

Fracture of shaft of humerus

11.7

9.1

K75.9

ICD-10 Finland

Inflammatory liver disease, unspecified

9.2

9.1

F10.22

ICD-10 Finland

Alcohol dependence is currently on clinically controlled discontinuation medication

37.2

9.0

E13.7

ICD-10 Finland

Other specified diabetes mellitus, with multiple complications

37.2

9.0

SPAT1245

SPAT

Provision of support and information to patient’s family members

3.6

9.0

117

S06.3

ICD-10 Finland

Focal brain injury

5.6

9.0

T90.5

ICD-10 Finland

Sequelae of intracranial injury

5.9

9.0

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

4.9

8.9

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

3.0

8.9

179

L76

ICPC

Fracture: other

5.2

8.8

NA1AD

NOMESCO Finland

Cervical spine CT examination

3.5

8.8

119

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

5.5

8.8

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

2.6

8.8

255

30310

ICD-8 Finland

Alcoholism, Habitual excessive drinking

7.3

8.8

N06AB05

ATC

paroxetine; oral

3.0

8.8

175

S62.3

ICD-10 Finland

Fracture of other metacarpal bone

4.2

8.8

S70.0

ICD-10 Finland

Contusion of hip

4.0

8.7

N07BB04

ATC

naltrexone; oral

50.6

8.7

EBA30

NOMESCO Finland

Excision of root of tooth

2.8

8.6

208

E16.2

ICD-10 Finland

Hypoglycaemia, unspecified

7.1

8.6

P18

ICPC

Medication abuse

27.9

8.5

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.2

8.4

453

S01.8

ICD-10 Finland

Open wound of other parts of head

6.3

8.4

R33

ICD-10 Finland

Retention of urine

2.2

8.3

430

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

3.9

8.2

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.0

8.2

108

582

S02.20

ICD-10 Finland

Fracture of nasal bones, closed

6.1

8.2

J01FA10

ATC

azithromycin; systemic

0.6

8.2

176

2515

NG4AA

NOMESCO Finland

Lower leg X-ray examination

4.9

8.1

R40.2

ICD-10 Finland

Coma, unspecified

8.3

8.1

30320

ICD-8 Finland

Alcoholism, Alcoholic addiction

6.9

8.1

F02.89*G40.9

ICD-10 Finland

Dementia in epilepsy

33.7

8.1

G11.9

ICD-10 Finland

Hereditary ataxia, unspecified

33.7

8.1

5770D

ICD-9 Finland

Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA NONHAEMORHAGICA]

17.4

8.1

F60.9

ICD-10 Finland

Personality disorder, unspecified

9.1

8.1

B18.2

ICD-10 Finland

Chronic viral hepatitis C

9.1

8.1

3018X

ICD-9 Finland

Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]

9.1

8.1

F17.29

ICD-10 Finland

Addiction caused by tobacco UNS

4.7

8.1

S01

ICD-10 Finland

Open wound of head

6.4

8.1

SPAT1226

SPAT

Implementation of occupational therapy rehabilitation plan

4.6

7.9

S72.1

ICD-10 Finland

Pertrochanteric fracture

4.6

7.9

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.3

7.9

324

C10AA07

ATC

rosuvastatin; oral

0.5

7.8

1290

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

8.6

7.8

S22.4

ICD-10 Finland

Multiple fractures of ribs

3.9

7.8

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

3.9

7.8

N06DX01

ATC

memantine; oral

4.5

7.8

NE1AA

NOMESCO Finland

Pelvis X-ray examination

2.7

7.8

207

F05.8

ICD-10 Finland

Other delirium

9.5

7.8

P03

ICPC

Feeling depressed

3.0

7.8

153

Z02.4

ICD-10 Finland

Examination for driving licence

0.5

7.8

1403

Z09.4

ICD-10 Finland

Follow-up examination after treatment of fracture

3.3

7.8

121

S82.0

ICD-10 Finland

Fracture of patella

6.5

7.7

NGJ60

NOMESCO Finland

Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified

7.5

7.7

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

6.8

7.6

Y07

ICD-10 Finland

Other maltreatment

18.6

7.6

P19

ICPC

Drug abuse

18.6

7.6

K92.2

ICD-10 Finland

Gastrointestinal haemorrhage, unspecified

3.5

7.6

101

K86.9

ICD-10 Finland

Disease of pancreas, unspecified

12.0

7.6

G47.3

ICD-10 Finland

Sleep apnoea

0.5

7.6

1205

Z29

ICPC

Social problem NOS

6.3

7.6

K08.3

ICD-10 Finland

Retained dental root

2.4

7.6

291

N06AB08

ATC

fluvoxamine; oral

4.1

7.5

G25.0

ICD-10 Finland

Essential tremor

4.5

7.5

P99

ICPC

Psychological disorders other

4.9

7.5

N07BA03

ATC

varenicline; oral

2.8

7.4

166

S92.3

ICD-10 Finland

Fracture of metatarsal bone

3.9

7.4

SPAT1083

SPAT

Initiation and monitoring of IV fluid therapy

3.1

7.4

131

S52.5

ICD-10 Finland

Fracture of lower end of radius

2.5

7.4

239

K72.9

ICD-10 Finland

Hepatic failure, unspecified

13.5

7.4

OAB48

SPAT

0.0

7.4

212

N06AA09

ATC

amitriptyline; systemic

2.2

7.4

336

N02AX02

ATC

tramadol; systemic, rectal

1.6

7.3

311

2368

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

3.4

7.3

NFB20

NOMESCO Finland

Primary partial prosthetic replacement of hip joint using cement, other or unspecified

4.6

7.3

N03AE01

ATC

clonazepam; systemic

2.8

7.3

171

G40.59

ICD-10 Finland

Other special epileptic syndromes

+∞

7.3

C10AX09

ATC

ezetimibe; oral

0.3

7.3

562

R25.1

ICD-10 Finland

Tremor, unspecified

3.7

7.2

Z76.8

ICD-10 Finland

Persons encountering health services in other specified circumstances

3.8

7.2

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

3.2

7.2

117

2913A

ICD-9 Finland

Alcoholic psychoses, Alcohol withdrawal hallucinosis

30.3

7.2

SPAT1274

SPAT

Brief intervention in person with addiction symptoms

20.2

7.1

E87.0

ICD-10 Finland

Hyperosmolality and hypernatraemia

20.2

7.1

T50.9

ICD-10 Finland

Poisoning: Other and unspecified drugs, medicaments and biological substances

20.2

7.1

SPAT1241

SPAT

Extensive assessment of psychosocial situation

8.9

7.1

TPH04

NOMESCO Finland

Cathetrisation of vein

1.7

7.1

155

993

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.9

7.0

546

K25.0

ICD-10 Finland

Gastric ulcer, Acute with haemorrhage

7.1

7.0

S00.0

ICD-10 Finland

Superficial injury of scalp

4.5

7.0

WYA20

NOMESCO Finland

Home visit

6.4

7.0

G91.2

ICD-10 Finland

Normal-pressure hydrocephalus

6.4

7.0

F41.09

ICD-10 Finland

UNS Panic Syndrome

5.5

6.9

I95.1

ICD-10 Finland

Orthostatic hypotension

3.4

6.9

E000001

ATC

1.8

6.9

124

745

T51.0

ICD-10 Finland

Toxic effect: Ethanol

13.9

6.9

F10.0

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Acute intoxication

4.9

6.9

R13

ICD-10 Finland

Dysphagia

2.5

6.9

230

K05.31

ICD-10 Finland

Periodontitis pronounced

2.0

6.9

463

R01AD09

ATC

mometasone; nasal

0.6

6.9

126

1888

K22.6

ICD-10 Finland

Gastro-oesophageal laceration-haemorrhage syndrome

11.1

6.8

F60.30

ICD-10 Finland

Emotionally unstable personality disorder, impulsive

9.4

6.8

TNX33

NOMESCO Finland

Custom moulded cast, unspecified region

2.7

6.8

176

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

2.0

6.8

472

D07BA04

ATC

hydrocortisone and antiseptics; topical

2.3

6.8

299

RS110

NOMESCO Finland

40.4

6.8

IAB10

NOMESCO Finland

Psychiatric consultation concerning substance abuse

16.9

6.8

E14.9

ICD-10 Finland

Unspecified diabetes mellitus, without complications

4.8

6.8

A46

ICD-10 Finland

Erysipelas

1.8

6.7

113

665

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.2

6.7

313

EB1SA

NOMESCO Finland

Dental X-ray, bite-wing X-ray on one side of the mouth

0.6

6.7

128

1904

K76.7

ICD-10 Finland

Hepatorenal syndrome

22.7

6.7

F19.1

ICD-10 Finland

Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use

22.7

6.7

D07AA02

ATC

hydrocortisone; topical

2.0

6.7

437

ZXD35

NOMESCO Finland

Usual procedure

3.2

6.7

107

G30.1

ICD-10 Finland

Alzheimer disease with late onset

6.5

6.7

N03AX09

ATC

lamotrigine; oral

3.3

6.7

QAB00

NOMESCO Finland

Suture of skin of head or neck

5.6

6.6

K86.3

ICD-10 Finland

Pseudocyst of pancreas

7.9

6.6

S01.7

ICD-10 Finland

Multiple open wounds of head

7.9

6.6

XA800

NOMESCO Finland

Neuropsychological investigation

2.8

6.6

142

J44.9

ICD-10 Finland

Chronic obstructive pulmonary disease, unspecified

2.5

6.6

202

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

2.5

6.6

202

F17.2

ICD-10 Finland

Mental and behavioural disorders due to use of tobacco, dependence syndrome

12.4

6.6

L57.0

ICD-10 Finland

Actinic keratosis

0.3

6.6

376

K74.6

ICD-10 Finland

Other and unspecified cirrhosis of liver

4.9

6.6

E11.1

ICD-10 Finland

Type 2 diabetes mellitus, with ketoacidosis

8.8

6.6

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.9

6.6

543

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.8

6.6

121

733

N02AA05

ATC

oxycodone; systemic

1.8

6.6

113

671

P01

ICPC

Feeling anxious/nervous/tense

2.8

6.5

143

J44

ICD-10 Finland

Other chronic obstructive pulmonary disease

4.0

6.5

G57.3

ICD-10 Finland

Lesion of lateral popliteal nerve

5.4

6.5

Z53.2

ICD-10 Finland

Procedure not carried out because of patient's decision for other and unspecified reasons

6.3

6.5

S97

ICPC

Chronic ulcer skin

2.6

6.5

179

N05CM02

ATC

clomethiazole; systemic

70.4

6.4

R56.0

ICD-10 Finland

Febrile convulsions

70.4

6.4

N07

ICPC

Convulsion/seizure

70.4

6.4

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.6

6.4

181

Z28

ICPC

Limited function/disability (Z)

14.5

6.4

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

0.4

6.4

692

J01DA01

ATC

[U] cefalexin; systemic

1.5

6.4

408

3364

G40.29

ICD-10 Finland

Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures

4.1

6.3

R41.3

ICD-10 Finland

Other amnesia

3.9

6.3

L72

ICPC

Fracture: radius/ulna

11.1

6.3

K86.01

ICD-10 Finland

Late effects of pancreatitis caused by alcohol

11.1

6.3

G30.8

ICD-10 Finland

Other Alzheimer disease

9.4

6.3

E13.2

ICD-10 Finland

Other specified diabetes mellitus, with renal complications

+∞

6.3

F10.70

ICD-10 Finland

Residual or late-onset psychosis caused by alcohol flashbacks

+∞

6.3

G31.8

ICD-10 Finland

Other specified degenerative diseases of nervous system

+∞

6.3

5353A

ICD-9 Finland

Gastritis and duodenitis, Alcoholic gastritis

26.9

6.2

Z22.3

ICD-10 Finland

Carrier of other specified bacterial diseases

26.9

6.2

E78.0

ICD-10 Finland

Pure hypercholesterolaemia

0.5

6.2

887

R01AD12

ATC

fluticasone furoate; nasal

0.5

6.2

1041

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

2.6

6.2

178

F32.1

ICD-10 Finland

Moderate depressive episode

3.5

6.2

NFJ50

NOMESCO Finland

Internal fixation of fracture of neck of femur with nail or screw

7.8

6.1

S01.9

ICD-10 Finland

Open wound of head, part unspecified

4.1

6.1

D10

ICPC

Vomiting

3.3

6.1

S20.2

ICD-10 Finland

Contusion of thorax

2.6

6.1

162

R02

ICPC

Shortness of breath/dyspnoea

2.0

6.1

393

J90

ICD-10 Finland

Pleural effusion, not elsewhere classified

2.9

6.1

124

K20

ICD-10 Finland

Oesophagitis

5.0

6.1

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

2.8

6.1

132

RS230

NOMESCO Finland

8.7

6.1

SPAT1220

SPAT

Assessment of need for rehabilitation and/or rehabilitation plan

2.4

6.1

221

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

3.3

6.0

Y04.9

ICD-10 Finland

Assault by bodily force by unknown person

10.1

6.0

I69.1

ICD-10 Finland

Sequelae of intracerebral haemorrhage

5.2

6.0

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

6.0

195

1380

N06AA06

ATC

trimipramine; systemic

3.7

6.0

WX730

NOMESCO Finland

Conventional respirator

4.0

6.0

F32.11

ICD-10 Finland

Moderate depressive episode with somatic syndrome

4.0

6.0

NAME	G6_ALCODEGEN
CONTROL_EXCLUDE	G6_NEURODEG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G312
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G312
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
G6_ALCODEGEN	7.086 [6.16, 8.15]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.159

Parameter	HR [95% CI]	p-value
G6_ALCODEGEN	5.864 [5.32, 6.46]	< 0.001
Birth year	0.987 [0.98, 1.0]	0.005

N-year risk	Females	Males
1	0.797%	1.179%
5	3.618%	6.351%
10	9.524%	14.645%
15	18.008%	27.105%
20	29.468%	41.761%

Degeneration of the brain due to alcohol

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints