No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
863 |
4. Check minimum number of eventsNone |
863 |
5. Include endpointsNone |
863 |
6. Filter based on genotype QC (FinnGen only) |
863 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
IgA nephropathy (IgA glomerulonephritis)
based on the number of shared cases.
Similar with more cases:
- Other and unspecified disorders involving the immune mechanism, not elsewhere classified
- Other disorders involving the immune mechanism, not elsewhere classified
- Glomerular disorders in diseases classified elsewhere
- Glomerular diseases
- Certain disorders involving the immune mechanism
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4061 | 1386 | 2634 |
| Only index persons | 3760 | 1331 | 2429 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.07 |
| Only index persons | 0.08 | 0.05 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 46.98 | 42.39 | 49.52 |
| Only index persons | 46.14 | 42.13 | 48.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 863 | 312 | 551 |
| Unadjusted period prevalence (%) | 0.19 | 0.11 | 0.24 |
| Median age at first event (years) | 47.97 | 41.71 | 51.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 763
- Matched controls
- 7628
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
323.0
762
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
3465.2
279.9
253
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
3363.8
273.9
248
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
91.8
272.4
295
52
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
92.2
263.2
285
49
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
145.0
259.7
266
28
Z94.0
ICD-10 Finland
Kidney transplant status
134.3
225.7
234
25
A11CC03
ATC
alfacalcidol; systemic
69.8
221.5
251
53
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
114.8
214.9
227
28
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
31.3
206.8
283
141
L04AA06
ATC
mycophenolic acid; systemic
74.0
194.0
218
41
127
Kela drug reimbursment
Transplant complication
68.1
189.5
216
44
A12AA04
ATC
calcium carbonate; oral
91.7
186.3
203
30
TK800
NOMESCO Finland
Hemodialysis
53.3
181.2
216
56
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
128.2
176.5
185
19
Z49.1
ICD-10 Finland
Extracorporeal dialysis
95.5
163.0
177
24
C03CA01
ATC
furosemide; systemic
9.4
160.7
423
892
B03XA02
ATC
darbepoetin alfa; parenteral
70.6
154.3
175
32
205
Kela drug reimbursment
Chronic hypertension
8.4
151.9
444
1080
137
Kela drug reimbursment
Uraemia requiring dialysis
138.5
148.5
155
14
N18.8
ICD-10 Finland
Other chronic renal failure
37.1
146.4
189
67
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
136.3
146.3
153
14
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
74.0
141.1
159
27
KA1AE
NOMESCO Finland
Kidney ultrasound examination
43.2
138.2
172
51
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
170.9
136.4
140
10
N18.0
ICD-10 Finland
End-stage renal disease
84.9
131.2
145
21
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
127.0
128.9
136
13
B05DA
ATC
Isotonic solutions
153.4
123.4
128
10
Z49.0
ICD-10 Finland
Preparatory care for dialysis
85.2
121.2
134
19
R80
ICD-10 Finland
Isolated proteinuria
97.8
119.6
130
16
Z49.2
ICD-10 Finland
Other dialysis
179.3
118.1
121
8
C08CA01
ATC
amlodipine; oral
6.0
114.0
453
1485
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.7
113.8
283
486
M04AA01
ATC
allopurinol; systemic
9.1
113.3
270
432
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
62.4
112.2
130
25
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
256.4
109.8
110
5
C09AA02
ATC
enalapril; systemic
7.0
109.7
330
746
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.3
109.2
204
204
H02AB04
ATC
methylprednisolone; systemic
7.6
105.6
291
575
B05DB
ATC
Hypertonic solutions
177.3
104.1
107
7
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
16.8
102.2
170
128
V03AE01
ATC
polystyrene sulfonate; oral
60.7
97.9
114
22
L04AD01
ATC
ciclosporin; systemic
33.2
96.9
128
46
R31
ICD-10 Finland
Unspecified haematuria
8.6
96.0
232
367
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
11.5
87.2
173
189
V03AE02
ATC
sevelamer; oral
188.3
81.9
84
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
113.0
75.5
81
8
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
127.4
75.5
80
7
TK820
NOMESCO Finland
Peritoneal dialysis
276.6
74.8
75
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
109.9
73.4
79
8
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.3
73.2
153
181
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
767.1
72.4
70
*
C02AC05
ATC
moxonidine; oral
13.2
72.2
132
119
B03XA01
ATC
erythropoietin; parenteral
45.0
71.6
88
22
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
67.2
462
2173
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
66.4
332
1178
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
109.9
65.1
70
7
L04AA01
ATC
[U] ciclosporin; systemic
30.9
62.0
83
30
N19
ICD-10 Finland
Unspecified kidney failure
15.9
59.3
99
71
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
72.0
58.3
66
10
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
25.7
57.6
81
35
C09CA01
ATC
losartan; oral
4.0
57.3
285
979
H05BX01
ATC
cinacalcet; oral
85.8
56.9
63
8
N17.9
ICD-10 Finland
Acute renal failure, unspecified
13.4
56.2
101
86
5828A
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,EI NEFR SDR]
+∞
53.8
51
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
98.6
50.5
55
6
R4110
NOMESCO Finland
Physiotherapy
3.6
50.1
301
1182
TPX10
NOMESCO Finland
Implantation of vascular injection port
12.9
49.5
90
78
C07AG02
ATC
carvedilol; oral
7.6
49.1
122
186
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
8.5
48.8
112
151
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
261.3
48.6
49
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.6
48.2
154
329
L04AX01
ATC
azathioprine; systemic
9.1
47.6
105
132
C08CA13
ATC
lercanidipine; oral
4.9
47.6
174
432
M10.9
ICD-10 Finland
Gout, unspecified
7.4
47.4
120
188
V03AE03
ATC
lanthanum carbonate; oral
130.6
46.3
49
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
127.8
45.3
48
*
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
+∞
43.1
41
*
N39.1
ICD-10 Finland
Persistent proteinuria, unspecified
59.3
43.0
50
9
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.5
42.0
135
287
C08CA02
ATC
felodipine; oral
5.2
41.4
139
311
I10
ICD-10 Finland
Essential (primary) hypertension
2.8
41.2
468
2732
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
35.5
41.2
53
16
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
43.5
39.9
49
12
K65.0
ICD-10 Finland
Acute peritonitis
27.5
39.5
54
21
U14
ICPC
Kidney symptom/complaint
24.6
38.9
55
24
D69.0
ICD-10 Finland
Allergic purpura
32.0
38.8
51
17
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
21.5
38.0
56
28
ZX120
NOMESCO Finland
Intravenous
4.9
37.9
134
315
C09CA06
ATC
candesartan; oral
3.3
36.9
230
889
3AC01
NOMESCO Finland
NA
29.0
36.4
49
18
TPH04
NOMESCO Finland
Cathetrisation of vein
3.2
35.5
224
872
N03.8
ICD-10 Finland
Chronic nephritic syndrome, other
97.1
34.0
37
*
C02CA01
ATC
prazosin; oral
21.3
33.9
50
25
TK810
NOMESCO Finland
Hemofiltration
28.0
33.2
45
17
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.3
32.8
132
352
WW200
NOMESCO Finland
Immunization
9.1
32.4
70
84
58209
ICD-8 Finland
Chronic nephritis, Unspecified
91.6
32.0
35
*
RD210
NOMESCO Finland
NA
13.0
32.0
57
47
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
9.4
31.3
66
76
C10AA05
ATC
atorvastatin; oral
2.6
31.2
329
1736
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
325.4
31.1
31
*
N082, D898
ICD-10 Finland
NA
325.4
31.1
31
*
N05.9
ICD-10 Finland
Unspecified nephritic syndrome, unspecified
325.4
31.1
31
*
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
166.7
30.9
32
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
114.8
30.9
33
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
30.5
268
1271
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
30.3
459
6070
N08.2*D57.8
ICD-10 Finland
Glomerular disorders in sickle-cell disorders
+∞
29.4
28
*
TK824
NOMESCO Finland
Replacement of peritoneal dialysis catheter extension tube
+∞
29.4
28
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
83.4
29.0
32
*
R50.9
ICD-10 Finland
Fever, unspecified
3.4
28.9
159
550
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
107.5
28.9
31
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.2
28.0
114
305
C02EA02
ATC
NA
8.0
28.0
65
88
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
80.7
28.0
31
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.1
27.5
179
694
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.7
27.3
130
399
ZXA00
NOMESCO Finland
Right side
2.6
26.9
246
1176
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
26.6
167
631
R4190
NOMESCO Finland
Nutritional therapy
6.7
26.3
69
112
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
62.3
26.1
30
5
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
62.3
26.1
30
5
XPX08
NOMESCO Finland
Intraoperative flow measurement
34.4
25.7
33
10
KBV00
NOMESCO Finland
Insertion of stent into ureter
29.6
25.6
34
12
WX203
NOMESCO Finland
Infraclavicular plexus blockade
9.3
25.2
53
61
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
60.1
25.2
29
5
H02AB06
ATC
prednisolone; systemic
2.3
25.0
383
2358
RS220
NOMESCO Finland
NA
13.7
25.0
43
33
C07AB02
ATC
metoprolol; systemic
2.9
24.7
178
734
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.0
24.6
70
126
ZXA05
NOMESCO Finland
Left side
2.6
24.0
219
1034
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
10.6
23.1
45
45
N04.9
ICD-10 Finland
Nephrotic syndrome, unspecified
41.5
22.8
28
7
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
86.1
22.8
25
*
B01AB10
ATC
tinzaparin; parenteral
4.4
22.7
86
214
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
24.8
22.3
31
13
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
22.3
357
2206
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
11.6
22.1
41
37
UKC02
NOMESCO Finland
Cystoscopy
2.8
21.9
156
632
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.3
21.9
69
141
N25.0
ICD-10 Finland
Renal osteodystrophy
82.5
21.8
24
*
L04AA05
ATC
[U] tacrolimus; systemic
118.4
21.7
23
*
M05BA04
ATC
alendronic acid; oral
5.1
21.7
70
147
M10.3
ICD-10 Finland
Gout due to impairment of renal function
32.2
21.6
28
9
7151
FHL
Kidney transplantation
61.8
21.0
24
*
D89.8
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
20.9
20
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
20.9
20
*
N00.9
ICD-10 Finland
Acute nephritic syndrome, Unspecified
215.5
20.7
21
*
T86.1
ICD-10 Finland
Kidney transplant failure and rejection
113.1
20.7
22
*
N02.9
ICD-10 Finland
Recurrent and persistent haematuria, unspecified
113.1
20.7
22
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
20.1
72
169
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
20.1
230
1206
M10.0
ICD-10 Finland
Idiopathic gout
6.3
20.0
54
91
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
36.8
19.9
25
7
C10AA01
ATC
simvastatin; oral
2.1
19.7
314
1906
N03.0
ICD-10 Finland
Chronic nephritic syndrome, minor glomerular abnormality
107.8
19.6
21
*
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
41.2
19.6
24
6
C07AB07
ATC
bisoprolol; oral
2.1
19.5
343
2165
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.1
19.3
79
211
A02BC01
ATC
omeprazole; systemic
2.3
19.1
220
1151
JAL10
NOMESCO Finland
Laparotomy and removal of foreign body
+∞
18.8
18
*
7910X
ICD-9 Finland
Nonspecific findings on examination of urine, Proteinuria[PROTEINURIA NUD]
71.7
18.8
21
*
K06.18
ICD-10 Finland
Another gingival hyperplasia
71.7
18.8
21
*
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
71.7
18.8
21
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
102.5
18.6
20
*
I15.0
ICD-10 Finland
Renovascular hypertension
30.9
18.4
24
8
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.9
18.4
46
70
WX002
NOMESCO Finland
Sedation and analgesia
2.4
18.2
172
814
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
33.8
18.0
23
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.3
17.8
48
81
N082, D899
ICD-10 Finland
NA
+∞
17.8
17
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
17.7
147
646
A46
ICD-10 Finland
Erysipelas
2.7
17.7
128
521
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.7
17.5
81
240
5997A
ICD-9 Finland
Other disorders of urethra and urinary tract, Haematuria
29.6
17.5
23
8
A10BH05
ATC
linagliptin; oral
4.9
17.4
58
126
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
17.3
82
248
212
Kela drug reimbursment
Gout
8.0
17.3
39
51
J01MA02
ATC
ciprofloxacin; systemic
2.0
17.1
299
1857
58399
ICD-8 Finland
Nephritis, unqualified
35.9
16.7
21
6
N06.9
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, unspecified
92.1
16.6
18
*
58200
ICD-8 Finland
Chronic nephritis, Cum uraemia
173.6
16.6
17
*
C08CA03
ATC
isradipine; systemic
10.7
16.3
31
30
WX892
NOMESCO Finland
Monitored bed care
3.4
16.3
81
255
WW500
NOMESCO Finland
Blood transfusion
5.2
16.3
51
104
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
15.8
102
383
H05BX02
ATC
paricalcitol; systemic
61.3
15.8
18
*
C10AA04
ATC
fluvastatin; oral
3.4
15.8
81
261
N08.2*D89.1
ICD-10 Finland
Glomerular disorders in cryoglobulinaemia
+∞
15.7
15
*
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
6.0
15.6
43
75
C09AA05
ATC
ramipril; oral
2.2
15.6
186
976
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.3
15.5
59
147
WX202
NOMESCO Finland
Supraclavicular plexus blockade
8.6
15.4
33
40
N02AX02
ATC
tramadol; systemic, rectal
1.9
15.2
330
2188
3025
Kela drug reimbursment
Calcium carbonate
20.5
15.2
22
11
H15.1
ICD-10 Finland
Episcleritis
8.5
14.9
32
39
78900
ICD-8 Finland
Abnormal urinary constituents of unspecified cause, Albuminuria
57.8
14.8
17
*
5839X
ICD-9 Finland
Nephritis and nephropathy, not specified as acute or chronic, With unspecified pathological lesion in kidney
81.7
14.6
16
*
U88
ICPC
Glomerulonephritis/nephrosis
152.7
14.5
15
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
19.6
14.3
21
11
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
14.2
173
912
K65.8
ICD-10 Finland
Other peritonitis
43.3
14.1
17
*
WX610
NOMESCO Finland
Patient controlled analgesia
14.8
14.1
23
16
A02BC02
ATC
pantoprazole; systemic
1.8
14.1
466
3533
M01AH05
ATC
etoricoxib; oral
0.5
14.0
228
3376
J01FF01
ATC
clindamycin; systemic
2.0
14.0
225
1329
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.9
14.0
265
1662
78930
ICD-8 Finland
Abnormal urinary constituents of unspecified cause, Haematuria
17.9
13.9
21
12
N02BE01
ATC
paracetamol; systemic, rectal
2.1
13.8
636
5399
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
13.7
142
694
J01CA04
ATC
amoxicillin; systemic
2.0
13.7
614
5141
Z99.2
ICD-10 Finland
Dependence on renal dialysis
76.5
13.6
15
*
M08.2
ICD-10 Finland
Juvenile arthritis with systemic onset
76.5
13.6
15
*
KAS96
NOMESCO Finland
Other transplantation of kidney or related procedure
+∞
13.6
13
*
N02.8
ICD-10 Finland
Recurrent and persistent haematuria, other
+∞
13.6
13
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
34.7
13.5
17
5
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
13.5
78
274
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
142.4
13.5
14
*
C09BA02
ATC
enalapril and diuretics; systemic
3.1
13.5
77
268
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.6
13.2
38
71
ZX108
NOMESCO Finland
Inhalation
15.4
13.1
21
14
J01MA12
ATC
levofloxacin; systemic
2.2
13.1
151
775
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.7
13.1
57
161
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
11.2
13.1
24
22
E87.5
ICD-10 Finland
Hyperkalaemia
9.6
13.0
26
28
M01AB05
ATC
diclofenac; systemic, rectal
0.6
12.8
293
3994
J01DB01
ATC
cefalexin; oral
2.0
12.7
625
5314
L01AA01
ATC
cyclophosphamide; systemic
71.0
12.6
14
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
12.6
171
937
M10
ICD-10 Finland
Gout
3.9
12.5
51
137
187
Kela drug reimbursment
MPA
132.0
12.5
13
*
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
132.0
12.5
13
*
TKA00
NOMESCO Finland
Needle biopsy of kidney or pelvis of kidney
132.0
12.5
13
*
WX402
NOMESCO Finland
General anaesthesia
2.2
12.3
143
736
A41.1
ICD-10 Finland
Sepsis due to other specified staphylococcus
18.4
12.1
18
10
C08CA05
ATC
nifedipine; systemic
3.3
12.1
61
195
C02DE10
ATC
NA
9.5
12.0
24
26
WX204
NOMESCO Finland
Axillary plexus blockaced
4.6
12.0
41
93
RS221
NOMESCO Finland
NA
7.2
11.9
28
40
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.6
11.8
53
154
B01AA03
ATC
warfarin; systemic
2.2
11.8
136
696
C03AA03
ATC
hydrochlorothiazide; oral
2.9
11.8
74
275
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
66.0
11.6
13
*
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
66.0
11.6
13
*
306
Kela drug reimbursment
Erythropoietin and darbepoetin
23.3
11.6
16
7
KBV10
NOMESCO Finland
Removal of stent from ureter
11.3
11.6
21
19
L57.0
ICD-10 Finland
Actinic keratosis
3.0
11.5
66
230
5828B
ICD-9 Finland
Chronic glomerulonephritis, With other specified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA ALIA DEF,NEFR SDR]
+∞
11.5
11
*
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
11.5
11
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
11.5
43
107
5829A
ICD-9 Finland
Chronic glomerulonephritis with unspecified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA NUD ,EI NEFR SDR]
121.7
11.5
12
*
4059B
ICD-9 Finland
Secondary hypertension, Unspecified[HYPERTONIA SECUNDARIA ALIA DEFINITA]
121.7
11.5
12
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
11.3
90
383
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.8
11.2
74
283
RS222
NOMESCO Finland
NA
7.2
11.1
26
37
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
10.2
11.0
21
21
E0000UV
ATC
NA
1.7
11.0
283
1934
5AB14
NOMESCO Finland
NA
44.0
10.9
13
*
L01BB01
ATC
NA
44.0
10.9
13
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
9.0
10.8
22
25
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
10.8
105
496
B01AB04
ATC
dalteparin; parenteral
3.7
10.8
47
134
WW400
NOMESCO Finland
Plasmaferesis
28.5
10.7
14
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
10.7
165
947
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
13.1
10.7
18
14
TJW99
NOMESCO Finland
Other minor procedure in gastrointestinal endoscopy
60.8
10.6
12
*
XF402
NOMESCO Finland
ECG with work load test
2.4
10.6
92
411
N18.4
ICD-10 Finland
Chronic kidney disease, stage 4
111.4
10.4
11
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
111.4
10.4
11
*
K65.9
ICD-10 Finland
Peritonitis, unspecified
33.0
10.4
13
*
N17.8
ICD-10 Finland
Other acute renal failure
9.0
10.3
21
24
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
7.6
10.2
23
31
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
10.2
74
300
B01AC04
ATC
clopidogrel; oral
2.1
10.2
116
589
A12BA01
ATC
potassium chloride; oral
4.3
10.1
36
86
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
5.2
10.1
30
59
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
10.1
73
294
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
10.0
74
303
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
5.7
10.0
28
51
E83.51
ICD-10 Finland
Hypocalcemia
14.8
10.0
16
11
M31.3
ICD-10 Finland
Wegener granulomatosis
40.6
10.0
12
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.2
9.9
51
166
N04.1
ICD-10 Finland
Nephrotic syndrome, focal and segmental glomerular lesions
26.4
9.8
13
5
C08DB01
ATC
diltiazem; oral
3.7
9.8
41
114
5820A
ICD-9 Finland
Chronic glomerulonephritis, With lesion of proliferative glomerulonephritis[GLOMERULONEPHRITIS CHRONICA PROLIF,EI NEFR SDR]
55.7
9.7
11
*
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
15.3
9.5
15
10
TK830
NOMESCO Finland
Ultrafiltration
101.2
9.4
10
*
PB1DE
NOMESCO Finland
Upper extremity arteries ultrasound examination with Doppler method
17.8
9.4
14
8
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
9.4
9
*
TK823
NOMESCO Finland
Peritoneal permeability analysis
+∞
9.4
9
*
D89.9
ICD-10 Finland
Disorder involving the immune mechanism, unspecified
+∞
9.4
9
*
GD1LA
NOMESCO Finland
GD
6.8
9.2
22
33
UJF32
NOMESCO Finland
Coloscopy
1.8
9.1
174
1072
GD1AD
NOMESCO Finland
Thorax CT examination
3.4
9.0
43
133
J01MA14
ATC
moxifloxacin; systemic
2.4
9.0
78
346
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
9.0
290
2082
UJF92
NOMESCO Finland
Capsular endoscopy
5.6
9.0
25
46
A41.9
ICD-10 Finland
Sepsis, unspecified
3.9
8.9
35
92
BBA50
NOMESCO Finland
Total parathyroidectomy
50.6
8.7
10
*
40399
ICD-8 Finland
Hypertensive renal disease
50.6
8.7
10
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
8.7
66
276
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
8.6
84
397
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
11.7
8.6
15
13
PG1AE
NOMESCO Finland
Ultrasound examination of artery not elsewher classified
16.5
8.6
13
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
8.5
116
630
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
5.2
8.5
25
49
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.5
8.5
38
112
ECA35
NOMESCO Finland
Complicated excision of lesion of gingiva
27.8
8.5
11
*
KH1EE
NOMESCO Finland
Urologic ultrasound examination
20.3
8.5
12
6
B07.9
ICD-10 Finland
Verruca simplex
3.6
8.5
37
107
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.0
8.4
32
82
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
8.4
106
560
B05D
ATC
PERITONEAL DIALYTICS
91.0
8.4
9
*
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
12.9
8.4
14
11
WX110
NOMESCO Finland
Local anesthesy
1.6
8.4
509
4249
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
8.4
124
695
N082, D890
ICD-10 Finland
NA
+∞
8.3
8
*
N04.89
ICD-10 Finland
Nephrotic syndrome, other
+∞
8.3
8
*
N082, D8989
ICD-10 Finland
NA
+∞
8.3
8
*
N082, Z940
ICD-10 Finland
NA
+∞
8.3
8
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
8.2
74
339
M13.9
ICD-10 Finland
Arthritis, unspecified
2.5
8.2
63
266
T92
ICPC
Gout
4.9
8.1
25
52
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
17.4
8.1
12
7
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
22.3
8.0
11
5
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.3
8.0
38
118
C09CA07
ATC
telmisartan; oral
2.6
8.0
58
237
K05.30
ICD-10 Finland
Periodontitis complex
2.1
7.9
96
498
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
7.9
63
268
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.6
7.8
55
221
K05.11
ICD-10 Finland
Gingivitis (chronic) hyperplastic
45.4
7.7
9
*
ZX197
NOMESCO Finland
NA
45.4
7.7
9
*
SPAT1262
SPAT
Handing over of treatment supplies
1.8
7.7
137
820
J01CF05
ATC
flucloxacillin; systemic
3.2
7.6
39
128
A41.8
ICD-10 Finland
Other specified sepsis
6.8
7.6
18
27
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
7.6
72
336
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
25.3
7.6
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.6
146
898
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.8
7.6
46
170
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.6
7.6
32
91
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
6.6
7.4
18
28
4019X
ICD-9 Finland
Essential hypertension, Unspecified
4.6
7.4
24
53
KAS40
NOMESCO Finland
Excision of transplanted kidney
80.8
7.4
8
*
I12.9
ICD-10 Finland
Hypertensive renal disease without renal failure
80.8
7.4
8
*
SCB02
NOMESCO Finland
Training for mouth care at home
80.8
7.4
8
*
L95.8
ICD-10 Finland
Other vasculitis limited to skin
80.8
7.4
8
*
O12.1
ICD-10 Finland
Gestational proteinuria
13.5
7.4
12
9
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
7.4
52
210
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
3.6
7.3
31
88
H02AB07
ATC
prednisone; oral
2.0
7.3
98
530
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.3
7.3
65
293
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
11.0
7.3
13
12
4AA09
NOMESCO Finland
NA
+∞
7.3
7
*
D89.0
ICD-10 Finland
Polyclonal hypergammaglobulinaemia
+∞
7.3
7
*
5829B
ICD-9 Finland
Chronic glomerulonephritis with unspecified pathological lesion in kidney[GLOMERULONEPHRITIS CHRONICA NUD ,NEFR SDR]
+∞
7.3
7
*
6119
FHL
Other measure in this category
+∞
7.3
7
*
5809A
ICD-9 Finland
Acute glomerulonephritis with unspecified pathological lesion in kidney[GLOMERULONEPHRITIS ACUTA NUD,EI NEFR SDR]
+∞
7.3
7
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
7.3
65
296
E21.2
ICD-10 Finland
Other hyperparathyroidism
15.9
7.2
11
7
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
7.2
77
380
XF600
NOMESCO Finland
Bloodpressure measurement
2.5
7.2
53
217
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
20.2
7.1
10
5
XF612
NOMESCO Finland
Measurement of central venous pressure
20.2
7.1
10
5
288
Kela drug reimbursment
Febuxostat
12.2
7.1
12
10
M04AA03
ATC
febuxostat; oral
12.2
7.1
12
10
I50.0
ICD-10 Finland
Congestive heart failure
2.9
7.1
41
146
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.6
7.1
30
86
A06AD11
ATC
lactulose; oral
2.1
7.1
82
420
C07AG01
ATC
labetalol; systemic
7.1
7.0
16
23
K05.31
ICD-10 Finland
Periodontitis pronounced
2.2
7.0
73
357
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
5.9
6.9
18
31
FM1LE
NOMESCO Finland
Combined ultrasound and EKG examination of heart with tolerance test
13.9
6.9
11
8
J05AB11
ATC
valaciclovir; oral
2.0
6.9
91
491
WZC30
NOMESCO Finland
Teaching
1.9
6.9
98
541
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.9
6.9
21
44
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.7
6.9
45
174
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
6.8
204
1415
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.2
6.8
24
58
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.1
6.8
25
63
Z94.4
ICD-10 Finland
Liver transplant status
16.9
6.8
10
6
PG9AC
NOMESCO Finland
Arteriography with X-ray not elsewhere classified
16.9
6.8
10
6
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.8
6.7
128
782
C10AA03
ATC
pravastatin; oral
2.5
6.7
48
196
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.4
6.7
53
227
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
22.7
6.7
9
*
C10AX09
ATC
ezetimibe; oral
2.0
6.7
83
435
B02.9
ICD-10 Finland
Zoster without complication
3.0
6.7
38
133
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.2
6.7
19
37
WX882
NOMESCO Finland
High dependency care
4.3
6.7
23
55
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
7.9
6.6
14
18
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.6
147
942
SPAT1255
SPAT
Intravenous administration of medicine
2.5
6.6
50
210
JN4AD
NOMESCO Finland
Body CT examination
2.3
6.6
56
250
SCD01
NOMESCO Finland
Simple removal of tooth plaque or tartar
8.8
6.6
13
15
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
6.5
84
446
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
5.1
6.5
19
38
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.6
6.5
174
1172
PBM09
NOMESCO Finland
Closure of arteriovenous fistula of brachial artery
70.4
6.4
7
*
58199
ICD-8 Finland
Nephrotic syndrome
70.4
6.4
7
*
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.1
6.4
33
110
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
6.4
54
238
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
14.4
6.4
10
7
TPX15
NOMESCO Finland
Removal of vascular injection port
14.4
6.4
10
7
58099
ICD-8 Finland
Acute nephritis
14.4
6.4
10
7
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.4
6.4
51
219
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
5.0
6.4
19
39
C09DA01
ATC
losartan and diuretics; oral
2.1
6.4
71
359
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.2
6.3
61
287
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
6.3
141
901
H26.3
ICD-10 Finland
Drug-induced cataract
11.1
6.3
11
10
EE1AA
NOMESCO Finland
X-ray of upper jaw or palate
11.1
6.3
11
10
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
11.1
6.3
11
10
RJ420
NOMESCO Finland
NA
11.1
6.3
11
10
N03.5
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangiocapillary glomerulonephritis
+∞
6.3
6
*
N06.3
ICD-10 Finland
Isolated proteinuria with specified morphological lesion, diffuse mesangial proliferative glomerulonephritis
+∞
6.3
6
*
4059A
ICD-9 Finland
Secondary hypertension, Unspecified[HYPERTONIA RENOVASCULARIS]
+∞
6.3
6
*
N00.3
ICD-10 Finland
Acute nephritic syndrome, Diffuse mesangial proliferative glomerulonephritis
+∞
6.3
6
*
N0839, D8980
ICD-10 Finland
NA
+∞
6.3
6
*
7101
FHL
Needle biopsy in the operating room
+∞
6.3
6
*
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
6.3
6
*
K02.9
ICD-10 Finland
Dental caries, unspecified
4.8
6.3
19
40
R60.0
ICD-10 Finland
Localized oedema
2.0
6.2
72
369
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
5.4
6.2
17
32
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
6.2
69
347
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
6.2
178
1221
XQ848
NOMESCO Finland
Dermatological photography
4.3
6.2
21
50
C02DE02
ATC
NA
7.8
6.1
13
17
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
6.1
168
1137
HA1AA
NOMESCO Finland
X-ray mammography
2.8
6.1
37
138
EB1WA
NOMESCO Finland
NA
8.7
6.1
12
14
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.6
6.1
43
174
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.2
6.0
21
51
Mortality – FinRegistry
↥Association
Association between endpoint N14_IGA_NEPHROPATHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_IGA_NEPHROPATHY | 2.567 [2.14, 3.08] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.191 |
During the follow-up period (1.1.1998 — 31.12.2019), 172 out of 1288 females with N14_IGA_NEPHROPATHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_IGA_NEPHROPATHY | 2.249 [1.99, 2.54] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 541 out of 2443 males with N14_IGA_NEPHROPATHY died.
Mortality risk
Mortality risk for people of age
years, who have N14_IGA_NEPHROPATHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.378% |
| 5 | 1.454% | 2.341% |
| 10 | 3.623% | 6.074% |
| 15 | 7.022% | 11.139% |
| 20 | 12.642% | 18.605% |
Relationships between endpoints
↥Index endpoint: N14_IGA_NEPHROPATHY – IgA nephropathy (IgA glomerulonephritis)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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