This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Polyclonal hypergammaglobulinaemia
D3_POLYCLOHYPERGAMMA
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
38 |
4. Check minimum number of eventsNone |
38 |
5. Include endpointsNone |
38 |
6. Filter based on genotype QC (FinnGen only) |
38 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D89
- Name in latin
- Hypergammaglobulinaemia polyclonalis
Similar endpoints
↥List of similar endpoints to
Polyclonal hypergammaglobulinaemia
based on the number of shared cases.
Similar with more cases:
- Other disorders involving the immune mechanism, not elsewhere classified
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 293 | 131 | 156 |
| Only index persons | 226 | 111 | 115 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 59.57 | 60.32 | 58.32 |
| Only index persons | 56.72 | 57.87 | 55.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 38 | 17 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 53.84 | 47.20 | 59.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3022948) Iron [Moles/volume] in Serum or Plasma
17
50
5.34
5.86
6.6
3.5
umol/l
10.8
14.4
1.40
17
45
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
7
6
13.87
4.47
1.7
1.3
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
7
6
13.87
4.47
1.7
1.3
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
27
136
4.40
4.34
12.9
5.4
g/l
34.9
35.7
0.26
27
131
(42870588) Differential panel, method unspecified - Blood
24
113
4.05
4.20
15.7
4.5
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
6
5
13.86
3.90
1.0
1.8
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
6
5
13.86
3.90
1.0
1.4
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
23
117
3.45
3.37
6.8
3.0
ug/l
122.3
138.9
0.23
23
105
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
11
36
3.89
3.10
3.8
1.6
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
9
23
4.79
3.00
2.3
1.3
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
13
49
3.51
2.99
3.3
1.5
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
19
5.03
2.86
3.1
1.8
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
11
38
3.67
2.86
3.9
1.4
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
19
93
3.09
2.86
6.6
3.3
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
6
10
6.88
2.81
2.0
1.3
mg/l
11.0
11.2
—
6
10
(3000991) Gas panel - Venous blood
10
33
3.76
2.76
25.2
9.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
18
87
3.03
2.74
7.0
5.0
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
7
17
4.79
2.49
1.4
1.1
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
25
152
2.88
2.42
18.2
5.1
%
58.3
58.5
0.02
25
140
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
14
64
2.88
2.29
7.6
3.4
e6/l
0.7
0.7
—
9
40
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
16
79
2.77
2.27
3.3
2.4
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
7
19
4.27
2.27
20.6
9.9
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
9
31
3.48
2.25
17.4
9.9
g/l
119.1
122.5
—
9
31
(3042936) Bacteria identified in Isolate by Culture
11
46
2.96
2.08
4.6
1.7
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
6
16
4.24
2.02
2.0
1.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
17
92
2.53
1.97
10.6
8.1
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
13
62
2.67
1.93
8.1
3.5
e6/l
0.3
2.8
—
8
38
(3020682) Albumin/Creatinine [Ratio] in Urine
19
110
2.45
1.90
9.5
4.2
mg/mmol
16.9
13.6
0.15
19
72
(3032080) INR in Blood by Coagulation assay
22
139
2.38
1.78
6.8
7.3
inr
1.0
1.2
—
5
40
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
14
72
2.50
1.78
4.4
2.2
mg/l
3.4
3.1
0.25
14
63
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
20
124
2.29
1.66
4.4
2.7
nmol/l
65.0
76.4
1.48
20
105
(3007853) Bacteria identified in Skin by Aerobe culture
8
33
2.79
1.65
2.1
1.8
—
—
—
0
0
(4010399)
6
21
3.19
1.57
1.5
1.2
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
15
84
2.30
1.56
3.9
3.5
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
17
103
2.18
1.45
3.4
2.4
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
5
110
0.37
1.43
3.8
2.8
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
17
104
2.15
1.41
5.4
2.6
u/l
24.4
28.1
0.97
17
94
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
20
131
2.11
1.39
9.1
3.3
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
26
192
2.12
1.28
14.3
4.6
mmol/l
7.4
6.7
0.70
26
175
(3019832) Treponema pallidum Ab [Presence] in Serum
5
19
2.87
1.25
2.0
1.5
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
20
2.72
1.19
27.8
8.5
mmol/l
23.0
25.4
—
5
20
(3002032) Base excess in Venous blood by calculation
8
41
2.20
1.17
13.9
5.4
mmol/l
-0.2
2.2
—
8
34
(3037522) Nuclear Ab [Titer] in Serum
9
46
2.25
1.14
1.8
1.5
—
858.5
—
0
13
(3019060) Gas panel - Arterial blood
5
21
2.58
1.12
2.4
6.5
—
—
—
0
0
(3022145) Colonoscopy Study observation
7
33
2.37
1.12
1.4
1.2
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
47
2.19
1.12
2.7
1.6
—
—
—
0
0
(3002256) Pathology report gross observation
7
34
2.29
1.09
1.1
1.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
34
2.29
1.09
2.9
1.7
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
28
219
2.06
1.09
11.5
4.7
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
18
122
1.90
1.07
3.0
2.1
pmol/l
86.8
99.1
0.68
13
67
(3004588) Protein electrophoresis panel - Serum or Plasma
5
22
2.46
1.06
14.0
2.8
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
37
2.09
1.00
2.7
1.7
—
—
—
0
0
(3012544) pH of Venous blood
8
42
2.14
0.96
13.9
5.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
13
82
1.89
0.93
6.0
3.4
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
8
46
1.93
0.89
1.6
1.2
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
23
176
1.78
0.88
2.6
2.7
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
17
123
1.69
0.76
2.2
1.9
—
—
—
0
0
(3019225) pH of Specimen
5
26
2.06
0.73
12.0
3.5
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
14
97
1.70
0.72
1.6
1.7
mmol/l
2.0
1.4
1.24
14
80
(3022621) pH of Urine by Test strip
5
27
1.98
0.71
3.2
2.3
—
—
—
0
0
(4035726)
5
30
1.76
0.63
3.0
1.2
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
21
0.00
0.62
0.0
1.2
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
0
21
0.00
0.62
0.0
1.4
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
6
40
1.59
0.54
5.2
3.2
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
7
45
1.68
0.53
1.6
1.3
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
10
69
1.61
0.50
1.6
1.8
mg/l
1.4
1.2
—
10
53
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
31
1.70
0.45
1.4
1.1
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
27
236
1.50
0.44
8.6
4.1
mm/h
19.3
13.0
0.74
27
217
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
22
185
1.45
0.44
11.0
7.3
umol/l
8.9
10.3
0.90
22
180
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
18
0.00
0.41
0.0
1.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
10
129
0.69
0.36
11.1
3.9
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
10
127
0.71
0.32
3.6
2.9
ng/l
26.8
36.6
—
5
97
(3021960) Folate [Moles/volume] in Serum or Plasma
9
73
1.30
0.28
2.3
1.7
nmol/l
20.7
20.9
—
9
61
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
13
106
1.34
0.28
4.5
3.0
u/l
73.4
56.0
1.04
13
100
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
5
37
1.40
0.25
4.2
3.5
umol/l
3.6
6.3
—
5
31
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.22
0.0
1.6
—
—
—
0
0
(4034850)
0
12
0.00
0.21
0.0
11.3
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
10
81
1.32
0.21
2.1
1.3
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
25
270
0.78
0.21
60.0
18.5
%
14.2
13.8
0.61
25
263
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
17
152
1.21
0.16
7.4
4.0
—
—
—
0
0
(3044889) 12 lead EKG panel
21
226
0.84
0.13
7.8
3.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
8
92
0.84
0.07
11.1
3.8
—
—
—
0
0
(3013512) EKG study
9
102
0.85
0.07
4.3
3.6
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
12
111
1.12
0.04
2.9
4.6
%
16.6
21.3
—
5
57
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
14
145
0.95
0.00
3.9
5.4
ug/l
1.6
4.2
0.58
14
123
(3009542) Hematocrit [Volume Fraction] of Blood
28
284
0.95
0.00
53.8
16.6
%
38.3
39.2
0.25
21
201
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011363) Streptococcus pneumoniae Ag [Presence] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44790049)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(44790048)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4146454)
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
6.0
—
10.2
—
0
9
(44806118)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
7
70
1.00
0.00
16.6
6.0
—
—
—
0
0
(44790047)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.6
—
64.0
—
0
5
(3011648) Oxygen content in Venous blood
0
8
0.00
0.00
0.0
2.5
—
11.8
—
0
8
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
4.4
—
3.8
—
0
8
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_POLYCLOHYPERGAMMA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_POLYCLOHYPERGAMMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_POLYCLOHYPERGAMMA – Polyclonal hypergammaglobulinaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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