Acute thyroiditis

E4_THYROIDITACU

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E06.0
  • Hospital discharge: ICD-9 2450
  • Cause of death: ICD-10 E06.0
  • Cause of death: ICD-9 2450

2 out of 7 registries used, show all original rules.

151

4. Check minimum number of events

None

151

5. Include endpoints

None

151

6. Filter based on genotype QC (FinnGen only)

151

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E06
Name in latin
Thyreoiditis acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1138 842 289
Only index persons 1081 812 269
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.03 0.01
Median age at first event (years)
Whole population 46.43 45.51 49.44
Only index persons 45.78 44.95 48.29

-FinnGen-

Key figures

All Female Male
Number of individuals 151 116 35
Unadjusted period prevalence (%) 0.03 0.04 0.02
Median age at first event (years) 46.66 45.10 51.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
135
Matched controls
1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E06.0
ICD-10 Finland
Acute thyroiditis
+∞
174.6
127
*
H03AA01
ATC
levothyroxine sodium; systemic
76.6
59.0
65
16
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
33.8
31
*
104
Kela drug reimbursment
Thyroid insufficiency
304.0
25.6
25
*
H03BB01
ATC
carbimazole; oral
289.2
24.5
24
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
45.7
19.3
23
6
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
19.2
18
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
+∞
15.9
15
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
13.7
15.1
26
23
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
14.9
14
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
142.7
12.7
13
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
71.3
11.8
13
*
H02AB06
ATC
prednisolone; systemic
3.2
9.8
82
436
E03.89
ICD-10 Finland
Other specified hypothyroidism
+∞
9.5
9
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
9.5
9
*
H02AB07
ATC
prednisone; oral
4.2
8.6
34
99
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
95.8
8.5
9
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
7.4
7
*
2450A
ICD-9 Finland
Thyroiditis, Acute thyroiditis
+∞
7.4
7
*
T86
ICPC
Hypothyroidism/myxoedema
42.2
6.8
8
*
J01FA06
ATC
roxithromycin; oral
2.6
6.5
68
380
C07AA05
ATC
propranolol; systemic
3.0
6.2
40
165
R03AC02
ATC
salbutamol; inhalant
2.5
6.2
84
536

Mortality – FinRegistry

Association

Association between endpoint E4_THYROIDITACU and mortality.

Females

Parameter HR [95% CI] p-value
E4_THYROIDITACU 1.181 [0.92, 1.52] 0.199
Birth year 0.999 [0.99, 1.01] 0.739

During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 742 females with E4_THYROIDITACU died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITACU.

N-year risk Females Males
1 0.117% No data
5 0.776% No data
10 1.927% No data
15 3.803% No data
20 6.664% No data

Relationships between endpoints

Index endpoint: E4_THYROIDITACU – Acute thyroiditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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