No definition available.
Drug-induced headache, not elsewhere classified
DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
196 |
4. Check minimum number of eventsNone |
196 |
5. Include endpointsNone |
196 |
6. Filter based on genotype QC (FinnGen only) |
196 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced headache, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other headache syndromes
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1129 | 777 | 342 |
| Only index persons | 1067 | 749 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.97 | 46.58 | 48.11 |
| Only index persons | 46.83 | 46.39 | 47.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 196 | 155 | 41 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.02 |
| Median age at first event (years) | 48.48 | 46.97 | 54.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1827
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G44.4
ICD-10 Finland
Drug-induced headache, not elsewhere classified
+∞
264.8
183
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
21.0
56.8
91
82
N03AX11
ATC
topiramate; oral
29.1
43.9
60
30
G43.3
ICD-10 Finland
Complicated migraine
42.1
42.1
52
17
R51.80
ICD-10 Finland
Headache
10.7
42.1
98
178
G44.2
ICD-10 Finland
Tension-type headache
10.0
37.8
89
158
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
8.5
35.7
97
214
G43.9
ICD-10 Finland
Migraine, unspecified
12.4
34.8
68
83
N02CC07
ATC
frovatriptan; oral
14.6
30.7
54
51
3007
Kela drug reimbursment
Erenumab and fremanezumab
41.7
30.1
37
11
N02CD01
ATC
erenumab; parenteral
55.0
27.5
32
7
C09CA06
ATC
candesartan; oral
6.4
27.4
91
245
N06CA01
ATC
amitriptyline and psycholeptics; systemic
8.2
26.5
66
117
N02CC04
ATC
rizatriptan; oral
10.2
26.0
55
74
N03AG01
ATC
valproic acid; systemic, rectal
11.8
25.4
49
55
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
9.5
24.6
54
77
G43
ICD-10 Finland
Migraine
12.2
24.4
46
49
N02CC05
ATC
almotriptan; oral
13.0
23.7
43
42
N02CC06
ATC
eletriptan; oral
11.7
21.5
41
44
N02CC03
ATC
zolmitriptan; nasal, oral
9.1
21.2
47
67
N02CD03
ATC
fremanezumab; systemic
47.9
21.1
25
6
N02CC02
ATC
naratriptan; oral
24.3
20.7
29
14
N06AA09
ATC
amitriptyline; systemic
7.4
20.5
53
96
N03AX12
ATC
gabapentin; oral
6.1
19.3
59
133
M03AX01
ATC
botulinum toxin; parenteral
34.2
18.9
24
8
N03AX16
ATC
pregabalin; oral
4.6
17.8
74
233
N01
ICPC
Headache
6.0
17.4
53
117
G43.8
ICD-10 Finland
Other migraine
18.7
17.1
26
16
A03FA01
ATC
metoclopramide; systemic, rectal
4.4
16.6
73
239
N06AX21
ATC
duloxetine; oral
5.8
16.3
50
111
C07AA05
ATC
propranolol; systemic
4.2
16.0
76
266
N89
ICPC
Migraine
9.7
15.6
32
39
C07AB02
ATC
metoprolol; systemic
4.7
14.8
56
156
N02AX02
ATC
tramadol; systemic, rectal
3.5
14.5
103
491
M01AG02
ATC
tolfenamic acid; oral, rectal
4.0
14.4
68
233
A02BC03
ATC
lansoprazole; oral
3.7
14.2
82
331
G44.0
ICD-10 Finland
Cluster headache syndrome
16.8
13.5
21
14
N05BA01
ATC
diazepam; systemic, rectal
4.9
12.8
45
114
C07AB07
ATC
bisoprolol; oral
3.2
12.8
98
482
N06AX16
ATC
venlafaxine; oral
4.4
12.6
51
149
M03BX02
ATC
tizanidine; oral
3.5
12.3
144
944
A02BC02
ATC
pantoprazole; systemic
3.3
12.2
138
877
C08DA01
ATC
verapamil; systemic
9.6
11.4
23
27
M79.1
ICD-10 Finland
Myalgia
4.2
11.3
46
135
A02BA02
ATC
ranitidine; systemic
3.6
10.8
54
189
N02CA52
ATC
ergotamine, combinations excl. psycholeptics; oral
25.1
10.4
14
6
A02BC05
ATC
esomeprazole; systemic
2.8
10.3
98
528
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
10.1
94
499
AA1AD
NOMESCO Finland
CT of head and brain
3.3
9.8
56
214
R53
ICD-10 Finland
Malaise and fatigue
3.3
9.8
57
222
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
9.6
61
250
M01AE02
ATC
naproxen; oral, rectal
2.8
9.5
130
854
N06AA10
ATC
nortriptyline; systemic
11.6
9.5
17
16
M03BC51
ATC
orphenadrine, combinations; systemic
2.8
9.4
75
360
N02CX04
ATC
NA
12.4
9.3
16
14
N06AX11
ATC
mirtazapine; oral
2.7
8.9
80
409
M03BC01
ATC
orphenadrine (citrate); systemic
2.9
8.9
64
286
H02AB06
ATC
prednisolone; systemic
2.6
8.9
105
624
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.7
8.8
41
134
R51
ICD-10 Finland
Headache
5.2
8.8
27
59
G43.2
ICD-10 Finland
Status migrainosus
29.1
8.6
11
*
N05AH04
ATC
quetiapine; oral
3.2
8.5
49
186
H02AB07
ATC
prednisone; oral
3.3
8.4
46
170
N02BE01
ATC
paracetamol; systemic, rectal
3.8
8.2
167
1339
M01AE03
ATC
ketoprofen; systemic, rectal
2.5
7.9
83
454
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
7.9
34
104
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
7.8
29
77
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.7
7.8
64
303
N02CD02
ATC
galcanezumab; parenteral
47.0
7.8
9
*
N06AB04
ATC
citalopram; systemic
2.8
7.6
57
256
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
7.6
101
619
N03AX09
ATC
lamotrigine; oral
5.4
7.6
22
45
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
7.4
60
281
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
7.4
26
66
R07.4
ICD-10 Finland
Chest pain, unspecified
2.8
7.3
55
246
Z76.0
ICD-10 Finland
Issue of repeat prescription
3.1
7.2
43
167
N03AE01
ATC
clonazepam; systemic
4.7
7.0
23
54
N05BA04
ATC
oxazepam; oral
2.5
6.9
62
307
M01AB05
ATC
diclofenac; systemic, rectal
2.4
6.9
135
985
K07.61
ICD-10 Finland
Cracking jaw joint
12.9
6.7
11
9
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
3.1
6.6
37
137
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.8
6.6
44
183
N06AX12
ATC
bupropion; oral
4.3
6.5
23
59
N02CA01
ATC
dihydroergotamine; nasal, systemic
18.8
6.3
9
5
R42
ICD-10 Finland
Dizziness and giddiness
2.6
6.3
48
217
P01AB01
ATC
metronidazole; oral, rectal
2.2
6.3
87
528
G44.3
ICD-10 Finland
Chronic post-traumatic headache
+∞
6.3
6
*
SPAT1050
SPAT
Extensive neurological examination
9.1
6.2
12
14
N06AB03
ATC
fluoxetine; oral
3.0
6.1
37
143
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.32 [1.0, 1.74] | 0.046 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 665 females with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.614 [1.08, 2.4] | 0.019 |
| Birth year | 0.989 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 305 males with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.348% |
| 5 | 0.718% | 1.909% |
| 10 | 1.867% | 4.967% |
| 15 | 3.603% | 9.259% |
| 20 | 6.513% | 15.684% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED – Drug-induced headache, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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