Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
307 |
4. Check minimum number of eventsNone |
307 |
5. Include endpointsNone |
307 |
6. Filter based on genotype QC (FinnGen only) |
307 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma uninodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2093 | 1687 | 393 |
| Only index persons | 1884 | 1532 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.27 | 53.98 | 60.60 |
| Only index persons | 53.93 | 52.58 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 307 | 253 | 54 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.02 |
| Median age at first event (years) | 52.31 | 49.52 | 65.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 277
- Matched controls
- 2771
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
323.0
257
*
H03BB01
ATC
carbimazole; oral
1991.3
232.2
193
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2125.9
136.4
121
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
2004.6
131.4
117
*
H03AA01
ATC
levothyroxine sodium; systemic
12.5
78.3
202
491
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
807.0
66.9
63
*
BAA60
NOMESCO Finland
Total thyroidectomy
47.0
62.7
76
22
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
43.9
50.5
62
18
104
Kela drug reimbursment
Thyroid insufficiency
8.8
35.9
84
130
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
18.7
35.8
56
37
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
337.1
30.4
30
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
26.5
25
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
23.2
23.2
33
16
2421A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic uninodular goitre
+∞
20.0
19
*
C07AA05
ATC
propranolol; systemic
3.9
19.2
97
339
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.8
16.4
27
20
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
35.7
16.0
20
6
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
12.8
16.0
28
24
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
90.3
15.7
17
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.8
14.1
41
81
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
13.6
13
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
146.9
13.6
14
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
6.7
13.2
34
57
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.3
12.0
66
238
H062, E050
ICD-10 Finland
NA
+∞
11.5
11
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
41.7
10.0
12
*
T86
ICPC
Hypothyroidism/myxoedema
5.2
9.2
28
59
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
51.6
8.7
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
8.7
114
662
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
7.5
8.4
19
27
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.5
8.2
17
21
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
46.3
7.8
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
7.5
130
836
C07AB07
ATC
bisoprolol; oral
2.0
6.8
128
839
106
Kela drug reimbursment
Hypoparathyroidism
41.1
6.8
8
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.2
6.4
23
59
2504
FHL
Unilateral resection or enucleation
11.4
6.3
11
10
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
6.3
6
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
+∞
6.3
6
*
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXNOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.287 [1.09, 1.53] | 0.004 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1340 females with E4_THYTOXNOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.204 [0.89, 1.62] | 0.223 |
| Birth year | 0.987 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 290 males with E4_THYTOXNOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXNOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.275% |
| 5 | 0.855% | 1.442% |
| 10 | 2.072% | 3.605% |
| 15 | 3.994% | 6.787% |
| 20 | 6.997% | 11.648% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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