Secondary sideroblastic anaemia

D3_SIDEROANASCND

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D64.1, D64.2# Hospital discharge: ICD-9 — 2850B Cause of death: ICD-10 — D64.1, D64.2# Cause of death: ICD-9 — 2850B 2 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Control exclude: D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	D3_SIDEROANASCND
CONTROL_EXCLUDE	D3_APLASTICANDOTHANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D64[1-2]
HD_ICD_9	2850B
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D64[1-2]
COD_ICD_9	2850B
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Secondary sideroblastic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Secondary sideroblastic anaemia due to drugs and toxins

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1282	722	533
Only index persons	764	448	316
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	73.93	74.43	73.16
Only index persons	71.08	70.32	72.17

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	53	50
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	67.79	62.67	73.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
96: Matched controls
958

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D64.1

ICD-10 Finland

Secondary sideroblastic anaemia due to disease

+∞

92.0

D64.9

ICD-10 Finland

Anaemia, unspecified

179.6

56.6

D64.2

ICD-10 Finland

Secondary sideroblastic anaemia due to drugs and toxins

+∞

23.9

B03XA02

ATC

darbepoetin alfa; parenteral

135.6

11.7

ZX120

NOMESCO Finland

Intravenous

7.5

10.3

XW000

NOMESCO Finland

Bone marrow biopsy

23.1

10.1

A04AA01

ATC

ondansetron; systemic, rectal

12.0

10.0

UJF32

NOMESCO Finland

Coloscopy

4.6

9.3

115

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

4.3

9.3

148

WW500

NOMESCO Finland

Blood transfusion

14.5

9.2

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

19.3

8.3

A49.9

ICD-10 Finland

Bacterial infection, unspecified

5.6

8.3

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

7.4

8.1

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

20.4

7.8

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

9.6

7.7

D46.9

ICD-10 Finland

Myelodysplastic syndrome, unspecified

+∞

7.4

D46.1

ICD-10 Finland

Refractory anaemia with ring sideroblasts

+∞

7.4

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

12.3

7.0

Z51.5

ICD-10 Finland

Palliative care

6.9

6.7

C03CA01

ATC

furosemide; systemic

3.0

6.4

252

Z48.0

ICD-10 Finland

Attention to surgical dressings and sutures

13.8

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(4281824)

15.63

6.54

1.5

1.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

7.28

6.43

2.1

1.5

—

(3025159) Blasts/100 leukocytes in Blood

3.64

4.87

5.8

5.5

0.7

0.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

4.11

4.83

1.6

1.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

107

2.91

4.78

3.3

2.9

mmol/l

0.8

0.12

(3017181) Myelocytes/100 leukocytes in Blood

3.36

4.55

6.5

5.2

1.7

0.7

—

(3021440) Promyelocytes/100 leukocytes in Blood

3.44

4.48

6.2

5.4

0.2

0.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

169

2.51

4.30

2.7

1.7

mg/l

3.2

3.0

0.21

145

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

4.11

4.22

5.2

5.5

mmol/l

24.9

24.8

0.05

(3042111) Morphology [Interpretation] in Bone marrow Narrative

8.56

4.14

1.6

—

(3022217) INR in Platelet poor plasma by Coagulation assay

102

2.76

4.12

14.3

28.3

—

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.21

3.64

2.3

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

208

2.22

3.45

7.6

2.2

—

(3012544) pH of Venous blood

2.97

3.41

4.6

3.8

—

(3002179) Metamyelocytes/100 leukocytes in Blood

3.02

3.13

6.6

5.6

0.8

0.3

—

(21494434) Karyotype in Bone marrow

10.41

3.01

1.4

1.0

—

(3018095) Leukocytes [#/volume] in Urine

266

1.98

2.77

5.2

3.5

e6/l

23.3

39.1

0.64

187

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

102

2.33

2.71

3.7

2.5

e6/l

5.4

3.5

0.32

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

251

1.97

2.69

4.0

3.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

4.92

2.64

1.6

1.1

—

(3003694) ABO and Rh group [Type] in Blood

149

2.10

2.56

1.7

1.3

—

(3000991) Gas panel - Venous blood

2.89

2.55

10.5

8.2

—

(3003396) Base excess in Arterial blood by calculation

2.45

2.54

8.1

6.7

mmol/l

1.9

1.5

0.08

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

6.50

2.40

1.4

1.1

u/l

43.5

12.6

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

6.50

2.40

4.0

2.0

34.4

31.8

—

(1616796) Gas panel - Central venous blood

4.09

2.29

1.3

1.9

—

(4035726)

2.46

2.19

1.6

1.4

—

(3023368) Bacteria identified in Blood by Culture

223

1.86

2.19

8.9

3.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

2.20

2.04

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

308

1.75

1.99

13.7

3.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.91

1.96

1.3

1.8

kpa

4.7

5.0

—

(3027315) Oxygen [Partial pressure] in Blood

3.91

1.96

1.3

1.8

kpa

9.1

8.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.18

1.92

1.6

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.06

1.78

2.7

1.6

—

(42870588) Differential panel, method unspecified - Blood

228

1.73

1.75

12.0

4.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

290

1.69

1.74

2.4

1.9

pmol/l

89.9

98.2

0.59

148

(40760888) Immunoglobulin light chains.free panel - Serum

3.98

1.73

3.0

8.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.98

1.73

1.2

1.5

—

(3013512) EKG study

229

1.72

4.5

4.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

277

1.66

1.61

4.3

—

(3000494) Fungus identified in Specimen by Culture

2.09

1.57

2.2

1.4

—

(3025941) Bacteria identified in Stool by Culture

2.54

1.57

1.5

1.1

—

(3032080) INR in Blood by Coagulation assay

298

1.62

1.54

10.3

9.7

inr

1.3

0.15

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

139

0.40

1.54

5.0

2.9

mmol/l

2.5

—

119

(3037522) Nuclear Ab [Titer] in Serum

2.00

1.49

1.5

1.4

titre

1154.3

712.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

311

1.59

1.45

4.8

3.9

ng/l

64.4

30.8

0.44

223

(3026008) Bacteria identified in Urine by Culture

222

1.64

1.43

3.5

3.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.31

1.41

5.4

2.9

g/l

114.6

128.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

3.04

1.37

1.2

2.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.46

1.32

4.0

2.6

0.6

0.7

—

(3019150) Specific gravity of Urine by Refractometry

166

1.67

1.31

4.1

4.5

kg/l

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.39

1.30

4.4

2.5

1.0

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.86

1.30

2.0

1.2

—

(40758558) Short blood count panel - Blood

167

1.66

1.28

18.4

6.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.15

1.26

1.6

2.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.48

1.26

2.3

2.1

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.71

1.23

2.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

152

1.66

1.23

6.3

2.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

195

1.60

1.22

3.4

3.5

—

(3002030) Lymphocytes/100 leukocytes in Blood

333

1.50

1.17

12.0

4.8

23.8

27.3

1.45

309

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.57

1.16

1.0

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

432

1.47

1.10

7.2

4.1

mmol/l

7.5

6.7

0.47

392

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.13

1.05

15.3

7.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

142

1.60

1.03

6.7

6.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

2.07

1.02

5.3

2.9

mmol/l

20.5

23.9

—

(3022096) Basophils/100 leukocytes in Blood

315

1.44

0.97

11.5

4.6

0.7

0.6

0.29

292

(3019069) Monocytes/100 leukocytes in Blood

326

1.43

0.94

11.7

4.9

10.1

8.6

1.02

305

(3018010) Neutrophils/100 leukocytes in Blood

327

1.42

0.92

10.9

4.6

59.3

58.0

0.27

305

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

654

0.71

0.90

3.5

4.4

mmol/l

1.5

0.06

594

(40768443) Skin Pathology biopsy report

1.93

0.83

1.0

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

324

1.38

0.81

11.6

4.6

2.5

0.04

303

(36304419) Bacteria [Presence] in Urine

186

1.45

0.80

4.4

2.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

481

1.36

0.78

7.2

4.7

—

3818.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.81

0.77

1.0

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.85

0.74

1.6

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

199

1.41

0.72

4.9

4.1

estimate

0.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

349

1.34

0.71

5.7

5.4

estimate

0.0

—

(3009261) Glucose [Presence] in Urine by Test strip

351

1.33

0.68

4.5

4.0

estimate

0.0

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

677

0.76

0.65

4.0

5.0

mmol/l

2.5

2.7

0.58

611

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

667

0.76

0.64

4.1

4.7

mmol/l

6.1

6.0

0.22

602

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.5

—

(3000330) Specific gravity of Urine by Test strip

1.76

0.59

2.7

4.5

—

(3035350) Ketones [Presence] in Urine by Test strip

349

1.29

0.56

4.4

4.0

estimate

0.0

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.61

0.55

8.3

7.4

0.6

0.8

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.61

0.55

8.5

6.7

1.0

1.4

—

(1761868) Lipid panel - Serum or Plasma

219

0.73

0.50

2.8

3.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.64

0.43

1.0

1.4

—

(3018418) pH of Serum or Plasma

217

1.27

0.41

11.5

3.6

7.4

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.49

0.41

2.6

1.6

ug/l

1.6

1.4

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.40

0.0

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

117

1.33

0.38

4.1

1.7

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.45

0.36

3.5

4.0

mmol/l

4.1

1.9

—

(3009343) pH of Capillary blood

1.42

0.35

3.5

4.0

—

7.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.35

0.34

2.3

1.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.40

0.32

2.7

3.9

mmol/l

1.2

—

(3022621) pH of Urine by Test strip

1.40

0.32

1.4

3.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

487

1.18

0.32

6.1

4.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

140

1.26

0.30

1.1

1.2

u/ml

4.1

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

726

0.85

0.27

42.9

17.2

umol/l

96.8

79.7

1.08

726

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.22

0.26

5.4

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.30

0.25

2.7

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.30

0.23

2.4

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.23

0.22

2.8

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.7

—

17.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.3

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.4

—

(3044889) 12 lead EKG panel

482

0.88

0.21

4.7

3.8

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(40761536) Microorganisms panel - Urine sediment

1.27

0.20

5.8

3.5

—

(4010399)

1.27

0.20

1.2

—

(40761511) CBC panel - Blood by Automated count

719

0.88

0.20

39.9

13.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

100

1.23

0.19

1.9

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

388

0.89

0.18

3.6

2.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.16

0.18

3.3

1.4

—

(40768797) Stomach Pathology biopsy report

1.22

0.17

1.2

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.16

6.3

3.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

104

1.17

0.13

4.0

2.3

e6/l

0.8

0.7

—

(3002256) Pathology report gross observation

1.20

0.13

1.6

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.12

0.10

1.4

—

(3000492) Spirometry study

1.12

0.10

1.2

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

214

1.10

0.09

3.0

3.6

mg/mmol

58.5

8.8

0.56

132

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.06

0.07

6.0

1.6

—

(3022145) Colonoscopy Study observation

1.09

0.07

1.2

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

586

1.06

0.06

39.3

14.6

32.8

39.0

3.80

406

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

699

1.05

0.04

36.2

14.7

mg/l

24.6

23.4

0.13

571

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

651

0.96

0.04

32.2

13.7

ml/min/173m2

73.4

76.2

0.39

529

(3011397) Hemoglobin [Presence] in Urine by Test strip

164

1.04

0.00

5.2

4.0

—

(40768804) Tissue Pathology biopsy report

267

1.02

0.00

3.3

2.1

—

(3012516) Albumin [Mass/volume] in Urine

194

0.97

0.00

2.0

2.9

mg/l

210.9

385.5

0.20

122

(4268621)

0.00

0.0

1.6

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

13.0

—

(3019060) Gas panel - Arterial blood

0.98

0.00

12.0

3.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3007368) IgG [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

31.8

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.93

0.00

3.0

1.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.0

—

(4306422)

0.00

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3019225) pH of Specimen

0.86

0.00

5.8

4.0

—

(40761535) Cells panel - Urine sediment

0.93

0.00

8.3

3.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.7

—

(4146454)

0.00

0.0

2.6

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

17.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.0

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

18.8

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.90

0.00

22.6

9.6

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

2.0

—

(36660697) Celiac disease serology panel - Serum

0.92

0.00

1.2

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.2

—

(4024509)

0.00

0.0

1.1

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.1

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.6

—

2300.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.3

—

10.9

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.4

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

4.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_SIDEROANASCND and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_SIDEROANASCND	3.542 [2.71, 4.64]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.186

During the follow-up period (1.1.1998 — 31.12.2019), 412 out of 577 females with D3_SIDEROANASCND died.

Males

Parameter	HR [95% CI]	p-value
D3_SIDEROANASCND	3.319 [2.26, 4.86]	< 0.001
Birth year	0.983 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 305 out of 410 males with D3_SIDEROANASCND died.

Mortality risk

Mortality risk for people of age

years, who have D3_SIDEROANASCND.

N-year risk	Females	Males
1	0.2%	0.499%
5	2.037%	3.407%
10	5.222%	7.914%
15	9.388%	15.3%
20	16.198%	24.868%

Relationships between endpoints

↥

Index endpoint: D3_SIDEROANASCND – Secondary sideroblastic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Secondary sideroblastic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints