Toxic Nodular Goiter: Nodular enlargement of the thyroid gland associated with hyperthyroidism.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2195 |
4. Check minimum number of eventsNone |
2195 |
5. Include endpointsNone |
2195 |
6. Filter based on genotype QC (FinnGen only) |
2195 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma multinodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic multinodular goitre
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18329 | 15393 | 2783 |
| Only index persons | 14535 | 12435 | 2100 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.38 | 0.44 | 0.08 |
| Only index persons | 0.40 | 0.46 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 60.94 | 60.51 | 63.51 |
| Only index persons | 60.38 | 59.55 | 65.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2195 | 1782 | 413 |
| Unadjusted period prevalence (%) | 0.53 | 0.61 | 0.18 |
| Median age at first event (years) | 60.77 | 59.30 | 67.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1944
- Matched controls
- 19439
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
323.0
472
*
BAA60
NOMESCO Finland
Total thyroidectomy
37.7
323.0
453
155
H03BB01
ATC
carbimazole; oral
815.3
323.0
1174
36
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
743.3
323.0
580
11
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
14100.9
323.0
1600
*
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
+∞
316.5
295
*
H03AA01
ATC
levothyroxine sodium; systemic
6.0
286.1
1124
3592
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
37.0
247.2
320
103
104
Kela drug reimbursment
Thyroid insufficiency
8.0
221.6
566
949
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
736.1
205.4
199
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
9.7
159.6
346
423
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
162.4
143.6
150
10
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
55.9
142.3
169
33
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
212.0
134.6
138
7
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
21.3
122.3
184
95
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.5
85.2
183
211
T85
ICPC
Hyperthyroidism/thyrotoxicosis
51.1
73.1
88
18
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.7
64.1
233
542
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
63.9
61
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
60.7
58
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
10.4
60.6
122
124
2422A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic multinodular goitre
+∞
55.5
53
*
C07AA05
ATC
propranolol; systemic
2.5
49.0
483
2309
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
45.3
43.3
53
12
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
54.6
40.6
48
9
C07AB07
ATC
bisoprolol; oral
1.9
39.8
1058
7521
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
32.7
347
1682
E05.89
ICD-10 Finland
Other thyrotoxicosis
322.1
31.9
32
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
5.0
31.3
104
218
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
10.0
31.2
63
65
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
44.5
28.7
35
8
A11CC03
ATC
alfacalcidol; systemic
5.5
28.6
87
165
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
9.5
28.5
59
64
T86
ICPC
Hypothyroidism/myxoedema
3.5
28.3
139
419
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
27.6
830
5874
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.7
27.2
122
341
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.3
23.3
72
140
H062, E050
ICD-10 Finland
NA
+∞
23.0
22
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
232.6
22.7
23
*
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
21.9
21
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
16.2
21.9
35
22
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
21.5
93
253
106
Kela drug reimbursment
Hypoparathyroidism
17.6
21.3
33
19
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.8
20.1
67
142
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
19.4
477
3108
E03
ICD-10 Finland
Other hypothyroidism
2.4
18.8
168
739
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
14.3
18.6
31
22
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
18.0
725
5358
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
17.4
416
2675
T81
ICPC
Goitre
11.2
17.2
32
29
E83.51
ICD-10 Finland
Hypocalcemia
13.4
17.0
29
22
H03BA02
ATC
propylthiouracil; oral
+∞
16.7
16
*
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
16.7
16
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
4.8
16.5
55
118
WX402
NOMESCO Finland
General anaesthesia
1.8
16.4
316
1898
Z3231
NOMESCO Finland
Registered nurse
1.6
16.0
519
3613
B01AA03
ATC
warfarin; systemic
1.7
15.4
406
2671
E04.8
ICD-10 Finland
Other specified nontoxic goitre
12.0
14.6
26
22
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
14.4
754
5830
N02BE01
ATC
paracetamol; systemic, rectal
1.6
14.3
1660
15167
ZXA10
NOMESCO Finland
Bilateral
1.6
14.3
404
2702
207
Kela drug reimbursment
Chronic arrhythmias
1.7
14.2
308
1912
A11CC02
ATC
dihydrotachysterol; oral
22.4
14.2
20
9
Z2221
NOMESCO Finland
Medical doctor
1.5
13.9
524
3758
TFP20
NOMESCO Finland
Cardiodefibrillation
2.2
13.7
144
685
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
13.7
487
3450
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.7
13.4
299
1873
GB1AA
NOMESCO Finland
Tracheal X-ray examination
21.3
13.3
19
9
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
21.3
13.3
19
9
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.8
13.2
265
1607
I50.9
ICD-10 Finland
Heart failure, unspecified
1.7
12.9
280
1737
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.9
12.6
28
36
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
32.2
12.6
16
5
C03CA01
ATC
furosemide; systemic
1.5
12.3
598
4518
R06.0
ICD-10 Finland
Dyspnoea
1.5
12.2
481
3475
ZXE00
NOMESCO Finland
One hour or less
1.4
12.1
721
5663
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
12.0
167
892
C07AA07
ATC
sotalol; systemic
2.5
12.0
94
388
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
12.0
326
2151
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
6.5
11.9
30
47
L28
ICPC
Limited function/disability (L)
1.6
11.8
324
2144
E05.5
ICD-10 Finland
Thyroid crisis or storm
+∞
11.5
11
*
R4110
NOMESCO Finland
Physiotherapy
1.5
10.8
493
3656
H05.2
ICD-10 Finland
Exophthalmic conditions
15.6
10.8
17
11
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
10.8
1146
9900
24220
ICD-8 Finland
Thyrotoxicosis with or without goitre, Thyrotoxicosis without mention of goitre
+∞
10.4
10
*
A12AA04
ATC
calcium carbonate; oral
4.1
10.3
39
97
C07AB02
ATC
metoprolol; systemic
1.5
10.1
420
3051
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
9.5
359
2552
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
9.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
9.0
789
6529
R53
ICD-10 Finland
Malaise and fatigue
1.5
9.0
381
2771
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
18.7
8.9
13
7
E04
ICD-10 Finland
Other nontoxic goitre
7.5
8.9
20
27
Z3226
NOMESCO Finland
Physiotherapist
1.5
8.9
339
2414
ZXA05
NOMESCO Finland
Left side
1.4
8.8
487
3726
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
8.8
150
863
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
8.6
8.8
18
21
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
8.7
78
346
Z01.7
ICD-10 Finland
Laboratory examination
1.6
8.5
197
1246
R03BB04
ATC
tiotropium bromide; inhalant
1.7
8.4
176
1079
J01DA01
ATC
[U] cefalexin; systemic
1.3
8.2
1117
9827
R00.2
ICD-10 Finland
Palpitations
1.8
8.1
127
711
C01AA05
ATC
digoxin; systemic
1.7
7.5
162
999
K78
ICPC
Atrial fibrillation/flutter
1.7
7.5
147
886
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.3
7.5
35
107
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
7.4
287
2044
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
6.5
7.4
18
28
C03DA01
ATC
spironolactone; oral
1.6
7.4
198
1299
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
7.3
369
2765
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.3
834
7112
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.4
7.3
57
237
B01AB05
ATC
enoxaparin; parenteral
1.3
7.2
565
4556
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.2
527
4213
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
30.1
7.1
9
*
J01DB01
ATC
cefalexin; oral
1.3
7.1
1448
13346
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
7.0
404
3103
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
7.5
6.9
15
20
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
6.9
173
1114
Z71.8
ICD-10 Finland
Other specified counselling
1.4
6.8
378
2879
A02BC02
ATC
pantoprazole; systemic
1.3
6.7
1198
10788
XF400
NOMESCO Finland
ECG with 12 standard connections
1.4
6.7
276
1991
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
6.6
270
1942
R03AC02
ATC
salbutamol; inhalant
1.3
6.6
904
7858
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
12.3
6.6
11
9
WZC30
NOMESCO Finland
Teaching
1.5
6.5
214
1472
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.4
6.5
369
2823
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.6
6.5
166
1078
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.0
6.5
81
419
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.5
475
3787
J01AA02
ATC
doxycycline; systemic
1.3
6.5
1428
13192
A27
ICPC
Fear of other disease NOS
1.9
6.4
87
468
2504
FHL
Unilateral resection or enucleation
3.5
6.3
27
78
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
+∞
6.3
6
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
+∞
6.3
6
*
WX892
NOMESCO Finland
Monitored bed care
1.7
6.2
120
718
ZXE20
NOMESCO Finland
More than three and less than five hours
1.5
6.1
231
1639
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
6.1
236
1682
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
6.0
501
4058
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
2.8
6.0
36
131
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXGOITMULT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.258 [1.14, 1.39] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.248 |
During the follow-up period (1.1.1998 — 31.12.2019), 1886 out of 8353 females with E4_THYTOXGOITMULT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXGOITMULT | 1.226 [1.04, 1.45] | 0.016 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 410 out of 1483 males with E4_THYTOXGOITMULT died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXGOITMULT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.251% |
| 5 | 0.77% | 1.437% |
| 10 | 1.909% | 3.544% |
| 15 | 3.56% | 6.687% |
| 20 | 6.338% | 11.5% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXGOITMULT – Thyrotoxicosis with toxic multinodular goitre
GWS hits: 22
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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