Other and/or unspecified nontoxic goitre

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E04.8, E04.9
  • Hospital discharge: ICD-9 2419
  • Cause of death: ICD-10 E04.8, E04.9
  • Cause of death: ICD-9 2419

2 out of 7 registries used, show all original rules.

3263

4. Check minimum number of events

None

3263

5. Include endpoints

None

3263

6. Filter based on genotype QC (FinnGen only)

3263

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 22270 18757 3408
Only index persons 20487 17456 3031
Unadjusted period prevalence (%)
Whole population 0.47 0.54 0.10
Only index persons 0.56 0.64 0.12
Median age at first event (years)
Whole population 57.28 56.61 61.03
Only index persons 56.26 55.63 59.94

-FinnGen-

Key figures

All Female Male
Number of individuals 3263 2724 539
Unadjusted period prevalence (%) 0.81 0.93 0.24
Median age at first event (years) 54.43 53.01 61.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2910
Matched controls
29098
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
362.0
323.0
952
39
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
323.0
369
*
104
Kela drug reimbursment
Thyroid insufficiency
522.9
323.0
688
17
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
128.1
323.0
568
55
H03AA01
ATC
levothyroxine sodium; systemic
96.4
323.0
1583
355
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2307.9
323.0
2364
53
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
2151.0
323.0
358
*
BAA60
NOMESCO Finland
Total thyroidectomy
648.8
323.0
489
9
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
292.8
323.0
806
38
E04.8
ICD-10 Finland
Other specified nontoxic goitre
570.7
315.5
308
6
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
142.7
257.4
272
21
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
589.2
223.5
219
*
2504
FHL
Unilateral resection or enucleation
185.5
199.7
207
12
E03
ICD-10 Finland
Other hypothyroidism
61.7
194.7
228
40
H03BB01
ATC
carbimazole; oral
86.0
192.4
215
27
E03.89
ICD-10 Finland
Other specified hypothyroidism
331.8
184.4
185
6
T86
ICPC
Hypothyroidism/myxoedema
71.0
184.0
211
32
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
228.3
168.1
172
8
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
572.9
165.8
163
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
28.2
146.9
203
77
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.0
145.3
384
615
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
1359.5
134.4
130
*
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
31.5
132.7
178
60
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
96.0
132.4
146
16
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
326.5
123.3
124
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
122.8
117
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
124.0
110.9
119
10
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
30.1
101.9
138
48
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
99.5
95
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
97.4
93
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
12.3
83.5
155
132
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
82.2
951
4975
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
30.2
77.8
105
36
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
211.0
60.3
62
*
T81
ICPC
Goitre
47.7
57.6
70
15
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
49.9
44.9
54
11
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
44.9
715
4097
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
4.3
44.4
172
417
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
64.8
44.3
51
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
41.2
1160
8026
E04
ICD-10 Finland
Other nontoxic goitre
37.8
41.0
52
14
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
207.8
39.9
41
*
N02BE01
ATC
paracetamol; systemic, rectal
2.0
39.7
2550
22566
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
65.2
39.1
45
7
R13
ICD-10 Finland
Dysphagia
2.9
39.1
250
902
R06.0
ICD-10 Finland
Dyspnoea
1.8
36.8
754
4673
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
351.3
35.0
35
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
34.4
33
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
34.3
200
676
R03AC02
ATC
salbutamol; inhalant
1.6
33.6
1512
11687
106
Kela drug reimbursment
Hypoparathyroidism
56.4
33.3
39
7
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
32.3
31
*
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
32.3
31
*
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
32.3
31
*
ZXA05
NOMESCO Finland
Left side
1.7
32.1
785
5112
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
166.8
31.7
33
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
31.5
1022
7204
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
30.3
29
*
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
107.8
29.7
32
*
ZXA00
NOMESCO Finland
Right side
1.7
29.5
834
5634
A02BC02
ATC
pantoprazole; systemic
1.6
29.1
1889
15717
E83.51
ICD-10 Finland
Hypocalcemia
13.7
29.0
50
37
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
28.2
27
*
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
273.5
26.8
27
*
2506
FHL
Thyroidectomy
141.3
26.6
28
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
25.7
829
5759
A02BC05
ATC
esomeprazole; systemic
1.5
24.3
1181
9028
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
24.2
755
5189
M79.6
ICD-10 Finland
Pain in limb
1.5
23.6
1018
7565
N02AX02
ATC
tramadol; systemic, rectal
1.5
23.5
1159
8872
BA1AE
SPAT
NA
10.1
23.3
46
46
R49.01
ICD-10 Finland
Functional dysphonia
3.3
23.1
121
380
A11CC03
ATC
alfacalcidol; systemic
4.5
22.8
82
186
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
16.6
22.7
36
22
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
120.9
22.6
24
*
J01DB01
ATC
cefalexin; oral
1.6
22.4
2253
20003
H02AB06
ATC
prednisolone; systemic
1.5
22.3
1282
10104
T85
ICPC
Hyperthyroidism/thyrotoxicosis
27.5
22.2
30
11
GB1AA
NOMESCO Finland
Tracheal X-ray examination
+∞
21.9
21
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
21.8
598
3957
J01AA02
ATC
doxycycline; systemic
1.5
21.1
2232
19854
R53
ICD-10 Finland
Malaise and fatigue
1.7
20.6
543
3546
4CJ01
NOMESCO Finland
NA
110.8
20.6
22
*
ZXA10
NOMESCO Finland
Bilateral
1.6
20.4
544
3561
C07AB07
ATC
bisoprolol; oral
1.5
20.3
1261
10027
E06.3
ICD-10 Finland
Autoimmune thyroiditis
27.2
20.0
27
10
BAA30
NOMESCO Finland
Excision of thyroid isthmus
57.9
19.9
23
*
A11CC02
ATC
dihydrotachysterol; oral
36.0
19.8
25
7
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
19.8
19
*
A02BC03
ATC
lansoprazole; oral
1.5
19.7
844
6201
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
19.7
348
2008
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
19.4
1221
9705
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
19.3
640
4426
T72
ICPC
Benign neoplasm thyroid
26.2
19.1
26
10
M25.5
ICD-10 Finland
Pain in joint
1.5
18.9
800
5852
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
18.8
18
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
18.7
297
1653
J01FA10
ATC
azithromycin; systemic
1.4
18.5
1563
13090
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.0
18.4
59
120
M03BX02
ATC
tizanidine; oral
1.4
18.3
1695
14423
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
18.3
1044
8114
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
25.2
18.2
25
10
J01FA06
ATC
roxithromycin; oral
1.4
18.1
1137
8996
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.1
17.9
99
325
A48
ICPC
General and Unspecified, Clarification/discussion RFE/demand
2.4
17.9
158
684
A02BA02
ATC
ranitidine; systemic
1.6
17.8
562
3832
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
26.9
17.8
24
9
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
67.0
17.7
20
*
R4110
NOMESCO Finland
Physiotherapy
1.5
17.7
735
5343
R03DC03
ATC
montelukast; oral
1.6
17.5
449
2898
E06.9
ICD-10 Finland
Thyroiditis, unspecified
42.2
17.3
21
5
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
17.3
702
5073
UJF32
NOMESCO Finland
Coloscopy
1.5
17.2
720
5236
M01AB05
ATC
diclofenac; systemic, rectal
1.4
17.1
1815
15733
N03AX16
ATC
pregabalin; oral
1.5
17.1
640
4538
R21
ICPC
Throat symptom/complaint
1.6
17.0
465
3053
J02AC01
ATC
fluconazole; systemic
1.4
16.7
1214
9820
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
16.7
16
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
16.7
16
*
L28
ICPC
Limited function/disability (L)
1.6
16.6
435
2821
R42
ICD-10 Finland
Dizziness and giddiness
1.5
16.6
611
4312
Z71.8
ICD-10 Finland
Other specified counselling
1.5
16.5
609
4298
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
16.5
446
2917
WX110
NOMESCO Finland
Local anesthesy
1.4
16.2
1798
15635
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
16.0
478
3206
SPAT1336
SPAT
Request for examination
2.6
16.0
119
472
ZX114
NOMESCO Finland
Intramuscular
4.5
16.0
56
126
UJD02
NOMESCO Finland
Gastroscopy
2.3
15.9
153
692
M54.5
ICD-10 Finland
Low back pain
1.4
15.7
848
6476
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
15.6
15
*
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
85.5
15.6
17
*
WX002
NOMESCO Finland
Sedation and analgesia
1.5
15.5
545
3795
M01AE02
ATC
naproxen; oral, rectal
1.4
15.2
1504
12749
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
15.0
561
3962
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
15.0
940
7366
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
15.0
459
3092
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
14.8
1210
9923
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
14.6
14
*
R01AD09
ATC
mometasone; nasal
1.4
14.5
1196
9809
R52.9
ICD-10 Finland
Pain, unspecified
1.9
14.4
232
1298
G44.2
ICD-10 Finland
Tension-type headache
1.6
14.3
361
2312
R03BA05
ATC
fluticasone; inhalant
1.5
14.2
487
3370
N06AX11
ATC
mirtazapine; oral
1.4
14.1
818
6302
WX402
NOMESCO Finland
General anaesthesia
1.6
14.1
418
2794
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
4.3
14.1
52
124
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.3
14.0
71
221
R07.0
ICD-10 Finland
Pain in throat
2.1
14.0
155
751
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
12.7
13.9
24
19
A02BC01
ATC
omeprazole; systemic
1.4
13.8
741
5622
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
13.8
292
1779
G47.3
ICD-10 Finland
Sleep apnoea
1.5
13.8
456
3128
J01DA01
ATC
[U] cefalexin; systemic
1.4
13.7
1693
14763
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
13.7
746
5679
UJC01
NOMESCO Finland
Scopy of lower throat
5.7
13.6
38
67
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
13.5
13
*
S18
ICPC
Laceration/cut
1.4
13.5
1093
8903
E05.89
ICD-10 Finland
Other thyrotoxicosis
140.6
13.5
14
*
R51.80
ICD-10 Finland
Headache
1.6
13.4
365
2387
S21
ICPC
Skin texture symptom/complaint
1.6
13.3
334
2136
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.9
13.3
190
1015
J01FA09
ATC
clarithromycin; systemic
1.4
13.3
840
6557
C07AA05
ATC
propranolol; systemic
1.5
13.2
494
3479
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
12.9
494
3496
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.0
12.9
165
849
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
11.6
12.8
23
20
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
12.7
594
4380
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
12.6
422
2894
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
12.6
354
2330
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
12.5
439
3043
N03AX12
ATC
gabapentin; oral
1.5
12.5
408
2784
BAA99
NOMESCO Finland
Other operation on thyroid gland
+∞
12.5
12
*
K30
ICD-10 Finland
Functional dyspepsia
1.7
12.4
295
1860
R02
ICPC
Shortness of breath/dyspnoea
1.6
12.4
312
1997
R05
ICD-10 Finland
Cough
1.5
12.4
513
3689
L17
ICPC
Foot/toe symptom/complaint
1.4
12.3
665
5036
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
11.7
12.3
22
19
R01BA52
ATC
pseudoephedrine, combinations; oral
1.4
12.1
870
6922
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
12.1
219
1270
B60
ICPC
Blood and Immunity, Result test/procedure
3.8
12.0
49
129
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.6
11.9
321
2089
M02AA07
ATC
piroxicam; topical
1.3
11.9
1015
8296
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.7
11.9
266
1649
R01AD08
ATC
fluticasone; nasal
1.4
11.8
729
5648
R06.5
ICD-10 Finland
Mouth breathing
1.9
11.7
183
1012
EP1AE
SPAT
NA
4.2
11.5
42
100
R60.0
ICD-10 Finland
Localized oedema
1.6
11.5
292
1873
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
11.5
11
*
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
11.5
11
*
2509
FHL
Other measure in this category
+∞
11.5
11
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
11.4
281
1786
T71
ICPC
Malignant neoplasm thyroid
120.4
11.4
12
*
WZC30
NOMESCO Finland
Teaching
1.6
11.4
326
2152
J01FF01
ATC
clindamycin; systemic
1.4
11.3
670
5152
R05FB02
ATC
cough suppressants and expectorants
1.3
11.2
1049
8673
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
11.2
469
3374
H02AB07
ATC
prednisone; oral
1.5
11.2
380
2617
M01AH05
ATC
etoricoxib; oral
1.3
11.2
1555
13604
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
11.1
171
943
R01AD12
ATC
fluticasone furoate; nasal
1.4
11.0
719
5610
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.7
11.0
223
1341
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
11.0
386
2673
S29
ICPC
Skin symptom/complaint other
1.5
11.0
430
3050
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
11.0
1090
9083
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
10.9
1205
10187
P01AB01
ATC
metronidazole; oral, rectal
1.3
10.9
1085
9041
E07.89
ICD-10 Finland
Other specified disorders of thyroid
43.5
10.9
13
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.6
10.9
289
1876
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
10.8
228
1387
J01MA02
ATC
ciprofloxacin; systemic
1.3
10.8
955
7818
C07AB02
ATC
metoprolol; systemic
1.4
10.7
528
3921
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
10.7
2452
23023
A60
ICPC
General and Unspecified, Result test/procedure
2.1
10.6
119
582
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
10.5
1422
12344
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.6
10.5
283
1844
E03.8
ICD-10 Finland
Other specified hypothyroidism
110.4
10.4
11
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
5.0
10.3
32
65
K02.1
ICD-10 Finland
Caries of dentine
1.3
10.2
1357
11730
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.6
10.2
300
1993
R03AC03
ATC
terbutaline; inhalant
1.5
10.2
361
2504
XF402
NOMESCO Finland
ECG with work load test
1.6
10.2
269
1741
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
10.1
1272
10910
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.4
10.1
85
363
R07.3
ICD-10 Finland
Other chest pain
1.6
10.1
242
1528
K59.09
ICD-10 Finland
Constipation, unspecified
1.9
9.9
151
828
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
9.9
493
3662
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
1.8
9.8
156
867
2409X
ICD-9 Finland
Simple and unspecified goitre, Goitre, unspecified
26.1
9.8
13
5
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.6
9.8
286
1901
UKC02
NOMESCO Finland
Cystoscopy
1.5
9.7
324
2219
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
9.7
563
4302
EB1AA
SPAT
NA
2.0
9.6
119
607
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.3
9.5
672
5295
N17
ICPC
Vertigo/dizziness
1.5
9.5
293
1971
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
9.5
967
8048
B01AB05
ATC
enoxaparin; parenteral
1.3
9.4
804
6521
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.6
9.4
273
1811
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
9.4
625
4878
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
9.2
1503
13275
M01AH02
ATC
rofecoxib; oral
1.5
9.2
363
2576
M01AC06
ATC
meloxicam; systemic, rectal
1.3
9.2
993
8318
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
9.1
336
2348
K48
ICPC
Cardiovascular, Clarification/discussion RFE/demand
5.6
9.0
25
45
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
3.7
9.0
38
105
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
9.0
762
6165
SPAT1212
SPAT
Extensive examination of musculoskeletal system
1.6
8.9
205
1279
M01AG02
ATC
tolfenamic acid; oral, rectal
1.4
8.9
419
3078
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
12.6
8.9
15
12
L01
ICPC
Neck symptom/complaint
1.5
8.8
349
2477
Z01.2
ICD-10 Finland
Dental examination
1.3
8.8
999
8408
XF600
NOMESCO Finland
Bloodpressure measurement
1.8
8.8
142
797
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
8.8
365
2614
N01
ICPC
Headache
1.6
8.7
220
1407
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
8.7
576
4486
R03BA02
ATC
budesonide; inhalant
1.4
8.7
444
3311
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
14.1
8.7
14
10
L12
ICPC
Hand/finger symptom/complaint
1.5
8.6
348
2477
R4130
NOMESCO Finland
Speech therapy
2.7
8.6
57
216
K43
ICPC
Cardiovascular, Other diagnostic procedure
3.5
8.6
38
109
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
8.6
177
1069
J01CA04
ATC
amoxicillin; systemic
1.3
8.6
2137
19816
N06AX21
ATC
duloxetine; oral
1.5
8.6
258
1727
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
8.6
252
1678
R29
ICPC
Respiratory symptom/complaint other
1.8
8.5
145
831
C08CA01
ATC
amlodipine; oral
1.3
8.5
877
7281
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.9
8.5
124
675
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.6
8.5
197
1235
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
8.5
362
2612
A29
ICPC
General symptom/complaint other
1.5
8.4
264
1781
C03AA03
ATC
hydrochlorothiazide; oral
1.5
8.4
252
1682
S48
ICPC
Skin, Clarification/discussion RFE/demand
5.6
8.4
23
41
A12AA04
ATC
calcium carbonate; oral
3.3
8.4
40
122
A01
ICPC
Pain general/multiple sites
1.6
8.4
192
1199
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.7
8.4
170
1022
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
90.3
8.4
9
*
L03
ICPC
Low back symptom/complaint
1.3
8.4
591
4647
24100
ICD-8 Finland
Non-toxic nodular goitre, Endemic
+∞
8.3
8
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
8.3
8
*
M79.7
ICD-10 Finland
Fibromyalgia
2.1
8.3
93
454
F01
ICPC
Eye pain
2.3
8.3
73
322
WZB00
SPAT
NA
2.2
8.3
79
363
Z00.8
ICD-10 Finland
Other general examinations
1.7
8.3
157
930
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
8.2
1366
12024
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.5
8.2
258
1745
A98
ICD-10 Finland
Other viral haemorrhagic fevers, not elsewhere classified
2.6
8.1
57
224
E66.8
ICD-10 Finland
Other obesity
1.9
8.1
123
677
M01AX17
ATC
nimesulide; oral
1.3
8.1
659
5289
C03CA01
ATC
furosemide; systemic
1.3
8.1
667
5359
D06
ICPC
Abdominal pain localized other
1.6
8.1
209
1348
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
2.4
8.0
66
283
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
7.9
154
920
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
7.9
541
4229
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.7
7.9
172
1061
L15
ICPC
Knee symptom/complaint
1.3
7.9
542
4238
R49.08
ICD-10 Finland
Other specified dysphonia
2.4
7.8
65
280
A01AB09
ATC
miconazole; local oral
1.5
7.8
229
1524
D01
ICPC
Abdominal pain/cramps general
1.5
7.8
255
1741
R4110
SPAT
NA
2.1
7.8
80
380
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.6
7.8
193
1231
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.4
7.7
502
3890
R06AE07
ATC
cetirizine; oral
1.3
7.7
1135
9821
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
5.3
7.7
22
42
M01AH01
ATC
celecoxib; oral (coxibs)
1.4
7.7
492
3808
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.6
7.7
206
1343
Z50.1
ICD-10 Finland
Other physical therapy
1.7
7.7
148
883
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
3.3
7.6
36
110
WZC30
SPAT
NA
2.5
7.6
56
224
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
7.6
314
2247
R05
ICPC
Cough
1.3
7.5
555
4383
N05AH04
ATC
quetiapine; oral
1.4
7.5
319
2295
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
7.5
650
5252
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
7.4
1771
16160
L04
ICPC
Chest symptom/complaint
1.7
7.4
140
827
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.4
7.4
460
3543
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
2.4
7.3
59
251
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
1.9
7.3
103
556
2462A
ICD-9 Finland
Other disorders of thyroid, Cyst of thyroid
+∞
7.3
7
*
C739
ICD-10 Finland
NA
+∞
7.3
7
*
R96
ICPC
Asthma
1.5
7.3
217
1450
J34.2
ICD-10 Finland
Deviated nasal septum
1.9
7.2
94
491
A04
ICPC
Weakness/tiredness general
1.4
7.2
293
2087
M54
ICD-10 Finland
Dorsalgia
1.5
7.2
261
1820
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.3
7.2
655
5330
M54.2
ICD-10 Finland
Cervicalgia
1.6
7.2
167
1049
L48
ICPC
Musculoskeletal, Clarification/discussion RFE/demand
3.4
7.2
33
99
I49.3
ICD-10 Finland
Ventricular premature depolarization
1.6
7.2
160
991
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
7.3
7.2
16
22
E23.05
ICD-10 Finland
Lack of TSH
30.1
7.1
9
*
H57.1
ICD-10 Finland
Ocular pain
2.1
7.1
80
394
S01
ICPC
Pain/tenderness of skin
1.9
7.1
101
543
A12AA06
ATC
calcium lactate gluconate; oral
20.1
7.1
10
5
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
20.1
7.1
10
5
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
7.1
244
1681
J37.0
ICD-10 Finland
Chronic laryngitis
2.0
7.1
82
409
WW200
SPAT
NA
1.5
7.0
233
1591
WX704
NOMESCO Finland
Intubation
1.6
7.0
168
1063
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.2
7.0
69
322
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
7.0
295
2123
H02AB04
ATC
methylprednisolone; systemic
1.4
7.0
369
2766
SXC05
NOMESCO Finland
Other oral or dental procedure
1.8
6.9
120
690
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.3
6.9
460
3577
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.5
6.9
199
1323
K80
ICPC
Cardiac arrhythmia NOS
1.6
6.9
188
1229
S04
ICPC
Lump/swelling localized
1.5
6.8
209
1405
Z01.7
ICD-10 Finland
Laboratory examination
1.5
6.8
252
1765
XCH00
NOMESCO Finland
Eye pressure measurement
1.8
6.8
106
590
N04BC05
ATC
pramipexole; oral
1.6
6.8
186
1218
Z97.4
ICD-10 Finland
Presence of external hearing-aid
1.8
6.8
106
592
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
1.9
6.8
88
459
N05CF01
ATC
zopiclone; oral
1.3
6.8
812
6836
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.4
6.8
269
1911
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
40.1
6.8
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
6.8
348
2596
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
16.7
6.7
10
6
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
6.7
228
1566
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.5
6.7
190
1255
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.3
6.7
460
3591
M79.1
ICD-10 Finland
Myalgia
1.4
6.7
297
2155
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.7
6.7
43
160
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.4
6.7
318
2338
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.4
6.6
406
3117
R69
ICD-10 Finland
Unknown and unspecified causes of morbidity
2.5
6.6
50
205
R68.2
ICD-10 Finland
Dry mouth, unspecified
3.9
6.6
25
65
C10AA07
ATC
rosuvastatin; oral
1.3
6.5
576
4657
R60.9
ICD-10 Finland
Oedema, unspecified
1.7
6.5
116
676
A99
ICPC
Disease/condition unspecnature/site
1.5
6.5
190
1265
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
2.7
6.4
42
159
RD210
NOMESCO Finland
NA
2.6
6.4
44
173
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
1.7
6.4
116
680
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
1.7
6.4
119
700
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.6
6.4
141
872
E06.0
ICD-10 Finland
Acute thyroiditis
70.0
6.4
7
*
J01DA06
ATC
[U] cefuroxime; systemic
1.4
6.4
356
2687
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.3
6.4
429
3335
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
6.4
224
1551
R74
ICPC
Upper respiratory infection acute
1.3
6.4
612
5004
T90
ICPC
Diabetes non-insulin dependent
1.3
6.4
497
3954
J45
ICD-10 Finland
Asthma
1.5
6.4
232
1620
K99
ICPC
Cardiovascular disease other
2.1
6.4
63
297
A62
ICPC
General and Unspecified, Administrative procedure
2.2
6.4
58
264
D19
ICPC
Teeth/gum symptom/complaint
1.3
6.3
585
4760
A98
ICPC
Health maint/preventive medicine
1.4
6.3
2709
26278
XF404
NOMESCO Finland
Ambulatory ECG
1.5
6.3
207
1413
WX110
SPAT
NA
1.8
6.3
98
548
F29
ICPC
Eye symptom/complaint other
1.5
6.3
192
1293
C73.94
ICD-10 Finland
Medullary thyroid carcinoma (thyroid)
+∞
6.2
6
*
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
6.2
6
*
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
6.2
6
*
2400A
ICD-9 Finland
Simple and unspecified goitre, Goitre, specified as simple
+∞
6.2
6
*
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.7
6.2
129
789
C08CA13
ATC
lercanidipine; oral
1.4
6.2
315
2346
E66.01
ICD-10 Finland
Obesity due to excess calories
1.6
6.2
159
1026
A97
ICPC
No disease
1.4
6.2
325
2431
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
1.7
6.1
113
667
L29
ICPC
Musculoskeletal sympt/complt other
1.5
6.1
186
1250
S54
ICPC
Skin, Repair/fix-suture/cast/prosth device
1.9
6.1
79
414
J31.0
ICD-10 Finland
Chronic rhinitis
1.5
6.1
177
1177
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
6.1
1561
14203
J01FA01
ATC
erythromycin; systemic
1.4
6.1
315
2347
C10AA05
ATC
atorvastatin; oral
1.2
6.1
886
7607
D21
ICPC
Swallowing problem
2.9
6.1
35
123
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
6.1
317
2369

Mortality – FinRegistry

Association

Association between endpoint E4_GOITRENAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_GOITRENAS 1.061 [0.97, 1.17] 0.221
Birth year 0.996 [0.99, 1.0] 0.364

During the follow-up period (1.1.1998 — 31.12.2019), 2088 out of 13454 females with E4_GOITRENAS died.

Males

Parameter HR [95% CI] p-value
E4_GOITRENAS 1.154 [1.02, 1.31] 0.028
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 606 out of 2491 males with E4_GOITRENAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_GOITRENAS.

N-year risk Females Males
1 0.089% 0.195%
5 0.636% 1.32%
10 1.595% 3.405%
15 3.024% 6.447%
20 5.332% 10.87%

Relationships between endpoints

Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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