Drug-induced thyroiditis

E4_THYROIDITDRUG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E06.4#
  • Hospital discharge: ICD-9 2454
  • Cause of death: ICD-10 E06.4#
  • Cause of death: ICD-9 2454

2 out of 7 registries used, show all original rules.

80

4. Check minimum number of events

None

80

5. Include endpoints

None

80

6. Filter based on genotype QC (FinnGen only)

80

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E06
Name in latin
Thyreoiditis ex medicamento

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 273 126 144
Only index persons 239 112 127
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 56.73 52.31 60.48
Only index persons 55.96 50.66 60.63

-FinnGen-

Key figures

All Female Male
Number of individuals 80 35 45
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 57.19 53.14 60.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
71
Matched controls
709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.4
ICD-10 Finland
Drug-induced thyroiditis
+∞
99.2
70
*
C01BD01
ATC
amiodarone; systemic
311.7
57.3
52
6
H03BB01
ATC
carbimazole; oral
+∞
57.2
47
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
31.6
28
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
25.9
31.4
53
72
207
Kela drug reimbursment
Chronic arrhythmias
23.8
27.9
44
45
TFP20
NOMESCO Finland
Cardiodefibrillation
30.7
26.9
37
24
H03AA01
ATC
levothyroxine sodium; systemic
111.0
22.2
23
*
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
62.3
19.6
22
5
B01AA03
ATC
warfarin; systemic
11.7
17.5
37
60
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
11.1
16.6
36
60
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
25.4
16.5
23
13
TFP34
NOMESCO Finland
Electrophysiological investigation
38.9
16.3
20
7
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
16.3
15
*
C07AB07
ATC
bisoprolol; oral
9.9
15.7
59
235
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
11.2
15.4
32
48
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
11.8
14.7
29
39
TFP35
NOMESCO Finland
Electroanatomical mapping
67.6
14.5
16
*
K78
ICPC
Atrial fibrillation/flutter
24.7
14.4
20
11
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
12.9
12
*
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
37.3
12.2
15
5
I42.0
ICD-10 Finland
Dilated cardiomyopathy
37.3
12.2
15
5
XF400
NOMESCO Finland
ECG with 12 standard connections
8.2
12.1
30
58
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
10.4
11.8
24
33
C07AA07
ATC
sotalol; systemic
34.2
11.2
14
5
C01AA05
ATC
digoxin; systemic
14.6
10.8
18
16
C03DA01
ATC
spironolactone; oral
10.1
10.8
22
30
104
Kela drug reimbursment
Thyroid insufficiency
+∞
10.7
10
*
C03CA01
ATC
furosemide; systemic
6.1
10.3
33
88
I50.9
ICD-10 Finland
Heart failure, unspecified
8.7
10.2
23
37
XF404
NOMESCO Finland
Ambulatory ECG
9.8
10.2
21
29
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
9.8
49
211
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.7
9.8
34
99
C09AA05
ATC
ramipril; oral
5.4
9.4
34
103
C01BC04
ATC
flecainide; systemic
17.0
9.1
14
10
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
17.0
9.1
14
10
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
17.3
8.6
13
9
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
14.2
8.5
14
12
201
Kela drug reimbursment
Chronic cardiac insufficiency
13.1
8.2
14
13
B01AF02
ATC
apixaban; oral
8.9
8.1
17
24
I50.1
ICD-10 Finland
Left ventricular failure
15.7
7.7
12
9
B01AB04
ATC
dalteparin; parenteral
15.7
7.7
12
9
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.6
7.2
28
87
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.4
7.0
22
54
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
76.4
6.5
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
9.1
6.5
13
17
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
14.3
6.3
10
8
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.9
6.1
17
36
K04
ICPC
Palpitations/awareness of heart
12.7
6.0
10
9

Mortality – FinRegistry

Association

Association between endpoint E4_THYROIDITDRUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITDRUG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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