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Subacute thyroiditis

DOID EFO Endpoint Browser PheWeb

E4_THYROIDITSUBAC

subacute thyroiditis: Spontaneously remitting inflammatory condition of the THYROID GLAND, characterized by FEVER; MUSCLE WEAKNESS; SORE THROAT; severe thyroid PAIN; and an enlarged damaged gland containing GIANT CELLS. The disease frequently follows a viral infection.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — E06.1
  • Hospital discharge: ICD-10 — E06.1
  • Hospital discharge: ICD-9 — 2451
  • Hospital discharge: ICD-8 — 2450[0-1]
  • Cause of death: ICD-10 — E06.1
  • Cause of death: ICD-9 — 2451
  • Cause of death: ICD-8 — 2450[0-1]

3 out of 7 registries used, show all original rules.

1376

4. Check minimum number of events

None

1376

5. Include endpoints

None

1376

6. Filter based on genotype QC (FinnGen only)

1376

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF10
Parent code in ICD-10
E06
Name in latin
Thyreoiditis subacuta

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8817 6740 2008
Only index persons 8221 6380 1841
Unadjusted period prevalence (%)
Whole population 0.16 0.19 0.06
Only index persons 0.20 0.23 0.07
Median age at first event (years)
Whole population 48.24 47.71 50.24
Only index persons 47.78 47.28 49.55

-FinnGen-

Key figures

All Female Male
Number of individuals 1376 1131 245
Unadjusted period prevalence (%) 0.34 0.39 0.11
Median age at first event (years) 47.99 47.57 49.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1219
Matched controls
12191
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
323.0
989
*
H03AA01
ATC
levothyroxine sodium; systemic
54.0
323.0
483
146
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
107.3
204.3
220
25
104
Kela drug reimbursment
Thyroid insufficiency
373.6
133.4
132
*
2451A
ICD-9 Finland
Thyroiditis, Subacute thyroiditis
+∞
125.2
118
*
H02AB06
ATC
prednisolone; systemic
3.9
108.9
807
4059
H03BB01
ATC
carbimazole; oral
120.9
93.5
100
9
E06.9
ICD-10 Finland
Thyroiditis, unspecified
413.1
78.8
78
*
24500
ICD-8 Finland
Thyroiditis, Subacuta de Quervain
+∞
74.8
71
*
E03
ICD-10 Finland
Other hypothyroidism
64.3
72.7
84
14
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
159.6
71.8
75
5
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
112.5
59.4
64
6
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
57.8
55
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
84.4
57.5
64
8
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
56.7
54
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
61.3
55.0
64
11
BAA60
NOMESCO Finland
Total thyroidectomy
518.6
50.8
50
*
24501
ICD-8 Finland
Thyroiditis, Subacuta alia
+∞
47.2
45
*
T86
ICPC
Hypothyroidism/myxoedema
54.2
43.9
52
10
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.8
43.7
130
244
H02AB07
ATC
prednisone; oral
3.1
42.3
268
1010
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
26.8
39.2
54
21
C07AA05
ATC
propranolol; systemic
2.6
35.9
315
1440
E06
ICD-10 Finland
Thyroiditis
180.0
33.9
35
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
309.7
29.9
30
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
22.2
29.7
43
20
E06.3
ICD-10 Finland
Autoimmune thyroiditis
106.0
28.8
31
*
R07.0
ICD-10 Finland
Pain in throat
4.0
27.5
116
313
A02BC02
ATC
pantoprazole; systemic
2.0
27.2
820
6215
R50.9
ICD-10 Finland
Fever, unspecified
2.7
27.0
205
847
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
19.6
25.3
38
20
R53
ICD-10 Finland
Malaise and fatigue
2.3
24.7
275
1387
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
49.4
24.4
29
6
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
22.0
330
1883
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
29.7
21.9
29
10
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
20.8
471
3112
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
19.7
553
3897
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
17.4
18.8
29
17
R21
ICPC
Throat symptom/complaint
2.0
18.2
270
1514
E03.82
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
17.7
17
*
R51.80
ICD-10 Finland
Headache
2.1
17.3
214
1112
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
17.2
313
1891
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
14.3
16.8
28
20
A02BC05
ATC
esomeprazole; systemic
1.7
15.9
508
3644
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
15.7
15
*
A02BC03
ATC
lansoprazole; oral
1.7
15.1
354
2311
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
45.6
15.1
18
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
13.4
14.7
25
19
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
14.5
290
1796
A03
ICPC
Fever
1.9
12.9
193
1073
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
12.8
281
1784
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
12.7
324
2151
J01AA02
ATC
doxycycline; systemic
1.6
12.5
927
8035
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
12.5
12
*
R03AC02
ATC
salbutamol; inhalant
1.6
12.4
614
4822
M79.6
ICD-10 Finland
Pain in limb
1.6
12.3
433
3124
M54.5
ICD-10 Finland
Low back pain
1.6
12.3
396
2795
J01DA01
ATC
[U] cefalexin; systemic
1.5
12.1
745
6139
A02BC01
ATC
omeprazole; systemic
1.7
12.0
320
2144
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.8
11.7
49
133
J02AC01
ATC
fluconazole; systemic
1.5
11.7
540
4150
T85
ICPC
Hyperthyroidism/thyrotoxicosis
23.1
11.6
16
7
G44.2
ICD-10 Finland
Tension-type headache
1.9
11.3
181
1033
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
10.6
203
1227
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
10.6
203
1230
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
10.5
455
3420
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
10.5
383
2767
R52.9
ICD-10 Finland
Pain, unspecified
2.2
10.5
107
509
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
110.9
10.4
11
*
C07AB07
ATC
bisoprolol; oral
1.5
10.2
470
3576
P01AB01
ATC
metronidazole; oral, rectal
1.5
10.2
492
3782
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.9
10.1
146
800
BA1AE
SPAT
NA
10.1
10.0
19
19
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
40.4
10.0
12
*
M25.5
ICD-10 Finland
Pain in joint
1.6
9.9
338
2397
J01FA10
ATC
azithromycin; systemic
1.5
9.8
691
5736
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
9.7
194
1190
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
9.4
9
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
9.4
9
*
L02
ICPC
Back symptom/complaint
2.0
9.3
114
588
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.0
9.2
113
582
R01AD09
ATC
mometasone; nasal
1.5
9.2
523
4137
R13
ICD-10 Finland
Dysphagia
2.4
9.1
74
316
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
24.2
8.9
12
5
N03AX16
ATC
pregabalin; oral
1.6
8.9
267
1830
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
8.6
235
1571
SPAT1283
SPAT
Restricted health certificate
1.6
8.5
209
1359
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
8.3
8
*
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.3
8.3
76
346
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
8.2
146
859
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.2
8.2
79
366
R01AD08
ATC
fluticasone; nasal
1.5
8.2
329
2404
R42
ICD-10 Finland
Dizziness and giddiness
1.6
8.1
228
1532
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
8.1
117
644
Z71.8
ICD-10 Finland
Other specified counselling
1.5
8.0
270
1894
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.8
8.0
134
774
R00.2
ICD-10 Finland
Palpitations
2.1
7.9
89
442
N02BE01
ATC
paracetamol; systemic, rectal
1.5
7.9
1002
9146
R51
ICD-10 Finland
Headache
2.3
7.9
69
305
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.6
7.8
237
1622
UJF32
NOMESCO Finland
Coloscopy
1.5
7.8
265
1861
N02AX02
ATC
tramadol; systemic, rectal
1.4
7.8
441
3452
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
2.5
7.7
60
251
R03DC03
ATC
montelukast; oral
1.6
7.7
188
1217
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
3.8
7.7
31
84
J01MA02
ATC
ciprofloxacin; systemic
1.4
7.6
396
3046
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
7.6
448
3528
J01DB01
ATC
cefalexin; oral
1.5
7.6
940
8484
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
7.6
89
452
N76.0
ICD-10 Finland
Acute vaginitis
2.2
7.5
77
368
N05CF01
ATC
zopiclone; oral
1.5
7.5
340
2543
M79.1
ICD-10 Finland
Myalgia
1.7
7.5
158
979
L17
ICPC
Foot/toe symptom/complaint
1.5
7.5
271
1933
C07AB02
ATC
metoprolol; systemic
1.6
7.4
191
1252
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.4
266
1889
J01FA06
ATC
roxithromycin; oral
1.4
7.4
457
3629
L01
ICPC
Neck symptom/complaint
1.7
7.3
161
1010
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
7.3
7
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
7.3
7
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
7.3
7
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
7.3
84
422
R74
ICPC
Upper respiratory infection acute
1.5
7.2
322
2398
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.2
534
4375
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
2.8
7.1
44
163
K30
ICD-10 Finland
Functional dyspepsia
1.8
7.1
125
734
SPAT1301
SPAT
No procedures
1.4
6.9
334
2522
A04
ICPC
Weakness/tiredness general
1.7
6.8
129
774
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.7
249
1779
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.7
169
1102
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.7
157
1005
N01
ICPC
Headache
1.8
6.7
123
734
SPAT1263
SPAT
Sampling
1.4
6.7
465
3751
M03BX02
ATC
tizanidine; oral
1.4
6.6
715
6199
N06AX11
ATC
mirtazapine; oral
1.4
6.6
335
2550
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
6.5
134
828
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
6.5
129
787
R39.1
ICD-10 Finland
Other difficulties with micturition
3.5
6.4
28
82
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.4
185
1249
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
14.4
6.4
10
7
R52.2
ICD-10 Finland
Other chronic pain
2.6
6.4
42
162
H02AB04
ATC
methylprednisolone; systemic
1.6
6.4
163
1068
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.9
6.4
92
507
K02.1
ICD-10 Finland
Caries of dentine
1.4
6.3
622
5300
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.0
6.3
34
117
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.2
6.3
59
273
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
6.3
272
2007
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
1.9
6.3
89
488
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
6.3
6
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
6.3
6
*
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
6.3
6
*
EP1AE
SPAT
NA
4.1
6.2
22
54
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
6.2
611
5198
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
6.2
245
1773
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
6.2
192
1317
F51.0
ICD-10 Finland
Nonorganic insomnia
1.7
6.1
139
880
S18
ICPC
Laceration/cut
1.4
6.1
426
3425
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.0
790
7014
R06AX27
ATC
desloratadine; oral
1.4
6.0
304
2309

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITSUBAC and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITSUBAC 0.833 [0.71, 0.98] 0.025
Birth year 0.993 [0.98, 1.0] 0.139

During the follow-up period (1.1.1998 — 31.12.2019), 208 out of 4418 females with E4_THYROIDITSUBAC died.

Males

Parameter HR [95% CI] p-value
E4_THYROIDITSUBAC 0.597 [0.48, 0.74] < 0.001
Birth year 0.986 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 1239 males with E4_THYROIDITSUBAC died.

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITSUBAC.

N-year risk Females Males
1 0.066% 0.092%
5 0.527% 0.625%
10 1.263% 1.65%
15 2.331% 3.15%
20 4.065% 5.585%

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITSUBAC – Subacute thyroiditis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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